AR109355A2 - Moléculas de unión al receptor ox40 humano - Google Patents
Moléculas de unión al receptor ox40 humanoInfo
- Publication number
- AR109355A2 AR109355A2 ARP170102289A ARP170102289A AR109355A2 AR 109355 A2 AR109355 A2 AR 109355A2 AR P170102289 A ARP170102289 A AR P170102289A AR P170102289 A ARP170102289 A AR P170102289A AR 109355 A2 AR109355 A2 AR 109355A2
- Authority
- AR
- Argentina
- Prior art keywords
- molecules
- binding molecules
- binding
- amino acid
- acid sequence
- Prior art date
Links
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 title 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente descripción proporciona moléculas de unión aisladas que se unen al OX40R humano, las moléculas de ácido nucleico que codifican la secuencia de aminoácidos de las moléculas de unión, los vectores que comprenden las moléculas de ácido nucleicos, las células huésped que contienen los vectores, los métodos de obtención de las moléculas de unión, las composiciones farmacéuticas que contienen las moléculas de unión, y los métodos de uso de las moléculas de unión o composiciones. Reivindicación 1: Una molécula de unión aislada que compite por la unión a OX40R humano con un anticuerpo que comprende: (a) una región variable de cadena pesada que comprende la secuencia de aminoácidos de la SEC ID Nº 7; y (b) una región variable de cadena liviana que comprende la secuencia de aminoácidos de la SEC ID Nº 8.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1394707P | 2007-12-14 | 2007-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109355A2 true AR109355A2 (es) | 2018-11-21 |
Family
ID=40552119
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105418A AR069681A1 (es) | 2007-12-14 | 2008-12-12 | Moleculas de union al receptor ox40 humano |
| ARP170102289A AR109355A2 (es) | 2007-12-14 | 2017-08-16 | Moléculas de unión al receptor ox40 humano |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105418A AR069681A1 (es) | 2007-12-14 | 2008-12-12 | Moleculas de union al receptor ox40 humano |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US7960515B2 (es) |
| EP (4) | EP2851374B1 (es) |
| JP (4) | JP5761997B2 (es) |
| KR (2) | KR101577843B1 (es) |
| CN (1) | CN101918447B (es) |
| AR (2) | AR069681A1 (es) |
| AU (1) | AU2008338591B8 (es) |
| BR (1) | BRPI0820875B1 (es) |
| CA (2) | CA2949772A1 (es) |
| CL (1) | CL2008003706A1 (es) |
| CO (1) | CO6280541A2 (es) |
| DK (3) | DK2242771T3 (es) |
| ES (3) | ES2628093T3 (es) |
| HR (1) | HRP20141188T8 (es) |
| HU (1) | HUE032735T2 (es) |
| IL (3) | IL206297A (es) |
| MX (1) | MX2010006466A (es) |
| PA (1) | PA8807601A1 (es) |
| PE (1) | PE20091269A1 (es) |
| PH (1) | PH12015500806B1 (es) |
| PL (2) | PL2594590T3 (es) |
| PT (3) | PT2242771E (es) |
| RU (1) | RU2010129045A (es) |
| SG (2) | SG186656A1 (es) |
| SI (3) | SI2242771T1 (es) |
| TW (1) | TW200932268A (es) |
| UY (1) | UY31533A1 (es) |
| WO (1) | WO2009079335A1 (es) |
| ZA (1) | ZA201003579B (es) |
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| WO2013028231A1 (en) * | 2011-08-23 | 2013-02-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| JP6105470B2 (ja) | 2010-09-09 | 2017-03-29 | ファイザー・インク | ４−１ｂｂ結合分子 |
| EA036047B1 (ru) * | 2011-07-11 | 2020-09-18 | Икнос Сайенсиз Са | Антитела, которые связываются с ox40, и их применение |
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| KR20080090406A (ko) | 2005-11-28 | 2008-10-08 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| EP2851374B1 (en) * | 2007-12-14 | 2017-05-03 | Bristol-Myers Squibb Company | Binding molecules to the human OX40 receptor |
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