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AR054475A1 - Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion - Google Patents

Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion

Info

Publication number
AR054475A1
AR054475A1 ARP060102527A ARP060102527A AR054475A1 AR 054475 A1 AR054475 A1 AR 054475A1 AR P060102527 A ARP060102527 A AR P060102527A AR P060102527 A ARP060102527 A AR P060102527A AR 054475 A1 AR054475 A1 AR 054475A1
Authority
AR
Argentina
Prior art keywords
substituted
alkyl
propharmaces
phenylphosphates
broncoconstriction
Prior art date
Application number
ARP060102527A
Other languages
English (en)
Original Assignee
Corus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corus Pharma Inc filed Critical Corus Pharma Inc
Publication of AR054475A1 publication Critical patent/AR054475A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1) o (2) y sales aceptables para uso farmacéutico de las mismas, donde: X es S, N o un heterociclo que nitrogenado, en el cual el átomo de N del heterociclo está unido a R1 y R2; W se selecciona del grupo que incluye Cl, F, OH, ONO2, OCO-alquilo, OCO-arilo, CN, S-alquilo y S-arilo; Cicl es cicloalquilo o cicloalquilo con átomo(s) de C sustituido(s) con S u O; Y está ausente o es -Z(CH2)n, donde n = 0-6 y Z es S, O, N o N-alquilo; R1 y R2 se seleccionan independientemente del grupo que consiste en H, arilo, alquilo inferior y alquilo inferior sustituido, o están ausentes, o se toman conjuntamente para formar un anillo no aromático que posee 2 a 10 átomos seleccionados de C, O, S y N; R3 es como se muestra en el resto de formula (3) donde R6 es un grupo alquilo de 1-12 átomos de C, arilalquilo o arilalquilo sustituido con 1-3 grupos CH2 en la cadena de C sustituida con átomos(s) seleccionado(s) e O, S y N, y R4 y R5 son independientemente H, Cl o F.
ARP060102527A 2005-06-14 2006-06-14 Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion AR054475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69054505P 2005-06-14 2005-06-14

Publications (1)

Publication Number Publication Date
AR054475A1 true AR054475A1 (es) 2007-06-27

Family

ID=37570763

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102527A AR054475A1 (es) 2005-06-14 2006-06-14 Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion

Country Status (14)

Country Link
US (1) US20100209508A1 (es)
EP (1) EP1893220A4 (es)
JP (1) JP2008546694A (es)
KR (1) KR20060130515A (es)
CN (1) CN101227912A (es)
AR (1) AR054475A1 (es)
AU (1) AU2006259604A1 (es)
BR (1) BRPI0611567A2 (es)
CA (1) CA2612364A1 (es)
IL (1) IL187816A0 (es)
NO (1) NO20080182L (es)
RU (1) RU2008100237A (es)
TW (1) TW200718707A (es)
WO (1) WO2006138212A1 (es)

Families Citing this family (29)

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NZ575549A (en) * 2006-09-19 2012-06-29 Cipla Ltd Processes for the preparation of ciclesonide and its crystal form
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
CN101657460A (zh) * 2006-12-13 2010-02-24 基利得科学公司 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯
JP2011507879A (ja) * 2007-12-21 2011-03-10 シェーリング コーポレイション グルココルチコイド受容体アゴニストとしてのｃ−２１チオエーテル
PE20091525A1 (es) * 2007-12-21 2009-09-25 Schering Corp Agonista del receptor glucocorticoide c-20-c21 sustituido
TW201010707A (en) * 2008-06-10 2010-03-16 Gilead Sciences Inc Corticosteroid linked beta-agonist compounds for use in therapy
WO2010126953A1 (en) * 2009-04-29 2010-11-04 Gilead Sciences, Inc. Corticosteroid linked beta-agonist compounds for use in therapy
WO2010132743A1 (en) * 2009-05-15 2010-11-18 Gilead Sciences, Inc. Corticosteroid beta-agonist compounds for use in therapy
US20120171126A1 (en) * 2009-06-16 2012-07-05 Purakkattle Biju J NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS COMPOSITIONS AND USES THEREOF
PE20120894A1 (es) * 2009-09-11 2012-08-13 Chiesi Farma Spa Derivados de isoxazolidina
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
JP6124176B2 (ja) * 2013-03-26 2017-05-10 株式会社伏見製薬所 樹脂成形体用組成物
CN104510726A (zh) * 2013-09-27 2015-04-15 张金华 一种用于清洁呼吸道系统的食盐干粉吸入剂
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
SG10202001787QA (en) 2016-06-02 2020-04-29 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
ES3046537T3 (en) * 2016-11-08 2025-12-02 Regeneron Pharma Steroids and protein-conjugates thereof
IL270594B2 (en) 2017-05-18 2024-06-01 Regeneron Pharma Cyclodextrin protein drug conjugates
SG11202004151YA (en) 2017-11-07 2020-06-29 Regeneron Pharma Hydrophilic linkers for antibody drug conjugates
PE20201286A1 (es) 2017-12-01 2020-11-24 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados de este
IL319417A (en) 2018-01-08 2025-05-01 Regeneron Pharma Steroids and their anti-inflammatory properties
CN112533951A (zh) 2018-05-09 2021-03-19 里珍纳龙药品有限公司 抗msr1抗体及其使用方法
IT201900014178A1 (it) * 2019-08-06 2021-02-06 Genetic S P A Esteri del montelukast e loro formulazioni farmaceutiche
JP7656784B2 (ja) * 2020-11-26 2025-04-04 国立医薬品食品衛生研究所長 新規化合物及び抗コロナウイルス剤
CN112592280B (zh) * 2020-12-09 2023-05-23 青岛职业技术学院 一种消旋沙丁胺醇的制备方法
AR125079A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas de receptores de glucocorticoides sustituidos con carboxi
TW202304464A (zh) 2021-03-23 2023-02-01 美商美國禮來大藥廠 新穎糖皮質素受體激動劑
TWI899455B (zh) 2021-03-23 2025-10-01 美商美國禮來大藥廠 糖皮質素受體激動劑
CN117580849A (zh) * 2021-06-24 2024-02-20 江苏先声药业有限公司 甾体类化合物、其药物组合物及其应用
CN118201943A (zh) * 2021-09-14 2024-06-14 映恩生物制药（苏州）有限公司 一种抗炎症的化合物及其用途

Family Cites Families (9)

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BE585432A (fr) * 1958-12-08 1960-06-08 American Cyanamid Co Stéroïdes fluorés.
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
WO1994022899A1 (de) * 1993-04-02 1994-10-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue prednisolonderivate
US6300326B1 (en) * 1994-11-02 2001-10-09 Michael R. Dobbs Composition and method for control and treatment of cutaneous inflammation
IT1303671B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio
EP1635844A1 (en) * 2003-05-22 2006-03-22 ALTANA Pharma AG Salmeterol and ciclesonide combination
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
WO2005063777A1 (en) * 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation

Also Published As

Publication number Publication date
JP2008546694A (ja) 2008-12-25
KR20060130515A (ko) 2006-12-19
WO2006138212A1 (en) 2006-12-28
TW200718707A (en) 2007-05-16
EP1893220A1 (en) 2008-03-05
RU2008100237A (ru) 2009-07-20
CN101227912A (zh) 2008-07-23
IL187816A0 (en) 2008-08-07
AU2006259604A1 (en) 2006-12-28
US20100209508A1 (en) 2010-08-19
EP1893220A4 (en) 2011-06-15
BRPI0611567A2 (pt) 2016-11-16
CA2612364A1 (en) 2006-12-28
NO20080182L (no) 2008-02-21

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