AR086109A1 - Formulaciones topicas de tipo suspension que comprenden depsipeptido ciclico - Google Patents
Formulaciones topicas de tipo suspension que comprenden depsipeptido ciclicoInfo
- Publication number
- AR086109A1 AR086109A1 ARP120101325A AR086109A1 AR 086109 A1 AR086109 A1 AR 086109A1 AR P120101325 A ARP120101325 A AR P120101325A AR 086109 A1 AR086109 A1 AR 086109A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition according
- depsipeptide
- topic
- suspension formulations
- hydrophobic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 108010002156 Depsipeptides Proteins 0.000 title 1
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 abstract 1
- 239000004264 Petrolatum Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003925 fat Substances 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000004200 microcrystalline wax Substances 0.000 abstract 1
- 235000019808 microcrystalline wax Nutrition 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 235000010446 mineral oil Nutrition 0.000 abstract 1
- 229940066842 petrolatum Drugs 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- -1 polysiloxanes Polymers 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Una composición farmacéutica tópica, la cual comprende un depsipéptido cíclico de la fórmula (1), una matriz hidrofóbica, y un agente de consistencia.Reivindicación 3: Una composición farmacéutica de acuerdo con la reivindicación 1 a 2, en donde la matriz hidrofóbica incluye uno o más compuestos seleccionados a partir del grupo que consiste en parafinas, aceites vegetales, grasas animales, glicéridos sintéticos, ceras, perfluorocarbonos, semi-perfluorocarbonos y polisiloxanos líquidos. Reivindicación 4: Una composición de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde la matriz hidrofóbica incluye cuando menos dos tipos de hidrocarburos seleccionados a partir de aceite mineral, petrolato, y cera microcristalina. Reivindicación 5: Una composición de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde el agente de consistencia es miristato de isopropilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477297P | 2011-04-20 | 2011-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086109A1 true AR086109A1 (es) | 2013-11-20 |
Family
ID=46148908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101325 AR086109A1 (es) | 2011-04-20 | 2012-04-18 | Formulaciones topicas de tipo suspension que comprenden depsipeptido ciclico |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8680054B2 (es) |
| EP (1) | EP2699231B1 (es) |
| JP (1) | JP5906304B2 (es) |
| KR (1) | KR101612170B1 (es) |
| CN (1) | CN103476396B (es) |
| AR (1) | AR086109A1 (es) |
| AU (1) | AU2012245960B2 (es) |
| BR (1) | BR112013026698A2 (es) |
| CA (1) | CA2833326A1 (es) |
| CL (1) | CL2013003036A1 (es) |
| EA (1) | EA201391555A1 (es) |
| ES (1) | ES2651639T3 (es) |
| GT (1) | GT201300257A (es) |
| IL (1) | IL228863A0 (es) |
| MA (1) | MA35158B1 (es) |
| MX (1) | MX338156B (es) |
| PE (1) | PE20141068A1 (es) |
| PH (1) | PH12013502054A1 (es) |
| SG (1) | SG11201402441WA (es) |
| TN (1) | TN2013000386A1 (es) |
| TW (1) | TW201247218A (es) |
| WO (1) | WO2012143868A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120123579A (ko) | 2007-08-17 | 2012-11-08 | 노파르티스 아게 | 시클릭 뎁시펩티드 |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8614289B2 (en) | 2011-04-20 | 2013-12-24 | Novartis Ag | Processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9226890B1 (en) | 2013-12-10 | 2016-01-05 | Englewood Lab, Llc | Polysilicone base for scar treatment |
| CN108888590A (zh) * | 2018-08-06 | 2018-11-27 | 江苏知原药业有限公司 | 包含他克莫司的混悬类型的局部制剂 |
| CN115397398A (zh) * | 2020-03-06 | 2022-11-25 | 生脉药业股份有限公司 | 环状酯肽的局部药物制剂 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3043252C2 (de) | 1980-11-15 | 1982-12-02 | Degussa Ag, 6000 Frankfurt | Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| DE4421113A1 (de) | 1994-06-16 | 1995-12-21 | Biotechnolog Forschung Gmbh | Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung |
| DE19828043A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
| JP2000154198A (ja) | 1998-11-20 | 2000-06-06 | Nisshin Flour Milling Co Ltd | 環状デプシペプチドの固相合成方法及びその中間体 |
| JP2001131085A (ja) * | 1999-08-25 | 2001-05-15 | Saitama Daiichi Seiyaku Kk | 経皮・経粘膜吸収用の医薬組成物 |
| GB0108234D0 (en) | 2001-04-02 | 2001-05-23 | Pharma Mar Sa | Process for producing trunkamide A compounds |
| US20040110228A1 (en) | 2002-04-01 | 2004-06-10 | Mcalpine Shelli R. | Combinatorial organic synthesis of unique biologically active compounds |
| CA2525383C (en) | 2003-06-06 | 2012-03-06 | Arexis Ab | Use of heterocyclic compounds as scce inhibitors |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| DE10358525A1 (de) * | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| EP1716248A1 (en) | 2004-02-03 | 2006-11-02 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7) |
| CA2651796A1 (en) | 2006-02-27 | 2007-09-07 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Identification and use of novopeptides for the treatment of cancer |
| EP2183270B1 (en) | 2007-08-17 | 2014-12-17 | Novartis AG | Use of cyclic depsipeptides to inhibit kallikrein 7 |
| KR20120123579A (ko) * | 2007-08-17 | 2012-11-08 | 노파르티스 아게 | 시클릭 뎁시펩티드 |
| DE102007052391A1 (de) | 2007-10-31 | 2009-05-07 | Henkel Ag & Co. Kgaa | Mattwachs |
| JP2010241784A (ja) * | 2008-06-19 | 2010-10-28 | Mitsubishi Tanabe Pharma Corp | 経皮投与製剤 |
| US20110112121A1 (en) | 2009-07-06 | 2011-05-12 | Joerg Berghausen | Pharmaceutical Compositions and Solid Forms |
| KR101004362B1 (ko) | 2010-03-19 | 2010-12-28 | 가톨릭대학교 산학협력단 | 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제 |
| US20120064136A1 (en) | 2010-09-10 | 2012-03-15 | Nanobio Corporation | Anti-aging and wrinkle treatment methods using nanoemulsion compositions |
| WO2012035468A2 (en) | 2010-09-14 | 2012-03-22 | Trima - Israel Pharmaceutical Products Maabarot Ltd. | Foamable topical composition |
| KR20140003572A (ko) | 2011-01-24 | 2014-01-09 | 안테리오스, 인코퍼레이티드 | 나노입자 조성물 |
| IL293156A (en) | 2011-01-24 | 2022-07-01 | Anterios Inc | Nanoparticle compounds, their formulations, and their use |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8614289B2 (en) | 2011-04-20 | 2013-12-24 | Novartis Ag | Processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
-
2012
- 2012-04-12 US US13/445,202 patent/US8680054B2/en active Active
- 2012-04-18 JP JP2014505768A patent/JP5906304B2/ja not_active Expired - Fee Related
- 2012-04-18 AU AU2012245960A patent/AU2012245960B2/en not_active Ceased
- 2012-04-18 PE PE2013002371A patent/PE20141068A1/es not_active Application Discontinuation
- 2012-04-18 KR KR1020137027256A patent/KR101612170B1/ko not_active Expired - Fee Related
- 2012-04-18 WO PCT/IB2012/051946 patent/WO2012143868A1/en not_active Ceased
- 2012-04-18 CN CN201280018749.8A patent/CN103476396B/zh active Active
- 2012-04-18 EP EP12723241.1A patent/EP2699231B1/en active Active
- 2012-04-18 SG SG11201402441WA patent/SG11201402441WA/en unknown
- 2012-04-18 CA CA 2833326 patent/CA2833326A1/en not_active Abandoned
- 2012-04-18 EA EA201391555A patent/EA201391555A1/ru unknown
- 2012-04-18 PH PH1/2013/502054A patent/PH12013502054A1/en unknown
- 2012-04-18 AR ARP120101325 patent/AR086109A1/es unknown
- 2012-04-18 ES ES12723241.1T patent/ES2651639T3/es active Active
- 2012-04-18 MX MX2013012187A patent/MX338156B/es active IP Right Grant
- 2012-04-18 BR BR112013026698A patent/BR112013026698A2/pt not_active IP Right Cessation
- 2012-04-19 TW TW101114020A patent/TW201247218A/zh unknown
-
2013
- 2013-09-25 TN TNP2013000386A patent/TN2013000386A1/fr unknown
- 2013-10-14 IL IL228863A patent/IL228863A0/en unknown
- 2013-10-18 CL CL2013003036A patent/CL2013003036A1/es unknown
- 2013-10-18 GT GT201300257A patent/GT201300257A/es unknown
- 2013-11-15 MA MA36445A patent/MA35158B1/fr unknown
-
2014
- 2014-02-04 US US14/171,807 patent/US9114110B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ615551A (en) | 2015-08-28 |
| EP2699231B1 (en) | 2017-09-13 |
| MX2013012187A (es) | 2013-11-04 |
| TN2013000386A1 (en) | 2015-01-20 |
| CL2013003036A1 (es) | 2014-04-04 |
| US20120270796A1 (en) | 2012-10-25 |
| PE20141068A1 (es) | 2014-09-04 |
| EP2699231A1 (en) | 2014-02-26 |
| CA2833326A1 (en) | 2012-10-26 |
| AU2012245960A1 (en) | 2013-10-17 |
| WO2012143868A1 (en) | 2012-10-26 |
| KR101612170B1 (ko) | 2016-04-12 |
| ES2651639T3 (es) | 2018-01-29 |
| SG11201402441WA (en) | 2014-09-26 |
| TW201247218A (en) | 2012-12-01 |
| JP5906304B2 (ja) | 2016-04-20 |
| MA35158B1 (fr) | 2014-06-02 |
| CN103476396A (zh) | 2013-12-25 |
| GT201300257A (es) | 2015-02-19 |
| KR20130133295A (ko) | 2013-12-06 |
| JP2014512377A (ja) | 2014-05-22 |
| MX338156B (es) | 2016-04-05 |
| AU2012245960B2 (en) | 2014-09-25 |
| US9114110B2 (en) | 2015-08-25 |
| BR112013026698A2 (pt) | 2016-12-27 |
| PH12013502054A1 (en) | 2013-12-16 |
| US8680054B2 (en) | 2014-03-25 |
| EA201391555A1 (ru) | 2014-11-28 |
| US20140162959A1 (en) | 2014-06-12 |
| CN103476396B (zh) | 2015-08-05 |
| IL228863A0 (en) | 2013-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |