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DE60138020D1 - Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden - Google Patents

Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden

Info

Publication number
DE60138020D1
DE60138020D1 DE60138020T DE60138020T DE60138020D1 DE 60138020 D1 DE60138020 D1 DE 60138020D1 DE 60138020 T DE60138020 T DE 60138020T DE 60138020 T DE60138020 T DE 60138020T DE 60138020 D1 DE60138020 D1 DE 60138020D1
Authority
DE
Germany
Prior art keywords
hemostatic
compositions
bioadhesive
adhesion
bioresorbable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138020T
Other languages
English (en)
Inventor
Stephanie M Cortese
Herbert E Schwartz
William G Oppelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FzioMed Inc
Original Assignee
FzioMed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FzioMed Inc filed Critical FzioMed Inc
Application granted granted Critical
Publication of DE60138020D1 publication Critical patent/DE60138020D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424—Anti-adhesion agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Polyurethanes Or Polyureas (AREA)
DE60138020T 2000-04-28 2001-04-26 Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden Expired - Lifetime DE60138020D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20045700P 2000-04-28 2000-04-28
US20063700P 2000-04-28 2000-04-28
PCT/US2001/013520 WO2001082937A1 (en) 2000-04-28 2001-04-26 Hemostatic compositions of polyacids and polyalkylene oxides and methods for their use

Publications (1)

Publication Number Publication Date
DE60138020D1 true DE60138020D1 (de) 2009-04-30

Family

ID=26895782

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60138020T Expired - Lifetime DE60138020D1 (de) 2000-04-28 2001-04-26 Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden

Country Status (9)

Country Link
US (1) US20020010150A1 (de)
EP (1) EP1292316B1 (de)
JP (1) JP2003531682A (de)
KR (1) KR20030031480A (de)
AT (1) ATE425776T1 (de)
AU (3) AU2001255716B2 (de)
CA (1) CA2407235A1 (de)
DE (1) DE60138020D1 (de)
WO (2) WO2001082863A2 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
CA2363048A1 (en) 1999-02-23 2000-08-31 Phairson Medical, Inc. Treatment of trauma
JP4737805B2 (ja) * 2000-07-27 2011-08-03 京セラ株式会社 止血材
US20030007951A1 (en) * 2000-08-23 2003-01-09 Richard Franklin Treatment of trauma
US20020177680A1 (en) * 2000-08-23 2002-11-28 Hubbell Jeffrey A. Novel polymer compounds
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
EP1423093A4 (de) * 2001-04-23 2005-11-30 Wisconsin Alumni Res Found Bifunktional modifizierte hydrogele
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
MXPA04004665A (es) * 2001-11-14 2004-09-10 Alza Corp Composiciones de deposito inyectable y uso de los mismos.
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US6923961B2 (en) 2002-04-30 2005-08-02 Fziomed, Inc. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AU2003256849A1 (en) 2002-07-31 2004-02-16 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
NZ537955A (en) * 2002-07-31 2007-10-26 Alza Corp Injectable depot compositions and uses thereof
US7074425B2 (en) * 2002-09-26 2006-07-11 Bonewax, Llc Hemostatic compositions and methods
BR0317237A (pt) * 2002-12-11 2005-11-01 Ferrosan As Dispositivo para amostragem ou coleta, kit, usos de um dispositivo e de um kit, e, métodos para diminuir a quantidade de um marcador em uma área de amostra, para amostrar de modo qualitativo ou quantitativo uma área quanto ao teor de um marcador e para cultivar microorganismos ou células de mamìferos coletados
US8709038B2 (en) 2002-12-20 2014-04-29 Boston Scientific Scimed, Inc. Puncture hole sealing device
US20040122349A1 (en) 2002-12-20 2004-06-24 Lafontaine Daniel M. Closure device with textured surface
US7942897B2 (en) * 2003-07-10 2011-05-17 Boston Scientific Scimed, Inc. System for closing an opening in a body cavity
US20060019868A1 (en) 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US8440225B2 (en) 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7226622B2 (en) * 2003-09-18 2007-06-05 Boston Scientific Scimed, Inc. Chemoablation of tissue using biodegradable, solid salt dosage forms
US7906125B2 (en) * 2003-09-18 2011-03-15 Boston Scientific Scimed, Inc. Solid or semi-solid therapeutic formulations
US20050064045A1 (en) * 2003-09-18 2005-03-24 Sheng-Ping Zhong Injectable therapeutic formulations
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
WO2005072700A2 (en) * 2004-01-30 2005-08-11 Ferrosan A/S Haemostatic sprays and compositions
BRPI0508939A (pt) 2004-03-17 2007-08-14 Genzyme Corp pulverização antiadesão
US8021684B2 (en) * 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
WO2006006861A1 (en) 2004-07-15 2006-01-19 Mark Hans Emanuel Composition and method for medical imaging of body cavities
KR20060040329A (ko) * 2004-11-05 2006-05-10 나건 내시경을 통하여 도포 가능한 체내 지혈제 및 그 도포 방법
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
NZ562002A (en) * 2005-03-02 2010-05-28 Technion Res & Dev Foundation Novel adhesive compositions comprising phloroglucinol (1,3,5-trihydroxybenzene), manufacturing thereof, and applications thereof
EP1879606B1 (de) 2005-04-25 2013-06-12 Massachusetts Institute of Technology Selbstorganisierende Peptide zur Förderung der Hämostase
US20060251581A1 (en) * 2005-05-09 2006-11-09 Mcintyre Jon T Method for treatment of uterine fibroid tumors
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US8263109B2 (en) * 2005-05-09 2012-09-11 Boston Scientific Scimed, Inc. Injectable bulking compositions
US20070248653A1 (en) * 2006-04-20 2007-10-25 Cochrum Kent C Hemostatic compositions and methods for controlling bleeding
HUE037994T2 (hu) 2006-04-25 2018-09-28 Massachusetts Inst Technology Készítmények és eljárások szennyezõ anyagok, testfolyadékok vagy más anyagok mozgásának befolyásolására és/vagy más fiziológiai állapotok befolyásolására
EP2207537B1 (de) 2007-10-02 2017-06-14 Fremont Group Ltd Systemische hämostasefördernde wirkung von sympathikomimetika mit agonistischen wirkungen auf die alpha-adrenergen und/oder beta-adrenergen rezeptoren des sympathischen nervensystems im zusammenhang mit verbesserter gerinnselstärke
US8642831B2 (en) * 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
BRPI0801422B8 (pt) * 2008-03-26 2021-05-25 Fund Sao Francisco Xavier composição e método para inibição da severidade das aderências pós-cirúrgicas
EP2437797B1 (de) 2009-06-01 2013-08-14 Technion Research & Development Foundation Ltd. Mehrkomponenten-klebstoff, dessen herstellung und anwendung
WO2010149172A2 (en) 2009-06-24 2010-12-29 Rigshospitalet SYSTEMIC PRO-HEMOSTATIC EFFECT OF CLOTTING FACTORS IN COMBINATION WITH SYMPATHICOMIMETICS WITH AGONISTIC EFFECTS ON α-ADRENERGIC AND/OR β-ADRENERGIC RECEPTORS OF THE SYMPATHETIC NERVOUS SYSTEM, RELATED TO IMPROVED CLOT STRENGTH.
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
NL2003660C2 (en) * 2009-10-16 2011-04-19 Giskit B V Composition and method for medical imaging of body cavities.
RU2539566C2 (ru) 2009-12-24 2015-01-20 Торэй Индастриз, Инк. Гидрофильное полимерное соединение, имеющее антикоагулянтный эффект
KR101142234B1 (ko) * 2009-12-28 2012-07-09 한남대학교 산학협력단 주사 주입이 용이한 다공성 미세입자 필러 시스템
RU2012145811A (ru) 2010-03-29 2014-05-10 Евоник Корпорейшн Композиции и способы улучшенного удержания фармацевтической композиции на участке местного введения
EP2739303B1 (de) * 2011-08-07 2020-04-01 Transgene Biotek Ltd. Neues verfahren zur peroralen verabreichung von insulin und analoga davon für therapeutische zwecke
CA2853655C (en) * 2011-11-01 2021-02-16 Abyrx, Inc. Compositions and methods for hemostasis
SG10201509573VA (en) * 2011-11-25 2015-12-30 Otsuka Pharma Co Ltd Pharmaceutical composition useful for adhesion prevention or hemostasis
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2572849C1 (ru) 2012-03-28 2016-01-20 Торэй Индастриз, Инк. Биоразрушаемый материал и способ получения биоразрушаемого материала
ES2746974T3 (es) 2012-03-28 2020-03-09 Toray Industries Material biodegradable y procedimiento de producción de un material biodegradable
BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
DE102012222365A1 (de) 2012-12-05 2014-06-05 Aesculap Ag Zusammensetzung zur Anwendung bei der Prophylaxe von post-chirurgischen Adhäsionen
EP3010419B1 (de) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vakuumerweiterte trockenzusammensetzung und spritze zum zurückhalten davon
IL229645A0 (en) 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス 押し出し増強因子を含んでいる乾燥組成物
US10353633B2 (en) * 2013-12-19 2019-07-16 Sony Interactive Entertainment LLC Mass storage virtualization for cloud computing
RU2546006C1 (ru) 2014-03-07 2015-04-10 Римма Ильинична Ашкинази Противовирусное средство
CN103948929A (zh) * 2014-05-04 2014-07-30 青岛市城阳区人民医院 骨科手术用防粘连粉雾剂及其制备方法
CN106659823B (zh) * 2014-07-24 2019-11-12 玫帝托克斯股份有限公司 热响应性防粘连用组合物及其用途
US9699436B2 (en) * 2014-09-16 2017-07-04 Microsoft Technology Licensing, Llc Display with eye-discomfort reduction
EP3206726B1 (de) 2014-10-13 2020-05-27 Ferrosan Medical Devices A/S Trockene zusammensetzung zur verwendung in der hämostase und wundheilung
US10184011B2 (en) * 2014-10-31 2019-01-22 Core Scientific Creations Ltd. Hemostatic devices with improved properties and methods of making same
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
WO2016118043A1 (ru) * 2015-01-20 2016-07-28 Виктор Вениаминович ТЕЦ Гемостатическое средство
JP6747651B2 (ja) 2015-07-03 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 保管状態で真空を保持するための、及び２種の成分を混合するためのシリンジ
RU2602305C1 (ru) * 2015-09-30 2016-11-20 Общество с ограниченной ответственностью "Санте Фарм" Гемостатическое средство
IL270759B2 (en) 2017-05-24 2025-01-01 Viktor Veniaminovich Tets Separated antibacterial preparations and their uses
US10953130B2 (en) 2017-08-31 2021-03-23 Victor Matthew Phillips Solid hemostatic composition and methods of making the same
WO2019215274A1 (en) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
WO2020227533A1 (en) * 2019-05-07 2020-11-12 The United States Government, As Represented By The Secretary Of The Army Plasma-alginate composite material having improved mechanical support for stem cell growth and delivery
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
JP7550390B2 (ja) * 2020-05-08 2024-09-13 国立大学法人 東京大学 止血用ポリマー材料キット
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
WO2025156055A1 (en) * 2024-01-25 2025-07-31 Kane Biotech Inc. System for dispensing spray gels for treatment of wounds and infections and methods of use thereof

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US550178A (en) * 1895-11-19 Fence
US3064313A (en) * 1960-06-14 1962-11-20 Hercules Powder Co Ltd Preparation of free acid cellulose ether films
US3328259A (en) * 1964-01-08 1967-06-27 Parachem Corp Dressing for a wound containing a hemostatic agent and method of treating a wound
US3387061A (en) * 1966-05-04 1968-06-04 Union Carbide Corp Chemical reaction product of polycarboxylic acid and a polymeric polyether
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4181718A (en) * 1975-12-29 1980-01-01 Mason Norbert S Polyanion-stabilized aluminum hydrogels
JPS5844711B2 (ja) * 1979-07-04 1983-10-05 日東電工株式会社 水溶性感圧接着剤組成物
US4768523A (en) * 1981-04-29 1988-09-06 Lifecore Biomedical, Inc. Hydrogel adhesive
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
SE8501022L (sv) * 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4616644A (en) * 1985-06-14 1986-10-14 Johnson & Johnson Products, Inc. Hemostatic adhesive bandage
US4610863A (en) * 1985-09-04 1986-09-09 The United States Of America As Represented By The United States Department Of Energy Process for forming transparent aerogel insulating arrays
IN166447B (de) * 1985-11-27 1990-05-12 Ethicon Inc
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US4684558A (en) * 1986-06-30 1987-08-04 Nepera Inc. Adhesive polyethylene oxide hydrogel sheet and its production
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US4983585A (en) * 1987-05-04 1991-01-08 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US5068225A (en) * 1987-05-04 1991-11-26 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US5156839A (en) * 1987-05-04 1992-10-20 Mdr Group, Inc. Viscoelastic fluid for use in spine and general surgery and other surgery and therapies and method of using same
US4853374A (en) * 1987-06-09 1989-08-01 M.D.R. Group, Inc. Viscoelastic vitreous substitute with UV blocker
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
FR2640995B1 (de) * 1988-12-23 1992-04-17 Avenir 2000 Ste Civile Rech
US5143071A (en) * 1989-03-30 1992-09-01 Nepera, Inc. Non-stringy adhesive hydrophilic gels
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
DE3931624A1 (de) * 1989-09-22 1991-04-04 Lechner Gmbh Verfahren zum herstellen eines behaelters mit innenbeutel
US5093319A (en) * 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
AU639069B2 (en) * 1989-10-31 1993-07-15 Columbia Laboratories, Inc. Tissue moisturizing composition and method
US5169037A (en) * 1990-01-26 1992-12-08 Ccl Industries Inc. Product bag for dispensing and method for producing the same
US5066709A (en) * 1990-09-20 1991-11-19 Gaf Chemicals Corporation Bioadhesive composition
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
US5192802A (en) * 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5266326A (en) * 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
DE69629010T2 (de) * 1995-01-16 2004-04-15 Baxter International Inc., Deerfield Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
US5621093A (en) * 1995-06-06 1997-04-15 Anika Research, Inc. Steam-sterilizing solid hyaluronic acid
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
AU1051597A (en) * 1995-11-09 1997-05-29 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
JPH09241973A (ja) * 1996-03-06 1997-09-16 Lion Corp スプレー用糊剤組成物
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
CA2219698C (en) * 1996-10-31 2007-09-04 Takeda Chemical Industries, Ltd. Sustained-release preparation
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) * 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
CA2295247C (en) * 1997-06-18 2009-05-26 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
CA2366880C (en) * 1999-04-02 2013-02-12 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US6566345B2 (en) * 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery

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