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PE20180481A1 - Anticuerpos de union a tau - Google Patents

Anticuerpos de union a tau

Info

Publication number
PE20180481A1
PE20180481A1 PE2017002750A PE2017002750A PE20180481A1 PE 20180481 A1 PE20180481 A1 PE 20180481A1 PE 2017002750 A PE2017002750 A PE 2017002750A PE 2017002750 A PE2017002750 A PE 2017002750A PE 20180481 A1 PE20180481 A1 PE 20180481A1
Authority
PE
Peru
Prior art keywords
seq
tau
binding antibody
variable region
heavy chain
Prior art date
Application number
PE2017002750A
Other languages
English (en)
Inventor
David Edward Ormonde Knight
Terence Seward Baker
David James Mcmillan
Robert Anthony Griffin
Georges Mairet-Coello
Patrick Downey
Jean-Philippe Courade
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53524640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20180481(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of PE20180481A1 publication Critical patent/PE20180481A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Referido a un anticuerpo aislado de union a Tau o fragmento de union del mismo caracterizado porque comprende una region variable de cadena ligera que comprende una CDR1 seleccionada a partir de SEQ ID No.: 1, una CDR2 seleccionada a partir de SEQ ID No.: 2 y una CDR3 seleccionada a partir de SEQ ID No.: 3; y una region variable de cadena pesada que comprende una CDR1 seleccionada a partir de SEQ ID No.: 4, una CDR2 seleccionada a partir de SEQ ID No.: 5, y/o una CDR3 seleccionada a partir de SEQ ID No.: 6. Tambien se refiere a una molecula aislada de acido nucleico, que codifica para la cadena ligera y/o pesada de un anticuerpo de union a Tau; un vector de clonacion o expresion, una celula hospedadora, y un metodo para producir un anticuerpo de union a Tau; en donde se utilizan en el tratamiento de una tauopatia, como en la enfermedad de Alzheimer o en la paralisis supranuclear progresiva.
PE2017002750A 2015-07-06 2016-07-05 Anticuerpos de union a tau PE20180481A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15175522 2015-07-06

Publications (1)

Publication Number Publication Date
PE20180481A1 true PE20180481A1 (es) 2018-03-07

Family

ID=53524640

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002750A PE20180481A1 (es) 2015-07-06 2016-07-05 Anticuerpos de union a tau

Country Status (25)

Country Link
US (4) US10287343B2 (es)
EP (1) EP3319983B1 (es)
JP (3) JP6630426B2 (es)
KR (2) KR102770650B1 (es)
CN (1) CN107849104B (es)
AR (1) AR105267A1 (es)
AU (1) AU2016289755C1 (es)
CA (1) CA2991451A1 (es)
CL (1) CL2018000043A1 (es)
CO (1) CO2017012971A2 (es)
EA (1) EA037092B1 (es)
EC (1) ECSP18000887A (es)
IL (1) IL256685B (es)
MA (2) MA41670A1 (es)
MX (1) MX2017015817A (es)
MY (1) MY193677A (es)
PE (1) PE20180481A1 (es)
PH (1) PH12017502207B1 (es)
SG (1) SG10202010735PA (es)
TN (1) TN2017000539A1 (es)
TW (1) TWI745295B (es)
UA (1) UA124616C2 (es)
UY (1) UY36773A (es)
WO (1) WO2017005734A1 (es)
ZA (1) ZA201800027B (es)

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Also Published As

Publication number Publication date
JP2020055849A (ja) 2020-04-09
WO2017005734A1 (en) 2017-01-12
JP7413448B2 (ja) 2024-01-15
KR20250027278A (ko) 2025-02-25
AU2016289755C1 (en) 2021-08-19
PH12017502207A1 (en) 2018-06-11
MA41670A1 (fr) 2018-05-31
JP2022141689A (ja) 2022-09-29
TW201713689A (zh) 2017-04-16
CL2018000043A1 (es) 2018-05-18
CA2991451A1 (en) 2017-01-12
UA124616C2 (uk) 2021-10-20
EA201890172A1 (ru) 2018-10-31
IL256685B (en) 2022-02-01
CN107849104A (zh) 2018-03-27
US20190284267A1 (en) 2019-09-19
EP3319983A1 (en) 2018-05-16
US11732034B2 (en) 2023-08-22
ECSP18000887A (es) 2018-03-31
NZ738058A (en) 2021-07-30
UY36773A (es) 2017-01-31
JP2018524001A (ja) 2018-08-30
ZA201800027B (en) 2019-06-26
JP6630426B2 (ja) 2020-01-15
AU2016289755A1 (en) 2018-01-04
BR112017028102A2 (en) 2018-09-04
MY193677A (en) 2022-10-25
PH12017502207B1 (en) 2022-08-10
US20230416350A1 (en) 2023-12-28
US20210115121A1 (en) 2021-04-22
EA037092B1 (ru) 2021-02-04
CO2017012971A2 (es) 2018-03-09
JP7100008B2 (ja) 2022-07-12
MA42377A (fr) 2018-05-16
AR105267A1 (es) 2017-09-20
AU2016289755B2 (en) 2020-12-03
US10287343B2 (en) 2019-05-14
IL256685A (en) 2018-03-29
HK1246804A1 (zh) 2018-09-14
CN107849104B (zh) 2021-08-27
TWI745295B (zh) 2021-11-11
EP3319983B1 (en) 2026-01-28
US20180201666A1 (en) 2018-07-19
KR102770650B1 (ko) 2025-02-19
US10889640B2 (en) 2021-01-12
MX2017015817A (es) 2018-04-10
KR20180025962A (ko) 2018-03-09
TN2017000539A1 (en) 2019-04-12
SG10202010735PA (en) 2020-11-27

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