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PE20080267A1 - Compuestos triarilicos y sus derivados - Google Patents

Compuestos triarilicos y sus derivados

Info

Publication number
PE20080267A1
PE20080267A1 PE2007000497A PE2007000497A PE20080267A1 PE 20080267 A1 PE20080267 A1 PE 20080267A1 PE 2007000497 A PE2007000497 A PE 2007000497A PE 2007000497 A PE2007000497 A PE 2007000497A PE 20080267 A1 PE20080267 A1 PE 20080267A1
Authority
PE
Peru
Prior art keywords
compounds
triarylic
derivatives
terphenyl
trifluoromethyl
Prior art date
Application number
PE2007000497A
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernandez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Formal Adeline Le
Andrew Cansfield
Yan Zhang
Chih Yung Ho
Svenja Burckhardt
Original Assignee
Cellzome Ltd
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080267(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Ltd, Ortho Mcneil Janssen Pharm filed Critical Cellzome Ltd
Publication of PE20080267A1 publication Critical patent/PE20080267A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE X ES UN ENLACE O UN GRUPO -CR5R6; R5 y R6 SON CADA UNO H, C2H5, SEC-C4H9, ENTRE OTROS; R1, R2, R3 Y R4 SON CADA UNO H, F, CN, OH, ENTRE OTROS; R9 Y R10 SON CADA UNO H, F, CF3; Y ES UN CARBOXI-C(O)OH, TETRAZOL SUSTITUIDO O NO. SON COMPUESTOS PREFERIDOS: ACIDO 4''-CLORO-4-TRIFLUOROMETIL-[1,1',3,1'']TERFENIL-5'-IL)ACETICO; ACIDO ( 3-CLORO-4''-TRIFLUOROMETIL-[1,1';3',1'']TERFENIL-5'-IL)ACETICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON MODULADORES DE LA ACTIVIDAD DE LA GAMMA-SECRETASA UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
PE2007000497A 2006-04-21 2007-04-20 Compuestos triarilicos y sus derivados PE20080267A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number Publication Date
PE20080267A1 true PE20080267A1 (es) 2008-05-16

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000497A PE20080267A1 (es) 2006-04-21 2007-04-20 Compuestos triarilicos y sus derivados

Country Status (34)

Country Link
US (1) US8106236B2 (es)
EP (2) EP1847524B1 (es)
JP (1) JP5422827B2 (es)
KR (1) KR101494906B1 (es)
CN (1) CN101484410B (es)
AR (1) AR060621A1 (es)
AT (1) ATE445586T1 (es)
AU (1) AU2007240382B2 (es)
BR (1) BRPI0710632A2 (es)
CA (1) CA2649845C (es)
CR (2) CR10376A (es)
CY (1) CY1109729T1 (es)
DE (1) DE602006009764D1 (es)
DK (1) DK1847524T3 (es)
EA (1) EA016908B1 (es)
ES (2) ES2333539T3 (es)
GE (1) GEP20115211B (es)
IL (2) IL194789A0 (es)
MA (1) MA30420B1 (es)
MX (1) MX2008013447A (es)
MY (1) MY148988A (es)
NO (1) NO20084516L (es)
NZ (1) NZ572999A (es)
PE (1) PE20080267A1 (es)
PL (1) PL1847524T3 (es)
PT (1) PT1847524E (es)
SI (1) SI1847524T1 (es)
SM (1) SMP200800062B (es)
TN (1) TNSN08414A1 (es)
TW (1) TWI435720B (es)
UA (1) UA95766C2 (es)
UY (1) UY30300A1 (es)
WO (1) WO2007124351A1 (es)
ZA (1) ZA200809857B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847524B1 (en) 2006-04-21 2009-10-14 Cellzome Limited Terphenyl derivatives for treatment of Alzheimer's disease
MX2010004311A (es) * 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Productos intermedios de moduladores de gamma-secretasa.
EP2212277B1 (en) 2007-10-19 2016-08-31 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
NZ584716A (en) 2007-10-19 2011-12-22 Janssen Pharmaceutica Nv PIPERIDINYL AND PIPERAZINYL MODULATORS OF gamma-SECRETASE
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CN101896461A (zh) * 2007-12-13 2010-11-24 安姆根有限公司 γ分泌酶调节剂
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
AU2009224738A1 (en) * 2008-03-11 2009-09-17 Neurosearch A/S Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
CA2828748C (en) * 2011-03-03 2019-06-25 Denovamed Inc. Antimicrobial / adjuvant compounds and methods
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
JP7656547B2 (ja) * 2019-05-15 2025-04-03 ケモセントリックス，インコーポレイティド Ｐｄ－ｌ１疾患治療用のトリアリール化合物
KR20230113770A9 (ko) * 2020-11-27 2024-03-25 미라이랩 바이오사이언스 인코퍼레이티드 고순도 β 니코틴아미드 모노뉴클레오티드(NMN) 및 그 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
JP2002544258A (ja) 1999-05-12 2002-12-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル調節剤
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
EP1278734A2 (en) * 2000-04-24 2003-01-29 Merck Frosst Canada &amp; Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
CN1277872C (zh) * 2001-02-20 2006-10-04 安德鲁斯街大学管理处 含金属的树状物
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
AU2003298740A1 (en) * 2002-12-05 2004-06-30 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
EP1635829A1 (en) * 2003-04-30 2006-03-22 Merck Frosst Canada Ltd. 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
JP4987871B2 (ja) * 2005-08-15 2012-07-25 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３アンタゴニストとしてのピペリジン及びピペラジン誘導体
US8148572B2 (en) 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
EP1847524B1 (en) 2006-04-21 2009-10-14 Cellzome Limited Terphenyl derivatives for treatment of Alzheimer's disease

Also Published As

Publication number Publication date
MX2008013447A (es) 2009-03-10
AU2007240382B2 (en) 2013-05-02
GEP20115211B (en) 2011-04-26
TNSN08414A1 (en) 2010-04-14
US8106236B2 (en) 2012-01-31
EA200802173A1 (ru) 2009-06-30
DK1847524T3 (da) 2010-01-11
EP1847524A1 (en) 2007-10-24
IL194789A0 (en) 2009-08-03
CR10376A (es) 2009-02-26
PT1847524E (pt) 2009-12-18
HK1134923A1 (en) 2010-05-20
CN101484410B (zh) 2013-08-21
MA30420B1 (fr) 2009-05-04
KR101494906B1 (ko) 2015-02-24
JP5422827B2 (ja) 2014-02-19
BRPI0710632A2 (pt) 2011-08-23
EA016908B1 (ru) 2012-08-30
EP2016039B1 (en) 2012-08-01
PL1847524T3 (pl) 2010-03-31
TWI435720B (zh) 2014-05-01
ES2333539T3 (es) 2010-02-23
NZ572999A (en) 2012-06-29
IL194853A0 (en) 2009-08-03
CA2649845C (en) 2014-09-16
ES2392352T3 (es) 2012-12-10
SMP200800062B (it) 2009-07-14
WO2007124351A1 (en) 2007-11-01
AU2007240382A1 (en) 2007-11-01
KR20090024678A (ko) 2009-03-09
NO20084516L (no) 2009-01-13
US20070254957A1 (en) 2007-11-01
SMAP200800062A (it) 2008-11-19
EP2016039A1 (en) 2009-01-21
UY30300A1 (es) 2007-08-31
CN101484410A (zh) 2009-07-15
EP1847524B1 (en) 2009-10-14
SI1847524T1 (sl) 2010-01-29
MY148988A (en) 2013-06-28
ATE445586T1 (de) 2009-10-15
TW200810746A (en) 2008-03-01
CA2649845A1 (en) 2007-11-01
JP2009538275A (ja) 2009-11-05
DE602006009764D1 (de) 2009-11-26
AR060621A1 (es) 2008-07-02
CR10452A (es) 2009-02-23
ZA200809857B (en) 2009-08-26
UA95766C2 (ru) 2011-08-25
CY1109729T1 (el) 2014-09-10

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Legal Events

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FD Application declared void or lapsed