AR088729A1 - Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica - Google Patents
Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceuticaInfo
- Publication number
- AR088729A1 AR088729A1 ARP120101017A ARP120101017A AR088729A1 AR 088729 A1 AR088729 A1 AR 088729A1 AR P120101017 A ARP120101017 A AR P120101017A AR P120101017 A ARP120101017 A AR P120101017A AR 088729 A1 AR088729 A1 AR 088729A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- methyl
- halogen
- carbamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados de 3-ureidoisoquinolin-8-ilo de la fórmula (1) útiles en prevención o tratamiento de enfermedades bacterianas. Reivindicación 1: Un compuesto de la fórmula (1) en donde R¹ es alquilo C₁₋₃, haloalquilo C₂₋₃ o ciclopropilo; R² es H, halógeno, piridazin-4-ilo, pirimidin-5-ilo o un grupo que tiene la fórmula (2), (3) ó (4), en donde Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente H o metilo, o cada uno de Rˣ y Rᶻ es H y Rʸ es halógeno, ciano, alquilo C₂₋₄, alcoxi C₁₋₄, amino, hidroxi, hidroxi-alquilo C₁₋₃, trifluorometilo, carbamoilo, carbamoil-alquilo C₁₋₂, (metilcarbamoil)-alquilo C₁₋₂, (dimetilcarbamoil)-alquilo C₁₋₂, terc-butoxicarbonilmetilo, ciclopropilo, pirrolidin-1-ilo, piperidin-1-ilo, morfolin-1-ilo o 1-morfolinometilo, o Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente halógeno, o Rˣ es metilo, Rʸ es metilo o halógeno y Rᶻ es H, o Rˣ es metilo o halógeno, Rʸ es H y Rᶻ es metilo o halógeno, o Rˣ es metilo o halógeno y cada uno de Rʸ y Rᶻ es H; Rˣ² es H, amino o hidroximetilo; Rˣ³ es hidroxi, carboxi, carbamoilo, hidroximetilo o aminometilo, Rʸ³ es H y Rᶻ³ es H o cada uno de Rˣ³ y Rᶻ³ es H y Rʸ³ es hidroxi, acetamidometilo, (dimetilamino)metilo, carboximetilo, carbamoilo o aminometilo, o cada uno de Rˣ³ y Rʸ³ es H y Rᶻ³ es hidroxi; R³ es alquilo C₁₋₄, alquinilo C₂₋₄, amino-alquilo C₁₋₃, carbamoil-alquilo C₁₋₃, (metilcarbamoil)-alquilo C₁₋₃, alcoxi C₁₋₄, haloalcoxi C₁₋₄, alquiniloxi C₃₋₄, (4-hidroxibut-2-en-1-il)oxi, (4-aminobut-2-en-1-il)oxi, dimetilamino-alcoxi C₂₋₃, carbamoil-alcoxi C₁₋₃, alquilamino C₁₋₃, cicloalquilo C₃₋₆, cicloalquil C₃₋₆-alquilo C₁₋₄, cicloalquil C₃₋₆-alcoxi C₁₋₄, hidroxi-alquilo C₁₋₃, hidroxi-alcoxi C₂₋₃, alcoxi C₁₋₃-alquilo C₁₋₃, alcoxi C₁₋₃-alcoxi C₁₋₃, carboxi-alquilo C₁₋₃, carboxi-alcoxi C₁₋₃, alcoxicarbonil C₁₋₂-alcoxi C₁₋₃, arilo, heteroarilo C₅₋₆, bencilo, benciloxi, 2-cianoetoxi, 2,3-dihidroxipropoxi, 3,4-dihidroxibutoxi, -CH₂Rᵃ, -CH₂CH₂Rᵇ, -(CH₂)ₙ-C(O)O-Rᵈ, (CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -O-(CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -(CH₂)ₙ-Rᵉ o -O-(CH₂)ₙ-Rᵉ; n es 1, 2 ó 3; Rᵃ es ciano, acetilamino, N,N-dimetilamino; y Rᵇ es ciano; Rᶜ es H o metilo; Rᵈ es alquilo C₁₋₄; Rᵉ es pirrolidin-1-ilo, piperidin-1-ilo, piperidin-3-ilo, morfolin-1-ilo, 2-oxopirrolidin-1-ilo, 5-oxopirrolidin-2-ilo, 2,5-dioxopirrolidin-1-ilo, 2-oxoimidazoliden-1-ilo, 4-(terc-butoxicarbonil)piperazin-1-ilo, 4-(aminometil)ciclohexilo o heteroarilo C₅₋₆; R⁴ es H o metilo; o una sal de dicho compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051320 | 2011-03-29 | ||
| IB2011054063 | 2011-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088729A1 true AR088729A1 (es) | 2014-07-02 |
Family
ID=45976978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101017A AR088729A1 (es) | 2011-03-29 | 2012-03-27 | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8889676B2 (es) |
| EP (1) | EP2691373A1 (es) |
| JP (1) | JP2014512352A (es) |
| KR (1) | KR20140019423A (es) |
| CN (1) | CN103476756A (es) |
| AR (1) | AR088729A1 (es) |
| AU (1) | AU2012235706A1 (es) |
| BR (1) | BR112013024899A2 (es) |
| CA (1) | CA2828423A1 (es) |
| IL (1) | IL228486A0 (es) |
| MA (1) | MA35048B1 (es) |
| MX (1) | MX2013011253A (es) |
| PH (1) | PH12013501981A1 (es) |
| RU (1) | RU2013147875A (es) |
| TW (1) | TW201249801A (es) |
| WO (1) | WO2012131588A1 (es) |
| ZA (1) | ZA201308049B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
| CN114846009B (zh) | 2019-12-24 | 2023-12-12 | 杭州中美华东制药有限公司 | 具有khk抑制作用的化合物 |
| JP2023044027A (ja) * | 2021-09-17 | 2023-03-30 | 三井化学株式会社 | 抗菌剤 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| DE60024631T2 (de) | 1999-07-26 | 2006-06-14 | Banyu Pharma Co Ltd | Biaryl-harnstoff-derivate |
| PE20010635A1 (es) * | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
| DE60139964D1 (de) | 2000-12-15 | 2009-10-29 | Vertex Pharma | Bakterielle Gyrase-Hemmer sowie deren Verwendung |
| US6831068B2 (en) | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| RU2333208C2 (ru) | 2002-06-13 | 2008-09-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций |
| US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| ES2328047T3 (es) | 2004-03-19 | 2009-11-06 | Warner-Lambert Company Llc | Derivados de imidazopiridina e imidazopirimidina como agentes antibacterianos. |
| JP2008515874A (ja) | 2004-10-07 | 2008-05-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌薬 |
| WO2006049941A2 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as cb1 antagonists |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| CN1958568B (zh) * | 2005-11-03 | 2011-04-13 | 中国科学院上海药物研究所 | 一类预防或治疗幽门螺杆菌感染化合物、其制法和用途 |
| AU2006311729A1 (en) | 2005-11-07 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Benzimidazole derivatives as gyrase inhibitors |
| JP2009535393A (ja) | 2006-05-01 | 2009-10-01 | ファイザー・プロダクツ・インク | 置換２−アミノ縮合複素環式化合物 |
| WO2007146230A2 (en) * | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
| KR20090086629A (ko) | 2006-12-04 | 2009-08-13 | 아스트라제네카 아베 | 항박테리아성 폴리시클릭 우레아 화합물 |
| CA2672940A1 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
| WO2008141010A2 (en) | 2007-05-11 | 2008-11-20 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| WO2009027732A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | 5-6-bicyclic heteroaromatic compounds with antibacterial activity |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| WO2009089083A1 (en) | 2008-01-04 | 2009-07-16 | Abbott Laboratories | Trpa1 antagonists |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| AU2009260447B2 (en) | 2008-05-30 | 2012-03-29 | Amgen Inc. | Inhibitors of PI3 kinase |
| US20090325902A1 (en) | 2008-06-04 | 2009-12-31 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| EP2303894A1 (en) | 2008-06-04 | 2011-04-06 | AstraZeneca AB | Thiazolo [5, 4-b] pyridine and oxazolo [5, 4-b] pyridine derivatives as antibacterial agents |
| BRPI0915471A2 (pt) | 2008-06-04 | 2017-06-27 | Astrazeneca Ab | composto, composição farmacêutica, métodos de inibir dna girase bacteriana e/ou topoisomerase bacteriana iv, para produzir um efeito antibacteriano em um animal de sangue quente e para tratar uma infecção bacteriana em um animal de sangue quente, e, uso de um composto |
| US20110166088A1 (en) | 2008-06-25 | 2011-07-07 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| UY32694A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Derivados heterocíclicos de urea y métodos de uso de los mismos |
| AR077971A1 (es) | 2009-08-26 | 2011-10-05 | Astrazeneca Ab | Derivados heterociclicos de urea y metodos de uso de los mismos |
| KR20130012072A (ko) | 2010-03-31 | 2013-01-31 | 액테리온 파마슈티칼 리미티드 | 항박테리아성 이소퀴놀린-３-일우레아 유도체 |
-
2012
- 2012-03-27 AR ARP120101017A patent/AR088729A1/es not_active Application Discontinuation
- 2012-03-28 CN CN2012800151068A patent/CN103476756A/zh active Pending
- 2012-03-28 US US14/009,093 patent/US8889676B2/en not_active Expired - Fee Related
- 2012-03-28 MX MX2013011253A patent/MX2013011253A/es not_active Application Discontinuation
- 2012-03-28 AU AU2012235706A patent/AU2012235706A1/en not_active Abandoned
- 2012-03-28 KR KR1020137028588A patent/KR20140019423A/ko not_active Withdrawn
- 2012-03-28 RU RU2013147875/04A patent/RU2013147875A/ru not_active Application Discontinuation
- 2012-03-28 WO PCT/IB2012/051473 patent/WO2012131588A1/en not_active Ceased
- 2012-03-28 CA CA2828423A patent/CA2828423A1/en not_active Abandoned
- 2012-03-28 TW TW101110929A patent/TW201249801A/zh unknown
- 2012-03-28 JP JP2014501786A patent/JP2014512352A/ja active Pending
- 2012-03-28 BR BR112013024899A patent/BR112013024899A2/pt not_active IP Right Cessation
- 2012-03-28 PH PH1/2013/501981A patent/PH12013501981A1/en unknown
- 2012-03-28 EP EP12715438.3A patent/EP2691373A1/en not_active Withdrawn
- 2012-03-28 MA MA36339A patent/MA35048B1/fr unknown
-
2013
- 2013-09-17 IL IL228486A patent/IL228486A0/en unknown
- 2013-10-29 ZA ZA2013/08049A patent/ZA201308049B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012235706A1 (en) | 2013-11-14 |
| CN103476756A (zh) | 2013-12-25 |
| US20140038961A1 (en) | 2014-02-06 |
| IL228486A0 (en) | 2013-12-31 |
| NZ617068A (en) | 2015-05-29 |
| ZA201308049B (en) | 2016-08-31 |
| JP2014512352A (ja) | 2014-05-22 |
| MA35048B1 (fr) | 2014-04-03 |
| RU2013147875A (ru) | 2015-05-10 |
| KR20140019423A (ko) | 2014-02-14 |
| US8889676B2 (en) | 2014-11-18 |
| WO2012131588A1 (en) | 2012-10-04 |
| EP2691373A1 (en) | 2014-02-05 |
| PH12013501981A1 (en) | 2013-11-25 |
| MX2013011253A (es) | 2013-10-17 |
| BR112013024899A2 (pt) | 2016-12-20 |
| CA2828423A1 (en) | 2012-10-04 |
| TW201249801A (en) | 2012-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |