AR073475A1 - Diaminopirimidinas sustituidas con 4- haloalquilo - Google Patents
Diaminopirimidinas sustituidas con 4- haloalquiloInfo
- Publication number
- AR073475A1 AR073475A1 ARP090103355A AR073475A1 AR 073475 A1 AR073475 A1 AR 073475A1 AR P090103355 A ARP090103355 A AR P090103355A AR 073475 A1 AR073475 A1 AR 073475A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- haloalkyl
- carbonyl
- Prior art date
Links
- 239000001257 hydrogen Substances 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 14
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 14
- 229910052757 nitrogen Inorganic materials 0.000 abstract 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 12
- -1 SOMe Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000005842 heteroatom Chemical group 0.000 abstract 8
- 229910052760 oxygen Inorganic materials 0.000 abstract 8
- 229920006395 saturated elastomer Polymers 0.000 abstract 8
- 229910052717 sulfur Inorganic materials 0.000 abstract 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 7
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 6
- 229910052801 chlorine Inorganic materials 0.000 abstract 6
- 239000000460 chlorine Substances 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 229910052731 fluorine Inorganic materials 0.000 abstract 6
- 239000011737 fluorine Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 5
- 229910052794 bromium Inorganic materials 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 2
- 101100212791 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YBL068W-A gene Proteins 0.000 abstract 2
- 101100495923 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr2 gene Proteins 0.000 abstract 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000006217 methyl sulfide group Chemical group [H]C([H])([H])S* 0.000 abstract 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 230000003032 phytopathogenic effect Effects 0.000 abstract 2
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 2
- ZBZJXHCVGLJWFG-UHFFFAOYSA-N trichloromethyl(.) Chemical compound Cl[C](Cl)Cl ZBZJXHCVGLJWFG-UHFFFAOYSA-N 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 abstract 1
- 125000006426 1-chlorocyclopropyl group Chemical group [H]C1([H])C([H])([H])C1(Cl)* 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 150000007579 7-membered cyclic compounds Chemical class 0.000 abstract 1
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 abstract 1
- 101000598778 Homo sapiens Protein OSCP1 Proteins 0.000 abstract 1
- 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 abstract 1
- 102100022673 Nuclear receptor subfamily 4 group A member 3 Human genes 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940058936 antimalarials diaminopyrimidines Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 238000003898 horticulture Methods 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical group NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
El uso de las mismas y también procedimientos y composiciones para controlar hongos daninos fitopatogenos en y/o sobre plantas o en y/o sobre semilla de plantas, procedimientos para preparar tales composiciones y semilla tratada y también su uso para controlar hongos daninos fitopatogenos en la agricultura, horticultura y silvicultura, en la proteccion de materiales y en el sector doméstico y de la higiene. La presente se refiere además a un procedimiento para preparar diaminopirimidinas sustituidas con 4-haloalquilo. Reivindicacion 1: Compuestos de la formula (1) en la que los símbolos son como se definen a continuacion: X1 representa nitrogeno o CR3, X2 representa nitrogeno o CR4, en la que X1 y X2 no representan ambos nitrogeno, R1 y R5 independientemente entre sí representan hidrogeno, alquilo C1-4, alcoxi C1-4, OH, haloalquilo C1-4 o halogeno, R2 representa hidrogeno, halogeno, nitro, ciano, alquilo C1-4, haloalquilo C1-2, hidroxilo, OR12, OCON(R12)2, haloalcoxi C1-3, COR12, CR12=NOR12, SF5, SR12, SOR12, SO2R12, CO2R12, N(R12)2, NR12COR12 o NR12CO2R13, R3 y R4 independientemente entre sí representan hidrogeno, halogeno, ciano, nitro, un ciclo de 3 a 8 miembros sin sustituir o sustituido saturado o insaturado que contiene ninguno o hasta cuatro heteroátomos seleccionados del grupo que está constituido por N, O y S, en el que des átomos de oxígeno no son adyacentes, OR12, OSO2N(R12)2, OCON(R12)2, OCOR13, SF5, SR12, SOR12, SO2R12, SON(R12)2, SO2N(R13)2, SO2NHR14, SO2NHCOR12, C=OR12, CH=NOR12, CR13=NOR12, COCI, CON(R12)2, COOR12, COO(CH2)mOR12, CO(CH2)mCN, CO(CH2)mN(R12)2, NR12COR12, NR12COOR13, NR12(C=S)R13, NR12(C=S)OR13 , N(R12)2, NR12(CH2)mN(R12)2, NR12SO2R13, NR12SOR13, [C(R12)2]mCN, (CH2)mSON(R12)2, (CH2)mSO2N(R12)2, (CH2)mCOOR12, (CH2)mCOR12, [C(R12)2]mCOR12, [C(R12)2]mCON(R12)2, (CH2)mN(R12)2, (CH2)mNR12COR12, (CH2)mNR12COOR13, [C(R12)2]mNR12COR12, [C(R12)2]mNR12COOR13, alquilo C1-8 sin sustituir o sustituido, alquenilo C2-6 sin sustituir o sustituido, haloalquilo C1-8 sin sustituir o sustituido, alquinilo C2-6 sin sustituir o sustituido; en las que m = 1 - 4, en la que adicionalmente o independientemente de los mismos R3 y R4, si procede mediante R12 y R13, pueden formar juntos un ciclo de 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener ninguno o hasta cuatro heteroátomos seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxígeno no son adyacentes, en la que los sustituyentes independientemente entre sí se seleccionan del grupo que está constituido por hidrogeno, fluor, cloro y bromo, alquilo C1-4, alcoxi C1-4, hidroxilo, oxo, haloalquilo C1-4, (alquil C1-4)carbonilo o ciano, R6 representa hidrogeno, alquilo C1-4, alcoxi C1-4-alquilo C1-4, formilo, (alquil C1-4)carbonilo, (alcoxi C1-4-alquil C1-4)carbonilo, (alqueniloxi C3-6)carbonilo, (cicloalquil C3-6)carbonilo, (haloalcoxi C1-4-alquil C1-4)carbonilo, (haloalquil C1-4)carbonilo, (alcoxi C1-4)carbonilo, (haloalcoxi C1-4)carbonilo, benciloxicarbonilo, bencilo sin sustituir o sustituido, benzoílo sin sustituir o sustituido, alquenilo C2-6 sin sustituir o sustituido, alquinilo C2-6 sin sustituir o sustituido, alquil C1-2-sulfinilo o alquil C1-2-sulfonilo, en la que los sustituyentes independientemente entre sí se seleccionan del grupo que está constituido por hidrogeno, fluor, cloro y bromo, alquilo C1-4, alcoxi C1-4, hidroxilo, haloalquilo C1-4 y ciano, R7 representa hidrogeno, alquilo C1-3, ciano o haloalquilo C1-3, R8 representa fluor, cloro, bromo, yodo, ciano, metilo, SMe, SOMe, SO2Me, CF3, CCl3, CFH2 o CF2H, R9 representa hidrogeno, alquilo C1-3, haloalquilo C2-3, alcoxi C1-4-alquilo C1-4, (alquil C1-4)carbonilo, (haloalquil C1-4)carbonilo, (alcoxi C1-4)carbonilo, bencilo sin sustituir o sustituido, alquenilo C2-4 sin sustituir o sustituido, alquinilo C2-4 sin sustituir o sustituido, alquil C1-6-sulfinilo, alquil C1-6-sulfonilo, haloalquil C1-6-sulfinilo o haloalquil C1-6-sulfonilo, en la que los sustituyentes independientemente entre sí se seleccionan del grupo que esta constituido por átomos de fluor, cloro y/o bromo, ciano, hidroxilo, metilo, metoxi, CF3, R10 representa un grupo de formula (2) en la que los símbolos son como se definen a continuacion y representa el punto de union al átomo de nitrogeno; R11a representa hidrogeno o alquilo C1-4, R11b representa hidrogeno, alquilo C1-4, haloalquilo C1-3, (CH2)mOH, (CH2)mO(alquilo C1-2), COOR12, CON(R12)2, (CH2)mCOOR12, COR12, bencilo sin sustituir o sustituido, alquenilo C2-6, sin sustituir o sustituido o alquinilo C2-6 sin sustituir o sustituido; en la que los sustituyentes independientemente entre sí se seleccionan del grupo que está constituido por hidrogeno, fluor, cloro o bromo, alquilo C1-4, alcoxi C1-4, hidroxilo, haloalquilo C1-4 y ciano, R11c representa hidrogeno, halogeno o alquilo C1-4, R11d representa hidrogeno, halogeno, alquilo C1-6, OR12, COOR12, (CH2)mCOOR12 o COR12, X representa halogeno o haloalquilo C1-6, en las que m = 1-4 y n = 1-4, R12 independientemente entre sí son idénticos o diferentes y son hidrogeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6 sin sustituir o sustituido, trialquil C1-4-sililo, alquenilo C2-4 sin sustituir o sustituido, alquinilo C2-4 sin sustituir o sustituido, arilo sin sustituir o sustituido, alcoxi C1-4-alquilo C1-4, bencilo sin sustituir o sustituido o un ciclo de 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener ninguno o hasta cuatro heteroátomos seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxígeno no son adyacentes, o si dos radicales R12 están unidos a un átomo de nitrogeno, dos radicales R12 pueden formar un ciclo 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener hasta cuatro heteroátomos adicionales seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxígeno no son adyacentes, o si dos radicales R12 son adyacentes en la agrupacion NR12COR12, NR12SOR12, NR12SO2R12, NR12SONR12, NR12SO2NR12, dos radicales R12 pueden formar un ciclo 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener hasta cuatro heteroátomos adicionales seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxígeno no son adyacentes, R13 independientemente entre sí son idénticos o diferentes y son alquilo C1-8, haloalquilo C1-8, trialquil C1-4-sililo, alquenilo C2-6 sin sustituir o sustituido, alquinilo C2-6 sin sustituir o sustituido, cicloalquilo C3-6 sin sustituir o sustituido, arilo sin sustituir o sustituido, alcoxi C1-4-alquilo C1-4, bencilo sin sustituir o sustituido o un ciclo 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener ninguno o hasta cuatro heteroátomos seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxigeno no son adyacentes, o si dos radicales R13 están unidos a un átomo de nitrogeno, dos radicales R13 pueden formar un ciclo 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener hasta cuatro heteroátomos adicionales seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxígeno no son adyacentes, R14 son idénticos o diferentes y son alquilo C1-6, haloalquilo C1-8, trialquil C1-4-sililo, alquenilo C2-6 sin sustituir o sustituido, alquinilo C2-6 sin sustituir o sustituido, cicloalquilo C3-6 sin sustituir o sustituido, arilo sin sustituir o sustituido, bencilo sin sustituir o sustituido o un ciclo 3 a 7 miembros sin sustituir o sustituido saturado o insaturado que puede contener ninguno o hasta cuatro heteroátomos seleccionados del grupo que está constituido por N, O y S, en el que dos átomos de oxigeno o dos átomos de nitrogeno no son adyacentes, y cuando se posible los sustituyentes se seleccionan de la siguiente lista: fluor, cloro, bromo, yodo, ciano, nitro, CF3, CFH2, CF2H, C2F5, CCl3, hidroxilo, OMe, OEt, OPr, OisoPr, OBu, OsecBu, OisoBu, OtercBu, O(CH2)2OCH3, O(CH2)3OCH3, O-ciclopentilo, O-fenilo, OCF3, OCF2H, OCF2CF3, OCF2CF2H, SH, SMe, SEt, SCF3, SCF2H, SPh, SCF5, SO2Me, SO2CF3, SOMe, SOEt, CO2H, CO2CH3, CO2Et, CO2Pr, CO2isoPr, CO2tercBu, COMe, COCF3, NH2, NHMe, NMe2, NHEt, NEt2, NHPr, NHisoPr, NHnBu, NHtercBu, NHisoBu, NHsecBu, ciclopropilamino, formilo, CH2CN, CHMeCN, CH2COCH3, CH2OMe, (CH2)2OMe, (CH2)3OMe, CH2OH, CH2SMe, (CH2)2SMe, metilo, etilo, propilo, 1-metiletilo, butilo, 1-metilpropilo, 2-metilpropilo, 1,1-dimetiletilo, ciclopropilo, 1-metoxiciclopropilo, 1-clorociclopropilo, ciclobutilo, 3-dimetilbutilo, ciclopentilo, ciclohexilo, ciclohexilmetilo, neopentilo, prop-2-en-1-ilo, 1-metilprop-2-en-1-ilo, but-3-en-1-ilo, (trimetilsilil)metilo, ciclopropilo, ciclobutilo, ciclopentilo, ciclohexilo, fenilo, bencilo, -CH2CH=CH2, -CH(CH3)CH=CH2, -CH2C:::CH, y las sales agroquímicamente activas de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08163552A EP2161259A1 (de) | 2008-09-03 | 2008-09-03 | 4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073475A1 true AR073475A1 (es) | 2010-11-10 |
Family
ID=40114412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103355 AR073475A1 (es) | 2008-09-03 | 2009-09-01 | Diaminopirimidinas sustituidas con 4- haloalquilo |
Country Status (4)
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|---|---|
| EP (1) | EP2161259A1 (es) |
| AR (1) | AR073475A1 (es) |
| TW (1) | TW201022236A (es) |
| WO (1) | WO2010025871A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012014158A (es) | 2010-06-04 | 2013-02-07 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2). |
| PT3124483T (pt) | 2010-11-10 | 2019-10-02 | Genentech Inc | Derivados de pirazol aminopirimidina como moduladores de lrrk2 |
| CN105481778B (zh) * | 2014-09-16 | 2019-06-04 | 深圳微芯生物科技股份有限公司 | 嘧啶衍生物、其制备方法及其应用 |
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| US2539406A (en) | 1948-10-16 | 1951-01-30 | Eastman Kodak Co | 1-fluoroalkylamino-2-trifluoromethyl-4-arylaminoanthraquinone compounds |
| GB1182584A (en) * | 1966-03-31 | 1970-02-25 | Ici Ltd | Pyrimidine derivates and the use thereof as fungicides |
| GR71929B (es) | 1979-11-13 | 1983-08-19 | Ici Ltd | |
| DE3429048A1 (de) | 1984-08-07 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Fluorierte alkylamidosulfochloride |
| JPS62155259A (ja) | 1985-12-27 | 1987-07-10 | Ishihara Sangyo Kaisha Ltd | アミノトリフルオロメチルピリジン系化合物及びその製造方法 |
| DE3611195A1 (de) | 1986-04-04 | 1987-10-08 | Bayer Ag | Fluorierte tertiaere butylamine |
| GB8810120D0 (en) | 1988-04-28 | 1988-06-02 | Plant Genetic Systems Nv | Transgenic nuclear male sterile plants |
| ES2081863T3 (es) * | 1989-03-22 | 1996-03-16 | Ciba Geigy Ag | Plaguicidas. |
| DE4029650A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide |
| ATE342968T1 (de) | 1995-04-20 | 2006-11-15 | Basf Ag | Auf basis ihrer struktur entworfene herbizid resistente produkte |
| JP3533134B2 (ja) | 1999-02-15 | 2004-05-31 | 三井化学株式会社 | フッ素化剤及びその製法と使用 |
| AU782948B2 (en) * | 2000-05-08 | 2005-09-15 | Janssen Pharmaceutica N.V. | Prodrugs of HIV replication inhibiting pyrimidines |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0025820D0 (en) | 2000-10-20 | 2000-12-06 | Novartis Ag | Organic compounds |
| MEP13408A (en) | 2001-05-29 | 2010-06-10 | Bayer Schering Pharma Ag | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| RS51752B (sr) | 2002-07-29 | 2011-12-31 | Rigel Pharmaceuticals | Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina |
| RS20050363A (sr) * | 2002-11-28 | 2007-11-15 | Schering Aktiengesellschaft, | Chk-,Pdk- I Akt-INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH SREDSTAVA |
| ES2338545T3 (es) | 2002-12-20 | 2010-05-10 | Pfizer Products Inc. | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| RS53109B (sr) | 2003-07-30 | 2014-06-30 | Rigel Pharmaceuticals Inc. | Jedinjenja 2,4 pirimidindiamina za upotrebu u tretmanu ili prevenciji autoimunih bolesti |
| JP4741491B2 (ja) | 2003-08-07 | 2011-08-03 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 抗増殖剤としての２，４−ピリミジンジアミン化合物および使用 |
| DE10349423A1 (de) * | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| MXPA06010520A (es) | 2004-03-30 | 2007-03-26 | Chiron Corp | Derivados de tiofeno sustituidos como agentes anticancerosos. |
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| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| DE102005008310A1 (de) | 2005-02-17 | 2006-08-24 | Schering Ag | Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle |
| US20070032514A1 (en) | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| US20080234130A1 (en) | 2005-08-24 | 2008-09-25 | Pioneer Hi-Bred International, Inc. | Compositions providing tolerance to multiple herbicides and methods of use thereof |
| JP4975747B2 (ja) | 2005-08-31 | 2012-07-11 | モンサント テクノロジー エルエルシー | 殺虫性タンパク質をコードするヌクレオチド配列 |
| AU2006327871A1 (en) | 2005-12-21 | 2007-06-28 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| TW200812962A (en) | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
-
2008
- 2008-09-03 EP EP08163552A patent/EP2161259A1/de not_active Ceased
-
2009
- 2009-08-27 WO PCT/EP2009/006203 patent/WO2010025871A1/de not_active Ceased
- 2009-09-01 AR ARP090103355 patent/AR073475A1/es unknown
- 2009-09-02 TW TW98129481A patent/TW201022236A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2161259A1 (de) | 2010-03-10 |
| WO2010025871A1 (de) | 2010-03-11 |
| TW201022236A (en) | 2010-06-16 |
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