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AR098979A1 - Los fragmentos fab de la inmunoglobulina en tándem y sus usos - Google Patents

Los fragmentos fab de la inmunoglobulina en tándem y sus usos

Info

Publication number
AR098979A1
AR098979A1 ARP140104935A ARP140104935A AR098979A1 AR 098979 A1 AR098979 A1 AR 098979A1 AR P140104935 A ARP140104935 A AR P140104935A AR P140104935 A ARP140104935 A AR P140104935A AR 098979 A1 AR098979 A1 AR 098979A1
Authority
AR
Argentina
Prior art keywords
binding protein
binding
human
antigen
subject
Prior art date
Application number
ARP140104935A
Other languages
English (en)
Inventor
Wu Chengbin
Original Assignee
Epimab Biotherapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epimab Biotherapeutics filed Critical Epimab Biotherapeutics
Publication of AR098979A1 publication Critical patent/AR098979A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Abstract

Reivindicación 1: Una proteína de unión caracterizada porque comprende, al menos, dos cadenas de polipéptidos, donde las cadenas de polipéptidos se unen para formar moléculas tipo IgG capaces de unir dos o más antígenos, donde la primera cadena de polipéptidos comprende a VLA, CL, VHB, y CH1; donde VL es un dominio variable de cadena liviana, CL es un dominio constante de cadena liviana, VH es un dominio variable de cadena pesada, CH1 es el primer dominio constante de la cadena pesada, A es un primer antígeno y B es un segundo antígeno. Reivindicación 24: La proteína de unión de la reivindicación 23, caracterizada porque la proteína de unión une IL-17 humana e IL-20 humana. Reivindicación 29: La proteína de unión de la reivindicación 28, caracterizada porque la proteína de unión es capaz de unir CD3 humana y CD20 humana. Reivindicación 49: Un método para tratar una enfermedad seleccionada del grupo de consiste en artritis reumatoidea, psoriasis, osteoporosis, accidente cerebrovascular, enfermedad hepática y cáncer oral en un sujeto que lo necesite; caracterizado porque el método porque comprende la administración al sujeto de una proteína de unión conforme a la reivindicación 1, donde la proteína de unión sea capaz de unir a IL-17 e IL-20.
ARP140104935A 2013-12-30 2014-12-29 Los fragmentos fab de la inmunoglobulina en tándem y sus usos AR098979A1 (es)

Applications Claiming Priority (1)

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CN2013090923 2013-12-30

Publications (1)

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AR098979A1 true AR098979A1 (es) 2016-06-22

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