AR077488A1 - Compuestos heterociclicos nitrogenados inhibidores de autotaxina, medicamentos que los contienen y uso de los mismos para el tratamiento y/o prevencion de cancer y enfermedades tumorales. - Google Patents
Compuestos heterociclicos nitrogenados inhibidores de autotaxina, medicamentos que los contienen y uso de los mismos para el tratamiento y/o prevencion de cancer y enfermedades tumorales.Info
- Publication number
- AR077488A1 AR077488A1 ARP100102610A ARP100102610A AR077488A1 AR 077488 A1 AR077488 A1 AR 077488A1 AR P100102610 A ARP100102610 A AR P100102610A AR P100102610 A ARP100102610 A AR P100102610A AR 077488 A1 AR077488 A1 AR 077488A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- mono
- cona2
- so2a
- nhcoa
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title abstract 2
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 229910017464 nitrogen compound Inorganic materials 0.000 title 1
- 150000002830 nitrogen compounds Chemical class 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- -1 COOA Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 4
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 3
- 125000000565 sulfonamide group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000000169 tricyclic heterocycle group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Los compuestos de la formula (1), R es Hal, Ar o Het1, R1 es SO2A, COOA, COOH, Cyc, Het, Ar, COHet, CONHHet, CONHAr, CHO, CONH2, CONHA, CONA2, (CH2)n2OH, (CH2)n2OA, OAr, NHAr, A, Hal, (CH2)n2NH2, (CH2)n2NHA, (CH2)n2NA2 o NHCOA, R2 es H, (CH2)n3NH2, (CH2)n3NHA, (CH2)n3NA2, (CH2)n3OH, (CH2)n3OA, (CH2)n3Het2, CH2COHet2, CH2CONH2, CH2CONHA, CH2CONA2 o A, X, X1 son cada uno, de modo independiente entre sí, CO, CH(OH), CH(OA), CH(NH2), CH2 o CF2, Y, Y1 son cada uno, de modo independiente entre sí, CH o N, Q es C=O, COO, C=S, C=NH, CH(OH), CH(NH2), SO, SO2 o CF2; E es CO, CH(OH), CA(CH), CH(OA), CA(OA), CH(NH2), Alk, formula (3) o (4); Alk es alquileno lineal o ramificado C1-8, en donde uno o dos grupos CH2 pueden estar reemplazados por O y/o NH, n1 es 0, 1 o 2, n2 es 0, 1,2, 3 o 4, n3 es 1, 2, 3 o 4, Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHSO2A, SO2NH2 y/o SO2A, Het es un heterociclo saturado, insaturado o aromático mono-, bi- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, Het2, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHSO2A, SO2NH2, SO2A, NHCONH2, CHO, COA, =S, =NH, =NA y/o =O (oxígeno del carbonilo), Het1 es un heterociclo aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHSO2A, SO2NH2, SO2A, NHCONH2, CHO y/o COA, Het2 es pirrolidinilo, piperidinilo, tiazolidinilo, morfolinilo, oxazolidinilo, tetrahidroquinazolinilo, tetrahidropiranilo, piperazinilo, tiazolilo, furilo, tienilo, pirrolilo, imidazolilo, pirazolilo, oxazolilo, isoxazolilo, isotiazolilo, piridilo, pirimidinilo, triazolilo, tetrazolilo, oxadiazolilo o tiadiazolilo no sustituido o monosustituido con A, Cyc es alquilo cíclico C3-7, A es alquilo no ramificado o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por F, Cl y/o Br, y/o en donde uno o dos grupos CH2 pueden estar reemplazados por O y/o NH, o es alquilo cíclico C3-7, Hal es F, Cl, Br o I, así como sus sales y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones, excluyendo los compuestos ôB1ö - ôB27ö, son inhibidores de autotaxina y se pueden utilizar para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033392A DE102009033392A1 (de) | 2009-07-16 | 2009-07-16 | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077488A1 true AR077488A1 (es) | 2011-08-31 |
Family
ID=42646326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102610A AR077488A1 (es) | 2009-07-16 | 2010-07-16 | Compuestos heterociclicos nitrogenados inhibidores de autotaxina, medicamentos que los contienen y uso de los mismos para el tratamiento y/o prevencion de cancer y enfermedades tumorales. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120115852A1 (es) |
| EP (1) | EP2454258A1 (es) |
| JP (1) | JP2012532901A (es) |
| KR (1) | KR20120090031A (es) |
| CN (1) | CN102471343A (es) |
| AR (1) | AR077488A1 (es) |
| AU (1) | AU2010272922A1 (es) |
| BR (1) | BR112012000792A2 (es) |
| CA (1) | CA2768095A1 (es) |
| DE (1) | DE102009033392A1 (es) |
| EA (1) | EA201200119A1 (es) |
| IL (1) | IL217466A0 (es) |
| MX (1) | MX2012000609A (es) |
| SG (1) | SG177522A1 (es) |
| WO (1) | WO2011006569A1 (es) |
| ZA (1) | ZA201201124B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| CA2878442A1 (en) * | 2012-09-25 | 2014-04-03 | F. Hoffmann-La Roche Ag | Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases |
| CN104968656B (zh) | 2012-12-19 | 2017-08-11 | 诺华股份有限公司 | 自分泌运动因子抑制剂 |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| US20160039825A1 (en) * | 2013-03-15 | 2016-02-11 | Biogen Ma Inc. | S1p and/or atx modulating agents |
| JP2016530209A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ビニルオートタキシン阻害剤化合物 |
| WO2015042052A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| JP2016531874A (ja) | 2013-09-26 | 2016-10-13 | ファーマケア，インク． | オートタキシン阻害剤化合物 |
| MY182095A (en) | 2013-11-22 | 2021-01-18 | Sabre Therapeutics Llc | Autotaxin inhibitor compounds |
| CA2930735A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Tetracyclic autotaxin inhibitors |
| PE20160845A1 (es) | 2013-11-26 | 2016-09-10 | Hoffmann La Roche | Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo |
| EA032357B1 (ru) * | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| HUE046820T2 (hu) | 2014-03-26 | 2020-03-30 | Hoffmann La Roche | Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként |
| AP2016009496A0 (en) | 2014-04-04 | 2016-10-31 | X-Rx Inc | Substituted spirocydic inhibitors of autotaxin |
| BR112016024473A2 (pt) * | 2014-04-23 | 2018-01-23 | X Rx Inc | composto, composição farmacêutica, e, método para tratamento de uma doença e/ou condição |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| ES2915267T3 (es) | 2015-05-27 | 2022-06-21 | Sabre Therapeutics Llc | Inhibidores de autotaxina y usos de los mismos |
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| MX377277B (es) | 2015-09-04 | 2025-03-07 | Hoffmann La Roche | Derivados de fenoximetilo. |
| BR112018006034A2 (pt) | 2015-09-24 | 2018-10-09 | Hoffmann La Roche | compostos bicíclicos como inibidores de atx |
| RU2725138C2 (ru) | 2015-09-24 | 2020-06-30 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca) |
| MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| KR20190129924A (ko) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물 |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| JP6687816B1 (ja) * | 2018-05-21 | 2020-04-28 | 株式会社アシックス | ブラジャー |
| WO2020040326A1 (ko) * | 2018-08-23 | 2020-02-27 | 가천대학교 산학협력단 | 페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
| WO2020072456A1 (en) * | 2018-10-02 | 2020-04-09 | Case Western Reserve University | Compounds for treating myelin related disorders |
| EP4476222A1 (en) * | 2022-02-10 | 2024-12-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| PT1147115E (pt) * | 1999-01-19 | 2004-02-27 | Ortho Mcneil Pharm Inc | Benzodiazepinas triciclicas como antagonistas do receptor da vasopressina |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| WO2001034203A1 (fr) * | 1999-11-09 | 2001-05-17 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Produit comprenant un inhibiteur de la transduction des signaux des proteines g heterotrimeriques en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer |
-
2009
- 2009-07-16 DE DE102009033392A patent/DE102009033392A1/de not_active Withdrawn
-
2010
- 2010-06-17 MX MX2012000609A patent/MX2012000609A/es not_active Application Discontinuation
- 2010-06-17 AU AU2010272922A patent/AU2010272922A1/en not_active Abandoned
- 2010-06-17 KR KR1020127004105A patent/KR20120090031A/ko not_active Withdrawn
- 2010-06-17 CA CA2768095A patent/CA2768095A1/en not_active Abandoned
- 2010-06-17 CN CN2010800318870A patent/CN102471343A/zh active Pending
- 2010-06-17 BR BR112012000792A patent/BR112012000792A2/pt not_active Application Discontinuation
- 2010-06-17 JP JP2012519902A patent/JP2012532901A/ja active Pending
- 2010-06-17 EA EA201200119A patent/EA201200119A1/ru unknown
- 2010-06-17 SG SG2012000774A patent/SG177522A1/en unknown
- 2010-06-17 WO PCT/EP2010/003661 patent/WO2011006569A1/de not_active Ceased
- 2010-06-17 US US13/383,908 patent/US20120115852A1/en not_active Abandoned
- 2010-06-17 EP EP10725398A patent/EP2454258A1/de not_active Withdrawn
- 2010-07-16 AR ARP100102610A patent/AR077488A1/es unknown
-
2012
- 2012-01-10 IL IL217466A patent/IL217466A0/en unknown
- 2012-02-15 ZA ZA2012/01124A patent/ZA201201124B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG177522A1 (en) | 2012-02-28 |
| ZA201201124B (en) | 2012-11-28 |
| EA201200119A1 (ru) | 2012-07-30 |
| DE102009033392A1 (de) | 2011-01-20 |
| AU2010272922A1 (en) | 2012-03-08 |
| WO2011006569A1 (de) | 2011-01-20 |
| CN102471343A (zh) | 2012-05-23 |
| JP2012532901A (ja) | 2012-12-20 |
| BR112012000792A2 (pt) | 2016-02-23 |
| CA2768095A1 (en) | 2011-01-20 |
| IL217466A0 (en) | 2012-02-29 |
| KR20120090031A (ko) | 2012-08-16 |
| EP2454258A1 (de) | 2012-05-23 |
| US20120115852A1 (en) | 2012-05-10 |
| MX2012000609A (es) | 2012-01-27 |
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