[go: up one dir, main page]

MX2014015768A - Microorganismo recombinante para la produccion fermentativa de metionina. - Google Patents

Microorganismo recombinante para la produccion fermentativa de metionina.

Info

Publication number
MX2014015768A
MX2014015768A MX2014015768A MX2014015768A MX2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A MX 2014015768 A MX2014015768 A MX 2014015768A
Authority
MX
Mexico
Prior art keywords
methionine
recombinant microorganism
fermentative production
microorganism
cobalamin
Prior art date
Application number
MX2014015768A
Other languages
English (en)
Other versions
MX355790B (es
Inventor
Rainer Figge
Wanda Dischert
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of MX2014015768A publication Critical patent/MX2014015768A/es
Publication of MX355790B publication Critical patent/MX355790B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01014—5-Methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (2.1.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un microorganismo recombinante optimizado para la producción fermentativa de metionina, en donde se atenúa la actividad de la metionina sintetasa independiente de cobalamina MetE en dicho microorganismo; la invención se refiere también a un método para producir metionina por medio de fermentación.
MX2014015768A 2012-06-18 2012-06-18 Microorganismo recombinante para la produccion fermentativa de metionina. MX355790B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/001336 WO2013190343A1 (en) 2012-06-18 2012-06-18 Recombinant microorganism for the fermentative production of methionine

Publications (2)

Publication Number Publication Date
MX2014015768A true MX2014015768A (es) 2015-04-10
MX355790B MX355790B (es) 2018-04-27

Family

ID=46579255

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015768A MX355790B (es) 2012-06-18 2012-06-18 Microorganismo recombinante para la produccion fermentativa de metionina.

Country Status (14)

Country Link
US (1) US9506093B2 (es)
EP (1) EP2861726B1 (es)
JP (1) JP6100370B2 (es)
KR (1) KR101944150B1 (es)
CN (1) CN104411821B (es)
AU (1) AU2012383221A1 (es)
BR (1) BR112014031425B1 (es)
CA (1) CA2875139A1 (es)
ES (1) ES2632170T3 (es)
MX (1) MX355790B (es)
MY (1) MY168199A (es)
PL (1) PL2861726T3 (es)
RU (1) RU2629760C2 (es)
WO (1) WO2013190343A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016529900A (ja) * 2013-08-30 2016-09-29 メタボリック エクスプローラー メチオニン流出が強化された、メチオニン生産のための微生物
BR112016004367B1 (pt) 2013-08-30 2022-06-14 Evonik Operations Gmbh Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados
CN103981206B (zh) * 2014-06-06 2016-03-02 中国科学院天津工业生物技术研究所 一种筛选高产苏氨酸菌株的方法
WO2016034536A1 (en) 2014-09-01 2016-03-10 Metabolic Explorer Method and microorganism for methionine production by fermentation with improved methionine efflux
CN108026516A (zh) * 2015-08-07 2018-05-11 赢创德固赛有限公司 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产
MY186059A (en) 2015-11-27 2021-06-17 Evonik Operations Gmbh Method for producing l-methionine
CN108603207A (zh) * 2016-01-08 2018-09-28 赢创德固赛有限公司 通过发酵生产来生产l-甲硫氨酸的方法
CN105886449B (zh) * 2016-04-14 2019-07-26 浙江工业大学 一种重组大肠杆菌及其生产l-甲硫氨酸的应用
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
JP7188385B2 (ja) * 2016-10-26 2022-12-13 味の素株式会社 Ｌ－メチオニンまたは合成にｓ－アデノシルメチオニンを要求する代謝物の製造方法
JP2020526205A (ja) 2017-07-11 2020-08-31 アディッソ・フランス・エス．エー．エス．Ａｄｉｓｓｅｏ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． メチオニン生産酵母
KR102016050B1 (ko) * 2018-03-20 2019-08-29 씨제이제일제당 주식회사 신규한 프로모터 및 이의 용도
WO2019212052A1 (en) 2018-05-04 2019-11-07 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-METHIONINE USING A BACTERIUM OF THE GENUS Pantoea
WO2020067487A1 (en) 2018-09-28 2020-04-02 Ajinomoto Co., Inc. Method for producing l-methionine using a bacterium
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7491314B2 (ja) 2019-02-22 2024-05-28 味の素株式会社 ｙｄｉＪ遺伝子を過剰発現する腸内細菌科に属する細菌を用いたＬ－アミノ酸の製造方法
JP7524909B2 (ja) 2019-04-05 2024-07-30 味の素株式会社 Ｌ－アミノ酸の製造方法
KR102147776B1 (ko) * 2019-09-20 2020-08-26 대상 주식회사 L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법
JP7655312B2 (ja) 2019-09-25 2025-04-02 味の素株式会社 細菌の発酵によるｌ－アミノ酸の製造方法
CN110819605B (zh) * 2020-01-07 2020-04-07 中国科学院天津工业生物技术研究所 甲硫氨酸合成酶突变体、突变基因及其在制备维生素b12中的应用
CN114381417B (zh) * 2022-03-24 2022-06-24 中国科学院天津工业生物技术研究所 一种提高谷氨酸棒杆菌对抑制物耐受性的方法
JPWO2024096123A1 (es) * 2022-11-04 2024-05-10

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19750493A1 (de) 1997-11-14 1999-06-02 Medos Medizintechnik Gmbh Implantat zur Stabilisierung einer Fraktur und Schraube zur Verwendung in der Chirurgie
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
JP2000157267A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
JP3614746B2 (ja) 2000-03-01 2005-01-26 松下電器産業株式会社 半導体レーザ装置および光ピックアップ装置
EP1307475A1 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
DK1404838T3 (da) * 2001-07-06 2010-07-12 Evonik Degussa Gmbh Fremgangsmåde til fremstilling af L-aminosyrer ved anvendelse af stammer fra enterobacteriaceae-familien, der overeksprimerer FBA
WO2004076659A2 (fr) 2003-02-18 2004-09-10 Metabolic Explorer Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
WO2005007862A2 (en) 2003-07-08 2005-01-27 Novus Internation, Inc Methionine recovery processes
DE10359594A1 (de) 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
DE10359668A1 (de) 2003-12-18 2005-07-14 Basf Ag Verfahren zur Herstellung von Methionin
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
KR100651220B1 (ko) 2004-06-29 2006-11-29 씨제이 주식회사 Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
DE102004035065A1 (de) * 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
BRPI0611909A2 (pt) 2005-06-17 2009-01-20 Microbia Inc biossÍntese aperfeiÇoada de aminoÁcido e metabàlito
KR20080036608A (ko) * 2005-07-18 2008-04-28 바스프 에스이 메티오닌 생산 재조합 미생물
US8389250B2 (en) * 2006-01-04 2013-03-05 Metabolic Explorer Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine
WO2007119576A1 (en) * 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
CN101454460A (zh) 2006-05-24 2009-06-10 赢创德固赛有限责任公司 制备l-甲硫氨酸的方法
KR20080061801A (ko) * 2006-12-28 2008-07-03 씨제이제일제당 (주) L-메티오닌 생산능을 향상시키는 폴리펩타이드, 상기 폴리펩타이드를 과발현하는 미생물 및 상기 미생물을 이용한 l- 메티오닌 생산방법
CN101573447A (zh) * 2006-12-29 2009-11-04 赢创德固赛有限责任公司 具有降低的产物抑制作用的甲硫氨酸合酶
WO2009043372A1 (en) * 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US8163532B2 (en) 2008-05-28 2012-04-24 Evonik Degussa Gmbh Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase
WO2010020290A1 (en) 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
WO2011073738A1 (en) * 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
AR083468A1 (es) * 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
WO2012090021A1 (en) 2010-12-30 2012-07-05 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada

Also Published As

Publication number Publication date
BR112014031425B1 (pt) 2022-01-18
MX355790B (es) 2018-04-27
KR20150033649A (ko) 2015-04-01
ES2632170T3 (es) 2017-09-11
WO2013190343A1 (en) 2013-12-27
RU2014151747A (ru) 2016-08-10
JP6100370B2 (ja) 2017-03-22
US9506093B2 (en) 2016-11-29
AU2012383221A1 (en) 2015-01-15
BR112014031425A2 (pt) 2017-08-01
RU2629760C2 (ru) 2017-09-06
EP2861726B1 (en) 2017-05-31
JP2015519917A (ja) 2015-07-16
CN104411821B (zh) 2017-08-08
US20150247175A1 (en) 2015-09-03
EP2861726A1 (en) 2015-04-22
CA2875139A1 (en) 2013-12-27
MY168199A (en) 2018-10-15
CN104411821A (zh) 2015-03-11
PL2861726T3 (pl) 2017-11-30
KR101944150B1 (ko) 2019-01-30

Similar Documents

Publication Publication Date Title
MX2014015768A (es) Microorganismo recombinante para la produccion fermentativa de metionina.
MY207701A (en) Methods of producing omega-hydroxylated fatty acid derivatives
MY157111A (en) Recombinant microorganisms and methods of production thereof
IN2014DN09244A (es)
MY181688A (en) Improved production of fatty acid derivatives
MX2014012810A (es) Sistemas de celulas y metodos para mejorar la sintesis de acidos grasos mediante la expresion de deshidrogenasas.
BR112012024799A2 (pt) método para a produção de l-ornitina por fermentação
PH12015500792A1 (en) Method for producing l-amino acid
MX347843B (es) Un microorganismo para la producción de metionina con importación de glucosa mejorada.
MX2012007717A (es) Cepas y metodo para la produccion de metionina.
GEP20186826B (en) Intermediate product for treprostinil synthesis and methods for preparation thereof
MY172080A (en) Microorganisms having putrescine productivity and process for producing putrescine using the same
IN2014MN01331A (es)
MY182946A (en) Production of organic acids by fermentation at low ph
MX2016002651A (es) Microorganismo modificado para la produccion mejorada de alanina.
EP4458858A3 (en) Method for the production of immunoglobulin single variable domains
MY164367A (en) Microorganism producing high-molecular-weight pha
ZA201302088B (en) Process for producing bioethanol by enzymatic hydrolysis of cellulose
WO2014049382A3 (en) Ethylenediamine fermentative production by a recombinant microorganism
PH12013502196A1 (en) Multistage cellulose hydrolysis and quench with or without acid
MX344582B (es) Control de espuma de procesos de fermentacion alcoholica.
IN2014MN01621A (es)
IN2014DN10038A (es)
MY170881A (en) Recombinant microorganism with improved butanol productivity and method for producing butanol by using same
IN2014DN03469A (es)

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: EVONIK DEGUSSA GMBH.*

FG Grant or registration