AR060621A1 - Compuestos triarilicos y sus derivados - Google Patents
Compuestos triarilicos y sus derivadosInfo
- Publication number
- AR060621A1 AR060621A1 ARP070101724A ARP070101724A AR060621A1 AR 060621 A1 AR060621 A1 AR 060621A1 AR P070101724 A ARP070101724 A AR P070101724A AR P070101724 A ARP070101724 A AR P070101724A AR 060621 A1 AR060621 A1 AR 060621A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- substituted
- unsubstituted
- independently selected
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- WPWHSFAFEBZWBB-UHFFFAOYSA-N 1-butyl radical Chemical compound [CH2]CCC WPWHSFAFEBZWBB-UHFFFAOYSA-N 0.000 abstract 1
- ULOIAOPTGWSNHU-UHFFFAOYSA-N 2-butyl radical Chemical compound C[CH]CC ULOIAOPTGWSNHU-UHFFFAOYSA-N 0.000 abstract 1
- RFONJRMUUALMBA-UHFFFAOYSA-N 2-methanidylpropane Chemical compound CC(C)[CH2-] RFONJRMUUALMBA-UHFFFAOYSA-N 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicacion 1: Un compuesto que tiene la formula general (1) donde X es un enlace o un grupo -CR5R6, donde R5 y R6 son, independientemente el uno del otro, seleccionados entre el grupo consistente en H; alquilo seleccionado entre el grupo C3, C2H5, i-C3H7, n-C3H7, i-C4H9, n-C4H9, sec-C4H9 y terc-C4H9 alquenilo seleccionado entre C2H3, i-C3H5, n-C3H5, n-C4H7, i-C4H7 y sec-C4H7; donde, en cualquiera de los grupos alquilo o alquenilo, uno o más átomos de H pueden estar eventualmente substituidos por uno o más substituyentes independientemente seleccionados entre el grupo consistente en OH, F, Cl, Br, I y CF3; o R5 y R6 forman parte de un anillo, ya sea saturado o insaturado, substituido o no substituido, de 3 a 6 átomos de C y que puede contener en el anillo uno o más heteroátomos del grupo N, S o O y cuyos heteroátomos pueden ser idénticos o diferentes si está presente más de un heteroátomo; R1, R2, R3, y R4 son independientemente seleccionados entre el grupo consistente en H, F, Cl, Br, I, CN, OH, C(O)N(R7R8), S(O)2R, SO2N(R7R8) , S(O)N(R7R8) , N(R7)S(O)2R8, N(R8)S(O)R8, S(O)2R7, N(R7)S(O)2N(R8Ra), SR7, N(R7R8), N(R7)C(O)R8, N(R7)C(O)N(R8R8a), N(R7)C(O)OR8, OC(O)N(R7R8), C(O)R7, alquilo C1-4 substituido y no substituido y alcoxi C1-4 substituido y no substituido, y donde los substituyentes de ambos grupos alquilo C1-4 y alcoxi C1-4 son seleccionados entre OH, F, Cl, Br, I y CF3; R7, R8, R8a son independientemente seleccionados entre el grupo consistente en H, alquilo C1-4, heterociclilo y cicloalquilo C3-7, donde el alquilo C1-4, el heterociclilo y el cicloalquilo C3-7 pueden estar eventualmente substituidos por uno o más substituyentes independientemente seleccionados entre el grupo consistente en OH, F, Cl, Br, I y CF3; R9 y R10 son independientemente H, F o CF3; Y es un grupo carboxi -C(O)OH o un grupo tetrazol substituido o no substituido; y sus solvatos, hidratos, ésteres y sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112934A EP1847524B1 (en) | 2006-04-21 | 2006-04-21 | Terphenyl derivatives for treatment of Alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060621A1 true AR060621A1 (es) | 2008-07-02 |
Family
ID=36293499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101724A AR060621A1 (es) | 2006-04-21 | 2007-04-20 | Compuestos triarilicos y sus derivados |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8106236B2 (es) |
| EP (2) | EP1847524B1 (es) |
| JP (1) | JP5422827B2 (es) |
| KR (1) | KR101494906B1 (es) |
| CN (1) | CN101484410B (es) |
| AR (1) | AR060621A1 (es) |
| AT (1) | ATE445586T1 (es) |
| AU (1) | AU2007240382B2 (es) |
| BR (1) | BRPI0710632A2 (es) |
| CA (1) | CA2649845C (es) |
| CR (2) | CR10376A (es) |
| CY (1) | CY1109729T1 (es) |
| DE (1) | DE602006009764D1 (es) |
| DK (1) | DK1847524T3 (es) |
| EA (1) | EA016908B1 (es) |
| ES (2) | ES2333539T3 (es) |
| GE (1) | GEP20115211B (es) |
| IL (2) | IL194789A0 (es) |
| MA (1) | MA30420B1 (es) |
| MX (1) | MX2008013447A (es) |
| MY (1) | MY148988A (es) |
| NO (1) | NO20084516L (es) |
| NZ (1) | NZ572999A (es) |
| PE (1) | PE20080267A1 (es) |
| PL (1) | PL1847524T3 (es) |
| PT (1) | PT1847524E (es) |
| SI (1) | SI1847524T1 (es) |
| SM (1) | SMP200800062B (es) |
| TN (1) | TNSN08414A1 (es) |
| TW (1) | TWI435720B (es) |
| UA (1) | UA95766C2 (es) |
| UY (1) | UY30300A1 (es) |
| WO (1) | WO2007124351A1 (es) |
| ZA (1) | ZA200809857B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1847524T3 (pl) | 2006-04-21 | 2010-03-31 | Cellzome Ltd | Pochodne terfenylu do leczenia choroby Alzheimera |
| JP5543354B2 (ja) | 2007-10-19 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | γ−セクレターゼのアミン結合調節物質 |
| CA2702911A1 (en) * | 2007-10-19 | 2009-04-23 | Chih Yung Ho | Gsm intermediates |
| MX2010004309A (es) | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| EP2215043B1 (en) | 2007-10-19 | 2013-03-06 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
| US20110092554A1 (en) * | 2007-11-19 | 2011-04-21 | Richard Chesworth | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| MX2010006046A (es) * | 2007-12-13 | 2010-06-23 | Amgen Inc | Moduladores de gamma secretasa. |
| WO2009086277A1 (en) | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
| MX2010009755A (es) * | 2008-03-11 | 2010-09-30 | Neurosearch As | Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos. |
| US7968725B2 (en) * | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
| ES2583093T3 (es) * | 2011-03-03 | 2016-09-19 | Denovamed Inc. | Compuestos antimicrobianos/adyuvantes |
| CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
| WO2015109109A1 (en) | 2014-01-15 | 2015-07-23 | Forum Pharmaceuticals Inc. | Fused morpholinopyrimidines and methods of use thereof |
| US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
| CA3139526A1 (en) | 2019-05-15 | 2020-11-19 | Chemocentryx, Inc. | Triaryl compounds for treatment of pd-l1 diseases |
| EP4253396A4 (en) * | 2020-11-27 | 2024-09-11 | Mirailab Bioscience Inc. | HIGH PURITY BETA-NICOTINAMIDE MONONUCLEOTIDE (NMN) AND PROCESS FOR ITS PRODUCTION |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08325182A (ja) * | 1995-05-31 | 1996-12-10 | Fuji Yakuhin Kogyo Kk | 置換テルフェニル誘導体とそれらを含有する抗血栓剤 |
| FR2767525B1 (fr) * | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
| AU4537400A (en) | 1999-05-12 | 2000-12-05 | Neurosearch A/S | Ion channel modulating agents |
| AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| JP2003531194A (ja) * | 2000-04-24 | 2003-10-21 | メルク フロスト カナダ アンド カンパニー | プロスタグランジンｅ阻害薬としてフェニルおよびビアリール誘導体を用いる治療方法および該方法に有用な化合物 |
| CN1277872C (zh) * | 2001-02-20 | 2006-10-04 | 安德鲁斯街大学管理处 | 含金属的树状物 |
| FR2838439B1 (fr) * | 2002-04-11 | 2005-05-20 | Sanofi Synthelabo | Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant |
| US20060122184A1 (en) * | 2002-12-05 | 2006-06-08 | Axys Pharmaceuticals, Inc. | Cyanomethyl derivatives as cysteine protease inhibitors |
| GB0305918D0 (en) | 2003-03-14 | 2003-04-23 | Glaxo Group Ltd | Novel compounds |
| AU2004234190A1 (en) * | 2003-04-30 | 2004-11-11 | Merck Frosst Canada Ltd | 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors |
| WO2005110963A1 (en) * | 2004-05-19 | 2005-11-24 | Cellzome Ag | (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy |
| GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| AU2006281497B2 (en) * | 2005-08-15 | 2012-06-07 | F. Hoffmann-La Roche Ag | Piperidine and piperazine derivatives as P2X3 antagonists |
| WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| PL1847524T3 (pl) | 2006-04-21 | 2010-03-31 | Cellzome Ltd | Pochodne terfenylu do leczenia choroby Alzheimera |
-
2006
- 2006-04-21 PL PL06112934T patent/PL1847524T3/pl unknown
- 2006-04-21 DK DK06112934T patent/DK1847524T3/da active
- 2006-04-21 ES ES06112934T patent/ES2333539T3/es active Active
- 2006-04-21 EP EP06112934A patent/EP1847524B1/en not_active Not-in-force
- 2006-04-21 DE DE602006009764T patent/DE602006009764D1/de active Active
- 2006-04-21 PT PT06112934T patent/PT1847524E/pt unknown
- 2006-04-21 AT AT06112934T patent/ATE445586T1/de active
- 2006-04-21 SI SI200630509T patent/SI1847524T1/sl unknown
-
2007
- 2007-04-19 EP EP07760900A patent/EP2016039B1/en active Active
- 2007-04-19 EA EA200802173A patent/EA016908B1/ru not_active IP Right Cessation
- 2007-04-19 AU AU2007240382A patent/AU2007240382B2/en not_active Ceased
- 2007-04-19 US US11/737,475 patent/US8106236B2/en not_active Expired - Fee Related
- 2007-04-19 ES ES07760900T patent/ES2392352T3/es active Active
- 2007-04-19 JP JP2009506772A patent/JP5422827B2/ja not_active Expired - Fee Related
- 2007-04-19 SM SM200800062T patent/SMP200800062B/it unknown
- 2007-04-19 MY MYPI20084202A patent/MY148988A/en unknown
- 2007-04-19 WO PCT/US2007/066951 patent/WO2007124351A1/en not_active Ceased
- 2007-04-19 CA CA2649845A patent/CA2649845C/en not_active Expired - Fee Related
- 2007-04-19 GE GEAP200710984A patent/GEP20115211B/en unknown
- 2007-04-19 BR BRPI0710632-7A patent/BRPI0710632A2/pt not_active IP Right Cessation
- 2007-04-19 NZ NZ572999A patent/NZ572999A/en not_active IP Right Cessation
- 2007-04-19 UA UAA200813475A patent/UA95766C2/ru unknown
- 2007-04-19 KR KR1020087028470A patent/KR101494906B1/ko not_active Expired - Fee Related
- 2007-04-19 MX MX2008013447A patent/MX2008013447A/es active IP Right Grant
- 2007-04-19 CN CN2007800184982A patent/CN101484410B/zh not_active Expired - Fee Related
- 2007-04-20 PE PE2007000497A patent/PE20080267A1/es not_active Application Discontinuation
- 2007-04-20 AR ARP070101724A patent/AR060621A1/es not_active Application Discontinuation
- 2007-04-20 UY UY30300A patent/UY30300A1/es unknown
- 2007-04-20 TW TW096114164A patent/TWI435720B/zh not_active IP Right Cessation
-
2008
- 2008-10-17 CR CR10376A patent/CR10376A/es not_active Application Discontinuation
- 2008-10-17 TN TNP2008000414A patent/TNSN08414A1/en unknown
- 2008-10-22 IL IL194789A patent/IL194789A0/en not_active IP Right Cessation
- 2008-10-22 IL IL194853A patent/IL194853A0/en unknown
- 2008-10-27 NO NO20084516A patent/NO20084516L/no not_active Application Discontinuation
- 2008-11-19 ZA ZA200809857A patent/ZA200809857B/xx unknown
- 2008-11-20 MA MA31394A patent/MA30420B1/fr unknown
- 2008-11-21 CR CR10452A patent/CR10452A/es unknown
-
2010
- 2010-01-14 CY CY20101100039T patent/CY1109729T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |