AR049418A1 - Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes. - Google Patents
Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.Info
- Publication number
- AR049418A1 AR049418A1 ARP050100628A ARP050100628A AR049418A1 AR 049418 A1 AR049418 A1 AR 049418A1 AR P050100628 A ARP050100628 A AR P050100628A AR P050100628 A ARP050100628 A AR P050100628A AR 049418 A1 AR049418 A1 AR 049418A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halo
- alkoxy
- alkylthio
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 16
- 125000005843 halogen group Chemical group 0.000 abstract 15
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 10
- 125000001424 substituent group Chemical group 0.000 abstract 10
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 5
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos pertenecen a la categoría de heteroarilaminopirazoles utilizados para el tratamiento de la diabetes. Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un derivado de heteroarilaminopirazol de formula (1) donde el resto de formula (2) es un radical anular heterocíclico aromático sustituido seleccionado de los restos de formulas (3); R es H, o alquilo C1-6; R1 es H, alquilo C1-6 sustituido opcionalmente con fenilo, estando dicho fenilo sustituido opcionalmente con halo, o [trialquil C1-4]sililo, alquenilo C3-6, alquinilo C3-6, cicloalquilo C3-6 sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo formado por alquilo C1-3, CF3 y halo, haloalquilo C1-3, o fenil sustituido opcionalmente con hasta dos sustituyentes seleccionados el grupo constituido por halo, alquilo C1-6, alcoxi C1-6, alquiltio C1-6, haloalquilo C1-3, haloalcoxi C1-3 y ciano; R2 es H, halo, alquilo C1-6, piridilo sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo constituido por alcoxi C1-6, alquiltio C1-6, halo y alquilo C1-6, fenilo sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo constituido por alquilo C1-6, alcoxi C1-6, alquiltio C1-6, ciano y halo, pirimidilo, tienilo sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo constituido por alquilo C1-6, alcoxi C1-6, alquiltio C1- 6, ciano y halo, benzotienilo, sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo constituido por alquilo C1-6, alcoxi C1-6, alquiltio C1-6, ciano y halo, o furilo sustituido opcionalmente con hasta dos sustituyentes seleccionados del grupo constituido por alquilo C1-6, alcoxi C1-6, alquiltio C1-6, ciano y halo; R3 es alquilo C1-6, cicloalquilo C3-6, haloalquilo C2-3 o fenilo opcionalmente sustituido con más de cuatro sustituyentes seleccionados del grupo constituido por alquilo C1-6 opcionalmente sustituido con un alcoxi C1-4, halo, haloalquilo C1-3, alcoxi C1-6, haloalcoxi C1-3, alquiltio C1-6, y ciano; R4 es alquilo C1-6 opcionalmente sustituido con un alcoxi C1-4, alcoxi C1-6, alquiltio C1-6, haloalquilo C1-3, haloalcoxi C1-3, o halo; n = 0, 1, 2, o 3; X es CO2R7, CONR5R6, o SO2NH2; R5 es H, alquilo C1-6, fenilo opcionalmente sustituido con halo o bencilo opcionalmente sustituido en el anillo fenilo con halo; R6 es H o alquilo C1-6; o R5 y R6, tomados junto con el átomo de N al cual están unidos, pueden formar un anillo de piperidina, morfolina, tiomorfolina o piperazina, dicha piperazina opcionalmente sustituida en el N con alquilo C1-3; R7 es H, alquilo C1-6, bencilo opcionalmente sustituido con hasta dos sustituyentes seleccionados del grupo constituido por halo, alquilo C1-6, alcoxi C1-3, haloalquilo C1-3, haloalcoxi C1-3 y alquiltio C1-6; fenilo opcionalmente sustituido con hasta dos sustituyentes seleccionados de alquilo C1-6, halo, alcoxi C1-6, haloalquilo C1-3, haloalcoxi C1-3 y alquiltio C1-6; y sales aceptables para uso farmacéutico del mismo con la condicion de que el compuesto de formula (1) no sea uno de los compuestos de formulas (4).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54833104P | 2004-02-27 | 2004-02-27 | |
| US57290604P | 2004-05-20 | 2004-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049418A1 true AR049418A1 (es) | 2006-08-02 |
Family
ID=34976070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100628A AR049418A1 (es) | 2004-02-27 | 2005-02-21 | Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7517878B2 (es) |
| EP (1) | EP1720863A4 (es) |
| JP (1) | JP2007525513A (es) |
| KR (1) | KR20060124727A (es) |
| AR (1) | AR049418A1 (es) |
| AU (1) | AU2005220723A1 (es) |
| BR (1) | BRPI0508051A (es) |
| CA (1) | CA2557527A1 (es) |
| EC (1) | ECSP066883A (es) |
| IL (1) | IL177232A0 (es) |
| MA (1) | MA28479B1 (es) |
| NO (1) | NO20064325L (es) |
| PE (1) | PE20051159A1 (es) |
| RU (1) | RU2006134004A (es) |
| TW (1) | TW200538130A (es) |
| UY (1) | UY28774A1 (es) |
| WO (1) | WO2005086656A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1812424A4 (en) | 2004-11-17 | 2009-07-08 | Miikana Therapeutics Inc | Kinase Inhibitors |
| WO2006065590A2 (en) * | 2004-12-16 | 2006-06-22 | Xtl Biopharmaceuticals Inc. | Pyridine and pyrimidine antiviral compositions |
| WO2006105127A2 (en) | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| WO2007041358A2 (en) * | 2005-09-30 | 2007-04-12 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| PT2013204E (pt) | 2006-03-24 | 2015-06-09 | Array Biopharma Inc | Análogos de 2-aminopiridina como activadores da glucoquinase |
| SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| WO2008118718A2 (en) * | 2007-03-23 | 2008-10-02 | Array Biopharma Inc. | 2-aminopyridine analogs as glucokinase activators |
| US20090029992A1 (en) * | 2007-06-11 | 2009-01-29 | Agoston Gregory E | Substituted pyrazole compounds |
| PL2209778T3 (pl) | 2007-09-21 | 2013-02-28 | Array Biopharma Inc | Pochodne pirydyn-2-ylo-amino-1,2,4-tiadiazolu jako aktywatory glukokinazy do leczenia cukrzycy |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| DE102008039083A1 (de) | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Aminopyrazole und ihre Verwendung |
| DE102008039082A1 (de) | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Azabicyclisch-substituierte 5-Aminopyrazole und ihre Verwendung |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| KR101947307B1 (ko) * | 2009-10-06 | 2019-02-12 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｐｄｋ１ 저해제로서 유용한 헤테로시클릭 화합물 |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| WO2017156493A1 (en) | 2016-03-11 | 2017-09-14 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| US20170291890A1 (en) * | 2014-09-17 | 2017-10-12 | Epizyme, Inc. | Heterocycle substituted amino-pyridine compounds and methods of use thereof |
| WO2016092559A1 (en) * | 2014-12-12 | 2016-06-16 | Oat & Iil India Laboratories Private Limited | Substituted pyrazole derivatives having activity as fungicides |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| KR101725292B1 (ko) * | 2016-03-30 | 2017-04-10 | 한국과학기술연구원 | 항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체 |
| PE20240221A1 (es) | 2016-06-16 | 2024-02-16 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4405207A1 (de) * | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
| US20020103185A1 (en) * | 2000-08-31 | 2002-08-01 | Sanner Mark A. | Pyrazole derivatives |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7319102B1 (en) * | 2003-12-09 | 2008-01-15 | The Procter & Gamble Company | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors |
-
2005
- 2005-02-21 AR ARP050100628A patent/AR049418A1/es unknown
- 2005-02-24 US US11/064,700 patent/US7517878B2/en not_active Expired - Fee Related
- 2005-02-24 JP JP2007500954A patent/JP2007525513A/ja active Pending
- 2005-02-24 WO PCT/US2005/005794 patent/WO2005086656A2/en not_active Ceased
- 2005-02-24 RU RU2006134004/04A patent/RU2006134004A/ru not_active Application Discontinuation
- 2005-02-24 EP EP05723606A patent/EP1720863A4/en not_active Withdrawn
- 2005-02-24 BR BRPI0508051-7A patent/BRPI0508051A/pt not_active IP Right Cessation
- 2005-02-24 CA CA002557527A patent/CA2557527A1/en not_active Abandoned
- 2005-02-24 AU AU2005220723A patent/AU2005220723A1/en not_active Abandoned
- 2005-02-24 KR KR1020067017159A patent/KR20060124727A/ko not_active Withdrawn
- 2005-02-25 PE PE2005000226A patent/PE20051159A1/es not_active Application Discontinuation
- 2005-02-25 UY UY28774A patent/UY28774A1/es not_active Application Discontinuation
- 2005-02-25 TW TW094105697A patent/TW200538130A/zh unknown
-
2006
- 2006-08-02 IL IL177232A patent/IL177232A0/en unknown
- 2006-09-22 MA MA29334A patent/MA28479B1/fr unknown
- 2006-09-25 NO NO20064325A patent/NO20064325L/no not_active Application Discontinuation
- 2006-09-26 EC EC2006006883A patent/ECSP066883A/es unknown
-
2009
- 2009-04-13 US US12/422,804 patent/US20090209451A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2557527A1 (en) | 2005-09-22 |
| US20050192294A1 (en) | 2005-09-01 |
| WO2005086656A2 (en) | 2005-09-22 |
| UY28774A1 (es) | 2005-08-31 |
| EP1720863A4 (en) | 2009-04-22 |
| EP1720863A2 (en) | 2006-11-15 |
| WO2005086656A3 (en) | 2005-12-29 |
| IL177232A0 (en) | 2006-12-10 |
| ECSP066883A (es) | 2006-11-24 |
| NO20064325L (no) | 2006-11-22 |
| MA28479B1 (fr) | 2007-03-01 |
| BRPI0508051A (pt) | 2007-07-17 |
| JP2007525513A (ja) | 2007-09-06 |
| TW200538130A (en) | 2005-12-01 |
| AU2005220723A1 (en) | 2005-09-22 |
| US20090209451A1 (en) | 2009-08-20 |
| US7517878B2 (en) | 2009-04-14 |
| KR20060124727A (ko) | 2006-12-05 |
| PE20051159A1 (es) | 2006-02-22 |
| RU2006134004A (ru) | 2008-04-10 |
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