AR082393A1 - Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1’-pirido[3,4-b]indol)-4 - Google Patents
Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1’-pirido[3,4-b]indol)-4Info
- Publication number
- AR082393A1 AR082393A1 ARP110102711A ARP110102711A AR082393A1 AR 082393 A1 AR082393 A1 AR 082393A1 AR P110102711 A ARP110102711 A AR P110102711A AR P110102711 A ARP110102711 A AR P110102711A AR 082393 A1 AR082393 A1 AR 082393A1
- Authority
- AR
- Argentina
- Prior art keywords
- pain
- halogen
- cis
- compound
- derivatives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 108010020615 nociceptin receptor Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 102000048266 Nociceptin Human genes 0.000 abstract 1
- 208000001294 Nociceptive Pain Diseases 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010045171 Tumour pain Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- RERZNCLIYCABFS-UHFFFAOYSA-N harmaline Chemical compound C1CN=C(C)C2=C1C1=CC=C(OC)C=C1N2 RERZNCLIYCABFS-UHFFFAOYSA-N 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se refiere a los derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1’-pirido[3,4-b]indol)-4, los cuales tienen efecto sobre el sistema de nociceptina/receptor ORL-1 y también sobre el sistema receptor opioide m, y que se presentan de manera más específica, por medio de una eficacia selectiva en el tratamiento del dolor crónico (entre otros, el dolor inflamatorio, el dolor visceral, el dolor de tumores, de preferencia, el dolor neuropático), sin mostrar al mismo tiempo una eficacia pronunciada en el dolor nociceptivo agudo.Reivindicación 1: Compuesto de la fórmula general (1), en donde R1 es-H o CH3; R2 es -H o -halógeno; R3 es -H o -halógeno; R4 es -H, -halógeno u -O alquilo C1-3; R5 es -H, -halógeno u -O alquilo C1-3; -Q1-Q2- forman el grupo -CH2- o -CR6=CH-; y R6 y R7 pueden ser -H al mismo tiempo, o bien, juntos forman un anillo de cinco elementos sobre el puente -S-; en la forma de bases libres o sales fisiológicamente aceptables. Reivindicación 2: Compuesto según la reivindicación 1, donde este es un compuesto de la fórmula general (2), (3) ó (4) en la forma de bases libres o sales fisiológicamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10007822 | 2010-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082393A1 true AR082393A1 (es) | 2012-12-05 |
Family
ID=44315152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102711A AR082393A1 (es) | 2010-07-28 | 2011-07-27 | Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1’-pirido[3,4-b]indol)-4 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20120029006A1 (es) |
| EP (2) | EP2740476B1 (es) |
| JP (1) | JP5898193B2 (es) |
| KR (1) | KR101927054B1 (es) |
| CN (1) | CN103025732B (es) |
| AR (1) | AR082393A1 (es) |
| AU (1) | AU2011285217B8 (es) |
| BR (1) | BR112013003642A2 (es) |
| CA (1) | CA2806633C (es) |
| CL (1) | CL2013000266A1 (es) |
| CO (1) | CO6650378A2 (es) |
| CY (2) | CY1115186T1 (es) |
| DK (2) | DK2598503T3 (es) |
| EC (1) | ECSP13012409A (es) |
| ES (2) | ES2474644T3 (es) |
| HR (2) | HRP20140569T1 (es) |
| HU (1) | HUE042732T2 (es) |
| IL (1) | IL223756A (es) |
| LT (1) | LT2740476T (es) |
| MX (1) | MX2013000751A (es) |
| NZ (1) | NZ607529A (es) |
| PE (1) | PE20130808A1 (es) |
| PL (2) | PL2598503T3 (es) |
| PT (2) | PT2598503E (es) |
| RS (2) | RS58036B1 (es) |
| RU (1) | RU2592283C2 (es) |
| SI (2) | SI2598503T1 (es) |
| TR (1) | TR201821273T4 (es) |
| TW (1) | TWI582092B (es) |
| WO (1) | WO2012013343A1 (es) |
| ZA (1) | ZA201301505B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9296749B2 (en) | 2013-03-15 | 2016-03-29 | Gruenenthal Gmbh | Crystalline cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H] |
| US10092550B2 (en) | 2014-10-21 | 2018-10-09 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof |
| US9907786B2 (en) | 2014-10-21 | 2018-03-06 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof |
| SI3402785T1 (sl) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-(karboksimetil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana |
| CN108602778B (zh) | 2016-01-13 | 2021-12-10 | 格吕伦塔尔有限公司 | 8-氨基-2-氧代-1，3-二氮杂-螺-[4.5]-癸烷衍生物 |
| HRP20250176T1 (hr) | 2016-01-13 | 2025-04-11 | Grünenthal GmbH | Derivati 3-((hetero-)aril)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| BR112018014303B1 (pt) | 2016-01-13 | 2023-10-03 | Grünenthal GmbH | Derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| EP3722283A1 (en) | 2016-01-13 | 2020-10-14 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| MX385678B (es) | 2016-01-26 | 2025-03-18 | Intra Cellular Therapies Inc | Gamma-carbolinas heterocíclicas fusionadas sustituidas, composiciones farmacéuticas y métodos de uso. |
| TW201832765A (zh) * | 2017-02-24 | 2018-09-16 | 德商歌林達有限公司 | 膀胱內投藥用於治療膀胱痛之組合物 |
| TW201908295A (zh) | 2017-07-12 | 2019-03-01 | 德商歌林達有限公司 | １，３－二氮雜－螺－［３．４］－辛烷衍生物 |
| JP2019073493A (ja) | 2017-10-17 | 2019-05-16 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヴルヴォディニアの治療 |
| JP7462568B2 (ja) | 2018-03-23 | 2024-04-05 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2020030777A1 (en) | 2018-08-10 | 2020-02-13 | Grünenthal GmbH | Composition for treating urinary frequency and/or urinary urgency |
| WO2020131899A1 (en) | 2018-12-17 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Organic compound |
| WO2020131911A1 (en) | 2018-12-17 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| WO2020132605A1 (en) | 2018-12-21 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US12195463B2 (en) | 2018-12-21 | 2025-01-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2020206391A1 (en) * | 2019-04-04 | 2020-10-08 | Intra-Cellular Therapies, Inc. | Methods of treating neuropathic pain |
| CN115190815B (zh) | 2019-12-26 | 2024-06-18 | 吉尔伽美什制药公司 | 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 |
| RU2725197C1 (ru) * | 2020-02-12 | 2020-06-30 | федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации | Метод оценки висцеральной гиперчувствительности |
| PL4084791T3 (pl) | 2020-02-18 | 2025-04-22 | Gilgamesh Pharmaceuticals, Inc. | Specyficzne tryptaminy do zastosowania w leczeniu zaburzeń nastroju |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
| US12180158B1 (en) | 2023-08-03 | 2024-12-31 | Gilgamesh Pharmaceuticals, Inc. | Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10323172A1 (de) | 2003-05-22 | 2004-12-09 | Ina-Schaeffler Kg | Treiberstufe für ein Solenoidventil |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004019502A1 (de) | 2004-04-22 | 2005-11-17 | Rheinmetall Landsysteme Gmbh | Munitionsmagazin |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US8425881B2 (en) | 2005-03-18 | 2013-04-23 | Colgate-Palmolive Company | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| WO2006110856A2 (en) | 2005-04-12 | 2006-10-19 | The Ohio State University | All wheel drive electrically-variable transmission |
| EP1996722A4 (en) | 2006-03-30 | 2009-09-09 | Innovative Dairy Products Pty | CHROMOSOMAL BLOCKS AS A MARKER FOR PROPERTIES |
| WO2007117173A1 (en) | 2006-04-07 | 2007-10-18 | Closed Joint Stock Company 'biocad' | Fluid dispensing system, methods and products |
| DE102006019597A1 (de) * | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| US20080201095A1 (en) | 2007-02-12 | 2008-08-21 | Yip Ping F | Method for Calibrating an Analytical Instrument |
| PT2260042E (pt) * | 2008-03-27 | 2011-12-06 | Gruenenthal Gmbh | Derivados de ciclo-hexano espirocíclicos substituídos |
| US9296749B2 (en) * | 2013-03-15 | 2016-03-29 | Gruenenthal Gmbh | Crystalline cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H] |
-
2011
- 2011-06-22 TW TW100121735A patent/TWI582092B/zh not_active IP Right Cessation
- 2011-07-27 PE PE2013000150A patent/PE20130808A1/es active IP Right Grant
- 2011-07-27 NZ NZ607529A patent/NZ607529A/en not_active IP Right Cessation
- 2011-07-27 PT PT117379040T patent/PT2598503E/pt unknown
- 2011-07-27 ES ES11737904.0T patent/ES2474644T3/es active Active
- 2011-07-27 LT LTEP14000496.1T patent/LT2740476T/lt unknown
- 2011-07-27 PL PL11737904T patent/PL2598503T3/pl unknown
- 2011-07-27 EP EP14000496.1A patent/EP2740476B1/de not_active Not-in-force
- 2011-07-27 HR HRP20140569AT patent/HRP20140569T1/hr unknown
- 2011-07-27 JP JP2013521013A patent/JP5898193B2/ja not_active Expired - Fee Related
- 2011-07-27 DK DK11737904.0T patent/DK2598503T3/da active
- 2011-07-27 AU AU2011285217A patent/AU2011285217B8/en not_active Ceased
- 2011-07-27 WO PCT/EP2011/003771 patent/WO2012013343A1/de not_active Ceased
- 2011-07-27 PL PL14000496T patent/PL2740476T3/pl unknown
- 2011-07-27 TR TR2018/21273T patent/TR201821273T4/tr unknown
- 2011-07-27 CA CA2806633A patent/CA2806633C/en not_active Expired - Fee Related
- 2011-07-27 MX MX2013000751A patent/MX2013000751A/es active IP Right Grant
- 2011-07-27 EP EP11737904.0A patent/EP2598503B1/de not_active Not-in-force
- 2011-07-27 RS RS20181491A patent/RS58036B1/sr unknown
- 2011-07-27 ES ES14000496T patent/ES2708930T3/es active Active
- 2011-07-27 CN CN201180038485.8A patent/CN103025732B/zh not_active Expired - Fee Related
- 2011-07-27 DK DK14000496.1T patent/DK2740476T3/en active
- 2011-07-27 BR BR112013003642A patent/BR112013003642A2/pt not_active IP Right Cessation
- 2011-07-27 SI SI201130137T patent/SI2598503T1/sl unknown
- 2011-07-27 RS RS20140312A patent/RS53341B/sr unknown
- 2011-07-27 PT PT14000496T patent/PT2740476T/pt unknown
- 2011-07-27 AR ARP110102711A patent/AR082393A1/es not_active Application Discontinuation
- 2011-07-27 KR KR1020137004985A patent/KR101927054B1/ko not_active Expired - Fee Related
- 2011-07-27 HU HUE14000496A patent/HUE042732T2/hu unknown
- 2011-07-27 RU RU2013108696/04A patent/RU2592283C2/ru active
- 2011-07-27 SI SI201131631T patent/SI2740476T1/sl unknown
- 2011-07-28 US US13/192,641 patent/US20120029006A1/en not_active Abandoned
-
2012
- 2012-12-20 IL IL223756A patent/IL223756A/en active IP Right Grant
-
2013
- 2013-01-28 EC ECSP13012409 patent/ECSP13012409A/es unknown
- 2013-01-28 CL CL2013000266A patent/CL2013000266A1/es unknown
- 2013-01-28 CO CO13014969A patent/CO6650378A2/es not_active Application Discontinuation
- 2013-02-27 ZA ZA2013/01505A patent/ZA201301505B/en unknown
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2014
- 2014-05-13 CY CY20141100338T patent/CY1115186T1/el unknown
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2015
- 2015-09-04 US US14/846,155 patent/US20160159787A1/en not_active Abandoned
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2017
- 2017-07-19 US US15/654,389 patent/US20170313703A1/en not_active Abandoned
-
2018
- 2018-12-10 HR HRP20182078TT patent/HRP20182078T1/hr unknown
- 2018-12-12 CY CY181101335T patent/CY1120993T1/el unknown
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