AR077417A1 - Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa o agente inductor de la produccion de eritropoyetina - Google Patents
Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa o agente inductor de la produccion de eritropoyetinaInfo
- Publication number
- AR077417A1 AR077417A1 ARP100102614A ARP100102614A AR077417A1 AR 077417 A1 AR077417 A1 AR 077417A1 AR P100102614 A ARP100102614 A AR P100102614A AR P100102614 A ARP100102614 A AR P100102614A AR 077417 A1 AR077417 A1 AR 077417A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl group
- aryl
- cycloalkyl
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 title 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 4
- 102000003951 Erythropoietin Human genes 0.000 abstract 3
- 108090000394 Erythropoietin Proteins 0.000 abstract 3
- 229940105423 erythropoietin Drugs 0.000 abstract 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 abstract 1
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
- 229940078467 Prolyl hydroxylase inhibitor Drugs 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
Abstract
También reivindica un inhibidor de la prolil hidroxilasa o un agente que induce la produccion de eritropoyetina que contiene el compuesto. El compuesto de la presente invencion muestra una accion inhibidora de prolil hidroxilasa y la capacidad de inducir la produccion de eritropoyetina y es util como agente profiláctico o terapéutico para varias enfermedades y patologías (trastornos) orinados por la produccion disminuida de la eritropoyetina, como anemia. Reivindicacion 1: Un compuesto caracterizado por la siguiente formula [1] o su sal aceptable para uso farmacéutico, o un solvato del mismo. Donde la formula estructural parcial: es un grupo representado por cualquiera de las siguientes formulas: R1 es (1) un átomo de halogeno, (2) un grupo alquilo C1-6, (3) un grupo arilo C6-14, (4) un grupo cicloalquilo C3-8, (5) un grupo aril C6-14-alquilo C1-6, o (6) un grupo cicloalquil C3-8-alquilo C1-6; R2 es (1) un átomo de halogeno, (2) un grupo alquilo C1-10, (3) un grupo arilo C6-14 opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B, (4) un grupo cicloalquilo C3-8 opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B, (5) un grupo cicloalquenilo C3-8 opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B, (6) un grupo heteroarilo opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B (donde el heteroarilo tiene, además de los átomos de carbono, 1 a 6 heteroátomos seleccionados de un átomo de nitrogeno, un átomo de oxígeno y un átomo de azufre), (7) un grupo aril C6-14-alquilo C1-6 (donde arilo C6-14 está opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B), o (8) un grupo cicloalquil C3-8-alquilo C1-6 (donde cicloalquilo C3-8 está opcionalmente sustituido con los mismos o diferentes 1 a 5 sustituyentes seleccionados del siguiente grupo B); R3 es (1) un átomo de halogeno, (2) un átomo de halogeno, (3) un grupo alquilo C1-6, (4) un grupo arilo C6-14, (5) un grupo cicloalquilo C3-8, o (6) un grupo aril C6-14-alquilo C1-6, y R4 y R5 son cada uno de ellos independientemente (1) un átomo de halogeno, o (2) un grupo alquilo C1-6, grupo B: (a) un átomo de halogeno; (b) un grupo alquilo C1-6, (c) un grupo cicloalquilo C3-8, (d) un grupo ciano, y (e) un grupo alquilo C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009169565 | 2009-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077417A1 true AR077417A1 (es) | 2011-08-24 |
Family
ID=43449466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102614A AR077417A1 (es) | 2009-07-17 | 2010-07-16 | Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa o agente inductor de la produccion de eritropoyetina |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US8283465B2 (es) |
| EP (3) | EP2746282A1 (es) |
| JP (9) | JP5021797B2 (es) |
| KR (4) | KR101850661B1 (es) |
| CN (1) | CN102471337B (es) |
| AR (1) | AR077417A1 (es) |
| AU (1) | AU2010271732B2 (es) |
| BR (1) | BR112012001157A2 (es) |
| CA (1) | CA2768505C (es) |
| CO (1) | CO6430426A2 (es) |
| DK (1) | DK2455381T5 (es) |
| ES (1) | ES2477968T3 (es) |
| HR (1) | HRP20140705T1 (es) |
| IL (1) | IL217541A (es) |
| ME (1) | ME01858B (es) |
| MX (1) | MX2012000766A (es) |
| MY (1) | MY160814A (es) |
| NZ (1) | NZ598242A (es) |
| PE (1) | PE20120629A1 (es) |
| PL (1) | PL2455381T3 (es) |
| PT (1) | PT2455381E (es) |
| RS (1) | RS53499B1 (es) |
| RU (1) | RU2538963C2 (es) |
| SG (1) | SG178049A1 (es) |
| SI (1) | SI2455381T1 (es) |
| SM (1) | SMT201500122B (es) |
| TW (1) | TWI485150B (es) |
| WO (1) | WO2011007856A1 (es) |
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| KR101850661B1 (ko) * | 2009-07-17 | 2018-04-19 | 니뽄 다바코 산교 가부시키가이샤 | 트리아졸로피리딘 화합물, 그리고 그 프롤릴 수산화효소 저해제 및 에리트로포이에틴 생성 유도제로서의 작용 |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| CA2896437C (en) | 2012-11-26 | 2021-01-19 | Takaaki Abe | Erythropoietin expression promoter |
| AP2015008502A0 (en) | 2012-12-24 | 2015-06-30 | Cadila Healthcare Ltd | Novel quinolone derivatives |
| EP3007695B1 (en) | 2013-06-13 | 2024-02-07 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| RU2534804C1 (ru) * | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
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| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| US20180243271A1 (en) * | 2015-05-28 | 2018-08-30 | Japan Tobacco Inc. | Method for Treating or Preventing Diabetic Nephropathy |
| US11434238B2 (en) * | 2016-11-25 | 2022-09-06 | Japan Tobacco Inc. | Method for producing triazolopyridine compound |
| ES2934361T3 (es) | 2017-05-09 | 2023-02-21 | Kind Pharmaceutical | Derivados de indolizina y aplicación de los mismos en medicina |
| CN111148735B (zh) * | 2017-10-04 | 2023-08-08 | 日本烟草产业株式会社 | 含氮杂芳基化合物及其药物用途 |
| CN107739378A (zh) * | 2017-11-14 | 2018-02-27 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| JP7458987B2 (ja) * | 2018-09-13 | 2024-04-01 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物 |
| CN110105355B (zh) * | 2019-05-24 | 2021-09-21 | 烟台大学 | 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法 |
| WO2021182490A1 (ja) * | 2020-03-11 | 2021-09-16 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物又はその塩の結晶 |
| JP7504822B2 (ja) * | 2020-03-12 | 2024-06-24 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物を含む医薬組成物 |
| TW202200134A (zh) | 2020-04-20 | 2022-01-01 | 美商阿克比治療有限公司 | 治療病毒感染、器官損傷及相關症狀之方法 |
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| CN116496269B (zh) * | 2021-12-02 | 2025-02-28 | 苏中药业集团股份有限公司 | 一种脯氨酰羟化酶抑制剂及其用途 |
| CN114031619A (zh) * | 2021-12-17 | 2022-02-11 | 山东汇海医药化工有限公司 | 一种图卡替尼中间体的制备方法 |
| TW202412778A (zh) * | 2022-09-19 | 2024-04-01 | 大陸商蘇中藥業集團股份有限公司 | 一種脯氨醯羥化酶抑制劑及其用途 |
| CN121443606A (zh) * | 2023-06-02 | 2026-01-30 | 苏中药业集团股份有限公司 | 一种脯氨酰羟化酶抑制剂及其用途 |
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| WO2025167739A1 (zh) * | 2024-02-05 | 2025-08-14 | 深圳信立泰药业股份有限公司 | 化合物在制备预防和/或治疗高原病的药物中的应用 |
| CN119039291A (zh) * | 2024-09-09 | 2024-11-29 | 南京药坦生物科技有限公司 | 一种恩那度司他中间体及其制备方法 |
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| KR101850661B1 (ko) * | 2009-07-17 | 2018-04-19 | 니뽄 다바코 산교 가부시키가이샤 | 트리아졸로피리딘 화합물, 그리고 그 프롤릴 수산화효소 저해제 및 에리트로포이에틴 생성 유도제로서의 작용 |
-
2010
- 2010-07-16 KR KR1020177003353A patent/KR101850661B1/ko active Active
- 2010-07-16 DK DK10799914.6T patent/DK2455381T5/en active
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