AR097561A2 - Un método para la obtención de una composición que comprende una población aislada de moléculas del antígeno 4 de linfocito t citotóxico ligado a la región constante de cadena pesada de inmunoglobulina (ctla-ig) a partir de un medio de cultivo líquido - Google Patents
Un método para la obtención de una composición que comprende una población aislada de moléculas del antígeno 4 de linfocito t citotóxico ligado a la región constante de cadena pesada de inmunoglobulina (ctla-ig) a partir de un medio de cultivo líquidoInfo
- Publication number
- AR097561A2 AR097561A2 ARP140103315A ARP140103315A AR097561A2 AR 097561 A2 AR097561 A2 AR 097561A2 AR P140103315 A ARP140103315 A AR P140103315A AR P140103315 A ARP140103315 A AR P140103315A AR 097561 A2 AR097561 A2 AR 097561A2
- Authority
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- Argentina
- Prior art keywords
- ctla4
- molecules
- composition
- obtaining
- medium
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 101710135378 pH 6 antigen Proteins 0.000 title 1
- 239000001963 growth medium Substances 0.000 abstract 3
- 238000009630 liquid culture Methods 0.000 abstract 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 abstract 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 abstract 2
- 239000000539 dimer Substances 0.000 abstract 2
- 125000005629 sialic acid group Chemical group 0.000 abstract 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Un método para la obtención de una composición que comprende una población aislada de moléculas CTLA4-Ig a partir de un medio de cultivo líquido, el medio comprende una población inicial de moléculas CTLA4-Ig, en donde (1) las moléculas CTLA4-Ig de la población inicial tienen uno o más residuos de ácido siálico, (2) el número de residuos de ácido siálico por molécula CTLA4-Ig varía dentro de la población inicial, y (3) la población inicial comprende el dímero CTLA4-Ig y agregados de alto peso molecular, y (4) el medio de cultivo liquido contiene MCP-1, que comprende: (i) cosechar el medio de cultivo liquido a partir de un cultivo de células de mamíferos que expresan las moléculas CTLA4-Ig; (ii) separar las moléculas CTLA4-Ig de los componentes celulares; (iii) usar una columna cromatográfica para reducir el contenido de MCP-1 en la composición; (iv) usar una columna cromatográfica para separar los dímeros de CTLA4-Ig de los agregados de alto peso molecular de CTLA4-Ig; y (v) usar una columna cromatográfica para separar las moléculas CTLA4-Ig en dos o más fracciones, en donde al menos una fracción tiene una relación molar mayor de ácido siálico a las moléculas CTLA4-Ig comparado con al menos otra fracción; vi) en donde las etapas (ii), (iii), (iv) y (v) se llevan a cabo simultáneamente o en cualquier orden, de manera de obtener la composición.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75215005P | 2005-12-20 | 2005-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR097561A2 true AR097561A2 (es) | 2016-03-23 |
Family
ID=38057529
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105626A AR058567A1 (es) | 2005-12-20 | 2006-12-19 | Formulaciones de proteinas estables |
| ARP140103315A AR097561A2 (es) | 2005-12-20 | 2014-09-04 | Un método para la obtención de una composición que comprende una población aislada de moléculas del antígeno 4 de linfocito t citotóxico ligado a la región constante de cadena pesada de inmunoglobulina (ctla-ig) a partir de un medio de cultivo líquido |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105626A AR058567A1 (es) | 2005-12-20 | 2006-12-19 | Formulaciones de proteinas estables |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8476239B2 (es) |
| EP (1) | EP1962886B2 (es) |
| JP (2) | JP5247467B2 (es) |
| KR (1) | KR101378194B1 (es) |
| CN (3) | CN101822820A (es) |
| AR (2) | AR058567A1 (es) |
| AU (1) | AU2006330593B2 (es) |
| BR (1) | BRPI0622256A2 (es) |
| CA (1) | CA2634547C (es) |
| CL (1) | CL2010000816A1 (es) |
| DK (1) | DK1962886T4 (es) |
| EA (1) | EA014232B1 (es) |
| ES (1) | ES2436616T5 (es) |
| HR (1) | HRP20131196T4 (es) |
| IL (1) | IL192104A (es) |
| NO (1) | NO347247B1 (es) |
| NZ (1) | NZ569108A (es) |
| PE (1) | PE20071063A1 (es) |
| PL (1) | PL1962886T6 (es) |
| PT (1) | PT1962886E (es) |
| RS (1) | RS53127B2 (es) |
| SG (1) | SG153832A1 (es) |
| TW (3) | TW200738261A (es) |
| WO (1) | WO2007076354A2 (es) |
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| WO2007076354A2 (en) * | 2005-12-20 | 2007-07-05 | Bristol-Myers Squibb Company | Stable protein formulations |
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| US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| US7915222B2 (en) | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
| EP4183425A1 (en) | 2008-10-06 | 2023-05-24 | 3-D Matrix Ltd. | Tissue plug |
| EP2445616B1 (en) * | 2009-06-23 | 2018-05-02 | GE Healthcare Bio-Sciences AB | Simulator device |
| GB201009676D0 (en) * | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| JP5847418B2 (ja) | 2011-03-30 | 2016-01-20 | 富士フイルム株式会社 | 細胞接着性タンパク質 |
| WO2012142434A2 (en) * | 2011-04-15 | 2012-10-18 | THE UNITED STATES OF AMERICA, as represented by the secretary, Depart.of Healtth and Human Services | Aav mediated ctla-4 gene transfer to treat sjogren's syndrome |
| EP2709653B1 (en) | 2011-04-20 | 2017-11-22 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Aav mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity |
| TWI527590B (zh) * | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
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| WO2024069420A2 (en) * | 2022-09-29 | 2024-04-04 | Pfizer Inc. | Immunogenic compositions comprising an rsv f protein trimer |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| WO2025196207A1 (en) | 2024-03-20 | 2025-09-25 | King's College London | Compositions and methods for use in depleting senescent cells and treating aging |
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| NZ262634A (en) * | 1993-02-23 | 1997-02-24 | Genentech Inc | Stabilizing polypeptides against degradation by organic solvents by admixing the peptide with trehalose or mannitol |
| DE4405426A1 (de) | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| ES2434840T3 (es) * | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| WO2003005465A1 (en) | 2001-04-25 | 2003-01-16 | Quallion, Llc | Rechargeable lithium battery for tolerating discharge to zero volts |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
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| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| CZ303959B6 (cs) * | 2000-07-03 | 2013-07-17 | Bristol-Myers Squibb Company | Solubilní CTLA4 fúzní molekula, farmaceutický prostredek s jejím obsahem a její pouzití |
| JP2004535364A (ja) | 2001-01-26 | 2004-11-25 | エモリー・ユニバーシティ | 臓器移植の免疫寛容を誘発し、異常血色素症を処置する方法 |
| ATE482716T1 (de) | 2001-11-13 | 2010-10-15 | Genentech Inc | Zusammensetzungen basierend auf apo2-ligand/ trail und ihre verwendung |
| DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| CN101721362B (zh) | 2002-02-14 | 2018-07-03 | 中外制药株式会社 | 包含抗体的溶液制剂 |
| ES2354610T5 (es) | 2002-12-23 | 2020-09-14 | Bristol Myers Squibb Co | Mejora de la calidad del producto en procedimientos de cultivo de células de mamífero para la producción de proteína |
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| EP3178492A1 (en) * | 2003-04-04 | 2017-06-14 | Genentech, Inc. | High concentration antibody and protein formulations |
| RU2353384C2 (ru) | 2003-08-04 | 2009-04-27 | Бристол-Маерс Сквибб Компани | Способ лечения сердечно-сосудистого заболевания с применением растворимого ctla4 |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| AU2006295340B2 (en) * | 2005-08-05 | 2010-11-11 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
| WO2007076354A2 (en) * | 2005-12-20 | 2007-07-05 | Bristol-Myers Squibb Company | Stable protein formulations |
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