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AR040753A1 - Composiciones de deposito de polimeros multimodales injectables y usos de las mismas - Google Patents

Composiciones de deposito de polimeros multimodales injectables y usos de las mismas

Info

Publication number
AR040753A1
AR040753A1 AR20030102760A ARP030102760A AR040753A1 AR 040753 A1 AR040753 A1 AR 040753A1 AR 20030102760 A AR20030102760 A AR 20030102760A AR P030102760 A ARP030102760 A AR P030102760A AR 040753 A1 AR040753 A1 AR 040753A1
Authority
AR
Argentina
Prior art keywords
polymers
compositions
polymer
injectable
same
Prior art date
Application number
AR20030102760A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR040753A1 publication Critical patent/AR040753A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones de depósito inyectables que incluyen una matriz polimérica que consta de una pluralidad de polímeros biocompatibles bioerosionables en la cual cada polímero de la pluralidad de polímeros tiene un peso molecular medio en peso especificado y la matriz polimérica tiene una distribución amplia de peso molecular de la pluralidad de polímeros, un solvente que tiene una miscibilidad en agua inferior o igual a 7% a 25S C en una cantidad efectiva para plastificar el polímero y formar un gel con el mismo y un agente benéfico. Las composiciones han mejorado sustancialmente el comportamiento de aclarado de corte y tienen fuerza de inyección reducida,, lo que las hace fácilmente implantables debajo de la superficie del cuerpo de un paciente por medio de inyección.
AR20030102760A 2002-07-31 2003-07-31 Composiciones de deposito de polimeros multimodales injectables y usos de las mismas AR040753A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39983202P 2002-07-31 2002-07-31

Publications (1)

Publication Number Publication Date
AR040753A1 true AR040753A1 (es) 2005-04-20

Family

ID=31188625

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102760A AR040753A1 (es) 2002-07-31 2003-07-31 Composiciones de deposito de polimeros multimodales injectables y usos de las mismas

Country Status (19)

Country Link
US (2) US8501215B2 (es)
EP (2) EP1539101B1 (es)
JP (1) JP4639400B2 (es)
KR (1) KR20050083605A (es)
CN (2) CN1684663A (es)
AR (1) AR040753A1 (es)
AT (1) ATE419831T1 (es)
AU (2) AU2003256849A1 (es)
BR (1) BR0313539A (es)
CA (1) CA2494400A1 (es)
DE (1) DE60325742D1 (es)
DK (1) DK1539101T3 (es)
ES (1) ES2321505T3 (es)
IL (1) IL166463A0 (es)
MX (1) MXPA05001244A (es)
NO (1) NO20051025L (es)
NZ (1) NZ537953A (es)
WO (1) WO2004011054A2 (es)
ZA (1) ZA200501645B (es)

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US20140051770A1 (en) 2014-02-20
IL166463A0 (en) 2006-01-15
JP4639400B2 (ja) 2011-02-23
DK1539101T3 (da) 2009-04-27
BR0313539A (pt) 2005-06-21
CN101057824A (zh) 2007-10-24
AU2003256849A1 (en) 2004-02-16
US20040022859A1 (en) 2004-02-05
NZ537953A (en) 2007-02-23
NO20051025L (no) 2005-02-25
CA2494400A1 (en) 2004-02-05
DE60325742D1 (de) 2009-02-26
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US8501215B2 (en) 2013-08-06
WO2004011054A3 (en) 2004-04-01
HK1079443A1 (en) 2006-04-07
EP2030611A1 (en) 2009-03-04
KR20050083605A (ko) 2005-08-26
ZA200501645B (en) 2006-05-31
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ATE419831T1 (de) 2009-01-15
MXPA05001244A (es) 2005-06-08
WO2004011054A2 (en) 2004-02-05
ES2321505T3 (es) 2009-06-08
AU2010200348A1 (en) 2010-02-18

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