AR074997A1 - Derivados de piridazinona - Google Patents
Derivados de piridazinonaInfo
- Publication number
- AR074997A1 AR074997A1 ARP100100034A ARP100100034A AR074997A1 AR 074997 A1 AR074997 A1 AR 074997A1 AR P100100034 A ARP100100034 A AR P100100034A AR P100100034 A ARP100100034 A AR P100100034A AR 074997 A1 AR074997 A1 AR 074997A1
- Authority
- AR
- Argentina
- Prior art keywords
- nhet1
- atoms
- het1
- hal
- oconh
- Prior art date
Links
- 125000004429 atom Chemical group 0.000 abstract 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000169 tricyclic heterocycle group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la formula 1 en donde D es un heterociclo insaturado o aromático de cinco miembros con 1 a 3 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono- di- o trisustituido con Hal y/o A, R1 es Ar, Het, A, OH, OA, O[C(R3)2]nAr, O[C(R3)2]nHet, N(R3)2, NR3[C(R3)2]nAr o NR3[C(R3)2]nHet, R2 es un heterociclo insaturado o aromático de cinco o seis miembros con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono- o disustituido con Hal, A, OH, OA, N(R3)2, SR3, NO2, CN, CO-OR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, CO-Het1, Het1, [C(R3)2]n, N(R3)2, [C(R3)2]nHet1, O[C(R3)2]pN(R3)2, O[C(R3)2]nHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]pN(R3)2, NHCOO[C(R3)2]nHet1, NHCONH[C(R3)2]pN(R3)2, NHCONH[C(R3)2]nHet1, OCONH[C(R3)2]pN(R3)2, OCONH[C(R3)2]nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo) R3 es H o A', R4 es H, A o Hal, A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OH, F, CI y/o Br, y/o en donde uno o dos grupos CH2 pueden estar reemplazados por O, NH, S, SO, SO2 y/o grupos CH=CH, o es alquilo cíclico con 3-7 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OH, F, CI y/o Br, A' es alquilo no ramificado o ramificado con 1-6 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por F, Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OH, OA, N(R3)2, SR3, NO2, CN, COOR3, CON(R3),, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA CO-Het1, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, O[C(R3)2]pN(R3)2, O[C(R3)2]nHet1, NHCOOA, NHCON(R3)2,, NHCOO[C(R3)2]pN(R3)2, NHCOO[C(R3)2]nHet1, NHCONH[C(R3)2]pN(R3)2, NHCONH[C(R3)2]nHet1, OCONH[C(R3)2]pN(R3)2 y/u OCONH[C(R3)2]nHet1, Het es un heterociclo mono-, bi- o tricíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OH, OA, N(R3)2, SR3, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, Het1, [C(R3)2]nN(R3)2, [C(R3)2]nHet1, O[C(R3)2]pN(R3)2, O[C(R3)2]nHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]pN(R3)2, NHCOO[C(R3)2]nHet1, NHCONH[C(R3)2]pN(R3)2, NHCONH[C(R3)2]nHet1, OCONH[C(R3)2]pN(R3)2, OCONH[C(R3)2]nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo), Het1 es un heterociclo saturado monocíclico con 1 a 2 átomos de N y/u o, que puede estar mono- o disustituido con A, OA, OH, Hal y/u O (oxígeno del carbonilo) Hal es F, CI, Br o I, m es 0, 1 o 2, n es 0, 1, 2, 3 o 4, p es 2, 3, 4, 5 o 6, así como sus sales, tautomeros y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Son inhibidores de las tirosina quinasas, en especial de la Metquinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009004061A DE102009004061A1 (de) | 2009-01-08 | 2009-01-08 | Pyridazinonderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074997A1 true AR074997A1 (es) | 2011-03-02 |
Family
ID=41581157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100034A AR074997A1 (es) | 2009-01-08 | 2010-01-08 | Derivados de piridazinona |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8623870B2 (es) |
| EP (1) | EP2373647B1 (es) |
| JP (1) | JP5683488B2 (es) |
| KR (1) | KR101669696B1 (es) |
| CN (1) | CN102272131A (es) |
| AR (1) | AR074997A1 (es) |
| AU (1) | AU2009336851B2 (es) |
| BR (1) | BRPI0923903B8 (es) |
| CA (1) | CA2749015C (es) |
| CY (1) | CY1113700T1 (es) |
| DE (1) | DE102009004061A1 (es) |
| DK (1) | DK2373647T3 (es) |
| EA (1) | EA020574B1 (es) |
| ES (1) | ES2398023T3 (es) |
| HR (1) | HRP20120976T1 (es) |
| IL (1) | IL213826A (es) |
| MX (1) | MX2011007209A (es) |
| PL (1) | PL2373647T3 (es) |
| PT (1) | PT2373647E (es) |
| SG (1) | SG172458A1 (es) |
| SI (1) | SI2373647T1 (es) |
| SM (1) | SMT201300010B (es) |
| WO (1) | WO2010078909A1 (es) |
| ZA (1) | ZA201105781B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN117126150A (zh) * | 2023-08-29 | 2023-11-28 | 仁合益康集团有限公司 | 一种阿齐沙坦酯钾盐杂质a的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| IL115889A0 (en) | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| AU738595B2 (en) | 1997-11-19 | 2001-09-20 | Kowa Co., Ltd. | Novel pyridazine derivatives and medicines containing the same as effective ingredients |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
| HUP0401984A3 (en) | 2001-10-31 | 2005-06-28 | Merck Patent Gmbh | Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions and combination with other active ingredients |
| IL162292A0 (en) | 2001-12-05 | 2005-11-20 | Ortho Mcneil Pharm Inc | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials |
| WO2005121132A1 (ja) | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| DE102005057924A1 (de) * | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| BRPI0619424B1 (pt) | 2005-12-05 | 2022-02-08 | Pfizer Products Inc | Uso de inibidores c-met/hgfrs para a fabricação de medicamentos |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
| TW200845991A (en) * | 2007-01-12 | 2008-12-01 | Smithkline Beecham Corp | N-substituted glycine derivatives: hydroxylase inhibitors |
| DE102007061963A1 (de) * | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| EP2379547A1 (en) * | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| DE102009003954A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
-
2009
- 2009-01-08 DE DE102009004061A patent/DE102009004061A1/de not_active Withdrawn
- 2009-12-10 HR HRP20120976AT patent/HRP20120976T1/hr unknown
- 2009-12-10 EP EP09768339A patent/EP2373647B1/de active Active
- 2009-12-10 SG SG2011048568A patent/SG172458A1/en unknown
- 2009-12-10 PT PT97683395T patent/PT2373647E/pt unknown
- 2009-12-10 ES ES09768339T patent/ES2398023T3/es active Active
- 2009-12-10 WO PCT/EP2009/008839 patent/WO2010078909A1/de not_active Ceased
- 2009-12-10 PL PL09768339T patent/PL2373647T3/pl unknown
- 2009-12-10 AU AU2009336851A patent/AU2009336851B2/en not_active Ceased
- 2009-12-10 DK DK09768339.5T patent/DK2373647T3/da active
- 2009-12-10 CN CN2009801537887A patent/CN102272131A/zh active Pending
- 2009-12-10 JP JP2011544797A patent/JP5683488B2/ja not_active Expired - Fee Related
- 2009-12-10 US US13/143,646 patent/US8623870B2/en active Active
- 2009-12-10 CA CA2749015A patent/CA2749015C/en active Active
- 2009-12-10 BR BRPI0923903A patent/BRPI0923903B8/pt not_active IP Right Cessation
- 2009-12-10 KR KR1020117018119A patent/KR101669696B1/ko not_active Expired - Fee Related
- 2009-12-10 EA EA201101038A patent/EA020574B1/ru not_active IP Right Cessation
- 2009-12-10 MX MX2011007209A patent/MX2011007209A/es active IP Right Grant
- 2009-12-10 SI SI200930433T patent/SI2373647T1/sl unknown
-
2010
- 2010-01-08 AR ARP100100034A patent/AR074997A1/es active IP Right Grant
-
2011
- 2011-06-28 IL IL213826A patent/IL213826A/en not_active IP Right Cessation
- 2011-08-05 ZA ZA2011/05781A patent/ZA201105781B/en unknown
-
2012
- 2012-12-21 CY CY20121101250T patent/CY1113700T1/el unknown
-
2013
- 2013-01-18 SM SM201300010T patent/SMT201300010B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009336851B2 (en) | 2016-03-03 |
| JP2012514612A (ja) | 2012-06-28 |
| HRP20120976T1 (hr) | 2012-12-31 |
| EA020574B1 (ru) | 2014-12-30 |
| CA2749015C (en) | 2017-10-31 |
| EA201101038A1 (ru) | 2012-01-30 |
| SMT201300010B (it) | 2013-03-08 |
| CY1113700T1 (el) | 2016-06-22 |
| KR20110099799A (ko) | 2011-09-08 |
| PT2373647E (pt) | 2013-01-30 |
| ZA201105781B (en) | 2012-04-25 |
| ES2398023T3 (es) | 2013-03-13 |
| IL213826A0 (en) | 2011-07-31 |
| SG172458A1 (en) | 2011-08-29 |
| SI2373647T1 (sl) | 2013-01-31 |
| KR101669696B1 (ko) | 2016-10-27 |
| IL213826A (en) | 2016-07-31 |
| DE102009004061A1 (de) | 2010-07-15 |
| EP2373647A1 (de) | 2011-10-12 |
| CA2749015A1 (en) | 2010-07-15 |
| BRPI0923903A2 (pt) | 2015-07-28 |
| MX2011007209A (es) | 2011-08-04 |
| US20110269771A1 (en) | 2011-11-03 |
| BRPI0923903B8 (pt) | 2021-05-25 |
| DK2373647T3 (da) | 2012-12-10 |
| BRPI0923903B1 (pt) | 2020-03-24 |
| JP5683488B2 (ja) | 2015-03-11 |
| US8623870B2 (en) | 2014-01-07 |
| WO2010078909A1 (de) | 2010-07-15 |
| EP2373647B1 (de) | 2012-10-31 |
| CN102272131A (zh) | 2011-12-07 |
| PL2373647T3 (pl) | 2013-03-29 |
| AU2009336851A1 (en) | 2011-08-25 |
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