AR054852A1 - Procesos para preparar derivados de pirazol 0- glucosido y nuevos intermediarios de dichos procesos - Google Patents
Procesos para preparar derivados de pirazol 0- glucosido y nuevos intermediarios de dichos procesosInfo
- Publication number
- AR054852A1 AR054852A1 ARP060103114A ARP060103114A AR054852A1 AR 054852 A1 AR054852 A1 AR 054852A1 AR P060103114 A ARP060103114 A AR P060103114A AR P060103114 A ARP060103114 A AR P060103114A AR 054852 A1 AR054852 A1 AR 054852A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- designates
- processes
- cycloalkyl
- alkoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229930182478 glucoside Natural products 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Además, se refiere a pocesos para preparar eductos e intermediarios en los procesos anteriores y a los intermediarios como tales. Reivindicacion 1: Proceso para preparar compuestos de la formula general 19 en donde: R1 designa alquilo C1-4, un grupo alquilo C1-4 sustituido con uno o varios átomos de F, o cicloalquilo C3-6, y R2 designa alquilo C1-4, un grupo alquilo C1-4 sustituido con uno o varios átomos de F, o cicloalquilo C3-6; y R3 designa F, Cl, Br, alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4 o cicloalquil C3-6-oxi; yR4, R5 designan, de modo independiente entre sí, H, F, Cl, Br, alquilo C1-4 o alcoxi C1-4; y R6, R7a, R7b, R7c tienen, de modo independiente entre sí, un significado seleccionado delgrupo H, (alquil C1- 6)carbonilo, fenilcarbonilo y fenil-(alquil C1-3)-carbonilo; incluyendo sus tautomeros, estereoisomeros, mezclas y sales; caracterizado porque la aglicona de la formula (3) en donde R1 a R5 se definen como se hizo con anteioridad en la presente; se obtiene por una hidrogenacion catalítica de un compuesto de la formula (4) en dodne R1 a R5 se definen como se hizo con anterioridad en la rpesente, y Qes Cl, BR, I, alcoxi C1-4, alquil C1-4-tio, feniltio, cicloalquil C3-6-oxi, alquil C1-4- carboniloxi, -NRaRb, en donde Ra, Rb designan, de modo independiente entre sí, alquilo C1-4, o -NRaRb designa pirrolidinilo, piperidinilo, morfolinilo, piperazinilo o N-alquil C1-4-piperazinilo; en un solvente o una mezcla de solventes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05015935 | 2005-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054852A1 true AR054852A1 (es) | 2007-07-18 |
Family
ID=37102155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103114A AR054852A1 (es) | 2005-07-22 | 2006-07-20 | Procesos para preparar derivados de pirazol 0- glucosido y nuevos intermediarios de dichos procesos |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1910391A1 (es) |
| JP (2) | JP4888840B2 (es) |
| KR (1) | KR20080036112A (es) |
| CN (1) | CN101218244A (es) |
| AR (1) | AR054852A1 (es) |
| AU (1) | AU2006271653A1 (es) |
| BR (1) | BRPI0613690A2 (es) |
| CA (1) | CA2621269A1 (es) |
| IL (1) | IL188898A0 (es) |
| MX (1) | MX2008000011A (es) |
| RU (1) | RU2008106461A (es) |
| TW (1) | TW200728286A (es) |
| WO (1) | WO2007010015A1 (es) |
| ZA (1) | ZA200709951B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2500873C (en) * | 2002-10-04 | 2012-01-17 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| US7375090B2 (en) | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| UY29694A1 (es) * | 2005-07-28 | 2007-02-28 | Boehringer Ingelheim Int | Metodos para prevenir y tratar trastornos metabolicos y nuevos derivados de pirazol-o-glucosido |
| UY30082A1 (es) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos |
| WO2012133783A1 (ja) * | 2011-03-31 | 2012-10-04 | キッセイ薬品工業株式会社 | ベンジルピラゾール誘導体の製造方法およびその製造中間体 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55157504A (en) * | 1979-05-24 | 1980-12-08 | Sankyo Co Ltd | Herbicide |
| WO2002036602A1 (en) * | 2000-11-02 | 2002-05-10 | Ajinomoto Co., Inc. | Novel pyrazole derivatives and diabetes remedies containing the same |
| WO2002053573A1 (en) * | 2000-12-28 | 2002-07-11 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and use thereof in medicines |
| EP1364957B1 (en) * | 2001-02-26 | 2008-12-31 | Kissei Pharmaceutical Co., Ltd. | Glycopyranosyloxypyrazole derivatives and medicinal use thereof |
| EP1364958B1 (en) * | 2001-02-27 | 2010-09-08 | Kissei Pharmaceutical Co., Ltd. | Glycopyranosyloxypyrazole derivatives and medicinal use thereof |
| CA2672001A1 (en) * | 2001-04-27 | 2002-11-07 | Ajinomoto Co., Inc. | N-substituted pyrazole-o-glycoside derivatives and therapeutic agent for diabetes containing the same |
| CA2448741C (en) * | 2001-05-30 | 2010-06-22 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate therefor |
| US20030087843A1 (en) * | 2001-09-05 | 2003-05-08 | Washburn William N. | O-pyrazole glucoside SGLT2 inhibitors and method of use |
| JP4424203B2 (ja) * | 2002-04-26 | 2010-03-03 | 味の素株式会社 | 糖尿病予防・治療剤 |
| DE60332743D1 (de) * | 2002-08-08 | 2010-07-08 | Kissei Pharmaceutical | Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, medizinische verwendung davon, und zwischenprodukt für dessen herstellung |
| JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| JP4606876B2 (ja) * | 2002-08-27 | 2011-01-05 | キッセイ薬品工業株式会社 | ピラゾール誘導体、それを含有する医薬組成物及びその医薬用途 |
| CA2500873C (en) * | 2002-10-04 | 2012-01-17 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| WO2004089966A1 (ja) * | 2003-04-01 | 2004-10-21 | Taisho Pharmaceutical Co., Ltd. | 選択的なヘテロアリール ５－チオ－β－Ｄ－アルドヘキソピラノシドの製造法 |
| ES2377741T3 (es) * | 2003-06-20 | 2012-03-30 | Kissei Pharmaceutical Co., Ltd. | Derivados de pirazol, composición farmacológica que los contiene e intermedios de producción de los mismos |
| UY29694A1 (es) * | 2005-07-28 | 2007-02-28 | Boehringer Ingelheim Int | Metodos para prevenir y tratar trastornos metabolicos y nuevos derivados de pirazol-o-glucosido |
-
2006
- 2006-07-20 CN CNA2006800246999A patent/CN101218244A/zh active Pending
- 2006-07-20 AU AU2006271653A patent/AU2006271653A1/en not_active Abandoned
- 2006-07-20 WO PCT/EP2006/064435 patent/WO2007010015A1/en not_active Ceased
- 2006-07-20 AR ARP060103114A patent/AR054852A1/es unknown
- 2006-07-20 JP JP2008521974A patent/JP4888840B2/ja not_active Expired - Fee Related
- 2006-07-20 MX MX2008000011A patent/MX2008000011A/es not_active Application Discontinuation
- 2006-07-20 CA CA002621269A patent/CA2621269A1/en not_active Abandoned
- 2006-07-20 RU RU2008106461/04A patent/RU2008106461A/ru not_active Application Discontinuation
- 2006-07-20 BR BRPI0613690-7A patent/BRPI0613690A2/pt not_active IP Right Cessation
- 2006-07-20 KR KR1020087004344A patent/KR20080036112A/ko not_active Ceased
- 2006-07-20 EP EP06777849A patent/EP1910391A1/en not_active Withdrawn
- 2006-07-21 TW TW095126625A patent/TW200728286A/zh unknown
-
2007
- 2007-11-19 ZA ZA200709951A patent/ZA200709951B/xx unknown
-
2008
- 2008-01-21 IL IL188898A patent/IL188898A0/en unknown
-
2011
- 2011-08-11 JP JP2011176119A patent/JP2012006956A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006271653A1 (en) | 2007-01-25 |
| JP2009502763A (ja) | 2009-01-29 |
| JP4888840B2 (ja) | 2012-02-29 |
| IL188898A0 (en) | 2008-04-13 |
| CA2621269A1 (en) | 2007-01-25 |
| JP2012006956A (ja) | 2012-01-12 |
| WO2007010015A1 (en) | 2007-01-25 |
| ZA200709951B (en) | 2008-11-26 |
| MX2008000011A (es) | 2008-03-26 |
| RU2008106461A (ru) | 2009-08-27 |
| EP1910391A1 (en) | 2008-04-16 |
| CN101218244A (zh) | 2008-07-09 |
| TW200728286A (en) | 2007-08-01 |
| KR20080036112A (ko) | 2008-04-24 |
| BRPI0613690A2 (pt) | 2011-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |