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AR077567A1 - Derivados de aminopiridina - Google Patents

Derivados de aminopiridina

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Publication number
AR077567A1
AR077567A1 ARP100102541A ARP100102541A AR077567A1 AR 077567 A1 AR077567 A1 AR 077567A1 AR P100102541 A ARP100102541 A AR P100102541A AR P100102541 A ARP100102541 A AR P100102541A AR 077567 A1 AR077567 A1 AR 077567A1
Authority
AR
Argentina
Prior art keywords
nhet1
nhet
het1
nar
mono
Prior art date
Application number
ARP100102541A
Other languages
English (en)
Inventor
Christina Esdar
Michel Calderini
Ulrich Graedler
Wucherer-Plietker Margarita Dra
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR077567A1 publication Critical patent/AR077567A1/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Abstract

Incluyendo sus composiciones farmacéuticas y su uso en el tratamiento y/o la prevencion de diabetes, síndrome metabolico, obesidad, cáncer, inflamacion. Reivindicacion 1: Compuestos de la formula (1) en donde R1 es un heterociclo mono- o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que no está sustituido o que puede estar mono- o disustituido con Hal, A, OR5, SR5, NO2, CN, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, [C(R5)2]nCOOR5, [C(R5)2]nCON(R5)2, [C(R5)2]nCONR5[C(R5)2]nAr, [C(R5)2]nCONR5[C(R5)2]nHet, [C(R5)2]nCO-Het, [C(R5)2]nN(R5)2, [C(R5)2]nAr, [C(R5)2]nHet, O[C(R5)2]nN(R5)2, O[C(R5)2]nHet, NR5COOA, NR5CON(R5)2, NR5COO[C(R5)2]nN(R5)2, NR5COO[C(R5)2]nHet1, NR5CONR5[C(R5)2]nN(R5)2, NR5CONR5[C(R5)2]nHet1, OCONR5[C(R5)2]nN(R5)2, OCONR5[C(R5)2]nHet1, [C(R5)2]nOR5, [C(R5)2]nCONR5[C(R5)2]nN(R5)2, CHO, COA, =S, =NH, NA y/u =O (oxígeno del carbonilo), Y es, de modo independiente entre sí, N o C, en donde máximo dos Y pueden ser N, R2, R3, R4, R7 son en cada caso, de modo independiente entre sí, H, Hal, A, OA, SR5, NO2, CN, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, S(O)mHet, CO-Ar, CO-Het, [C(R5)2]nAr, [C(R5)2]nHet, C(R5)(OR5)Ar, C(R5)(OR5)Het, [C(R5)2]nOR5, [C(R5)2]nOAr, [C(R5)2]nOHet, [C(R5)2]nN(R5)2, [C(R5)2]nCON(R5)2, [C(R5)2]nCOOR5, [C(R5)2]nCONR5[C(R5)2]nAr, [C(R5)2]nCONR5[C(R5)2]nHet, [C(R5)2]nCOO[C(R5)2]nAr, [C(R5)2]nCOO[C(R5)2]nHet, [C(R5)2]nNR5CO[C(R5)2]nAr o [C(R5)2]nNR5CO[C(R5)2]nHet, con la condicion de que a) cuando un Y es N, R7 está ausente; b) cuando dos Y son N, R4 y R7 están ausentes; dos radicales adyacentes, seleccionados del grupo R2, R3, R4, R7 también sean juntos OCH2O, OCH2CH2O, NHCONH, OCF2O, CH=N-NH o NH-N=CH, R5 es A o H, A es alquilo no ramificado o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por F y/o en donde uno o dos grupos CH2 pueden estar reemplazados por O, S, NR5 y/o por grupos CH=CH, o alquilo cíclico C3-7, Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OR5, N(R5)2, SR5, NO2, CN, COOR5, CON(R5)2, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, CO-Het1, Het1, O[C(R5)2]nN(R5)2, O[C(R5)2]nHet1, NHCOOA, NHCON(R5)2, NHCOO[C(R5)2]nN(R5)2, NHCOO[C(R5)2]nHet1, NHCONH[C(R5)2]nN(R5)2, NHCONH[C(R5)2]nHet1, OCONH[C(R5)2]nN(R5)2, OCONH[C(R5)2]nHet1 y/o COA, Het es un heterociclo mono- o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono- a trisustituido con Has, A, OR5, N(R5)2, SR5, NO2, CN, COOR5, CON(R5)2, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, CO-Het1, Het1, [C(R5)2]nN(R5)2, [C(R5)2]nHet1, O[C(R5)2]nN(R5)2, O[C(R5)2]nHet1, NHCOOA, NHCON(R5)2, NHCOO[C(R5)2]nN(R5)2, NHCOO[C(R5)2]nHet1, NHCONH[C(R5)2]nN(R5)2, NHCONH[C(R5)2]nHet1, OCONH[C(R5)2]nN(R5)2, OCONH[C(R5)2]nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo), Het1 es un heterociclo saturado monocíclico con 1 a 2 átomos de N y/u O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo), Hal es F, CI, Br o I, m es 0,1 o 2, n es 0,1, 2, 3 o 4, así como sus sales, tautomeros y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones.
ARP100102541A 2009-07-15 2010-07-14 Derivados de aminopiridina AR077567A1 (es)

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AR077567A1 true AR077567A1 (es) 2011-09-07

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CA2768169C (en) 2017-06-13
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