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AR055071A1 - Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas. - Google Patents

Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas.

Info

Publication number
AR055071A1
AR055071A1 ARP060102891A ARP060102891A AR055071A1 AR 055071 A1 AR055071 A1 AR 055071A1 AR P060102891 A ARP060102891 A AR P060102891A AR P060102891 A ARP060102891 A AR P060102891A AR 055071 A1 AR055071 A1 AR 055071A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
group
pharmaceutical compositions
pyrimidine
pirrolo
Prior art date
Application number
ARP060102891A
Other languages
English (en)
Inventor
S Imamura
Y Oguro
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR055071A1 publication Critical patent/AR055071A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Composiciones farmacéuticas que los comprenden. Reivindicacion1: Un compuesto caracterizado por la formula (1) en donde el anillo A es un anillo pirrol opcionalmente sustituido, X es CH opcionalmente sustituido, Y es CH opcionalmente sustituido o átomo de nitrogeno, Z es un grupo hidrocarbonado divalente opcionalmente sustituido o un grupo heterocíclico divalente opcionalmente sustituido, T es un enlace simple o un grupo alquileno C1-3 opcionalmente sustituido, y U es un grupo amido opcionalmente sustituido, un grupo sulfonamido opcionalmente sustituido, un grupo ureído opcionalmente sustituido, un grupo carbamoílo opcionalmente sustituido o un grupo tioureído opcionalmente sustituido o una de sus sales.
ARP060102891A 2005-07-05 2006-07-05 Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas. AR055071A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005196866 2005-07-05
JP2006054102 2006-02-28

Publications (1)

Publication Number Publication Date
AR055071A1 true AR055071A1 (es) 2007-08-01

Family

ID=37055938

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102891A AR055071A1 (es) 2005-07-05 2006-07-05 Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas.

Country Status (8)

Country Link
US (1) US20090137580A1 (es)
EP (1) EP1904498A1 (es)
JP (1) JP2009500295A (es)
AR (1) AR055071A1 (es)
PE (1) PE20070174A1 (es)
TW (1) TW200740820A (es)
UY (1) UY31674A1 (es)
WO (1) WO2007004749A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0610322B8 (pt) 2005-05-20 2021-05-25 Methylgene Inc inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
KR20080075837A (ko) * 2005-10-28 2008-08-19 아이알엠 엘엘씨 단백질 키나제 억제제로서의 화합물 및 조성물
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
NZ551796A (en) * 2006-12-05 2009-07-31 Craig Robert Stuart Bump-resistant pin tumbler lock
US8450336B2 (en) 2006-12-14 2013-05-28 Nps Pharmaceuticals, Inc Use of D-serine derivatives for the treatment of anxiety disorders
MX2010002427A (es) 2007-08-29 2010-03-30 Methylgene Inc Inhibidores de actividad de la proteina tirosina cinasa.
WO2009096435A1 (ja) * 2008-01-29 2009-08-06 Takeda Pharmaceutical Company Limited 縮合複素環誘導体およびその用途
AR070539A1 (es) * 2008-03-05 2010-04-14 Methylgene Inc Inhibidores de la actividad de proteina tirosina quinasa
US8445509B2 (en) 2008-05-08 2013-05-21 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
US9951008B2 (en) * 2009-11-03 2018-04-24 University Of Notre Dame Du Lac Ionic liquids comprising heteraromatic anions
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
BR112012021806A2 (pt) * 2010-03-01 2015-09-08 Myrexis Inc compostos e seus usos terapêusticos.
MX2012010666A (es) 2010-03-31 2012-10-05 Actelion Pharmaceuticals Ltd Derivados de isoquinolin-3-ilurea antibacterianos.
WO2012008564A1 (ja) * 2010-07-16 2012-01-19 協和発酵キリン株式会社 含窒素芳香族複素環誘導体
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
AU2012332952B2 (en) * 2011-10-31 2016-05-05 Novartis Ag Pazopanib formulation
DK2981526T3 (da) 2013-04-02 2022-02-07 Oxular Acquisitions Ltd Naphthylureaderivater til anvendelse som kinaseinhibitorer
JP6612751B2 (ja) * 2013-07-31 2019-11-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋの阻害剤としてのピリジン、ピリミジン及びピラジンならびにその使用
WO2015048765A1 (en) 2013-09-30 2015-04-02 University Of Notre Dame Du Lac Compounds, complexes, compositions, methods and systems for heating and cooling
US10086331B2 (en) 2013-11-05 2018-10-02 University Of Notre Dame Du Lac Carbon dioxide capture using phase change ionic liquids
US9890185B2 (en) 2013-12-20 2018-02-13 Respivert Limited Urea derivatives useful as kinase inhibitors
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
MX2018002018A (es) 2015-08-31 2018-03-26 Toray Industries Derivado de urea y uso del mismo.
CN109071505B (zh) 2016-04-06 2021-11-16 奥苏拉收购有限公司 激酶抑制剂
EP3503888A4 (en) * 2016-08-25 2020-02-26 The Regents of The University of Michigan BCR-ABL MUTANT INHIBITORS AND THEIR USE
CN109180677A (zh) * 2017-06-30 2019-01-11 厦门大学 取代芳基醚类化合物、其制备方法、药用组合物及其应用
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
CN110128299B (zh) * 2019-05-13 2020-11-10 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法
US12523663B2 (en) 2019-06-04 2026-01-13 Inserm (Institut National De La Santé Et De La Rescherche Médicale) Use of CD9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN116789670A (zh) * 2022-03-17 2023-09-22 中国科学院合肥物质科学研究院 一种选择性csf1r抑制剂及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
AR004010A1 (es) * 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
BR9710362A (pt) * 1996-07-13 1999-08-17 Glaxo Group Ltd Composto formula-ao farmaceutica utiliza-ao de um composto processos de tratamento de um ser humano ou animal sofrendo de uma mediada por atividade anormal de cinase de proteina tirosina e para a prepara-ao de um composto
CN1227554A (zh) 1996-08-28 1999-09-01 辉瑞大药厂 取代的6,5－杂二环衍生物
ES2208261T3 (es) * 1999-01-22 2004-06-16 Kirin Beer Kabushiki Kaisha Derivados de quinolina y derivados de quinazolina.
KR100774855B1 (ko) 2000-04-27 2007-11-08 아스텔라스세이야쿠 가부시키가이샤 축합 헤테로아릴 유도체
ATE419239T1 (de) * 2000-10-20 2009-01-15 Eisai R&D Man Co Ltd Verfahren zur herstellung von 4-phenoxy chinolin derivaten
ES2256466T3 (es) * 2001-04-27 2006-07-16 Kirin Beer Kabushiki Kaisha Derivado de quinolina que tienen grupo azolilo y derivados de quinazolina.
GEP20105024B (en) * 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound

Also Published As

Publication number Publication date
EP1904498A1 (en) 2008-04-02
PE20070174A1 (es) 2007-03-12
US20090137580A1 (en) 2009-05-28
WO2007004749A1 (en) 2007-01-11
TW200740820A (en) 2007-11-01
JP2009500295A (ja) 2009-01-08
UY31674A1 (es) 2009-08-31

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