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AR050266A1 - Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa - Google Patents

Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa

Info

Publication number
AR050266A1
AR050266A1 ARP050103064A ARP050103064A AR050266A1 AR 050266 A1 AR050266 A1 AR 050266A1 AR P050103064 A ARP050103064 A AR P050103064A AR P050103064 A ARP050103064 A AR P050103064A AR 050266 A1 AR050266 A1 AR 050266A1
Authority
AR
Argentina
Prior art keywords
alkyl
triazolona
nucleosid
bencil
inhibitors
Prior art date
Application number
ARP050103064A
Other languages
English (en)
Inventor
James Patrick Dunn
Todd Richard Elworthy
Dimitrios Stefanidis
Zachary Kevin Sweeney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR050266A1 publication Critical patent/AR050266A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicacion 1: Un compuesto que se ajusta a la formula (1), en la que: R1 es halogeno, alquilo C1-6 o alcoxi C1-6; R2 es hidrogeno, halogeno o alquilo C1-6; R3 es un fenilo sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre el grupo formado por alquilo C1-6, cicloalquilo C3-8, haloalquilo C1-6, haloalcoxi C1-6, halogeno y ciano; R4 es CH2OH, CH2OC(=O)(CH2)2C(=O)OH o CH2OC(=O)-alquiloC1-6; R5 es hidrogeno o alquilo C1-6; y los hidratos, solvatos y sales del mismo.
ARP050103064A 2004-07-27 2005-07-25 Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa AR050266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59131104P 2004-07-27 2004-07-27

Publications (1)

Publication Number Publication Date
AR050266A1 true AR050266A1 (es) 2006-10-11

Family

ID=35056908

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103064A AR050266A1 (es) 2004-07-27 2005-07-25 Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa

Country Status (16)

Country Link
US (1) US7666891B2 (es)
EP (1) EP1773790B1 (es)
JP (1) JP4675959B2 (es)
CN (1) CN1993332B (es)
AR (1) AR050266A1 (es)
AU (1) AU2005266530B2 (es)
BR (1) BRPI0513858B8 (es)
CA (1) CA2574308C (es)
ES (1) ES2391461T3 (es)
IL (1) IL180495A (es)
MX (1) MX2007000788A (es)
NO (1) NO338376B1 (es)
RU (1) RU2394028C2 (es)
SG (1) SG148179A1 (es)
TW (1) TWI299334B (es)
WO (1) WO2006010545A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
CN101501002B (zh) * 2006-08-16 2012-06-27 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
CN101657433A (zh) * 2007-03-29 2010-02-24 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
CA2683046A1 (en) * 2007-04-09 2008-10-16 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
KR101541929B1 (ko) * 2007-05-30 2015-08-04 에프. 호프만-라 로슈 아게 트라이아졸론의 제조방법
CN101679294B (zh) * 2007-05-30 2012-08-08 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
JP2010530863A (ja) * 2007-06-22 2010-09-16 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としての尿素及びカルバマート誘導体
WO2009080534A1 (en) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
CN101723909B (zh) * 2008-10-29 2011-12-28 天津药物研究院 三唑酮类化合物、其制备方法和用途
CN101735023B (zh) * 2008-11-24 2014-07-09 联化科技股份有限公司 一种3-溴-5-氯苯酚的制备方法
EP2501698B1 (en) 2009-11-18 2018-04-25 National Research Council of Canada Fluorinated monomers, oligomers and polymers for use in organic electronic devices
CN102146022B (zh) * 2010-02-05 2013-07-03 中国中化股份有限公司 3-氯-5-溴苯酚的制备方法
CA2803103A1 (en) 2010-07-15 2012-01-19 Albemarle Corporation Processes for producing 4-bromo-2-methoxybenzaldehyde
ES2773105T3 (es) * 2012-09-26 2020-07-09 Merck Sharp & Dohme Forma cristalina de un inhibidor de transcriptasa inversa
DK2935228T3 (en) * 2012-12-20 2017-10-30 Inception 2 Inc TRIAZOLONE COMPOUNDS AND APPLICATIONS THEREOF
SG11201601066VA (en) 2013-09-06 2016-03-30 Inception 2 Inc Triazolone compounds and uses thereof
GB2598624A (en) * 2020-09-07 2022-03-09 Lorico Aurelio Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274185A (en) 1963-10-08 1966-09-20 S E Massengill Company Phthalazine derivatives
US3813384A (en) 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
US5436252A (en) 1986-12-19 1995-07-25 Merrell Dow Pharmaceuticals Inc. 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders
JP2593084B2 (ja) 1986-12-19 1997-03-19 メレルダウファーマスーティカルズ インコーポレーテッド ５−アリールー３ｈ−１，２，４−トリアゾールー３−オン類の神経変性障害の処置への用途
PH24094A (en) 1986-12-19 1990-03-05 Merrell Dow Pharma 5-aryl-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
US4942236A (en) 1987-09-30 1990-07-17 American Home Products Corporation 2-aryl substituted pyridyl-containing phenyl sulfonamido compounds as antiallergic and antiinflammatory agents
US4826990A (en) 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
US5103014A (en) 1987-09-30 1992-04-07 American Home Products Corporation Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives
US5331002A (en) 1990-04-19 1994-07-19 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
AU2381397A (en) 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
TW467902B (en) 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
US6367003B1 (en) * 1998-03-04 2002-04-02 Micron Technology, Inc. Digital signal processor having enhanced utilization of multiply accumulate (MAC) stage and method
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
UA82048C2 (uk) * 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агоністи альфа-рецепторів, активованих проліфератором пероксисом
WO2002040021A2 (en) * 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
TW200505441A (en) * 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ

Also Published As

Publication number Publication date
AU2005266530B2 (en) 2012-04-12
MX2007000788A (es) 2007-03-23
BRPI0513858B1 (pt) 2020-11-10
ES2391461T3 (es) 2012-11-27
NO20070258L (no) 2007-01-15
RU2007106928A (ru) 2008-09-10
US7666891B2 (en) 2010-02-23
CN1993332B (zh) 2011-04-06
US20060025462A1 (en) 2006-02-02
TWI299334B (en) 2008-08-01
WO2006010545A1 (en) 2006-02-02
RU2394028C2 (ru) 2010-07-10
EP1773790B1 (en) 2012-08-15
IL180495A (en) 2013-12-31
JP2008508211A (ja) 2008-03-21
BRPI0513858A (pt) 2008-05-20
AU2005266530A1 (en) 2006-02-02
SG148179A1 (en) 2008-12-31
JP4675959B2 (ja) 2011-04-27
NO338376B1 (no) 2016-08-15
IL180495A0 (en) 2007-06-03
EP1773790A1 (en) 2007-04-18
CN1993332A (zh) 2007-07-04
TW200616979A (en) 2006-06-01
CA2574308A1 (en) 2006-02-02
BRPI0513858B8 (pt) 2021-05-25
CA2574308C (en) 2014-03-25

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee