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AR093518A1 - Compuestos de pirrolpirimidina como inhibidores de quinasas - Google Patents

Compuestos de pirrolpirimidina como inhibidores de quinasas

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Publication number
AR093518A1
AR093518A1 ARP130104233A ARP130104233A AR093518A1 AR 093518 A1 AR093518 A1 AR 093518A1 AR P130104233 A ARP130104233 A AR P130104233A AR P130104233 A ARP130104233 A AR P130104233A AR 093518 A1 AR093518 A1 AR 093518A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
cycloalkyl
alkyl
independently
Prior art date
Application number
ARP130104233A
Other languages
English (en)
Inventor
Chen Wei
J Loury David
Wang Longcheng
Original Assignee
Pharmacyclics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50728514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR093518(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of AR093518A1 publication Critical patent/AR093518A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos que forman enlaces covalentes con la tirosina quinasa de Bruton (Btk). También se describen inhibidores irreversibles de Btk, inhibidores reversibles de Btk. Se divulgan asimismo composiciones farmacéuticas que incluyen a dichos compuestos y métodos para utilizar los inhibidores Btk, ya sea solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, inclusive el linfoma, y enfermedades o condiciones inflamatorias. Reivindicación 1: Un compuesto caracterizado porque tiene la estructura de fórmula (1) donde: R¹ es halógeno, -CN, -OR²¹, -N(R²¹)(R²²), -SR²¹, alquilo C₁₋₆ sustituido o no sustituido, alcoxi C₁₋₄ sustituido o no sustituido, heteroalquilo C₁₋₆ sustituido o no sustituido, fenilo sustituido o no sustituido, heteroarilo sustituido o no sustituido o cicloalquilo C₃₋₈ sustituido o no sustituido; G es alquenilo C₂₋₄ sustituido o no sustituido, alquinilo C₂₋₄ sustituido o no sustituido, cicloalquilo C₃₋₈ sustituido o no sustituido, alcoxi C₁₋₄ sustituido o no sustituido, heteroalquilo C₁₋₄ sustituido o no sustituido, heterocicloalquilo C₂₋₇ sustituido o no sustituido, halógeno, -CN, -NO₂, -OR²¹, -OCF₃, -OCH₂F, -OCF₂H, -CF₃, -SCH₃, -N(R²¹)S(=O)₂R²³, S(=O)₂N(R²¹)(R²²), -S(=O)R²³, -S(=O)₂R²³, -C(=O)R²³, -OC(=O)R²³, -CO₂R²¹, N(R²¹)(R²²), -C(=O)N(R²¹)(R²²), -N(R²¹)C(=O)R²³, N(R²¹)C(=O)OR²², N(R²¹)C(=O)N(R²¹)(R²²) o Lᵃ-A; Lᵃ es un enlace, -C(R²¹)(R²²)-, -CR²¹(OR²¹)-, -C(O)-, -O(R²¹)(R²²)-, -S(R²¹)(R²²)-, -C(R²¹)(R²²)S-, -N(R²¹)-, -N(R²¹)C(O)-, -C(O)N(R²¹)-, -N(R²¹)C(O)N(R²¹)-, -O-, -S-, -S(O)-, -S(O)₂-, -N(R²¹)S(O)₂-, o -S(O)₂N(R²¹)-; A es un cicloalquilo sustituido o no sustituido, heterocicloalquilo sustituido o no sustituido, arilo sustituido o no sustituido, o un heteroarilo sustituido o no sustituido; cada R²⁴ es en forma independiente halógeno, -CN, -NO₂, -OH, -OCF₃, -OCH₂F, -OCF₂H, -CF₃, -SCH₃, -N(R²¹)S(=O)₂R²³, S(=O)₂N(R²¹)(R²²), -S(=O)R²³, -S(=O)₂R²³, -C(=O)R²³, -OC(=O)R²³, -CO₂R²¹, N(R²¹)(R²²), -C(=O)N(R²¹)(R²²) -N(R²¹)C(=O)R²³, N(R²¹)C(=O)OR²², N(R²¹)C(=O)N(R²¹)(R²²), alquilo sustituido o no sustituido, alcoxi sustituido o no sustituido, heteroalquilo sustituido o no sustituido, heterocicloalquilo sustituido o no sustituido, o cicloalquilo sustituido o no sustituido; cada R²¹ y R²² es en forma independiente H, alquilo C₁₋₆ sustituido o no sustituido, o cicloalquilo C₃₋₈ sustituido o no sustituido; cada R²³ es cada uno en forma independiente alquilo C₁₋₆ sustituido o no sustituido, o cicloalquilo C₃₋₈ sustituido o no sustituido; n es 0 - 4; Y es un grupo opcionalmente sustituido seleccionado entre alquileno C₁₋₆, heteroalquileno C₁₋₆, arileno C₆₋₁₂, heteroarileno C₃₋₁₂, alquilen C₁₋₆arileno C₆₋₁₂, alquilen C₁₋₆heteroarileno C₃₋₁₂, alquilen C₁₋₆cicloalquileno C₃₋₈, alquilen C₁₋₆heterocicloalquileno C₂₋₇, cicloalquileno C₃₋₈, heterocicloalquileno C₂₋₇cicloalquilen C₃₋₈heterocicloalquileno C₂₋₇ fusionado, y cicloalquilen C₃₋₈heterocicloalquileno C₂₋₇ espiro; Z es -C(=O), -N(Rᵃ)C(=O), -S(=O)ˣ, o -N(Rᵃ)S(=O)ˣ, donde x es 1 ó 2, y Rᵃ es H, alquilo C₁₋₆ sustituido o no sustituido, o cicloalquilo C₃₋₈ sustituido o no sustituido; R⁶ es H, -CN, halógeno, o L-J-W; R⁷ y R⁸ son en forma independiente H, -CN, halógeno, o L-J-W; o R⁷ y R⁸ tomados juntos forman un enlace; L y J son en forma independiente entre sí un enlace, alquileno C₁₋₆ sustituido o no sustituido, cicloalquileno C₃₋₈ sustituido o no sustituido, heteroalquileno C₁₋₆ sustituido o no sustituido, heterocicloalquileno C₂₋₇ sustituido o no sustituido, arileno C₆₋₁₂ sustituido o no sustituido, heteroarileno C₃₋₁₂ sustituido o no sustituido, -CO-, -O-, o -S-; W es H o NR²⁵R²⁶; y R²⁵ y R²⁶ son en forma independiente entre sí H, alquilo C₁₋₆ sustituido o no sustituido, cicloalquilo C₃₋₈ sustituido o no sustituido, heteroalquilo C₁₋₆ sustituido o no sustituido, heterocicloalquilo C₂₋₇ sustituido o no sustituido, arilo C₆₋₁₂ sustituido o no sustituido, o heteroarilo C₃₋₁₂ sustituido o no sustituido; o un solvato farmacéuticamente aceptable, sal farmacéuticamente aceptable, o prodroga farmacéuticamente aceptable del mismo.
ARP130104233A 2012-11-15 2013-11-18 Compuestos de pirrolpirimidina como inhibidores de quinasas AR093518A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261727031P 2012-11-15 2012-11-15

Publications (1)

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AR093518A1 true AR093518A1 (es) 2015-06-10

Family

ID=50728514

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Country Status (24)

Country Link
US (3) US9096604B2 (es)
EP (1) EP2920180A4 (es)
JP (1) JP2015537033A (es)
KR (1) KR20150084923A (es)
CN (1) CN104854107A (es)
AR (1) AR093518A1 (es)
AU (1) AU2013344656A1 (es)
BR (1) BR112015011171A2 (es)
CA (1) CA2890934A1 (es)
CL (1) CL2015001268A1 (es)
CR (1) CR20150263A (es)
DO (1) DOP2015000108A (es)
EA (1) EA201590855A1 (es)
HK (1) HK1215253A1 (es)
IL (1) IL238728A0 (es)
MA (1) MA38183A1 (es)
MX (1) MX2015006168A (es)
NI (1) NI201500067A (es)
PE (1) PE20151495A1 (es)
PH (1) PH12015501067A1 (es)
SG (1) SG11201503842PA (es)
TN (1) TN2015000174A1 (es)
TW (1) TWI522359B (es)
WO (1) WO2014078578A1 (es)

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