AR057554A1 - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- AR057554A1 AR057554A1 ARP060104521A ARP060104521A AR057554A1 AR 057554 A1 AR057554 A1 AR 057554A1 AR P060104521 A ARP060104521 A AR P060104521A AR P060104521 A ARP060104521 A AR P060104521A AR 057554 A1 AR057554 A1 AR 057554A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- cycloalkyl
- amino
- nr6r7
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title 1
- 108090001060 Lipase Proteins 0.000 title 1
- 239000004367 Lipase Substances 0.000 title 1
- 102000015439 Phospholipases Human genes 0.000 title 1
- 108010064785 Phospholipases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 C1-6-mercapto alkyl Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000005702 oxyalkylene group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Composiciones farmacéuticas que los contienen, método de preparacion y usos para prevenir o tratar trastornos del metabolismo de ácidos grasos y trastornos de utilizacion de la glucosa. Reivindicacion 1: Un compuesto de formula (1) en la cual W es - (C=O)-, -SO-, -SO2-; R1 es alquilo C5-16, cicloalquilo C5-12, X-arilo, X-heteroarilo, X-cicloalquilo C5-12 o biciclo C8-14, donde arilo, heteroarilo, cicloalquilo o biciclo pueden estar sustituidos una o varias veces preferentemente con halogeno, alquilo C1-6, alquil C1-6-oxi, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, di-alquil C2-12-amino, mono-alquil C1-6-aminocarbonilo, di-alquil C2-8-aminocarbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquil C1-6-sulfonilo, aminosulfonilo, y pueden estar monosustituidos con Y-arilo, Y-heteroarilo, Y-cicloalquilo C3-12, en donde arilo, heteroarilo o cicloalquilo pueden estar mono- a trisustituidos preferentemente con halogeno, alquilo C1-6, alquil C1-6-oxi, hidroxi, alquil C1-6-mercapto, amino, alquil C1-6-amino, di-alquil C2-12-amino, mono-alquil C1-6-aminocarbonilo, di-alquil C2-8-aminocarbonilo, alcoxi C1-6-carbonilo, alquil C1-6-carbonilo, ciano, nitro, trifluorometilo, trifluorometoxi, alquil C1-6-sulfonilo, aminosulfonilo; X es alquileno C1-3 que puede estar sustituido una o varias veces con halogeno, alquilo C1-3, hidroxi o trifluorometilo; Y un enlace, alquileno C1-3, -O-, NH-; R2, R3, R4, R5 son, de forma idéntica o diferente, H, halogeno, alquilo C1-6, haloalquilo C1-3, alquil C1-3-oxi-alquileno C1-3, hidroxi, fenoxi, NR6R7, ciano, nitro, COOR6, CO-NR6R7, -S-R6, -SO-R6, -SO2-R6, aminosulfonilo, pentafluorosulfanilo, arilo, heteroarilo, O-heteroarilo, cicloalquilo C3-12, CO-R6, CO-NR6R7, O-CO-NR6R7, O-CO-alquilen C1-6-CO-O-alquilo C1-6, O-CO-alquilen C1-6-CO-OH, O-CO-alquilen C1-6-CO-NR6R7 o alquil C1-6-oxi no sustituido o mono- o poli-F-sustituido; R6, R7 son, de forma idéntica o diferente, H, alquilo C1-6, bencilo, las formas tautoméricas de los compuestos y sus sales fisiologicamente toleradas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005049953A DE102005049953A1 (de) | 2005-10-19 | 2005-10-19 | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057554A1 true AR057554A1 (es) | 2007-12-05 |
Family
ID=37667178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104521A AR057554A1 (es) | 2005-10-19 | 2006-10-17 | Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7897625B2 (es) |
| EP (1) | EP1940807B1 (es) |
| JP (1) | JP2009512650A (es) |
| KR (1) | KR20080063474A (es) |
| CN (1) | CN101291918A (es) |
| AR (1) | AR057554A1 (es) |
| AU (1) | AU2006303552A1 (es) |
| BR (1) | BRPI0617613A2 (es) |
| CA (1) | CA2625722A1 (es) |
| CR (1) | CR9850A (es) |
| DE (1) | DE102005049953A1 (es) |
| DO (1) | DOP2006000226A (es) |
| EC (1) | ECSP088377A (es) |
| GT (1) | GT200600463A (es) |
| HN (1) | HN2006035238A (es) |
| IL (1) | IL190714A0 (es) |
| MA (1) | MA29858B1 (es) |
| NO (1) | NO20081942L (es) |
| NZ (1) | NZ567573A (es) |
| PE (1) | PE20070724A1 (es) |
| RU (1) | RU2430096C2 (es) |
| TN (1) | TNSN08177A1 (es) |
| TW (1) | TW200730513A (es) |
| UY (1) | UY29872A1 (es) |
| WO (1) | WO2007045393A1 (es) |
| ZA (1) | ZA200802370B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541782A (zh) * | 2006-10-04 | 2009-09-23 | 先灵公司 | 作为凝血酶受体拮抗剂的二环和三环衍生物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| EP2351744B1 (en) * | 2008-10-17 | 2015-01-07 | Shionogi & Co., Ltd. | Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase |
| AR075111A1 (es) * | 2008-12-24 | 2011-03-09 | Bial Portela & Ca Sa | Derivados heterociclicos de diazoles y triazoles, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del metabolismo y del sistema nervioso, entre otros. |
| US8975286B2 (en) * | 2009-08-20 | 2015-03-10 | Merck Sharp & Dohme Corp. | Ether benzotriazole derivatives |
| KR20120123325A (ko) | 2009-12-15 | 2012-11-08 | 시오노기세야쿠 가부시키가이샤 | 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체 |
| US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| WO2012047580A1 (en) * | 2010-09-27 | 2012-04-12 | Janssen Pharmaceutica Nv | Alpha-ketoamide derivatives useful endothelial lipase inhibitors |
| EP3019482B1 (en) | 2013-02-25 | 2018-08-15 | Aurigene Discovery Technologies Limited | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
| RU2553987C1 (ru) * | 2013-12-26 | 2015-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения |
| CN104292172B (zh) * | 2014-09-12 | 2016-08-17 | 浙江理工大学 | 一种苯并三氮唑类衍生物及其制备方法 |
| HRP20211462T1 (hr) * | 2017-04-24 | 2021-12-24 | Aurigene Discovery Technologies Limited | Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze |
| US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| ES3038736T3 (en) | 2018-02-20 | 2025-10-14 | Servier Lab | Benzotriazole derivative for use in treating double and triple hit diffuse large b cell lymphoma |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1035188A (en) * | 1974-08-15 | 1978-07-25 | Eastman Kodak Company | Blocked development restrainers |
| US4273860A (en) * | 1977-12-28 | 1981-06-16 | Eastman Kodak Company | Inhibition of image formation utilizing cobalt(III) complexes |
| CA1124716A (en) | 1978-10-20 | 1982-06-01 | Michael J. Simons | Blocked benzotriazole compounds as development restrainer precursors |
| JPS6239573A (ja) * | 1985-08-13 | 1987-02-20 | Sumitomo Chem Co Ltd | シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤 |
| US6440648B1 (en) * | 2000-06-13 | 2002-08-27 | Eastman Kodak Company | Color photographic element having improved contrast and compatibility with both dry and conventional processing |
| US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
| MXPA03010129A (es) | 2001-05-05 | 2004-03-10 | Smithkline Beecham Plc | N-aroilaminas-ciclicas. |
| EP1458374A2 (en) | 2001-12-14 | 2004-09-22 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| ATE442139T1 (de) * | 2003-03-31 | 2009-09-15 | Lilly Co Eli | 3-oxo-1,3-dihydro-indazol-2-carbonsäureamid derivate als phospholipase inhibitoren |
-
2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
-
2006
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de not_active Ceased
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Withdrawn
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
-
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
-
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101291918A (zh) | 2008-10-22 |
| GT200600463A (es) | 2007-05-21 |
| EP1940807A1 (de) | 2008-07-09 |
| CA2625722A1 (en) | 2007-04-26 |
| CR9850A (es) | 2008-06-18 |
| WO2007045393A1 (de) | 2007-04-26 |
| ECSP088377A (es) | 2008-05-30 |
| UY29872A1 (es) | 2007-05-31 |
| HN2006035238A (es) | 2010-05-24 |
| KR20080063474A (ko) | 2008-07-04 |
| US20080287503A1 (en) | 2008-11-20 |
| AU2006303552A1 (en) | 2007-04-26 |
| US20110118321A1 (en) | 2011-05-19 |
| NO20081942L (no) | 2008-04-23 |
| EP1940807B1 (de) | 2015-06-17 |
| BRPI0617613A2 (pt) | 2011-08-02 |
| DE102005049953A1 (de) | 2007-04-26 |
| PE20070724A1 (es) | 2007-08-07 |
| DOP2006000226A (es) | 2007-05-15 |
| ZA200802370B (en) | 2008-12-31 |
| US7897625B2 (en) | 2011-03-01 |
| NZ567573A (en) | 2010-06-25 |
| JP2009512650A (ja) | 2009-03-26 |
| TW200730513A (en) | 2007-08-16 |
| RU2430096C2 (ru) | 2011-09-27 |
| MA29858B1 (fr) | 2008-10-03 |
| TNSN08177A1 (en) | 2009-10-30 |
| RU2008119460A (ru) | 2009-11-27 |
| IL190714A0 (en) | 2008-11-03 |
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