AR081875A1 - Utilizacion de la asociacion de un inhibidor de la corriente sinusal iy de un inhibidor de la enzima de conversion de la angiotensina para el tratamiento de la insuficiencia cardiaca - Google Patents
Utilizacion de la asociacion de un inhibidor de la corriente sinusal iy de un inhibidor de la enzima de conversion de la angiotensina para el tratamiento de la insuficiencia cardiacaInfo
- Publication number
- AR081875A1 AR081875A1 ARP110102044A ARP110102044A AR081875A1 AR 081875 A1 AR081875 A1 AR 081875A1 AR P110102044 A ARP110102044 A AR P110102044A AR P110102044 A ARP110102044 A AR P110102044A AR 081875 A1 AR081875 A1 AR 081875A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitor
- treatment
- methyl
- hydrates
- association
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102000015427 Angiotensins Human genes 0.000 title 1
- 108010064733 Angiotensins Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 150000004677 hydrates Chemical class 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 150000001483 arginine derivatives Chemical class 0.000 abstract 2
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 abstract 2
- 229960003825 ivabradine Drugs 0.000 abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 abstract 2
- 229960002582 perindopril Drugs 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 2
- IPQQGEVKGQKGQE-OAQYLSRUSA-N 3-[[(7s)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]-1-(7,8-dimethoxy-1,2,4,5-tetrahydro-3-benzazepin-3-yl)propan-1-one Chemical compound C1CC2=CC(OC)=C(OC)C=C2CCN1C(=O)CCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 IPQQGEVKGQKGQE-OAQYLSRUSA-N 0.000 abstract 1
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 abstract 1
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
Utilización de la asociación de un inhibidor selectivo y específico de la corriente sinusal If, más particularmente la ivabradina o la N-{[(7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3H-3-benzazepin-3-il)-N-metil-3-oxo-1-propanamina y de un agente inhibidor de la enzima de conversión de la angiotensina para la obtención de medicamentos destinados al tratamiento de la insuficiencia cardiaca, más particularmente de la insuficiencia cardiaca con función sistólica conservada.Reivindicación 10: Composiciones farmacéuticas que contienen como principios activos: la ivabradina, en forma de hidrocloruro o de uno de sus hidratos o formas cristalinas; y el perindopril, en forma de sal de terc-butilamina o de arginina o de uno de sus hidratos o formas cristalinas, solos o en combinación con uno o varios excipientes farmacéuticamente aceptables, para su utilización en el tratamiento de la insuficiencia cardiaca. Reivindicación 12: Composiciones farmacéuticas que contienen como principios activos: la N-{[(7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3H-3-benzazepin-3-il)-N-metil-3-oxo-1-propanamina, en forma de hidrocloruro o de fumarato o de uno de sus hidratos o formas cristalinas; y el perindopril, en forma de sal de terc-butilamina o de arginina o de uno de sus hidratos o formas cristalinas, solos o en combinación con uno o varios excipientes farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1002525A FR2961105B1 (fr) | 2010-06-15 | 2010-06-15 | Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR081875A1 true AR081875A1 (es) | 2012-10-24 |
Family
ID=42985210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102044A AR081875A1 (es) | 2010-06-15 | 2011-06-13 | Utilizacion de la asociacion de un inhibidor de la corriente sinusal iy de un inhibidor de la enzima de conversion de la angiotensina para el tratamiento de la insuficiencia cardiaca |
Country Status (47)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102603666A (zh) * | 2012-02-28 | 2012-07-25 | 石河子大学 | 肉桂酰牛磺酰噻唑烷酸类化合物及其应用 |
| FR3020810B1 (fr) * | 2014-05-06 | 2016-05-06 | Servier Lab | Nouveau sel de l'ivabradine et son procede de preparation. |
| EP3025705B8 (en) * | 2014-11-25 | 2018-11-28 | Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi | Stable ivabradine formulations |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
| KR20190001340A (ko) * | 2017-06-27 | 2019-01-04 | 에리슨제약(주) | 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법 |
| CN107714702A (zh) * | 2017-10-31 | 2018-02-23 | 泰州中国医药城中医药研究院 | 一种伊伐布雷定和米力农组合物及其在制药中的应用 |
| CN107550915A (zh) * | 2017-10-31 | 2018-01-09 | 泰州中国医药城中医药研究院 | 一种伊伐布雷定和咯利普兰组合物及其在制药中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| US6188743B1 (en) * | 1997-10-10 | 2001-02-13 | Analogic Corporation | Computed tomography scanner drive system and bearing |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| DE10018401A1 (de) * | 2000-04-13 | 2001-10-25 | Boehringer Ingelheim Pharma | Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen |
| FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
| ES2211846T3 (es) * | 2002-07-25 | 2004-07-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Uso de cilobradina o sus sales farmaceuticamente aceptables para el tratamiento o la prevencion de la insuficiencia cardiaca. |
| EP1799199B1 (en) * | 2004-10-08 | 2012-03-28 | Novartis AG | Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure |
| WO2007014051A2 (en) * | 2005-07-22 | 2007-02-01 | Amylin Pharmaceuticals, Inc. | Use of amylin and amylin agonists as cardioprotective or myoprotective agents |
| FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2894825B1 (fr) | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
| FR2911279B1 (fr) * | 2007-01-11 | 2009-03-06 | Servier Lab | Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale |
| FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2921365B1 (fr) * | 2007-09-21 | 2012-10-12 | Servier Lab | Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2927538B1 (fr) * | 2008-02-14 | 2010-02-19 | Servier Lab | Association d'un inhibiteur du courant if sinusal et d'un beta-bloquant. |
| RU2364401C1 (ru) * | 2008-05-12 | 2009-08-20 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции сосудистого ремоделирования у больных хронической сердечной недостаточностью ишемической этиологии |
| WO2009158005A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Benzazepinone compounds |
| RU2382644C1 (ru) * | 2008-11-05 | 2010-02-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гипертрофии левого желудочка у больных ибс в сочетании с гипертонической болезнью |
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2010
- 2010-06-15 FR FR1002525A patent/FR2961105B1/fr not_active Expired - Fee Related
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2011
- 2011-05-31 JO JOP/2011/0178A patent/JO3309B1/ar active
- 2011-05-31 PE PE2011001126A patent/PE20120019A1/es not_active Application Discontinuation
- 2011-05-31 SG SG2011039419A patent/SG177069A1/en unknown
- 2011-05-31 AU AU2011202607A patent/AU2011202607B2/en not_active Ceased
- 2011-05-31 SG SG10201500502WA patent/SG10201500502WA/en unknown
- 2011-06-01 MY MYPI2011002498A patent/MY179034A/en unknown
- 2011-06-02 UY UY0001033423A patent/UY33423A/es not_active Application Discontinuation
- 2011-06-07 ZA ZA2011/04222A patent/ZA201104222B/en unknown
- 2011-06-07 MX MX2011006001A patent/MX2011006001A/es active IP Right Grant
- 2011-06-08 MA MA33924A patent/MA33235B1/fr unknown
- 2011-06-09 TW TW100120215A patent/TWI468164B/zh not_active IP Right Cessation
- 2011-06-10 GE GEAP201112259A patent/GEP20146132B/en unknown
- 2011-06-10 CL CL2011001420A patent/CL2011001420A1/es unknown
- 2011-06-10 CA CA2743527A patent/CA2743527C/fr not_active Expired - Fee Related
- 2011-06-13 NZ NZ593437A patent/NZ593437A/xx not_active IP Right Cessation
- 2011-06-13 SA SA114360089A patent/SA114360089B1/ar unknown
- 2011-06-13 AR ARP110102044A patent/AR081875A1/es unknown
- 2011-06-13 NZ NZ600931A patent/NZ600931A/xx not_active IP Right Cessation
- 2011-06-13 SA SA111320527A patent/SA111320527B1/ar unknown
- 2011-06-14 CU CU20120166A patent/CU24161B1/es active IP Right Grant
- 2011-06-14 RS RS20160422A patent/RS54838B1/sr unknown
- 2011-06-14 PT PT112902697T patent/PT2404600E/pt unknown
- 2011-06-14 KR KR1020110057585A patent/KR101389879B1/ko not_active Expired - Fee Related
- 2011-06-14 SI SI201130879A patent/SI2921168T1/sl unknown
- 2011-06-14 US US13/134,667 patent/US20110306598A1/en not_active Abandoned
- 2011-06-14 UA UAA201107469A patent/UA108983C2/en unknown
- 2011-06-14 PH PH1/2012/502315A patent/PH12012502315B1/en unknown
- 2011-06-14 EP EP15162899.7A patent/EP2921168B1/fr active Active
- 2011-06-14 HU HUE11290269A patent/HUE027088T2/en unknown
- 2011-06-14 SI SI201130568T patent/SI2404600T1/sl unknown
- 2011-06-14 ES ES15162899.7T patent/ES2582157T3/es active Active
- 2011-06-14 ES ES11290269.7T patent/ES2545343T3/es active Active
- 2011-06-14 DK DK11290269.7T patent/DK2404600T3/en active
- 2011-06-14 AP AP2013006661A patent/AP3691A/xx active
- 2011-06-14 DK DK15162899.7T patent/DK2921168T3/en active
- 2011-06-14 PL PL11290269T patent/PL2404600T3/pl unknown
- 2011-06-14 HU HUE15162899A patent/HUE027788T2/en unknown
- 2011-06-14 EP EP11290269.7A patent/EP2404600B1/fr not_active Revoked
- 2011-06-14 ME MEP-2016-90A patent/ME02476B/me unknown
- 2011-06-14 EA EA201100773A patent/EA022612B1/ru unknown
- 2011-06-14 RS RS20150435A patent/RS54077B1/sr unknown
- 2011-06-14 ME MEP-2015-95A patent/ME02163B/me unknown
- 2011-06-14 WO PCT/FR2011/000345 patent/WO2011157908A1/fr not_active Ceased
- 2011-06-14 AP AP2016009002A patent/AP2016009002A0/xx unknown
- 2011-06-14 PL PL15162899.7T patent/PL2921168T3/pl unknown
- 2011-06-14 BR BRPI1102830A patent/BRPI1102830F1/pt not_active IP Right Cessation
- 2011-06-15 JP JP2011132849A patent/JP5480202B2/ja active Active
- 2011-06-15 CN CN201510337337.6A patent/CN104906579A/zh active Pending
- 2011-06-15 CN CN2011101600748A patent/CN102284060A/zh active Pending
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2012
- 2012-11-23 TN TNP2012000551A patent/TN2012000551A1/fr unknown
- 2012-11-27 IL IL223293A patent/IL223293A/en active IP Right Grant
- 2012-12-03 CR CR20120609U patent/CR20120609U/es unknown
- 2012-12-07 NI NI201200182A patent/NI201200182A/es unknown
- 2012-12-10 CO CO12223070A patent/CO6640265A2/es not_active Application Discontinuation
- 2012-12-14 GT GT201200341A patent/GT201200341A/es unknown
- 2012-12-14 EC ECSP12012337 patent/ECSP12012337A/es unknown
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2015
- 2015-06-08 CY CY20151100503T patent/CY1116438T1/el unknown
- 2015-07-08 HR HRP20150745TT patent/HRP20150745T1/hr unknown
- 2015-10-28 HK HK15110661.0A patent/HK1210012A1/xx unknown
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2016
- 2016-06-09 HR HRP20160643TT patent/HRP20160643T1/hr unknown
- 2016-06-10 CY CY20161100508T patent/CY1117724T1/el unknown
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