NO20082870L - Sammensmeltet heterocyklisk forbindelse - Google Patents
Sammensmeltet heterocyklisk forbindelseInfo
- Publication number
- NO20082870L NO20082870L NO20082870A NO20082870A NO20082870L NO 20082870 L NO20082870 L NO 20082870L NO 20082870 A NO20082870 A NO 20082870A NO 20082870 A NO20082870 A NO 20082870A NO 20082870 L NO20082870 L NO 20082870L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl group
- hydrogen atom
- alkyl
- merged
- heterocyclic compound
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en forbindelse representert ved formelen (I): hvori R1a er et hydrogenatom, R2a er en CI-6 alkylgruppe substituert med en gruppe representert ved -NR6a-CO-(CH2)n-S02- eventuelt halogenert C 1-4alkyl, hvori n er et heltall på I til 4, R6a er et hydrogenatom eller en C1-4 alkylgruppe, og -(CH2)n er eventuelt substituert med C1-4 alkyl, R3a er et hydrogenatom eller en C1-6 alkylgruppe, R4a er et halogenatom eller en C1-6 alkylgruppe, R5a er et halogenatom eller en C1-6 alkylgruppe, og Xa er et hydrogenatom eller et halogenatom, eller et salt derav. Forbindelsen ifølge oppfinnelsen har en overlegen tyrosinkinaseinhiberende virkning, er svært sikker og er tilstrekkelig tilfredsstillende som et farmasøytisk produkt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005349858 | 2005-12-02 | ||
| JP2006060648 | 2006-03-07 | ||
| PCT/JP2006/324499 WO2007064045A1 (en) | 2005-12-02 | 2006-12-01 | Fused heterocyclic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082870L true NO20082870L (no) | 2008-09-01 |
Family
ID=37897379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082870A NO20082870L (no) | 2005-12-02 | 2008-06-24 | Sammensmeltet heterocyklisk forbindelse |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100216788A1 (no) |
| EP (1) | EP1957495A1 (no) |
| JP (1) | JP2009517333A (no) |
| KR (1) | KR20080084823A (no) |
| AR (1) | AR057961A1 (no) |
| AU (1) | AU2006319787A1 (no) |
| BR (1) | BRPI0619911A2 (no) |
| CA (1) | CA2631066A1 (no) |
| CR (1) | CR10057A (no) |
| MA (1) | MA30046B1 (no) |
| NO (1) | NO20082870L (no) |
| PE (1) | PE20071089A1 (no) |
| RU (1) | RU2008126949A (no) |
| TW (1) | TW200730527A (no) |
| WO (1) | WO2007064045A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20105024B (en) * | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| US20100004238A1 (en) * | 2006-12-12 | 2010-01-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US7825127B2 (en) | 2006-12-28 | 2010-11-02 | Takeda Pharmaceutical Company, Limited | Method for treating cancer |
| US20100183604A1 (en) | 2007-06-19 | 2010-07-22 | Takeda Pharmaceutical Company Limited | Preventive/remedy for cancer |
| UY31683A (es) * | 2008-03-03 | 2009-11-10 | Takeda Pharmaceutical | Farmaco combinado |
| UY31704A (es) * | 2008-03-12 | 2009-11-10 | Takeda Pharmaceutical | Compuesto heterociclico fusionado |
| US20140113934A1 (en) | 2011-06-20 | 2014-04-24 | E I Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
| US9321750B2 (en) | 2012-04-20 | 2016-04-26 | Innov17 Llc | ROR modulators and their uses |
| JP6612751B2 (ja) * | 2013-07-31 | 2019-11-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋの阻害剤としてのピリジン、ピリミジン及びピラジンならびにその使用 |
| GB201520499D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
| AR119494A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
| MX2023012060A (es) | 2021-04-13 | 2024-01-22 | Nuvalent Inc | Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| GEP20105024B (en) * | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| BRPI0513982A (pt) * | 2004-07-30 | 2007-11-27 | Methylgene Inc | inibidores de sinalização de receptor de vegf e receptor de hgf |
| TW200740820A (en) * | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
-
2006
- 2006-11-30 TW TW095144339A patent/TW200730527A/zh unknown
- 2006-12-01 WO PCT/JP2006/324499 patent/WO2007064045A1/en not_active Ceased
- 2006-12-01 AU AU2006319787A patent/AU2006319787A1/en not_active Abandoned
- 2006-12-01 US US12/095,543 patent/US20100216788A1/en not_active Abandoned
- 2006-12-01 KR KR1020087016193A patent/KR20080084823A/ko not_active Withdrawn
- 2006-12-01 JP JP2008520459A patent/JP2009517333A/ja not_active Withdrawn
- 2006-12-01 CA CA002631066A patent/CA2631066A1/en not_active Abandoned
- 2006-12-01 AR ARP060105330A patent/AR057961A1/es unknown
- 2006-12-01 RU RU2008126949/04A patent/RU2008126949A/ru not_active Application Discontinuation
- 2006-12-01 EP EP06834254A patent/EP1957495A1/en not_active Withdrawn
- 2006-12-01 BR BRPI0619911A patent/BRPI0619911A2/pt not_active IP Right Cessation
- 2006-12-01 PE PE2006001541A patent/PE20071089A1/es not_active Application Discontinuation
-
2008
- 2008-06-09 CR CR10057A patent/CR10057A/es not_active Application Discontinuation
- 2008-06-11 MA MA31024A patent/MA30046B1/fr unknown
- 2008-06-24 NO NO20082870A patent/NO20082870L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0619911A2 (pt) | 2016-08-30 |
| EP1957495A1 (en) | 2008-08-20 |
| WO2007064045A1 (en) | 2007-06-07 |
| TW200730527A (en) | 2007-08-16 |
| CR10057A (es) | 2008-07-29 |
| US20100216788A1 (en) | 2010-08-26 |
| AU2006319787A1 (en) | 2007-06-07 |
| MA30046B1 (fr) | 2008-12-01 |
| AR057961A1 (es) | 2007-12-26 |
| PE20071089A1 (es) | 2007-11-19 |
| RU2008126949A (ru) | 2010-01-10 |
| KR20080084823A (ko) | 2008-09-19 |
| JP2009517333A (ja) | 2009-04-30 |
| CA2631066A1 (en) | 2007-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |