AR086065A2 - Compuestos de imidazolsulfonamidas y un proceso para su produccion - Google Patents
Compuestos de imidazolsulfonamidas y un proceso para su produccionInfo
- Publication number
- AR086065A2 AR086065A2 ARP120101436A ARP120101436A AR086065A2 AR 086065 A2 AR086065 A2 AR 086065A2 AR P120101436 A ARP120101436 A AR P120101436A AR P120101436 A ARP120101436 A AR P120101436A AR 086065 A2 AR086065 A2 AR 086065A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- aryl
- cyano
- nitro
- Prior art date
Links
- PMTLRCDQMKXMRZ-UHFFFAOYSA-N 1h-imidazole-2-sulfonamide Chemical class NS(=O)(=O)C1=NC=CN1 PMTLRCDQMKXMRZ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 7
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Estos compuestos poseen actividad antiinflamatoria.Reivindicación 1: Un compuesto de fórmula (1), caracterizado porque: R1 representa arilo o heteroarilo opcionalmente sustituido por uno o más grupos elegidos independientemente de entre halógeno, alquilo C1-8, haloalquilo C1-8, R2O-alquilo C0-8, R2S-alquilo C0-8, ciano, nitro, -NR2R4, -NR2SO2R3, -SOR3, -SO2R3, -SO2NR2R4 o -CONR2R4; R2 representa hidrógeno, alquilo C1-8 o aril-alquilo C0-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupos elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano, nitro, R5O-alquilo C0-8, R5S-alquilo C0-8, -NR5R6, -NR5COR3, -COR5 o -COOR5); R3 representa un grupo alquilo C1-8 o haloalquilo C1-8; R4 representa hidrógeno, alquilo C1-8, aril-alquilo C1-8 (donde el grupo arilo puede estar opcionalmente sustituido por uno o más grupos elegidos de entre alquilo C1-8, halógeno, haloalquilo C1-8, ciano, nitro, R5O-alquilo C0-8, R5S-alquilo C0-8, -NR5R6, -NR5COR3, -COR5, -COOR5), -COR6 o -COOR6; R5 representa hidrógeno, alquilo C1-8 o bencilo; R6 representa alquilo C1-8 o haloalquilo C1-8; arilo representa fenilo o naftilo; y heteroarilo representa piridina, pirazina, pirimidina o piridazina, que pueden estar opcionalmente fusionadas a un anillo de benceno; y But representa tert-butilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101853A ES2184633B1 (es) | 2001-08-07 | 2001-08-07 | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086065A2 true AR086065A2 (es) | 2013-11-13 |
Family
ID=8498662
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102972A AR037231A1 (es) | 2001-08-07 | 2002-08-06 | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos |
| ARP120101436A AR086065A2 (es) | 2001-08-07 | 2012-04-25 | Compuestos de imidazolsulfonamidas y un proceso para su produccion |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102972A AR037231A1 (es) | 2001-08-07 | 2002-08-06 | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida e compuestos intermedios para la obtencion de los mismos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7351836B2 (es) |
| EP (1) | EP1424329B1 (es) |
| JP (1) | JP4309262B2 (es) |
| KR (1) | KR100888905B1 (es) |
| AR (2) | AR037231A1 (es) |
| AT (1) | ATE396976T1 (es) |
| BR (1) | BRPI0211749B8 (es) |
| CA (1) | CA2456531C (es) |
| CY (1) | CY1108861T1 (es) |
| DE (1) | DE60226879D1 (es) |
| DK (1) | DK1424329T3 (es) |
| ES (2) | ES2184633B1 (es) |
| MX (1) | MXPA04001147A (es) |
| NO (1) | NO326162B1 (es) |
| PT (1) | PT1424329E (es) |
| WO (1) | WO2003016285A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN00202A (es) | 2012-07-12 | 2015-06-12 | Chiesi Farma Spa | |
| WO2022269384A1 (en) * | 2021-06-24 | 2022-12-29 | Ami Organics Ltd. | A process for the direct synthesis of fedratinib intermediate |
| KR102703324B1 (ko) * | 2022-11-08 | 2024-09-06 | 국민대학교산학협력단 | 아미노벤즈이미다졸 유도체 및 이의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| CA2334597C (en) * | 1998-07-02 | 2007-09-04 | Cryptography Research, Inc. | Leak-resistant cryptographic indexed key update |
| AR024222A1 (es) * | 1998-10-16 | 2002-09-25 | Palau Pharma Sa | Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen |
| ES2159489B1 (es) * | 2000-03-23 | 2002-04-16 | Uriach & Cia Sa J | Nuevos derivados de imidazol con actividad antiinflamatoria. |
-
2001
- 2001-08-07 ES ES200101853A patent/ES2184633B1/es not_active Expired - Fee Related
-
2002
- 2002-08-01 MX MXPA04001147A patent/MXPA04001147A/es active IP Right Grant
- 2002-08-01 PT PT02794802T patent/PT1424329E/pt unknown
- 2002-08-01 KR KR1020047001749A patent/KR100888905B1/ko not_active Expired - Fee Related
- 2002-08-01 EP EP02794802A patent/EP1424329B1/en not_active Expired - Lifetime
- 2002-08-01 JP JP2003521211A patent/JP4309262B2/ja not_active Expired - Fee Related
- 2002-08-01 ES ES02794802T patent/ES2307817T3/es not_active Expired - Lifetime
- 2002-08-01 DE DE60226879T patent/DE60226879D1/de not_active Expired - Lifetime
- 2002-08-01 CA CA2456531A patent/CA2456531C/en not_active Expired - Lifetime
- 2002-08-01 DK DK02794802T patent/DK1424329T3/da active
- 2002-08-01 WO PCT/ES2002/000385 patent/WO2003016285A1/es not_active Ceased
- 2002-08-01 AT AT02794802T patent/ATE396976T1/de active
- 2002-08-01 BR BRPI0211749A patent/BRPI0211749B8/pt not_active IP Right Cessation
- 2002-08-01 US US10/485,950 patent/US7351836B2/en not_active Expired - Fee Related
- 2002-08-06 AR ARP020102972A patent/AR037231A1/es not_active Application Discontinuation
-
2004
- 2004-03-05 NO NO20040981A patent/NO326162B1/no not_active IP Right Cessation
-
2008
- 2008-04-01 US US12/060,574 patent/US8476456B2/en not_active Expired - Fee Related
- 2008-08-21 CY CY20081100892T patent/CY1108861T1/el unknown
-
2012
- 2012-04-25 AR ARP120101436A patent/AR086065A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0211749B1 (pt) | 2013-09-10 |
| DK1424329T3 (da) | 2008-09-29 |
| BR0211749A (pt) | 2004-10-13 |
| HK1066214A1 (en) | 2005-03-18 |
| EP1424329B1 (en) | 2008-05-28 |
| ATE396976T1 (de) | 2008-06-15 |
| ES2307817T3 (es) | 2008-12-01 |
| CA2456531A1 (en) | 2003-02-27 |
| US8476456B2 (en) | 2013-07-02 |
| PT1424329E (pt) | 2008-08-06 |
| MXPA04001147A (es) | 2004-07-08 |
| CA2456531C (en) | 2010-12-14 |
| US7351836B2 (en) | 2008-04-01 |
| JP2005502659A (ja) | 2005-01-27 |
| EP1424329A1 (en) | 2004-06-02 |
| KR20040020079A (ko) | 2004-03-06 |
| BRPI0211749B8 (pt) | 2021-05-25 |
| NO326162B1 (no) | 2008-10-13 |
| ES2184633A1 (es) | 2003-04-01 |
| WO2003016285A1 (es) | 2003-02-27 |
| DE60226879D1 (de) | 2008-07-10 |
| AR037231A1 (es) | 2004-11-03 |
| US20090012307A1 (en) | 2009-01-08 |
| NO20040981L (no) | 2004-03-05 |
| ES2184633B1 (es) | 2004-08-01 |
| US20040242872A1 (en) | 2004-12-02 |
| JP4309262B2 (ja) | 2009-08-05 |
| WO2003016285A8 (es) | 2003-08-28 |
| KR100888905B1 (ko) | 2009-03-16 |
| CY1108861T1 (el) | 2014-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |