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AR007128A1 - Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto - Google Patents

Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto

Info

Publication number
AR007128A1
AR007128A1 ARP970102012A ARP970102012A AR007128A1 AR 007128 A1 AR007128 A1 AR 007128A1 AR P970102012 A ARP970102012 A AR P970102012A AR P970102012 A ARP970102012 A AR P970102012A AR 007128 A1 AR007128 A1 AR 007128A1
Authority
AR
Argentina
Prior art keywords
group
compound
alkyl group
alkyl
antipicornaviral
Prior art date
Application number
ARP970102012A
Other languages
English (en)
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27360847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR007128(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/850,398 external-priority patent/US5856530A/en
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of AR007128A1 publication Critical patent/AR007128A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Tiene por objeto un compuesto antipicornaviral. Los inhibidores de proteasas de 3C picornavirales, obtenibles por síntesis química, inhiben obloquean la actividad biológica de las proteasas de 3C picornavirales. Estos compuestos, asícomo las composiciones farmacéuticas que contienen estoscompuestos, y que también forman parte, son aptos para tratar a pacientes o huéspedes infectados con un picornavirus o más. Asimismo forman parte métodospara preparar los inhibidores deproteasa s de 3C picornavirales. Un compuesto antipicornaviral, que responde a la fórmula (I), donde R1 es H, F, un grupoalquilo, OH, SH, un grupo O-alquilo o un grupo S-alquilo; R2 y R5 se seleccionan independientemente de H (fórmulas(II)), o u n grupo alquilo, dondedicho grupo alquilo es distinto a fórmulas (III) con la salvedad de que por lo menos uno de R2 o R5, debe ser según fórmulas (IV) y donde, cuando R2 o R5es fórmula (V); X es =CH o =CF e Y1 es =CH o =CF o X e Y1junto con Q f orman un anillo de tres miembros en el cual Q es -C(R10)(R11)- u -O-, X es -CH- o-CF- e Y1 es -CH-, -CF-, o -C(alquilo)-, donde R10 y R11 son independientemente H, un halógeno o un grupo alquilo o, junto con el átomo de carbono alcualestán unidos, forman un grupo cicloalquilo o un grupo heterocicloalquilo, o X es -CH2-, -CF3-, -CHF- o -S- e Y1 es -O-, -S-, -NR12-, -C(R13)(R14)-, -C(O)-,-C(S)- o -C(CR13R14)- donde R12 es H o alquilo y R13 y R14 sonindependientemente H, F o un grupo alquilo o, junto con el átomo con el cualestán enlazados, forman un grupo cicloalquilo o un grupo heterocicloalquilo; y A1 es C, CH, CF, S, P, Se, N, NR15, S(O), Se(O), P-OR15 o P-NR15R16, dondeR15 y R16 sonindependientemente un grupo al quilo, un grupo cicloalquilo, un grupo heterocicloalquilo, un grupo arilo o un grupo heteroarilo o, junto con el
ARP970102012A 1996-05-14 1997-05-14 Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto AR007128A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64568796A 1996-05-14 1996-05-14
US1766696P 1996-05-14 1996-05-14
US08/850,398 US5856530A (en) 1996-05-14 1997-05-02 Antipicornaviral compounds and methods for their use and preparation

Publications (1)

Publication Number Publication Date
AR007128A1 true AR007128A1 (es) 1999-10-13

Family

ID=27360847

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102012A AR007128A1 (es) 1996-05-14 1997-05-14 Un compuesto antipicornaviral, composicion farmaceutica que lo contiene y metodos para preparar a dicho compuesto

Country Status (12)

Country Link
EP (1) EP0910572B1 (es)
JP (1) JP2000506903A (es)
AR (1) AR007128A1 (es)
AT (1) ATE294187T1 (es)
AU (1) AU722704B2 (es)
CA (1) CA2254343A1 (es)
CO (1) CO4950551A1 (es)
DE (1) DE69733137T2 (es)
ES (1) ES2242225T3 (es)
GT (1) GT199700061A (es)
PA (1) PA8429901A1 (es)
WO (1) WO1997043305A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214799B1 (en) 1996-05-14 2001-04-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
EP1073672B1 (en) 1998-04-30 2003-08-27 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, their preparation and use
EP1329457B1 (en) * 1998-04-30 2005-11-02 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds, their preparation and use
DK1206484T3 (da) 1999-08-04 2005-01-24 Agouron Pharma Antipicornavirale forbindelser og sammensætninger, deres farmaceutiske anvendelser og materialer til deres syntese
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PE20010517A1 (es) * 1999-08-24 2001-05-16 Agouron Pharma Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
PA8507801A1 (es) * 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PE20011277A1 (es) * 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
EP1283199A4 (en) * 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd MELANINE CONCENTRATING HORMONE ANTAGONISTS
JP2004503533A (ja) * 2000-06-14 2004-02-05 アグロン・ファーマシュウティカルズ・インコーポレーテッド 抗ピコルナウイルス化合物及び組成物、その医薬的使用、並びにその合成のための物質
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
KR101208266B1 (ko) * 2002-03-22 2012-12-05 에자이 알앤드디 매니지먼트 가부시키가이샤 헤미아스텔린 유도체 및 이의 용도
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
EP1704142A4 (en) 2003-12-31 2008-08-20 Taigen Biotechnology Co Ltd PROTEASE INHIBITORS
ES2640814T3 (es) 2008-05-21 2017-11-06 Genesis Technologies Limited Inhibidores selectivos de caspasa y usos de los mismos
TWI386395B (zh) * 2008-12-15 2013-02-21 Taigen Biotechnology Co Ltd 哌啶衍生物的立體有擇合成
WO2010133000A1 (en) 2009-05-21 2010-11-25 New World Laboratories Inc. Selective caspase inhibitors and uses thereof
DK2697246T3 (en) 2011-04-15 2018-05-28 Genesis Tech Limited SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF
WO2013049382A2 (en) 2011-09-27 2013-04-04 Kansas State University Research Foundation Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
WO2013166319A1 (en) 2012-05-02 2013-11-07 Kansas State University Research Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses
WO2021188620A1 (en) * 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
CN116648240B (zh) * 2021-01-22 2025-12-23 中国人民解放军军事科学院军事医学研究院 一种环肽类病毒蛋白酶抑制剂，其制备方法，及其在抗病毒药物中的应用

Also Published As

Publication number Publication date
DE69733137D1 (de) 2005-06-02
EP0910572B1 (en) 2005-04-27
JP2000506903A (ja) 2000-06-06
PA8429901A1 (es) 2000-09-29
AU3005997A (en) 1997-12-05
DE69733137T2 (de) 2006-03-02
GT199700061A (es) 1998-11-04
CO4950551A1 (es) 2000-09-01
ES2242225T3 (es) 2005-11-01
ATE294187T1 (de) 2005-05-15
EP0910572A1 (en) 1999-04-28
CA2254343A1 (en) 1997-11-20
AU722704B2 (en) 2000-08-10
WO1997043305A1 (en) 1997-11-20

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