DE60325742D1 - Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen - Google Patents
Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungenInfo
- Publication number
- DE60325742D1 DE60325742D1 DE60325742T DE60325742T DE60325742D1 DE 60325742 D1 DE60325742 D1 DE 60325742D1 DE 60325742 T DE60325742 T DE 60325742T DE 60325742 T DE60325742 T DE 60325742T DE 60325742 D1 DE60325742 D1 DE 60325742D1
- Authority
- DE
- Germany
- Prior art keywords
- injectable
- depot compositions
- multimodal polymers
- multimodal
- polymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39983202P | 2002-07-31 | 2002-07-31 | |
| PCT/US2003/023439 WO2004011054A2 (en) | 2002-07-31 | 2003-07-28 | Injectable multimodal polymer depot compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60325742D1 true DE60325742D1 (de) | 2009-02-26 |
Family
ID=31188625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60325742T Expired - Lifetime DE60325742D1 (de) | 2002-07-31 | 2003-07-28 | Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8501215B2 (de) |
| EP (2) | EP1539101B1 (de) |
| JP (1) | JP4639400B2 (de) |
| KR (1) | KR20050083605A (de) |
| CN (2) | CN1684663A (de) |
| AR (1) | AR040753A1 (de) |
| AT (1) | ATE419831T1 (de) |
| AU (2) | AU2003256849A1 (de) |
| BR (1) | BR0313539A (de) |
| CA (1) | CA2494400A1 (de) |
| DE (1) | DE60325742D1 (de) |
| DK (1) | DK1539101T3 (de) |
| ES (1) | ES2321505T3 (de) |
| IL (1) | IL166463A0 (de) |
| MX (1) | MXPA05001244A (de) |
| NO (1) | NO20051025L (de) |
| NZ (1) | NZ537953A (de) |
| WO (1) | WO2004011054A2 (de) |
| ZA (1) | ZA200501645B (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001036000A1 (en) * | 1999-11-15 | 2001-05-25 | Bio Syntech Canada, Inc. | Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution |
| US20030158302A1 (en) * | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
| DE60004710T2 (de) * | 1999-12-09 | 2004-07-08 | Biosyntech Canada Inc., Laval | Mineral-polymer hybrid-zusammensetzung |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| ATE320277T1 (de) * | 2000-06-29 | 2006-04-15 | Biosyntech Canada Inc | Zusammensetzung und verfahren zur reparatur und regenerierung von knorpel und anderen geweben |
| AU2002221370A1 (en) * | 2000-11-15 | 2002-05-27 | Bio Syntech Canada Inc | Method for restoring a damaged or degenerated intervertebral disc |
| GB0116341D0 (en) | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| RU2355385C2 (ru) * | 2002-11-06 | 2009-05-20 | Алза Корпорейшн | Композиции пролонгированного действия с контролируемым высвобождением |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US8119154B2 (en) * | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| MX366832B (es) | 2004-10-01 | 2019-07-24 | Ramscor Inc | Composiciones de farmaco de liberacion sostenida convenientemente implantables. |
| US9993558B2 (en) | 2004-10-01 | 2018-06-12 | Ramscor, Inc. | Sustained release eye drop formulations |
| US8541413B2 (en) | 2004-10-01 | 2013-09-24 | Ramscor, Inc. | Sustained release eye drop formulations |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| MX2007003789A (es) * | 2004-10-04 | 2007-07-20 | Qlt Usa Inc | Suministro ocular de formulaciones polimericas para suministro. |
| US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| JP2009511092A (ja) * | 2005-08-18 | 2009-03-19 | スミス アンド ネフュー ピーエルシー | マルチモーダル高強度デバイス及び複合材料 |
| US8852638B2 (en) * | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP1948810A4 (de) * | 2005-11-04 | 2010-06-30 | Biosyntech Canada Inc | Zusammensetzung und verfahren zur effizienten verabreichung von nukleinsäuren in zellen mithilfe von chitosan |
| US8236904B2 (en) | 2005-12-28 | 2012-08-07 | Ethicon, Inc. | Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates |
| US20070149640A1 (en) * | 2005-12-28 | 2007-06-28 | Sasa Andjelic | Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates |
| JP5143131B2 (ja) | 2006-05-30 | 2013-02-13 | インターシア セラピューティクス,インコーポレイティド | 浸透圧送出システムの二片構成内部チャネル型の流れモジュレータ |
| AU2007284759B2 (en) | 2006-08-09 | 2010-10-28 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| US20100178346A1 (en) * | 2007-02-01 | 2010-07-15 | The Trustees Of The University Of Pennsylvania | Disc augmentation with hyaluronic acid |
| US7867778B2 (en) * | 2007-02-23 | 2011-01-11 | Visiongate, Inc. | Fluid focusing for positional control of a specimen for 3-D imaging |
| EP2142353A1 (de) | 2007-04-18 | 2010-01-13 | Smith & Nephew PLC | Expansionsformen von formgedächtnis-polymeren |
| JP5520814B2 (ja) | 2007-04-19 | 2014-06-11 | スミス アンド ネフュー インコーポレーテッド | マルチモーダル形状記憶ポリマー |
| EP2150288B1 (de) | 2007-04-19 | 2011-04-13 | Smith & Nephew, Inc. | Graft-fixierung |
| CN101715340A (zh) | 2007-04-23 | 2010-05-26 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
| HUE030789T2 (en) | 2007-05-18 | 2017-06-28 | Durect Corp | Improved depot formulation |
| WO2008153611A2 (en) | 2007-05-25 | 2008-12-18 | Qlt Usa, Inc. | Sustained delivery formulations of risperidone compounds |
| US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| EP2240167B1 (de) * | 2007-12-21 | 2013-11-13 | Ludwig-Maximilians-Universität | Extrudierte stangenförmige vorrichtungen zur kontrollierten freisetzung von biologischen substanzen bei menschen oder tieren |
| US20090181068A1 (en) | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| CN101917969A (zh) * | 2008-01-30 | 2010-12-15 | 诺瓦提斯公司 | 包含奥曲肽和三种线形聚丙交酯-共-乙交酯聚合物的缓释制剂 |
| US8343140B2 (en) | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| US20090263456A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Methods and Compositions for Reducing Preventing and Treating Adhesives |
| ES2569556T3 (es) * | 2008-06-03 | 2016-05-11 | Indivior Uk Limited | Complejo de inclusión de hidrogel deshidratado de un agente bioactivo con sistema fluido de administración de medicamento |
| US8802126B2 (en) * | 2008-06-30 | 2014-08-12 | Abbott Cardiovascular Systems Inc. | Polyester implantable medical device with controlled in vivo biodegradability |
| JP2010232895A (ja) * | 2009-03-26 | 2010-10-14 | Fuji Xerox Co Ltd | 通信制御装置及び情報処理装置 |
| KR102093612B1 (ko) | 2009-09-28 | 2020-03-26 | 인타르시아 세라퓨틱스 인코포레이티드 | 실질 항정상태 약물 전달의 신속 확립 및/또는 종결 |
| EP2308478A1 (de) * | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Abgabesystem zur verzögerten Freisetzung von Calciumkanalblocker Arzneistoffen |
| HUE029895T2 (en) * | 2010-05-31 | 2017-04-28 | Farm Rovi Lab Sa | Antipsychotic injectable depot composition |
| US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| DE102011114986A1 (de) | 2011-09-28 | 2013-03-28 | Ethris Gmbh | Sprühsystem |
| US8735504B2 (en) * | 2012-05-02 | 2014-05-27 | Warsaw Orthopedic, Inc. | Methods for preparing polymers having low residual monomer content |
| AU2014249008B2 (en) | 2013-03-11 | 2018-12-06 | Durect Corporation | Injectable controlled release composition comprising high viscosity liquid carrier |
| US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
| DK3046584T3 (en) | 2013-09-16 | 2017-10-02 | Astrazeneca Ab | THERAPEUTIC POLYMER NANOPARTICLES AND PROCEDURES FOR PREPARING AND USING THEREOF |
| WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
| KR20190025635A (ko) | 2016-06-30 | 2019-03-11 | 듀렉트 코퍼레이션 | 데포 제형 |
| CA3049034A1 (en) | 2017-01-03 | 2018-07-12 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug |
| DE102017106216A1 (de) | 2017-03-22 | 2018-09-27 | Amw Gmbh | Extrudierte Depotform zur anhaltenden Wirkstofffreisetzung |
| WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| CN112816637A (zh) * | 2020-06-17 | 2021-05-18 | 湖南慧泽生物医药科技有限公司 | 一种吗替麦考酚酯片的体外溶出方法 |
| JP2024503402A (ja) | 2021-01-12 | 2024-01-25 | デュレクト コーポレーション | 徐放性薬物送達システム及び関連の方法 |
| US12318387B2 (en) | 2021-07-16 | 2025-06-03 | Laboratorios Farmaceuticos Rovi, S.A. | Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition |
| TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
| AU2023281232A1 (en) | 2022-05-18 | 2024-10-24 | Laboratorios Farmacéuticos Rovi, S.A. | Prolonged-release injectable compositions for use in treatment with risperidone together with cyp2d6 enzyme inhibitors |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US336254A (en) | 1886-02-16 | Eobeet t | ||
| US336307A (en) | 1886-02-16 | Feed-water regulator | ||
| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3923939A (en) | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| LU83485A1 (fr) * | 1981-07-09 | 1983-02-04 | Metallurgie Hoboken | Procede et installation pour couler une bande a oreilles en saillie laterale |
| US4443340A (en) * | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| US4708861A (en) | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
| US6217911B1 (en) * | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
| US4985404A (en) | 1984-10-04 | 1991-01-15 | Monsanto Company | Prolonged release of biologically active polypeptides |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4853218A (en) * | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| US4866050A (en) * | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
| US5181914A (en) * | 1988-08-22 | 1993-01-26 | Zook Gerald P | Medicating device for nails and adjacent tissue |
| US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5085866A (en) | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5300295A (en) * | 1990-05-01 | 1994-04-05 | Mediventures, Inc. | Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH |
| US5252318A (en) | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234693A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5620700A (en) * | 1990-10-30 | 1997-04-15 | Alza Corporation | Injectable drug delivery system and method |
| PT99345A (pt) * | 1990-10-30 | 1992-09-30 | Alza Corp | Processo para a preparacao de sistemas apropriados para a libertacao de agentes terapeuticos |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| WO1992011843A1 (en) * | 1991-01-09 | 1992-07-23 | Alza Corporation | Bioerodible devices and compositions for diffusional release of agents |
| DK0568651T3 (da) * | 1991-02-01 | 2002-08-05 | Massachusetts Inst Technology | Bionedbrydelige polymerblandinger til afgivelse af lægemidler |
| FR2673843B1 (fr) * | 1991-03-14 | 1995-01-13 | Centre Nat Rech Scient | Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale. |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5288214A (en) * | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| EP0542364B1 (de) * | 1991-11-13 | 1996-01-24 | Glaxo Canada Inc. | Vorrichtung zur kontrollierten Wirkstoffreigabe |
| ES2139646T3 (es) | 1991-12-19 | 2000-02-16 | Mitsui Chemicals Inc | Acido polihidroxido carboxilico y su procedimiento de obtencion. |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| WO1993020134A1 (en) | 1992-03-30 | 1993-10-14 | Alza Corporation | Additives for bioerodible polymers to regulate degradation |
| WO1993019739A1 (en) * | 1992-03-30 | 1993-10-14 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
| DE69331387T2 (de) * | 1992-09-10 | 2002-08-22 | Childrens Medical Center | Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika |
| US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| US5338822A (en) * | 1992-10-02 | 1994-08-16 | Cargill, Incorporated | Melt-stable lactide polymer composition and process for manufacture thereof |
| US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| DE69329295T2 (de) | 1992-12-02 | 2001-03-15 | Alkermes Controlled Therapeutics, Inc. | Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung |
| MY113268A (en) * | 1992-12-29 | 2002-01-31 | Insite Vision Incorporated | Plasticized bioerodible controlled delivery system |
| US5340614A (en) * | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
| US5330452A (en) * | 1993-06-01 | 1994-07-19 | Zook Gerald P | Topical medicating device |
| US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| US5415866A (en) * | 1993-07-12 | 1995-05-16 | Zook; Gerald P. | Topical drug delivery system |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| PT727210E (pt) * | 1993-10-13 | 2002-06-28 | Darwin Discovery Ltd | Agente analgesico e sua utilizacao |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| US5681873A (en) | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
| US5760077A (en) * | 1994-01-14 | 1998-06-02 | Shahinian, Jr.; Lee | Topical ophthalmic analgesic preparations for sustained and extended corneal analgesia |
| AU1567795A (en) * | 1994-01-14 | 1995-08-01 | Lee Shahinian Jr. | A method for sustained and extended corneal analgesia |
| US5556905A (en) | 1994-03-30 | 1996-09-17 | Reilly Industries, Inc. | Physically-modified degradable thermoplastic compositions |
| DE69524398T2 (de) * | 1994-04-08 | 2002-07-18 | Atrix Laboratories, Inc. | Flüssige mittel zur wirkstoffabgabe |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5599534A (en) * | 1994-08-09 | 1997-02-04 | University Of Nebraska | Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use |
| US5660817A (en) * | 1994-11-09 | 1997-08-26 | Gillette Canada, Inc. | Desensitizing teeth with degradable particles |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
| US6322548B1 (en) | 1995-05-10 | 2001-11-27 | Eclipse Surgical Technologies | Delivery catheter system for heart chamber |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| ATE267587T1 (de) | 1995-06-09 | 2004-06-15 | Euro Celtique Sa | Formulierungen und verfahren für eine verlängerte lokalanästhesie |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| US5787175A (en) * | 1995-10-23 | 1998-07-28 | Novell, Inc. | Method and apparatus for collaborative document control |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US5747060A (en) * | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| US6193994B1 (en) * | 1996-05-23 | 2001-02-27 | Samyang Corporation | Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof |
| ATE302599T1 (de) * | 1996-05-24 | 2005-09-15 | Angiotech Pharm Inc | Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege |
| CA2180601C (en) * | 1996-07-05 | 2007-12-18 | Chun Keung Mak | Heated nozzle manifolds in a common plane interconnected through connector manifolds |
| KR20000022239A (ko) * | 1996-07-11 | 2000-04-25 | 토마스 헤인 | 인돌 선택성 세로토닌 작용약을 함유한 내포 복합체 |
| US6106301A (en) * | 1996-09-04 | 2000-08-22 | Ht Medical Systems, Inc. | Interventional radiology interface apparatus and method |
| US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5766637A (en) * | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
| WO1998027962A2 (en) | 1996-12-20 | 1998-07-02 | Alza Corporation | Injectable depot gel composition and method of preparing the composition |
| GB9704351D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| JPH10255221A (ja) * | 1997-03-14 | 1998-09-25 | Mitsubishi Electric Corp | 複合型磁気ヘッド及び該複合型磁気ヘッドのヘッドコアの製造方法 |
| US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6197327B1 (en) | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6004295A (en) | 1997-06-26 | 1999-12-21 | An-Go-Gen Inc. | Catheters |
| EP1009390A4 (de) * | 1997-07-02 | 2004-05-06 | Euro Celtique Sa | Verlängerte narkose in gelenken und körperzwischenräumen |
| US6432986B2 (en) | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| US20010004644A1 (en) * | 1997-07-21 | 2001-06-21 | Levin Bruce H. | Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation |
| CA2294921C (en) | 1997-07-22 | 2009-04-07 | Darwin Discovery Limited | Levobupivacaine and its use |
| US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US6183444B1 (en) | 1998-05-16 | 2001-02-06 | Microheart, Inc. | Drug delivery module |
| US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
| US6050986A (en) * | 1997-12-01 | 2000-04-18 | Scimed Life Systems, Inc. | Catheter system for the delivery of a low volume liquid bolus |
| IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
| WO1999049908A1 (en) * | 1998-03-31 | 1999-10-07 | University Of Cincinnati | Temperature controlled solute delivery system |
| US6261547B1 (en) * | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6955819B2 (en) | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| RU2271196C2 (ru) * | 1999-06-04 | 2006-03-10 | Элзэ Копэрейшн | Имплантируемая композиция (варианты) и способ ее приготовления |
| US6423818B1 (en) * | 1999-07-30 | 2002-07-23 | Takehisa Matsuda | Coumarin endcapped absorbable polymers |
| US6352667B1 (en) * | 1999-08-24 | 2002-03-05 | Absorbable Polymer Technologies, Inc. | Method of making biodegradable polymeric implants |
| US6528086B2 (en) * | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
| US6432415B1 (en) * | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US6566345B2 (en) * | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| US6899731B2 (en) * | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
| DE60138020D1 (de) | 2000-04-28 | 2009-04-30 | Fziomed Inc | Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden |
| JP2004511431A (ja) * | 2000-06-28 | 2004-04-15 | アトゥル・ジェイ・シュクラ | 生物活性物質を含む生分解性ビヒクルおよび送達システム |
| US20020045668A1 (en) * | 2000-07-17 | 2002-04-18 | Wenbin Dang | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| US6543081B1 (en) * | 2000-08-15 | 2003-04-08 | Sheldon C. Cohen | Flip-up wringer sponge mop |
| US6823084B2 (en) * | 2000-09-22 | 2004-11-23 | Sri International | Method and apparatus for portably recognizing text in an image sequence of scene imagery |
| WO2002038185A2 (en) * | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
| KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
| WO2002058670A1 (en) | 2001-01-25 | 2002-08-01 | Euroceltique S.A. | Local anesthetic, and method of use |
| US6375659B1 (en) * | 2001-02-20 | 2002-04-23 | Vita Licensing, Inc. | Method for delivery of biocompatible material |
| ATE427760T1 (de) | 2001-02-23 | 2009-04-15 | Genentech Inc | Erodierbare polymere zur injektion |
| US20030027833A1 (en) * | 2001-05-07 | 2003-02-06 | Cleary Gary W. | Compositions and delivery systems for administration of a local anesthetic agent |
| MXPA04004664A (es) | 2001-11-14 | 2004-09-10 | Alza Corp | Composiciones de deposito inyectables. |
| MXPA04004665A (es) * | 2001-11-14 | 2004-09-10 | Alza Corp | Composiciones de deposito inyectable y uso de los mismos. |
| CA2466632C (en) | 2001-11-14 | 2014-02-11 | Alza Corporation | Injectable depot compositions and uses thereof |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| RU2355385C2 (ru) | 2002-11-06 | 2009-05-20 | Алза Корпорейшн | Композиции пролонгированного действия с контролируемым высвобождением |
| US20070184084A1 (en) | 2003-05-30 | 2007-08-09 | Guohua Chen | Implantable elastomeric caprolactone depot compositions and uses thereof |
| AU2004245022A1 (en) | 2003-05-30 | 2004-12-16 | Alza Corporation | Implantable elastomeric depot compositions, uses thereof and method of manufacturing |
-
2003
- 2003-07-28 BR BR0313539-0A patent/BR0313539A/pt not_active IP Right Cessation
- 2003-07-28 AT AT03771916T patent/ATE419831T1/de not_active IP Right Cessation
- 2003-07-28 CA CA002494400A patent/CA2494400A1/en not_active Abandoned
- 2003-07-28 AU AU2003256849A patent/AU2003256849A1/en not_active Abandoned
- 2003-07-28 EP EP03771916A patent/EP1539101B1/de not_active Expired - Lifetime
- 2003-07-28 US US10/628,984 patent/US8501215B2/en not_active Expired - Fee Related
- 2003-07-28 CN CNA038225581A patent/CN1684663A/zh active Pending
- 2003-07-28 KR KR1020057001821A patent/KR20050083605A/ko not_active Ceased
- 2003-07-28 DE DE60325742T patent/DE60325742D1/de not_active Expired - Lifetime
- 2003-07-28 ES ES03771916T patent/ES2321505T3/es not_active Expired - Lifetime
- 2003-07-28 CN CNA2007101096196A patent/CN101057824A/zh active Pending
- 2003-07-28 WO PCT/US2003/023439 patent/WO2004011054A2/en not_active Ceased
- 2003-07-28 NZ NZ537953A patent/NZ537953A/en not_active IP Right Cessation
- 2003-07-28 EP EP08166077A patent/EP2030611A1/de not_active Withdrawn
- 2003-07-28 DK DK03771916T patent/DK1539101T3/da active
- 2003-07-28 JP JP2004524891A patent/JP4639400B2/ja not_active Expired - Fee Related
- 2003-07-28 MX MXPA05001244A patent/MXPA05001244A/es unknown
- 2003-07-31 AR AR20030102760A patent/AR040753A1/es not_active Application Discontinuation
-
2005
- 2005-01-24 IL IL16646305A patent/IL166463A0/xx unknown
- 2005-02-24 ZA ZA200501645A patent/ZA200501645B/xx unknown
- 2005-02-25 NO NO20051025A patent/NO20051025L/no not_active Application Discontinuation
-
2010
- 2010-01-29 AU AU2010200348A patent/AU2010200348A1/en not_active Withdrawn
-
2013
- 2013-07-16 US US13/943,719 patent/US20140051770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1684663A (zh) | 2005-10-19 |
| JP2005538107A (ja) | 2005-12-15 |
| US20140051770A1 (en) | 2014-02-20 |
| IL166463A0 (en) | 2006-01-15 |
| JP4639400B2 (ja) | 2011-02-23 |
| DK1539101T3 (da) | 2009-04-27 |
| BR0313539A (pt) | 2005-06-21 |
| CN101057824A (zh) | 2007-10-24 |
| AU2003256849A1 (en) | 2004-02-16 |
| US20040022859A1 (en) | 2004-02-05 |
| NZ537953A (en) | 2007-02-23 |
| NO20051025L (no) | 2005-02-25 |
| CA2494400A1 (en) | 2004-02-05 |
| AR040753A1 (es) | 2005-04-20 |
| EP1539101A2 (de) | 2005-06-15 |
| US8501215B2 (en) | 2013-08-06 |
| WO2004011054A3 (en) | 2004-04-01 |
| HK1079443A1 (en) | 2006-04-07 |
| EP2030611A1 (de) | 2009-03-04 |
| KR20050083605A (ko) | 2005-08-26 |
| ZA200501645B (en) | 2006-05-31 |
| EP1539101B1 (de) | 2009-01-07 |
| ATE419831T1 (de) | 2009-01-15 |
| MXPA05001244A (es) | 2005-06-08 |
| WO2004011054A2 (en) | 2004-02-05 |
| ES2321505T3 (es) | 2009-06-08 |
| AU2010200348A1 (en) | 2010-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60325742D1 (de) | Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen | |
| DE60306670D1 (de) | 3,4-alkylendioxythiophen-verbindungen und ihre polymere | |
| DE60335933D1 (de) | Polymere Verbindung und ihre Verwendung in einer Elektrolumineszenzvorrichtung | |
| ATE400594T1 (de) | Alkali-quellbare assoziative polymere, methode und zusamensetzungen | |
| DE60232987D1 (de) | Injizierbare depotzusammensetzungen | |
| PL375599A1 (en) | Multi-purpose polymers, methods and compositions | |
| DE60326611D1 (de) | N und dergleichen | |
| DE60224724D1 (de) | 3,4-alkylendioxythiophen-verbindungen und ihre polymere | |
| DE50305988D1 (de) | Arylamin-einheiten enthaltende konjugierte polymere, deren darstellung und verwendung | |
| DE60310542D1 (de) | Kühlende zusammensetzungen und deren verwendungen | |
| DE60203235D1 (de) | Polymere Verbindung und ihre Verwendung in einer Elektrolumineszenzvorrichtung | |
| ATE339419T1 (de) | Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren | |
| DE602004021904D1 (de) | Gyraseinhibitoren und deren verwendungen | |
| DK1620437T3 (da) | 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension | |
| ATE550017T1 (de) | Lasofoxifen-tablette und ihre ummantelung | |
| DE60315241D1 (de) | Zusammensetzungen mehrstufiger Polymere mit ausgelöster Freisetzung | |
| DE602004012890D1 (de) | Getränke und ihre herstellung | |
| ATE433448T1 (de) | Kondensierte heterocyclen und deren verwendungen | |
| GB0221952D0 (en) | Wnt mediated ErbB1 signalling,compositions and uses related thereto | |
| DE602004011389D1 (de) | Getränke und ihre herstellung | |
| DE60316300D1 (de) | Maiswurzel-spezifische promotoren und ihre verwendungen | |
| ATE416196T1 (de) | Polymerisate und ihre verwendung | |
| DE60332633D1 (de) | Vierrädriges fahrzeug | |
| SE0302485L (sv) | Novel copolymer and cement additive comprising the same | |
| DE502005002170D1 (de) | Amphiphile polymerzusammensetzungen und ihre verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |