AR068658A1 - Derivados de tiazol - Google Patents
Derivados de tiazolInfo
- Publication number
- AR068658A1 AR068658A1 ARP080104329A ARP080104329A AR068658A1 AR 068658 A1 AR068658 A1 AR 068658A1 AR P080104329 A ARP080104329 A AR P080104329A AR P080104329 A ARP080104329 A AR P080104329A AR 068658 A1 AR068658 A1 AR 068658A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- atoms
- hal
- nhet
- nhet1
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 3
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 240000000543 Pentas lanceolata Species 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000169 tricyclic heterocycle group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de formula (1) en donde R1 es un heterociclo insaturado o aromático bicíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con A, Ar, SR, NR2, Hal, NO2, CN, (CR2)n[X(CR2)n)]p-Y, CONR2, OR5 y/u =O (oxígeno del carbonilo); R2 y R3 son en cada caso, de modo independiente entre sí, H, A, Ar, OR, SR, NR2, Hal, NO2, CN o (CR2)n[X(CR2)n)]p-Y; R4 es H, Hal, A, OR, NR2 o (CR2)n[X(CR2)n)]p-Y; X es O, NR o CR2; Y es OR o NR2; R5 es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por F y/o Cl; K es C=O, CR2CO, o CR2; E es COO(CR2)n, CO(CR2)mO, CONH(CR2)n, S(O)q(CR2)n, CO(CR2)n, (CR2)n, CO(CR2)mO(CR2)p, CO(CR2)mNH(CR2)p o C(=S)O(CR2)n; R es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C; W es Ar o Het; G es CH o N; Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, A, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, OCONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet y/o COA; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, (CR2)nOR, (CR2)nNR2, SR, NO2, CN, COOR, CONR2, NRCOA, NRSO2A, SO2NR2, S(O)qA, CO-Het1, (CR2)nHet1, O(CR2)nNR2, O(CR2)nHet1, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet1, NHCONH(CR2)NR2, NHCONH(CR2)nHet1, OCONH(CR2)nNR2, OCONH(CR2)nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo); Het1 es un heterociclo saturado monocíclico con 1 a 2 N y/o átomos de O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo); A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OR, CN, NR2, F y/o Cl y/o en donde uno o dos grupos CH2 no adyacentes pueden estar reemplazados por O, NH, S, SO, SO2 y/o por grupos CH=CH, o alquilo cíclico con 3-7 átomos de C; m es 1, 2, 3, 4, 5 o 6; n es 0, 1, 2, 3, 4, 5, 6, 7 u 8, p es 0, 1, 2, 3, 4, 5 o 6; q es 0, 1 o 2; Hal es F, Cl, Br o I; así como sus derivados, solvatos, tautomeros, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Se pueden utilizar para el tratamiento de tumores. También se reivindica medicamento y proceso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007047735A DE102007047735A1 (de) | 2007-10-05 | 2007-10-05 | Thiazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068658A1 true AR068658A1 (es) | 2009-11-25 |
Family
ID=40418145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104329A AR068658A1 (es) | 2007-10-05 | 2008-10-03 | Derivados de tiazol |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8557824B2 (es) |
| EP (1) | EP2209777B1 (es) |
| JP (2) | JP2010540580A (es) |
| KR (1) | KR20100080836A (es) |
| CN (1) | CN101815714A (es) |
| AR (1) | AR068658A1 (es) |
| AU (1) | AU2008310068B2 (es) |
| BR (1) | BRPI0817579A2 (es) |
| CA (1) | CA2701525C (es) |
| DE (1) | DE102007047735A1 (es) |
| EA (1) | EA201000550A1 (es) |
| ES (1) | ES2548525T3 (es) |
| IL (1) | IL204563A (es) |
| MX (1) | MX2010003365A (es) |
| WO (1) | WO2009046842A2 (es) |
| ZA (1) | ZA201003123B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2531256T3 (es) * | 2007-01-25 | 2015-03-12 | Du Pont | Amidas fungicidas |
| DE102009049211A1 (de) * | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| US9353113B2 (en) | 2011-03-18 | 2016-05-31 | Ono Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| HUE055213T2 (hu) | 2013-11-22 | 2021-11-29 | Sabre Therapeutics Llc | Autotaxin inhibitor vegyületek |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| CA2986759C (en) | 2015-05-27 | 2025-06-17 | Sabre Therapeutics Llc | AUTOTAXIN INHIBITORS AND THEIR USES |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| TW202110831A (zh) * | 2019-06-04 | 2021-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吡啶酮類衍生物、其製備方法及其在醫藥上的應用 |
| US11427558B1 (en) | 2019-07-11 | 2022-08-30 | ESCAPE Bio, Inc. | Indazoles and azaindazoles as LRRK2 inhibitors |
| CN113493453B (zh) * | 2020-04-07 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 稠合芳香环类衍生物、其制备方法及其在医药上的应用 |
| AU2022211957B2 (en) * | 2021-01-29 | 2024-05-23 | Txinno Bioscience Inc. | Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| EP0858457A1 (de) | 1995-10-20 | 1998-08-19 | Dr. Karl Thomae GmbH | 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
| GB0230162D0 (en) | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
| FR2856685B1 (fr) | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1735622A2 (en) * | 2004-04-13 | 2006-12-27 | Arena Pharmaceuticals, Inc. | Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders |
| EP1637529A1 (en) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| US7601745B2 (en) * | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| ATE430744T1 (de) | 2005-08-18 | 2009-05-15 | Hoffmann La Roche | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren |
| JPWO2007105448A1 (ja) | 2006-02-28 | 2009-07-30 | 出光興産株式会社 | ナフタセン誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
| EP1832586A1 (en) | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
| WO2007104557A2 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
-
2007
- 2007-10-05 DE DE102007047735A patent/DE102007047735A1/de not_active Withdrawn
-
2008
- 2008-09-19 CA CA2701525A patent/CA2701525C/en not_active Expired - Fee Related
- 2008-09-19 AU AU2008310068A patent/AU2008310068B2/en not_active Ceased
- 2008-09-19 CN CN200880110188A patent/CN101815714A/zh active Pending
- 2008-09-19 WO PCT/EP2008/007894 patent/WO2009046842A2/de not_active Ceased
- 2008-09-19 ES ES08802403.9T patent/ES2548525T3/es active Active
- 2008-09-19 EP EP08802403.9A patent/EP2209777B1/de not_active Not-in-force
- 2008-09-19 JP JP2010527350A patent/JP2010540580A/ja active Pending
- 2008-09-19 BR BRPI0817579 patent/BRPI0817579A2/pt not_active IP Right Cessation
- 2008-09-19 EA EA201000550A patent/EA201000550A1/ru unknown
- 2008-09-19 KR KR1020107009914A patent/KR20100080836A/ko not_active Withdrawn
- 2008-09-19 MX MX2010003365A patent/MX2010003365A/es not_active Application Discontinuation
- 2008-09-19 US US12/681,724 patent/US8557824B2/en not_active Expired - Fee Related
- 2008-10-03 AR ARP080104329A patent/AR068658A1/es unknown
-
2010
- 2010-03-16 IL IL204563A patent/IL204563A/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03123A patent/ZA201003123B/en unknown
-
2014
- 2014-07-14 JP JP2014144141A patent/JP5843930B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2701525A1 (en) | 2009-04-16 |
| IL204563A0 (en) | 2010-11-30 |
| WO2009046842A2 (de) | 2009-04-16 |
| US8557824B2 (en) | 2013-10-15 |
| JP2014240392A (ja) | 2014-12-25 |
| MX2010003365A (es) | 2010-04-30 |
| JP5843930B2 (ja) | 2016-01-13 |
| EA201000550A1 (ru) | 2010-10-29 |
| CA2701525C (en) | 2016-06-28 |
| WO2009046842A3 (de) | 2009-06-25 |
| ES2548525T3 (es) | 2015-10-19 |
| ZA201003123B (en) | 2011-04-28 |
| EP2209777B1 (de) | 2015-07-29 |
| AU2008310068B2 (en) | 2014-05-01 |
| IL204563A (en) | 2017-03-30 |
| US20100240676A1 (en) | 2010-09-23 |
| CN101815714A (zh) | 2010-08-25 |
| AU2008310068A1 (en) | 2009-04-16 |
| BRPI0817579A2 (pt) | 2015-04-07 |
| DE102007047735A1 (de) | 2009-04-09 |
| JP2010540580A (ja) | 2010-12-24 |
| KR20100080836A (ko) | 2010-07-12 |
| EP2209777A2 (de) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |