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AR086181A2 - Metodo para preparar inhibidores macrociclicos inhibidores de serina proteasas del virus de la hepatitis c - Google Patents

Metodo para preparar inhibidores macrociclicos inhibidores de serina proteasas del virus de la hepatitis c

Info

Publication number
AR086181A2
AR086181A2 ARP120101342A ARP120101342A AR086181A2 AR 086181 A2 AR086181 A2 AR 086181A2 AR P120101342 A ARP120101342 A AR P120101342A AR P120101342 A ARP120101342 A AR P120101342A AR 086181 A2 AR086181 A2 AR 086181A2
Authority
AR
Argentina
Prior art keywords
optionally substituted
inhibitors
compound
formula
proteasas
Prior art date
Application number
ARP120101342A
Other languages
English (en)
Inventor
Keith F Mdaniel
Hui Chen
Jason P Ju-Shanley
Yonghua Gai
Dale J Kempf
David J Grampovnik
Ying Sun
Dong Liu
Sable H Wagaw
Ken Engstrom
Tim Grieme
Yiyin Ku
Yat Sun Or
Original Assignee
Abbott Lab
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42005677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR086181(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab, Enanta Pharm Inc filed Critical Abbott Lab
Publication of AR086181A2 publication Critical patent/AR086181A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un método para producir un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, caracterizada porque comprende el paso de hacer reaccionar un compuesto de fórmula (2), donde, J es -C(O)-; A es heteroarilo opcionalmente sustituido; G es -E-R5; donde E es -N(R3)S(Op)-; p es 2; R5 es carbociclo opcionalmente sustituido; cada R3 es hidrógeno; L se encuentra ausente; j = 2; k = 2; m = 1; y - - - - - denota una unión carbono-carbono doble; y LG es un grupo saliente; con un compuesto de fórmula (3), donde: cada R1 se selecciona independientemente entre (i) halógeno, hidroxi, amino, -CN, -CF3, -N3, -NO2, -OR4, -SR4, -SOR4, -SO2R4, -N(R3)S(O)2-R4, -N(R3)S(O2)NR3R4, -NR3R4, -C(O)OR4, -C(O)R4, -C(O)NR3R4, o -N(R3)C(O)R4; (ii) arilo opcionalmente sustituido; (iii) heteroarilo opcionalmente sustituido; (iv) heterociclo opcionalmente sustituido; (v) carbociclo opcionalmente sustituido; o (vi) alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, o alquinilo opcionalmente sustituido, cada uno con 0, 1, 2, ó 3 heteroátomos seleccionados entre O, S, o N; R3 y R4 cada uno se selecciona independientemente en cada oportunidad entre los siguientes: alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido o alquinilo opcionalmente sustituido, cada uno con 0, 1, 2, ó 3 heteroátomos seleccionados entre O, S, o N; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; heterociclo opcionalmente sustituido; carbociclo opcionalmente sustituido; o hidrógeno; n es 0, 1, 2, 3, ó 4; Y es CR’’; donde R’ y R’’ juntos forman un anillo arilo; para de esa manera producir un compuesto de fórmula (1).
ARP120101342A 2008-09-11 2012-04-19 Metodo para preparar inhibidores macrociclicos inhibidores de serina proteasas del virus de la hepatitis c AR086181A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19172508P 2008-09-11 2008-09-11
US20968909P 2009-03-10 2009-03-10

Publications (1)

Publication Number Publication Date
AR086181A2 true AR086181A2 (es) 2013-11-27

Family

ID=42005677

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP090103469A AR073568A1 (es) 2008-09-11 2009-09-10 Inhibidores macrociclicos de serina proteasas de hepatitis c
ARP120101342A AR086181A2 (es) 2008-09-11 2012-04-19 Metodo para preparar inhibidores macrociclicos inhibidores de serina proteasas del virus de la hepatitis c
ARP130104634A AR093924A2 (es) 2008-09-11 2013-12-11 Inhibidores macrociclicos de serina proteasas de hepatitis c

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP090103469A AR073568A1 (es) 2008-09-11 2009-09-10 Inhibidores macrociclicos de serina proteasas de hepatitis c

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP130104634A AR093924A2 (es) 2008-09-11 2013-12-11 Inhibidores macrociclicos de serina proteasas de hepatitis c

Country Status (41)

Country Link
US (3) US8420596B2 (es)
EP (5) EP2468287B1 (es)
JP (4) JP5259537B2 (es)
KR (3) KR101379365B1 (es)
CN (3) CN101775017B (es)
AR (3) AR073568A1 (es)
AU (1) AU2009292182B2 (es)
BR (2) BRPI0918724B8 (es)
CA (1) CA2736895C (es)
CL (2) CL2011000512A1 (es)
CO (1) CO6341565A2 (es)
CR (1) CR20140180A (es)
CY (6) CY1115137T1 (es)
DK (5) DK2340029T3 (es)
DO (1) DOP2011000077A (es)
EA (2) EA022891B1 (es)
EC (2) ECSP11010879A (es)
ES (5) ES2459390T3 (es)
GT (2) GT201100056AA (es)
HR (5) HRP20140494T1 (es)
HU (2) HUE039478T2 (es)
IL (2) IL218441A (es)
LT (2) LT2805726T (es)
LU (1) LU92667I2 (es)
MX (1) MX2011002486A (es)
MY (1) MY159820A (es)
NL (1) NL300730I1 (es)
NO (1) NO2015014I1 (es)
NZ (2) NZ592170A (es)
PA (1) PA8842201A1 (es)
PE (3) PE20140961A1 (es)
PL (5) PL2468287T3 (es)
PT (5) PT2805726T (es)
SG (1) SG179414A1 (es)
SI (5) SI2468286T1 (es)
SM (1) SMT201800407T1 (es)
TR (1) TR201809771T4 (es)
TW (3) TWI450723B (es)
UY (3) UY32099A (es)
WO (1) WO2010030359A2 (es)
ZA (2) ZA201101558B (es)

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