AR086204A1 - Cefalosporinas como agentes antibacteriales - Google Patents
Cefalosporinas como agentes antibacterialesInfo
- Publication number
- AR086204A1 AR086204A1 ARP120101502A ARP120101502A AR086204A1 AR 086204 A1 AR086204 A1 AR 086204A1 AR P120101502 A ARP120101502 A AR P120101502A AR P120101502 A ARP120101502 A AR P120101502A AR 086204 A1 AR086204 A1 AR 086204A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- so2r6
- nhr4
- nr4r5
- cephalosporins
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
La presente proporciona derivados de cefalosporinas de la fórmula (1), su uso para el tratamiento de infecciones en mamíferos, composición farmacéutica que contiene estos compuestos y métodos para la preparación de estos compuestos.Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: R1 es -NR4R5, -SO2R6, -C(=O)NR4R4, -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, SC(=O)NHR4, -SP(=O)(OR4)2; o R1 es -alquilo C1-8 sustituido con -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, -SC(=O)NHR4, -SP(=O)(OR4)2, -C(=O)NR4R5, -SO2R6; o R1 es -O-alquilo C1-8 sustituido con -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, -SC(=O)NHR4, -SP(=O)(OR4)2, -C(=O)NR4R5, o -SO2R6; R2 y R3 son de manera independiente -H, -OH, -CN, halo, -NO2, -alquilo C1-10, -O-alquilo C1-10, -N(R4)2; o R1 y R3 tomados juntos con los carbonos a los cuales se unen forman un arilo o heteroarilo; R4 es -H o -alquilo C1-10; R5 es -SO2R4, -C(=O)alquilo C1-10; R6 es H, alquilo C1-6, o NR4R4; en cada presencia, alquilo C1-10 es opcionalmente sustituido con -OH, -CN, halo, -NO2, -O-alquilo C1-6, -SH, -S-alquilo C1-4, -S(C=O)alquilo C1-4, o -O(C=O)alquilo C1-4; y n es 1, 2, ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161481407P | 2011-05-02 | 2011-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086204A1 true AR086204A1 (es) | 2013-11-27 |
Family
ID=46062670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101502A AR086204A1 (es) | 2011-05-02 | 2012-04-27 | Cefalosporinas como agentes antibacteriales |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8722656B2 (es) |
| EP (1) | EP2705044A1 (es) |
| JP (1) | JP2014513116A (es) |
| CN (1) | CN103649097A (es) |
| AR (1) | AR086204A1 (es) |
| AU (1) | AU2012251438A1 (es) |
| CA (1) | CA2834999A1 (es) |
| MX (1) | MX2013012820A (es) |
| TW (1) | TW201311699A (es) |
| UY (1) | UY34047A (es) |
| WO (1) | WO2012150520A1 (es) |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776992A (en) | 1956-03-14 | 1957-01-08 | Du Pont | Trifluoromethylsulfonylphenyldichloracetamidopropandiol |
| US3294818A (en) | 1964-04-06 | 1966-12-27 | Warner Lambert Pharmaceutical | Substituted dioxolanes and process for their production |
| ES488154A0 (es) | 1979-02-05 | 1981-04-16 | Schering Corp | Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol |
| US4235892A (en) | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
| US4361557A (en) | 1980-01-28 | 1982-11-30 | Schering Corporation | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor |
| EP0061234A3 (en) * | 1981-03-05 | 1983-11-16 | Beecham Group Plc | Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them |
| JPH064643B2 (ja) * | 1985-12-20 | 1994-01-19 | ファイザー製薬株式会社 | セフアロスポリン化合物 |
| ATE113050T1 (de) * | 1986-11-21 | 1994-11-15 | Ici Pharma | Cephalosporine, verfahren zu ihrer herstellung und pharmazeutische präparate. |
| US4977288A (en) | 1988-01-29 | 1990-12-11 | President And Fellows Of Harvard College | M-aminophenyltrialkylstannane |
| US5143910A (en) | 1989-09-07 | 1992-09-01 | Shionogi & Co., Ltd. | Piperaziniocephalosporins |
| DE122005000055I2 (de) * | 1993-03-12 | 2008-06-05 | Upjohn Co | Kristallines ceftiofur (freie säure) |
| MXPA04008677A (es) | 2002-03-08 | 2004-12-06 | Schering Plough Ltd | Antibioticos novedosos del tipo florfenicol. |
| NZ547592A (en) | 2003-12-23 | 2009-07-31 | Schering Plough Ltd | Florfenicol prodrug having improved water solubility |
| WO2005066119A2 (en) | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof |
| EP1713820A1 (en) | 2004-01-22 | 2006-10-25 | Eli Lilly And Company | Selective estrogen receptor modulators |
| GB0417709D0 (en) | 2004-08-09 | 2004-09-08 | Glaxo Group Ltd | Compounds |
| JP5113754B2 (ja) | 2005-09-07 | 2013-01-09 | シェーリング−プラウ・リミテッド | エステルオキサゾリジン化合物を調製するためのプロセスおよびそれらのフロルフェニコールへの変換 |
| EP1945223B1 (en) * | 2005-10-29 | 2010-07-07 | Intervet International BV | Cefquinome compositions and methods of their use |
| US8119667B2 (en) | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
| WO2007124435A2 (en) | 2006-04-21 | 2007-11-01 | Board Of Regents, The University Of Texas System | Detection of histone deacetylase inhibition |
| EP2077998B1 (en) | 2006-09-05 | 2011-03-09 | Amgen Inc. | Phthalazine, aza- and diaza-phthalazine compounds and methods of use |
| WO2008076256A1 (en) | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
| US20080153906A1 (en) | 2006-12-13 | 2008-06-26 | Celly Chander S | Water-Soluble Phenicol Prodrugs in a Lipophilic Vehicle System |
| CN101605756A (zh) | 2006-12-13 | 2009-12-16 | 先灵-普劳有限公司 | 氟苯尼考及其类似物的水溶性前药 |
| KR20100022999A (ko) | 2007-05-30 | 2010-03-03 | 쉐링-프라우 리미티드 | 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조방법 |
| US20100240713A1 (en) | 2007-06-05 | 2010-09-23 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
| JP2010534667A (ja) | 2007-07-25 | 2010-11-11 | インターベツト・インターナシヨナル・ベー・ベー | オキサゾリジンおよびオキサゾリジノンアミノジオール類ならびに関連中間体を調製するためのプロセス |
| MX2010006531A (es) | 2007-12-14 | 2010-08-31 | Intervet Int Bv | Proceso para recuperar flunixin de composiciones farmaceuticas. |
| US20090170954A1 (en) | 2007-12-14 | 2009-07-02 | Schering-Plough Ltd. | Process for Recovering Florfenicol and Florfenicol Analogs |
| US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
-
2012
- 2012-04-19 MX MX2013012820A patent/MX2013012820A/es unknown
- 2012-04-19 AU AU2012251438A patent/AU2012251438A1/en not_active Abandoned
- 2012-04-19 CN CN201280033080.XA patent/CN103649097A/zh active Pending
- 2012-04-19 CA CA2834999A patent/CA2834999A1/en not_active Abandoned
- 2012-04-19 JP JP2014508893A patent/JP2014513116A/ja not_active Withdrawn
- 2012-04-19 WO PCT/IB2012/051973 patent/WO2012150520A1/en not_active Ceased
- 2012-04-19 EP EP12720640.7A patent/EP2705044A1/en not_active Withdrawn
- 2012-04-27 AR ARP120101502A patent/AR086204A1/es not_active Application Discontinuation
- 2012-04-30 US US13/459,851 patent/US8722656B2/en not_active Expired - Fee Related
- 2012-04-30 TW TW101115372A patent/TW201311699A/zh unknown
- 2012-04-30 UY UY0001034047A patent/UY34047A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US8722656B2 (en) | 2014-05-13 |
| MX2013012820A (es) | 2014-02-10 |
| CA2834999A1 (en) | 2012-11-08 |
| UY34047A (es) | 2013-01-03 |
| WO2012150520A1 (en) | 2012-11-08 |
| JP2014513116A (ja) | 2014-05-29 |
| US20120283237A1 (en) | 2012-11-08 |
| TW201311699A (zh) | 2013-03-16 |
| CN103649097A (zh) | 2014-03-19 |
| EP2705044A1 (en) | 2014-03-12 |
| AU2012251438A1 (en) | 2013-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |