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PE20170703A1 - Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo y metodos de uso de los mismos - Google Patents

Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo y metodos de uso de los mismos

Info

Publication number
PE20170703A1
PE20170703A1 PE2017000493A PE2017000493A PE20170703A1 PE 20170703 A1 PE20170703 A1 PE 20170703A1 PE 2017000493 A PE2017000493 A PE 2017000493A PE 2017000493 A PE2017000493 A PE 2017000493A PE 20170703 A1 PE20170703 A1 PE 20170703A1
Authority
PE
Peru
Prior art keywords
trifluoromethyl
methyl
rorc2
replaced
methods
Prior art date
Application number
PE2017000493A
Other languages
English (en)
Inventor
Andrew Christopher Flick
Peter Jones
Neelu Kaila
Scot Richard Mente
Mark Edward Schnute
John David Trzupek
Michael L Vazquez
Li Xing
Liying Zhang
Goran Mattias Wennerstål
Edouard Zamaratski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20170703A1 publication Critical patent/PE20170703A1/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract

Se refiere a derivados de pirrolopiridina de Formula I, en donde: Y es CH3, CF3; X es fenilo opcionalmente sustituido; W es una de las formulas descritas a continuacion. Estos compuestos inhiben la actividad de RORgamma y/o reducen la cantidad de IL-17, por lo que se emplean en el tratamiento de trastornos inmunes o inflamatorios como artritis reumatoide, psoriasis, enfermedad de Crohn, esclerosis multiples, entre otros. Entre los compuestos preferidos tenemos los siguientes: 3-ciano-N-(3-(1-(ciclopentancarbonil)piperidin-4-il)-1-metil-4-(trifluorometil)-1H-pirrolo[2,3-b]piridin-5-il)-5-metoxibenzamida; 3-ciano-N-(3-(1-(ciclopentancarbonil)piperidin-4-il)-1-metil-4-(trifluorometil)-1H-pirrolo[2,3-b]piridin-5-il)-4-metilbenzamida; 3-ciano-N-(3-(1-(ciclopentancarbonil)piperidin-4-il)-1-metil-4-(trifluorometil)-1H-pirrolo[2,3-b]piridin-5-il)-4-fluorobenzamida; entre otros
PE2017000493A 2014-09-26 2015-09-22 Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo y metodos de uso de los mismos PE20170703A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462055811P 2014-09-26 2014-09-26
US201562110048P 2015-01-30 2015-01-30
US201562209124P 2015-08-24 2015-08-24
PCT/IB2015/057314 WO2016046755A1 (en) 2014-09-26 2015-09-22 Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof

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PE20170703A1 true PE20170703A1 (es) 2017-06-03

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EP (1) EP3197882A1 (es)
JP (1) JP6224870B2 (es)
KR (1) KR101933328B1 (es)
CN (1) CN106715416B (es)
AP (1) AP2017009800A0 (es)
AU (2) AU2015323380B2 (es)
BR (2) BR122017023934A2 (es)
CA (1) CA2905407A1 (es)
CL (1) CL2017000716A1 (es)
CO (1) CO2017002427A2 (es)
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CU (1) CU24407B1 (es)
DO (1) DOP2017000087A (es)
EA (1) EA030635B1 (es)
GE (2) GEAP201814455A (es)
GT (1) GT201700063A (es)
IL (1) IL250675A0 (es)
MA (1) MA40759A (es)
MD (1) MD20170027A2 (es)
MX (1) MX2017003956A (es)
NI (1) NI201700031A (es)
NZ (1) NZ729252A (es)
PE (1) PE20170703A1 (es)
PH (1) PH12017500494A1 (es)
SG (1) SG11201701329QA (es)
SV (1) SV2017005395A (es)
TN (1) TN2017000074A1 (es)
TW (1) TWI583685B (es)
UA (1) UA119569C2 (es)
UY (1) UY36322A (es)
WO (1) WO2016046755A1 (es)
ZA (2) ZA201701292B (es)

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MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
JP2018510131A (ja) 2015-01-30 2018-04-12 ファイザー・インク Ｒｏｒｃ２のスルホンアミド置換インドールモジュレーターおよびその使用方法
WO2016120849A1 (en) 2015-01-30 2016-08-04 Pfizer Inc. Methoxy-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof
TN2018000188A1 (en) 2015-12-15 2019-10-04 Astrazeneca Ab Isoindole compounds
CN105753866A (zh) * 2016-04-05 2016-07-13 叶芳 一种4-卤素-7-氮杂吲哚及其制备方法
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
KR20200094493A (ko) 2019-01-30 2020-08-07 김남형 음성사후분포그램추출기와 tts 및 보코더를 이용한 음성 변조 어플리케이션의 동작방법
MX2022013650A (es) * 2020-04-30 2023-02-01 Janssen Pharmaceutica Nv Imidazopirimidinas como moduladores de il-17.
CN114591137B (zh) * 2022-05-10 2022-09-09 上海赛默罗生物科技有限公司 螺桨烷类衍生物的合成方法
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19
CN119119032B (zh) * 2024-08-05 2025-09-09 中山大学附属第三医院 一种吲哚苯甲酰胺类衍生物及其制备方法和应用

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