AR045793A1 - Compuestos derivados de 3-heterociclil-indol - Google Patents
Compuestos derivados de 3-heterociclil-indolInfo
- Publication number
- AR045793A1 AR045793A1 ARP040103394A ARP040103394A AR045793A1 AR 045793 A1 AR045793 A1 AR 045793A1 AR P040103394 A ARP040103394 A AR P040103394A AR P040103394 A ARP040103394 A AR P040103394A AR 045793 A1 AR045793 A1 AR 045793A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- heterocyclic group
- group
- heteroatoms independently
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 3
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 3
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 102000001267 GSK3 Human genes 0.000 abstract 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000001963 4 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
Abstract
Compuestos, proceso para su preparación, intermediarios utilizados en el mismo, formulaciones farmacéuticas que contienen dichos compuestos terapéuticamente activos y uso de dichos compuestos activos en terapia para la prevención y tratamiento de trastornos asociados con la glucógeno sintasa quinasa-3 (GSK-3). Reivindicación 1: Un compuesto que tiene la fórmula 1a o 1b en las cuales: P representa un anillo heteroaromático de 5 o 6 miembros que contiene uno o dos heteroátomos seleccionados independientemente entre N, O, y S, de los cuales por lo menos un heteroátomo es N; R1 es H, R2 es seleccionado entre: alquilo C1-6, ciano, halógeno, (CO)OR10 y CONR10R11; R3 es seleccionado entre alquilo C1-6, ciano, nitro, (CO)OR4, alquil C1-6- NR4R5, Oalquil C2-6-NR4R5, CONR4R5, SO2R4, OSO2R4 y (SO2)NR4R5; R4 es seleccionado entre H, CF3 y alquilo C1-6; R5 es seleccionado entre H, alquilo C1-6, alquil C1-6-NR6R7 y, donde R4 y R5 pueden formar juntos un grupo heterocíclico de 4, 5, 6 o 7 miembros que contiene uno o más heteroátomos seleccionados independientemente entre N, O y S, donde dicho grupo heterocíclico puede estar optativamente sustituido con el grupo Y; R6 y R7 son independientemente seleccionados entre H, alquilo c1-6, (CO)alquilo C1-6 y donde R6 y R7 pueden formar juntos un grupo heterocíclico de 5 o 6 miembros que contiene uno o más heteroátomos seleccionados independientemente entre N, O y S, donde dicho grupo heterocíclico puede estar optativamente sustituido con el grupo Y; R8 y R9 son independientemente seleccionados entre H y alquilo C1-6 y donde R8 y R9 pueden formar juntos un grupo heterocíclico de 5 o 6 miembros que contiene uno o más heteroátomos seleccionados independientemente entre N, O, y S; R10 es seleccionado entre H y alquilo C1-6; R11 es seleccionado entre H, alquilo C1-6, alquil C1-6CN, alquilarilo C0-6, alquil C2-6OR8, alquil C1-6(CO)NR6R7, alquil C1-6(SO2)R6, alquil C1-6(SO2)NR6R7, alquilheteroarilo C0-6, un grupo alquil C0- 6heterocíclico C3-6 y alquilo C1-6NR6R7, y donde cualquier alquilarilo C0-6 y alquilheteroarilo C0-6 puede estar sustituido con uno o más grupos Z y donde cualquier grupo alquil C0-6heterociclico C3-6 puede estar sustituido con uno o más grupos Y; Z es seleccionado entre halo, alquilo C1-6, alcoxi C1-6, OCF3 y CF3; Y es seleccionado entre oxo, alquil C2-6OR8, alquilo C1-6, alquilarilo C0-6, alquilheteroarilo C0-6, OR8 y alquilo C2-6NR8R9; m es 0, 1, 2, 3 o 4; n es 0, 1, 2, 3 o 4; en forma de base libre o sal de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302546A SE0302546D0 (sv) | 2003-09-24 | 2003-09-24 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045793A1 true AR045793A1 (es) | 2005-11-16 |
Family
ID=29212538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103394A AR045793A1 (es) | 2003-09-24 | 2004-09-21 | Compuestos derivados de 3-heterociclil-indol |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7683067B2 (es) |
| EP (1) | EP1667990A2 (es) |
| JP (1) | JP2007506734A (es) |
| CN (1) | CN1886397A (es) |
| AR (1) | AR045793A1 (es) |
| AU (1) | AU2004273771B2 (es) |
| BR (1) | BRPI0414632A (es) |
| CA (1) | CA2538381A1 (es) |
| MX (1) | MXPA06003195A (es) |
| SE (1) | SE0302546D0 (es) |
| TW (1) | TW200526627A (es) |
| UY (1) | UY28528A1 (es) |
| WO (1) | WO2005027823A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| WO2007089192A1 (en) * | 2006-02-02 | 2007-08-09 | Astrazeneca Ab | Pharmaceutical use of 2-hydroxy-3- [5- (morpholin-4- ylmethyl) pyridine-2-yl] -1h- indole-5-carbonitrile as a free base or salts |
| SA07280004B1 (ar) * | 2006-02-02 | 2011-10-29 | استرازينيكا ايه بي | ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات |
| JP2009528344A (ja) * | 2006-02-28 | 2009-08-06 | アストラゼネカ・アクチエボラーグ | インドール誘導体の新規な塩及び医薬におけるその使用 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007120102A1 (en) * | 2006-04-19 | 2007-10-25 | Astrazeneca Ab | New substituted oxindole derivatives |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20090291982A1 (en) * | 2008-05-22 | 2009-11-26 | Astrazeneca Ab | New Substituted Oxindole Derivative 352 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| TW201040191A (en) * | 2009-03-27 | 2010-11-16 | Abbott Gmbh & Co Kg | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| EP2377850A1 (en) * | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1 vanilloid receptor antagonists with a bicyclic portion |
| CN103380125B (zh) | 2010-12-21 | 2015-11-25 | 拜耳知识产权有限责任公司 | 制备三嗪基取代的羟吲哚的方法 |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| WO2020163812A1 (en) | 2019-02-08 | 2020-08-13 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| US20230212120A1 (en) * | 2020-05-29 | 2023-07-06 | The Regents Of The University Of Michigan | Small molecule inhibitors of grk5 and grk5 subfamily members and uses thereof |
| CN119118901B (zh) * | 2024-09-09 | 2025-09-30 | 中国人民解放军北部战区总医院 | 一种氧吲哚类衍生物及其制备方法与在trpa1抑制剂方向的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5940149B2 (ja) * | 1977-11-09 | 1984-09-28 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
| US5565580A (en) | 1994-01-27 | 1996-10-15 | Neurosearch A/S | Glutamate Antagonists |
| TW574214B (en) | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| US6569868B2 (en) * | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| KR100666514B1 (ko) | 1999-05-21 | 2007-02-28 | 브리스톨-마이어즈 스퀴브 컴페니 | 키나제의 피롤로트리아진 저해제 |
| AU770600B2 (en) | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| US6455525B1 (en) | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| PL366701A1 (en) | 2000-07-27 | 2005-02-07 | F.Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
| WO2002030868A1 (en) | 2000-10-13 | 2002-04-18 | Bristol-Myers Squibb Company | Selective maxi-k- potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| SE0104341D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| ES2289171T3 (es) * | 2001-12-21 | 2008-02-01 | Astrazeneca Ab | Uso de derivados de oxindol en el tratamiento de trastornos relacionados con la demencia, de la enfermedad de alzheimer y afecciones asociadas con glucogeno sintasa quinasa-3. |
| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| CN1671694A (zh) * | 2002-06-05 | 2005-09-21 | 詹森药业有限公司 | 作为激酶抑制剂的二吲哚基－顺丁烯二酰亚胺衍生物 |
-
2003
- 2003-09-24 SE SE0302546A patent/SE0302546D0/xx unknown
-
2004
- 2004-09-15 TW TW093127911A patent/TW200526627A/zh unknown
- 2004-09-21 CA CA002538381A patent/CA2538381A1/en not_active Abandoned
- 2004-09-21 AU AU2004273771A patent/AU2004273771B2/en not_active Ceased
- 2004-09-21 MX MXPA06003195A patent/MXPA06003195A/es not_active Application Discontinuation
- 2004-09-21 EP EP04775465A patent/EP1667990A2/en not_active Withdrawn
- 2004-09-21 WO PCT/SE2004/001363 patent/WO2005027823A2/en not_active Ceased
- 2004-09-21 JP JP2006527944A patent/JP2007506734A/ja active Pending
- 2004-09-21 BR BRPI0414632-8A patent/BRPI0414632A/pt not_active IP Right Cessation
- 2004-09-21 US US10/572,778 patent/US7683067B2/en not_active Expired - Fee Related
- 2004-09-21 AR ARP040103394A patent/AR045793A1/es unknown
- 2004-09-21 UY UY28528A patent/UY28528A1/es not_active Application Discontinuation
- 2004-09-21 CN CNA2004800347007A patent/CN1886397A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2538381A1 (en) | 2005-03-31 |
| WO2005027823A2 (en) | 2005-03-31 |
| UY28528A1 (es) | 2005-04-29 |
| JP2007506734A (ja) | 2007-03-22 |
| AU2004273771B2 (en) | 2008-11-06 |
| MXPA06003195A (es) | 2006-06-23 |
| EP1667990A2 (en) | 2006-06-14 |
| BRPI0414632A (pt) | 2006-11-07 |
| AU2004273771A1 (en) | 2005-03-31 |
| WO2005027823A3 (en) | 2005-06-02 |
| TW200526627A (en) | 2005-08-16 |
| CN1886397A (zh) | 2006-12-27 |
| US7683067B2 (en) | 2010-03-23 |
| SE0302546D0 (sv) | 2003-09-24 |
| US20080275041A1 (en) | 2008-11-06 |
Similar Documents
| Publication | Publication Date | Title |
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