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AR051966A1 - Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias - Google Patents

Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias

Info

Publication number
AR051966A1
AR051966A1 ARP050104896A ARP050104896A AR051966A1 AR 051966 A1 AR051966 A1 AR 051966A1 AR P050104896 A ARP050104896 A AR P050104896A AR P050104896 A ARP050104896 A AR P050104896A AR 051966 A1 AR051966 A1 AR 051966A1
Authority
AR
Argentina
Prior art keywords
halogen
alkyl
optionally substituted
independently selected
substituents independently
Prior art date
Application number
ARP050104896A
Other languages
English (en)
Inventor
Roger Victor Bonnert
Rukhsana Tasmneem Mohammed
Anthony Ronald Cokk
Stephen Thom
Timothy Jon Luker
Lilian Alcaraz
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0425673A external-priority patent/GB0425673D0/en
Priority claimed from GB0508923A external-priority patent/GB0508923D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR051966A1 publication Critical patent/AR051966A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composiciones farmacéuticas que los contienen, y procesos para su preparacion. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) o su sal aceptable para uso farmacéutico del mismo, en donde: R1 y R2 representan en forma independiente un átomo de hidrogeno, halogeno, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o un grupo alquilo C1-6, donde los ultimos cuatro grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, NR9R10, OR8, S(O)nR7 (donde n es 0, 1 o 2); o R1 y R2 juntos pueden formar un anillo de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S, NR11 y que a su vez está sustituido con uno o más alquilo C1-3 o halogeno; W es halogeno, ciano, nitro, SO2R7, SO2NR9R10, OR8, o alquilo C1-6 donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR8 y NR7R8, S(O)nR5 donde n es 0, 1 o 2; R3 es uno o más sustituyentes independientemente seleccionados entre hidrogeno, halogeno CN, nitro, SO2R7, OR8, SR7, SOR7, SO2NR9R10, CONR9R10, NR9R1O, NR11SO2R7, NR11CO2R7, NR11COR7 o alquilo C1-6, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR8 y NR9R10, S(O)nR7 donde n es 0, 1 o 2; X representa un enlace, o alquilo C1-6, opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, alquilo C1-6 donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, OR6 y NR7R8, S(O)nR5 donde n es 0, 1 o 2; Y representa una diamina del tipo de formula (2), donde R4 y R5 representan en forma independiente hidrogeno, SO2R7, C(O)R7, CO2R7 y alquilo C1-8, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre arilo, heteroarilo, halogeno, OR8 y NR9R10, S(O)nR7 donde n es 0, 1 o 2; R4 y R5 están unidos o uno de R4 y R5 está unido a P o Q para formar un anillo heterocíclico saturado de entre 3 y 10 miembros con 1 o 2 átomos de nitrogeno endocíclicos; P y Q representan en forma independiente, alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre (=O), halogeno, OR8 y NR9R10, S(O)nR7 (donde n es 0, 1 o 2), alquilo C1-6, cicloalquilo C3-6, arilo o heteroarilo (donde los ultimos dos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, -OR8 y NR9R10, CONR9R10, S(O)nR7 donde n es 0, 1 o 2); representa un enlace, (CR12)n-C(O), (CR12)n-S(O)n, C(O)(CR12)n, o S(O)2(CR12)n, S(O)2N(CR12)n, donde = 0, 1 o 2; HET representa arilo o heteroarilo; R6 representa uno o más sustituyentes independientemente seleccionados entre hidrogeno, halogeno, CN, nitro, COR7, CO2R8, SO2R7, OR8, SR8, SOR8, SO2NR9R10, CONR9R10, NR9R1O, NR8SO2R7, NR8CO2R8, NR8COR7, NR8CONR9R10, NR8SO2NR9R10, arilo, heteroarilo, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7 o alquilo C1-6, donde los ultimos cuatro grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, CN, OR8, NR9R10, S(O)nR7 (donde n es 0, 1 o 2), CONR9R10, NR8COR7, SO2NR9R10 y NR8SO2R7; R7 representa un grupo alquilo C1-6, arilo o heteroarilo donde todos pueden estar opcionalmente sustituidos con átomos de halogeno, OR8, NR14R15; R8 representa hidrogeno, alquilo C1-6, un grupo arilo o heteroarilo donde todos pueden estar opcionalmente sustituidos con átomos de halogeno, OR8, NR14R15; R9 y R10 representan en forma independiente hidrogeno, cicloalquilo C3-7 o alquilo C1-6, donde los dos ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, OR6 y NR14R15, S(O)nR6 (donde n = 0, 1 o 2), CONR7R8, NR6CO2R7, SO2NR7R8 y NR6SO2R5; o R9 y R10 junto con el átomo de nitrogeno al cual están unidos pueden formar un anillo heterocíclico saturado de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)n (donde n = 0, 1 o 2), NR13, y a su vez está opcionalmente sustituido con halogeno o alquilo C1-3; R11 representa un átomo de hidrogeno, C(O)R9, alquilo C1-6, un grupo arilo o heteroarilo (los ultimos tres pueden estar opcionalmente sustituidos halogeno); R12 representa uno o más hidrogeno, o un grupo alquilo C1-6, donde el ultimo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados entre halogeno, cicloalquilo C3-7, NR14R15, OR8, S(O)nR7 donde (n es 0, 1 o 2); R13 representa hidrogeno, C1-4 alquilo, -COalquiloC1-4, COYalquiloC1-4, donde Y es O o NR7; y R14 y R15 representan en forma independientemente hidrogeno, alquilo C1-4; o R14 y R15 junto con el átomo de nitrogeno al cual están unidos pueden formar un anillo heterocíclico saturado de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)n, (donde n = 0, 1 o 2), y que a su vez está opcionalmente sustituido con halogeno o alquilo C1-3.
ARP050104896A 2004-11-23 2005-11-22 Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias AR051966A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425673A GB0425673D0 (en) 2004-11-23 2004-11-23 Novel compounds
GB0508923A GB0508923D0 (en) 2005-04-30 2005-04-30 Novel compounds

Publications (1)

Publication Number Publication Date
AR051966A1 true AR051966A1 (es) 2007-02-21

Family

ID=35589515

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104896A AR051966A1 (es) 2004-11-23 2005-11-22 Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias

Country Status (14)

Country Link
US (1) US8524715B2 (es)
EP (1) EP1817282B1 (es)
JP (2) JP5208510B2 (es)
AR (1) AR051966A1 (es)
AT (1) ATE517085T1 (es)
CY (1) CY1112115T1 (es)
DK (1) DK1817282T3 (es)
PL (1) PL1817282T3 (es)
PT (1) PT1817282E (es)
SA (1) SA05260362B1 (es)
SI (1) SI1817282T1 (es)
TW (1) TW200630336A (es)
UY (1) UY29223A1 (es)
WO (1) WO2006056752A1 (es)

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TW200630336A (en) 2006-09-01
EP1817282B1 (en) 2011-07-20
UY29223A1 (es) 2006-06-30
JP5208510B2 (ja) 2013-06-12
CY1112115T1 (el) 2015-11-04
JP2013082729A (ja) 2013-05-09
JP2008520637A (ja) 2008-06-19
PL1817282T3 (pl) 2011-11-30
ATE517085T1 (de) 2011-08-15
US20090149448A1 (en) 2009-06-11
WO2006056752A1 (en) 2006-06-01
US8524715B2 (en) 2013-09-03
DK1817282T3 (da) 2011-10-10
PT1817282E (pt) 2011-09-19
SA05260362B1 (ar) 2009-04-18
EP1817282A1 (en) 2007-08-15

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