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AR049566A1 - Procedimiento para preparar diisopropil((1-(hidroximetil)-ciclopropil)oxi)metilfosfonato - Google Patents

Procedimiento para preparar diisopropil((1-(hidroximetil)-ciclopropil)oxi)metilfosfonato

Info

Publication number
AR049566A1
AR049566A1 ARP050102748A ARP050102748A AR049566A1 AR 049566 A1 AR049566 A1 AR 049566A1 AR P050102748 A ARP050102748 A AR P050102748A AR P050102748 A ARP050102748 A AR P050102748A AR 049566 A1 AR049566 A1 AR 049566A1
Authority
AR
Argentina
Prior art keywords
formula
compound
prepare
trityloxymethyl
preparing
Prior art date
Application number
ARP050102748A
Other languages
English (en)
Inventor
Suk Kyoon Yoon
Kun-Hye Nam
Sang-Who Lee
Won-Kyo Joung
Sang-Chul Choi
Ki-Kon Lee
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of AR049566A1 publication Critical patent/AR049566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

) La presente también se refiere a intermediarios y a un procedimiento para preparar el análogo de nucleosido antiviral a partir del compuesto de formula (1), preparado de acuerdo con la presente. Reivindicacion 1: Un procedimiento para preparar un compuesto de la formula (1), que comprende las etapas que consisten en hacer reaccionar un compuesto de la formula (2) con cloruro de tritilo para preparar el éster etílico del ácido tritiloxi-acético de la formula (3), hacer reaccionar el compuesto de formula (3) con haluro de etil magnesio para preparar 1-tritiloximetil-ciclopropanol de la formula (4), combinar el 1-tritiloximetil-ciclopropanol de formula (4) con fosfonato de diisopropilbromometilo en un solvente en presencia de una base para preparar el éster diisopropílico del ácido (1-tritiloximetil-ciclopropoximetil)-fosfonico de la formula (5) en forma de solido, y convertir el grupo tritilo del compuesto de formula (5) en un grupo hidroxilo.
ARP050102748A 2004-07-02 2005-07-01 Procedimiento para preparar diisopropil((1-(hidroximetil)-ciclopropil)oxi)metilfosfonato AR049566A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020040051558A KR101033290B1 (ko) 2004-07-02 2004-07-02 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법

Publications (1)

Publication Number Publication Date
AR049566A1 true AR049566A1 (es) 2006-08-16

Family

ID=36940541

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102748A AR049566A1 (es) 2004-07-02 2005-07-01 Procedimiento para preparar diisopropil((1-(hidroximetil)-ciclopropil)oxi)metilfosfonato

Country Status (15)

Country Link
US (2) US7795463B2 (es)
EP (1) EP1765838A4 (es)
JP (1) JP4422183B2 (es)
KR (1) KR101033290B1 (es)
CN (1) CN101061128B (es)
AR (1) AR049566A1 (es)
AU (1) AU2005260375B8 (es)
BR (1) BRPI0512886A (es)
CA (1) CA2571592C (es)
MX (1) MXPA06015262A (es)
NZ (1) NZ552246A (es)
RU (1) RU2326885C1 (es)
TW (1) TWI326685B (es)
WO (1) WO2006004330A1 (es)
ZA (1) ZA200610744B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008000070A1 (es) * 2007-01-17 2008-07-25 Lg Life Sciences Ltd Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
KR102694680B1 (ko) 2016-08-01 2024-08-14 삼성디스플레이 주식회사 전자 소자, 이의 실장 방법 및 이를 포함하는 표시 장치의 제조 방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN115181013B (zh) * 2022-07-22 2023-08-08 北京先通国际医药科技股份有限公司 修饰脂肪酸型pet试剂前体关键中间体的制备方法及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
CA2120743C (en) * 1991-10-11 2005-03-08 John C. Martin Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
RU2005108601A (ru) * 2002-09-26 2006-01-20 Эл Джи Лайф Сайенсиз Лтд. (Kr) (+)-транс-изомеры(1-фосфонометокси-2-алкилциклопропил)метилнуклеозидные производные, способ получения их стереоизомеров и применение указанных соединений в качестве противовирусных средств
WO2005079812A1 (en) * 2004-02-17 2005-09-01 Lg Life Sciences Ltd. Nucleoside phosphonate derivatives useful in the treatment of hiv infections

Also Published As

Publication number Publication date
US20100305364A1 (en) 2010-12-02
MXPA06015262A (es) 2007-03-21
BRPI0512886A (pt) 2008-04-15
JP2008505066A (ja) 2008-02-21
US7795463B2 (en) 2010-09-14
RU2007104036A (ru) 2008-08-10
CN101061128A (zh) 2007-10-24
NZ552246A (en) 2009-07-31
RU2326885C1 (ru) 2008-06-20
WO2006004330A1 (en) 2006-01-12
JP4422183B2 (ja) 2010-02-24
ZA200610744B (en) 2008-05-28
AU2005260375B2 (en) 2010-12-09
EP1765838A4 (en) 2009-05-27
US20090187019A1 (en) 2009-07-23
AU2005260375A1 (en) 2006-01-12
TW200606170A (en) 2006-02-16
EP1765838A1 (en) 2007-03-28
CA2571592A1 (en) 2006-01-12
TWI326685B (en) 2010-07-01
CN101061128B (zh) 2010-10-06
KR101033290B1 (ko) 2011-05-09
KR20060002501A (ko) 2006-01-09
CA2571592C (en) 2010-02-09
AU2005260375B8 (en) 2011-01-20

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