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AR061955A1 - Compuestos quimicos - Google Patents

Compuestos quimicos

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Publication number
AR061955A1
AR061955A1 ARP070103007A ARP070103007A AR061955A1 AR 061955 A1 AR061955 A1 AR 061955A1 AR P070103007 A ARP070103007 A AR P070103007A AR P070103007 A ARP070103007 A AR P070103007A AR 061955 A1 AR061955 A1 AR 061955A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
optionally
alkenyl
aryl
Prior art date
Application number
ARP070103007A
Other languages
English (en)
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of AR061955A1 publication Critical patent/AR061955A1/es

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  • Gastroenterology & Hepatology (AREA)

Abstract

Compuestos de la fórmula general (1), en donde R¹ y R² son seleccionados independientemente uno de otro desde hidrógeno, alquilo C₁₋₁₀ opcionalmente sustituido, -CO-(alquil C₁₋₁₀) opcionalmente sustituido, cicloalquil C₃₋₁₀ opcionalmente sustituido, -CO-(cicloalquil C₃₋₁₀) opcionalmente sustituido, alquenilo C₂₋₁₀ opcionalmente sustituido, -CO-(alquenil C₂₋₁₀) opcionalmente sustituido, arilo opcionalmente sustituido, -CO-arilo opcionalmente sustituido o R¹ y R² representando juntos un grupo alquilideno C₁₋₁₀ opcionalmente sustituido, saturado o no saturado o un grupo cicloalquilideno C₃₋₁₀ opcionalmente sustituido, saturado o no saturado o R¹ y R² juntos con el átomo de carbono al cual ellos son ligados representan un anillo orgánico saturado o no saturado que contiene 3, 4, 5, 6, 7 u 8 átomos de carbono y opcionalmente un anillo de 1, 2 ó 3 heteroátomos seleccionado desde O, N y S; R³ el cual puede ser el mismo como, o diferente de, ya sea de R¹ y R², seleccionado desde un alquilo C₁₋₁₀ opcionalmente sustituido, cicloalquilo C₃₋₁₀ opcionalmente sustituido, alquenilo C₂₋₁₀ opcionalmente sustituido y arilo opcionalmente sustituido; R⁴, R⁵ y R⁶ son seleccionados independientemente uno de otro desde hidrógeno, alquilo C₁₋₁₀ opcionalmente sustituido, OH, alcoxi C₁₋₁₀ opcionalmente sustituido, halo, ariloxi opcionalmente sustituido, (alquil C₁₋₁₀) opcionalmente sustituido-S(O)ₙ- donde n = 0, 1 ó 2, aril-S(O)ₙ-opcionalmente sustituido donde n = 0, 1 ó 2, o R⁴ y R⁵ representan juntos una cadena orgánica opcionalmente sustituida que contiene 1, 2, 3, 4, 5, 6 ó 7 átomos de carbono y opcionalmente cadena 1, 2 ó 3 heteroátomos seleccionados desde O, N y S, contemplando que la cadena es de a lo menos tres átomos de largo; con la provisión que cuando R¹ = R² = hidrógeno, luego cualquier alquilo C₁₋₁₀ opcionalmente sustituido o alquenil C₂₋₁₀ opcionalmente sustituido para R³, deben tener un punto de ramificación en una o más de las posiciones a y b contadas desde el grupo carbonilo (o forma tautómera de éstas) a las cuales es ligado R³; o una sal fisiológicamente aceptable, complejo o prodroga de estos; son descriptos per se y para el uso en el tratamiento o profilaxis de la hipersensibilidad, desordenes del músculo liso, condiciones espasmódicas condiciones alérgicas, condiciones inflamatorias y/o dolor.
ARP070103007A 2006-07-06 2007-07-05 Compuestos quimicos AR061955A1 (es)

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