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CO6150144A2 - Inhibidores de proteina tirosina fosfatasa humana y metodos de uso - Google Patents

Inhibidores de proteina tirosina fosfatasa humana y metodos de uso

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Publication number
CO6150144A2
CO6150144A2 CO09007333A CO09007333A CO6150144A2 CO 6150144 A2 CO6150144 A2 CO 6150144A2 CO 09007333 A CO09007333 A CO 09007333A CO 09007333 A CO09007333 A CO 09007333A CO 6150144 A2 CO6150144 A2 CO 6150144A2
Authority
CO
Colombia
Prior art keywords
substituted
linear
unsubstituted
branched
hydrogen
Prior art date
Application number
CO09007333A
Other languages
English (en)
Inventor
Jeffrey Lyle Gray
Mathew Brian Maier
Cynthia Clark
Ryan Nichols
Kande Amarasinghe
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO6150144A2 publication Critical patent/CO6150144A2/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

1.- Un compuesto que tiene la fórmula:en donde R es una unidad tiazolilo sustituida o no sustituida que tiene la fórmula:R4 y R5 se escogen cada uno independientemente de: i) hidrógeno; ii) alquilo C1-C6 lineal, ramificada o cíclico sustituido o no sustituido; iii) fenilo sustituido o no sustituido; iv) heteroarilo sustituido o no sustituido; o R4 y R5 se pueden tomar juntos para formar un anillo saturado o insaturado que tiene de 5 a 7 átomos; dichas sustituciones se escogen independientemente de una o más unidades alquilo C1-C6 lineal, cíclico o ramificado, halógeno, hidroxilo, o ciano; R6 es una unidad escogida de: i) hidrógeno; ii) alquilo C1-C6 lineal, ramificado o cíclico sustituido o no sustituido; iii) fenilo sustituido o no sustituido; y iv) heteroarilo sustituido o no sustituido; R1 se escoge de: i) hidrógeno; ii) alquilo lineal o ramificado C1-C6; iii) fenilo sustituido o no sustituido; o iv) bencilo sustituido o no sustituido; R2 se escoge de: i) alquilo lineal o ramificado C1-C6; o ii) alcoxi lineal o ramificado C1-C6; R3 es hidrógeno o alquilo lineal o ramificado C1-C4. 2.- Un compuesto de acuerdo con la Reivindicación 1 en donde R tiene la fórmula:3.- Un compuesto de acuerdo con la Reivindicación 2, en donde R4 y R5 son cada uno hidrógeno.
CO09007333A 2006-06-27 2009-01-27 Inhibidores de proteina tirosina fosfatasa humana y metodos de uso CO6150144A2 (es)

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US (13) US7622593B2 (es)
EP (3) EP2592072B1 (es)
JP (2) JP5232778B2 (es)
KR (1) KR101155365B1 (es)
CN (1) CN101506183B (es)
AU (1) AU2007265453B2 (es)
BR (1) BRPI0713570A2 (es)
CA (1) CA2657096C (es)
CO (1) CO6150144A2 (es)
DK (3) DK3323815T3 (es)
ES (3) ES2650598T3 (es)
IL (1) IL196128A (es)
MX (1) MX2009000288A (es)
NZ (1) NZ574407A (es)
PL (3) PL3323815T3 (es)
PT (3) PT3323815T (es)
RU (1) RU2447065C2 (es)
SI (1) SI2041102T1 (es)
WO (1) WO2008002569A2 (es)
ZA (1) ZA200900559B (es)

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