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AR078326A1 - Quinazolinas como inhibidores de los canales ionicos de potasio y composiciones farmaceuticas que los contienen - Google Patents

Quinazolinas como inhibidores de los canales ionicos de potasio y composiciones farmaceuticas que los contienen

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Publication number
AR078326A1
AR078326A1 ARP100103247A ARP100103247A AR078326A1 AR 078326 A1 AR078326 A1 AR 078326A1 AR P100103247 A ARP100103247 A AR P100103247A AR P100103247 A ARP100103247 A AR P100103247A AR 078326 A1 AR078326 A1 AR 078326A1
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Argentina
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alkyl
heterocyclyl
heteroaryl
cycloalkyl
alkenyl
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ARP100103247A
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English (en)
Inventor
John Lloyd
Heather Finlay
James Neels
Naveen Kumar Dhondi
Prashantha Gunaga
Ashokkumar Adisechan
Abhisek Banerjee
Ji Jiang
James A Johnson
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Bristol Myers Squibb Co
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Publication of AR078326A1 publication Critical patent/AR078326A1/es

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Abstract

Los compuestos son utiles como inhibidores de la funcion de los canales de potasio y en el tratamiento y prevencion de arritmia, trastornos asociados con IKur y otros trastornos mediados por la funcion de los canales ionicos. Reivindicacion 1: Un compuesto, caracterizado porque tiene la formula (1) o un enantiomero, diastereomero, tautomero o sales del mismo, en la que: X es H, -OH, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, alquenilo C2-12 alquinilo C2-12, cicloalquilo C3-10, un heteroarilo de 4 a 12 miembros, heterociclilo de 4 a 12 miembros, -CN, -NO2, -NR11SO2R12, -SO2NR11R12, -CONR11R12, -NR11CONR11R12, -NCOR11, -NR11SO2NR11R12, -OCONR11R12, -CO2R11 o -NR11R12; Y es H, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, alquenilo C2-12, alquinilo C2-12, cicloalquilo C3-10, un heteroarilo de 4 a 12 miembros, heterociclilo de 4 a 12 miembros, -CN, -NO2, -SO2NR11R12, -CONR11R12, -NR11CONR11R12, -NCOR11, -NR11SO2NR11R12, -OCONR11R12, -CO2R11 o -NR11R12; Z es H, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, alquenilo C2-12, alquinilo C2-12, cicloalquilo C3-10, un heteroarilo de 6 a 12 miembros, heterociclilo de 4 a 12 miembros, -NO2, -NR11SO2R12, -SO2NR11R12, -NR11CONR11R12, -NCOR11, -NR11SO2NR11R12, -OCONR11R12, -CO2R11 o -NR11R12; A es -(CH2)m-R2, -CH(R25)(R26), -CH(R26)CO2-R2a o -(CH2)n-1-NR25-CO2-R24; m es 0 a 4; n es 1 a 4; n-1 es 2 a 4; R1 es -OH, F, Cl, Br, I, alquilo C1-10, haloalquilo C1-10, alquenilo C2-12, cicloalquilo C3-10, -CN, -(CH2)n-SO2NR11R12, -(CH2)n-CO2R11 o -(CH2)n-NR11SO2R12, pudiendo estar el alquenilo y cicloalquilo opcionalmente sustituidos con uno o más R13; o R1 se selecciona del grupo de formulas (2); o R1 es el resto de formula (3); R2 es alquilo C1-10, ciclopropilo opcionalmente sustituido con uno o más R13; cicloalquilo C4-10 opcionalmente sustituido con uno o más R13bb; cicloalquenilo C3-10 opcionalmente sustituido con uno o más R13b; o -NR14R14; con la condicion de que R2 no sea -NR14R14 cuando m sea 0, 1 o 3; o R2 es el resto de formula (4); o R2 se selecciona del grupo de formulas (5); R2a es alquilo C1-10, cicloalquilo C3-10, arilo C6-10, -NR14R14, un heteroarilo de 4 a 12 miembros o heterociclilo de 4 a 12 miembros, cualquiera de los cuales está opcionalmente sustituido con uno o más R13 y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R11 y R12, en cada aparicion, se seleccionan independientemente de H, alquilo C1-10, haloalquilo C1-10, cicloalquilo C3-10, arilo C6-10, un heteroarilo de 4 a 12 miembros y un heterociclilo de 4 a 12 miembros, pudiendo estar el alquilo, cicloalquilo, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R13 y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; o R11 y R12 se toman junto con el nitrogeno al que están unidos formando un heterociclilo de 4 a 12 miembros, pudiendo estar el heterociclilo opcionalmente sustituido con uno o más R13 y el heterociclilo está constituido por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13, en cada aparicion, es independientemente H, -OH, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; con la condicion de que cuando R13 sea alquilo sustituido con un R14a, R14a no sea -OH; R13a, en cada aparicion, es independientemente H, -OH, F, Cl, Br, I, alquilo C2-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13aa, en cada aparicion, es independientemente H, -OH, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13a-1, en cada aparicion, es independientemente H, -OH, F, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13a-2, en cada aparicion, es independientemente H, -OH, F, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13a-4, en cada aparicion, es independientemente H, -OH, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -CONR14R14, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13b, en cada aparicion, es independientemente H, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un heterociclilo de 4 a 12 miembros, un heteroaril de 4 a 12 miembros-alquilo C1-10, -CN, -NO2, -(CH2)m-SO2R14, -NR14SO2R14, =O, -(CH2)m-SO2NR14R14, -(CH2)m-NR14SO2R14, -(CH2)n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C(=NOR14)NR14R14, -CONR14OR14 o -NCOR14, pudiendo estar el alquilo, cicloalquilo, alquenilo, alcoxi, arilo, heteroarilo y heterociclilo opcionalmente sustituidos con uno o más R14a y el heteroarilo y heterociclilo están constituidos por átomos de carbono y 1, 2, 3 o 4 heteroátomos seleccionados independientemente del grupo constituido por N, S u O; R13bb, en cada aparicion, es independientemente H, F, Cl, Br, I, alquilo C1-10, alcoxi C1-10, haloalquilo C1-10, cicloalquilo C3-10, alquenilo C2-12, alquinilo C2-12, arilo C6-10, un heteroarilo de 4 a 12 miembros, un
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