AR057961A1 - Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas. - Google Patents
Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas.Info
- Publication number
- AR057961A1 AR057961A1 ARP060105330A ARP060105330A AR057961A1 AR 057961 A1 AR057961 A1 AR 057961A1 AR P060105330 A ARP060105330 A AR P060105330A AR P060105330 A ARP060105330 A AR P060105330A AR 057961 A1 AR057961 A1 AR 057961A1
- Authority
- AR
- Argentina
- Prior art keywords
- atom
- alkyl group
- pharmaceutical compositions
- thirosine
- pirrolopirimidinas
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 3-chlorophenoxy Chemical group 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
El compuesto de la presente tiene una accion inhibidora de la tirosina quinasa superior. Composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto caracterizado por la formula (1) en donde R1a es un átomo de H; R2a es un grupo alquilo C1-6 sustituido con un grupo representado por alquilo C1-4 opcionalmente halogenado con -NR6a-CO-(CH2)n-SO2- en donde n es un numero entero de 1 a 4, R6a es un átomo de H o un grupo alquilo C1-4, y -(CH2)n-está opcionalmente sustituido con alquilo C1-4; R3a es un átomo de H o un grupo alquilo C1-6; R4a es un átomo de halogeno o un grupo alquilo C1-6; R5a es un átomo de halogeno o un grupo alquilo C1-6; y Xa es un átomo de H o un átomo de halogeno, o una de sus sales, con la condicion de que se excluya N-[2-(4-{[3-cloro-4-(3-clorofenoxi)fenil]amino}-5H-pirrolo[3,2-d]pirimidin-5-il)etil]-2-(metilsulfonil)acetamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005349858 | 2005-12-02 | ||
| JP2006060648 | 2006-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057961A1 true AR057961A1 (es) | 2007-12-26 |
Family
ID=37897379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105330A AR057961A1 (es) | 2005-12-02 | 2006-12-01 | Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100216788A1 (es) |
| EP (1) | EP1957495A1 (es) |
| JP (1) | JP2009517333A (es) |
| KR (1) | KR20080084823A (es) |
| AR (1) | AR057961A1 (es) |
| AU (1) | AU2006319787A1 (es) |
| BR (1) | BRPI0619911A2 (es) |
| CA (1) | CA2631066A1 (es) |
| CR (1) | CR10057A (es) |
| MA (1) | MA30046B1 (es) |
| NO (1) | NO20082870L (es) |
| PE (1) | PE20071089A1 (es) |
| RU (1) | RU2008126949A (es) |
| TW (1) | TW200730527A (es) |
| WO (1) | WO2007064045A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20105024B (en) * | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| US20100004238A1 (en) * | 2006-12-12 | 2010-01-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US7825127B2 (en) | 2006-12-28 | 2010-11-02 | Takeda Pharmaceutical Company, Limited | Method for treating cancer |
| US20100183604A1 (en) | 2007-06-19 | 2010-07-22 | Takeda Pharmaceutical Company Limited | Preventive/remedy for cancer |
| UY31683A (es) * | 2008-03-03 | 2009-11-10 | Takeda Pharmaceutical | Farmaco combinado |
| UY31704A (es) * | 2008-03-12 | 2009-11-10 | Takeda Pharmaceutical | Compuesto heterociclico fusionado |
| US20140113934A1 (en) | 2011-06-20 | 2014-04-24 | E I Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
| US9321750B2 (en) | 2012-04-20 | 2016-04-26 | Innov17 Llc | ROR modulators and their uses |
| JP6612751B2 (ja) * | 2013-07-31 | 2019-11-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋの阻害剤としてのピリジン、ピリミジン及びピラジンならびにその使用 |
| GB201520499D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
| AR119494A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
| MX2023012060A (es) | 2021-04-13 | 2024-01-22 | Nuvalent Inc | Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| GEP20105024B (en) * | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| BRPI0513982A (pt) * | 2004-07-30 | 2007-11-27 | Methylgene Inc | inibidores de sinalização de receptor de vegf e receptor de hgf |
| TW200740820A (en) * | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
-
2006
- 2006-11-30 TW TW095144339A patent/TW200730527A/zh unknown
- 2006-12-01 WO PCT/JP2006/324499 patent/WO2007064045A1/en not_active Ceased
- 2006-12-01 AU AU2006319787A patent/AU2006319787A1/en not_active Abandoned
- 2006-12-01 US US12/095,543 patent/US20100216788A1/en not_active Abandoned
- 2006-12-01 KR KR1020087016193A patent/KR20080084823A/ko not_active Withdrawn
- 2006-12-01 JP JP2008520459A patent/JP2009517333A/ja not_active Withdrawn
- 2006-12-01 CA CA002631066A patent/CA2631066A1/en not_active Abandoned
- 2006-12-01 AR ARP060105330A patent/AR057961A1/es unknown
- 2006-12-01 RU RU2008126949/04A patent/RU2008126949A/ru not_active Application Discontinuation
- 2006-12-01 EP EP06834254A patent/EP1957495A1/en not_active Withdrawn
- 2006-12-01 BR BRPI0619911A patent/BRPI0619911A2/pt not_active IP Right Cessation
- 2006-12-01 PE PE2006001541A patent/PE20071089A1/es not_active Application Discontinuation
-
2008
- 2008-06-09 CR CR10057A patent/CR10057A/es not_active Application Discontinuation
- 2008-06-11 MA MA31024A patent/MA30046B1/fr unknown
- 2008-06-24 NO NO20082870A patent/NO20082870L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0619911A2 (pt) | 2016-08-30 |
| EP1957495A1 (en) | 2008-08-20 |
| WO2007064045A1 (en) | 2007-06-07 |
| TW200730527A (en) | 2007-08-16 |
| CR10057A (es) | 2008-07-29 |
| US20100216788A1 (en) | 2010-08-26 |
| AU2006319787A1 (en) | 2007-06-07 |
| MA30046B1 (fr) | 2008-12-01 |
| PE20071089A1 (es) | 2007-11-19 |
| RU2008126949A (ru) | 2010-01-10 |
| KR20080084823A (ko) | 2008-09-19 |
| NO20082870L (no) | 2008-09-01 |
| JP2009517333A (ja) | 2009-04-30 |
| CA2631066A1 (en) | 2007-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |