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AR069775A1 - Anticuerpos bivalentes biespecificos - Google Patents

Anticuerpos bivalentes biespecificos

Info

Publication number
AR069775A1
AR069775A1 ARP080105486A ARP080105486A AR069775A1 AR 069775 A1 AR069775 A1 AR 069775A1 AR P080105486 A ARP080105486 A AR P080105486A AR P080105486 A ARP080105486 A AR P080105486A AR 069775 A1 AR069775 A1 AR 069775A1
Authority
AR
Argentina
Prior art keywords
bivespecific
bivalent antibodies
antibody
antigen
specifically binds
Prior art date
Application number
ARP080105486A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39682659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069775(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR069775A1 publication Critical patent/AR069775A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Métodos para su elaboracion, célula y composicion farmacéutica que lo comprende. Reivindicacion 1: Un anticuerpo bivalente biespecífico que comprende: a) la cadena ligera y la cadena pesada de un anticuerpo que se une específicamente a un primer antígeno; y b) la cadena ligera y la cadena pesada de un anticuerpo que se une específicamente a un segundo antígeno, en el que los dominios constantes CL y CH1 están reemplazados el uno por el otro.
ARP080105486A 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos AR069775A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07024865 2007-12-21

Publications (1)

Publication Number Publication Date
AR069775A1 true AR069775A1 (es) 2010-02-17

Family

ID=39682659

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP080105486A AR069775A1 (es) 2007-12-21 2008-12-17 Anticuerpos bivalentes biespecificos
ARP200100430A AR118118A2 (es) 2007-12-21 2020-02-17 Anticuerpos bivalentes biespecíficos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP200100430A AR118118A2 (es) 2007-12-21 2020-02-17 Anticuerpos bivalentes biespecíficos

Country Status (29)

Country Link
US (1) US8242247B2 (es)
EP (1) EP2225280B1 (es)
JP (1) JP5281098B2 (es)
KR (2) KR20130016397A (es)
CN (1) CN101903406B (es)
AR (2) AR069775A1 (es)
AU (1) AU2008340694B2 (es)
BR (1) BRPI0821777B8 (es)
CA (1) CA2709430C (es)
CL (1) CL2008003778A1 (es)
CO (1) CO6280543A2 (es)
CR (1) CR11465A (es)
CY (1) CY1115275T1 (es)
DK (1) DK2225280T3 (es)
EC (1) ECSP10010297A (es)
ES (1) ES2471266T3 (es)
HR (1) HRP20140727T1 (es)
IL (1) IL206108A (es)
MA (1) MA31925B1 (es)
MY (1) MY160736A (es)
NZ (1) NZ585774A (es)
PE (1) PE20091169A1 (es)
PL (1) PL2225280T3 (es)
PT (1) PT2225280E (es)
SI (1) SI2225280T1 (es)
TW (1) TWI359028B (es)
UA (1) UA100874C2 (es)
WO (1) WO2009080253A1 (es)
ZA (1) ZA201004300B (es)

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AU2008340694B2 (en) 2013-04-04
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CR11465A (es) 2010-08-16
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IL206108A (en) 2013-07-31
AR118118A2 (es) 2021-09-22
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SI2225280T1 (sl) 2014-07-31
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CL2008003778A1 (es) 2010-02-12
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