[go: up one dir, main page]

AR049276A1 - Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen - Google Patents

Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen

Info

Publication number
AR049276A1
AR049276A1 ARP050101970A ARP050101970A AR049276A1 AR 049276 A1 AR049276 A1 AR 049276A1 AR P050101970 A ARP050101970 A AR P050101970A AR P050101970 A ARP050101970 A AR P050101970A AR 049276 A1 AR049276 A1 AR 049276A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
compounds
opiood
carboxamid
Prior art date
Application number
ARP050101970A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35064532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR049276(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR049276A1 publication Critical patent/AR049276A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente está dirigida a los compuestos carboxamidos opioides farmacéuticamente utiles como agentes para el tratamiento o la regulacion de un desorden en el sistema nervioso central. Reivindicacion 1: Una composicion que contiene un compuesto de la formula (1) donde: R1 y R2 se seleccionan independientemente del grupo que consta de H, alquilo inferior, y alquildiilo donde R1 y R2 se toman junto con los átomos a los cuales están ligados para formar un anillo monocíclico. R3 y R4; se seleccionan inependientemente el grupo que consta de H, alquilo inferior, y alquildiilo donde R3 y R4 se toman junto con los átomos a los cuales están ligados para formar un anillo monocíclico. Y es un sustituyente seleccionado del grupo que consta de alquilo inferior, alcoxi inferior, halogeno y trifluorometilo; y los enantiomeros, diasestereoisomeros, tautomeros, solvatos farmacéuticamente aceptables y sales de los mismos.
ARP050101970A 2004-05-14 2005-05-13 Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen AR049276A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57129804P 2004-05-14 2004-05-14

Publications (1)

Publication Number Publication Date
AR049276A1 true AR049276A1 (es) 2006-07-12

Family

ID=35064532

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101970A AR049276A1 (es) 2004-05-14 2005-05-13 Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen

Country Status (21)

Country Link
US (2) US7244866B2 (es)
EP (1) EP1748978B1 (es)
JP (1) JP5420170B2 (es)
KR (1) KR101204751B1 (es)
CN (1) CN1984879B (es)
AR (1) AR049276A1 (es)
AU (1) AU2005245403B2 (es)
BR (1) BRPI0511137A (es)
CA (1) CA2566601C (es)
CR (1) CR8811A (es)
EA (1) EA013261B1 (es)
EC (1) ECSP067008A (es)
ES (1) ES2485867T3 (es)
IL (1) IL179196A (es)
MX (1) MXPA06013270A (es)
NO (1) NO20065768L (es)
NZ (1) NZ551288A (es)
TW (1) TWI418345B (es)
UA (1) UA90432C2 (es)
WO (1) WO2005113486A1 (es)
ZA (1) ZA200610446B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566601C (en) * 2004-05-14 2013-04-09 Janssen Pharmaceutica N.V. Carboxamido opioid compounds
US20060254029A1 (en) * 2005-05-11 2006-11-16 Conrad Swenson Pocket loss prevention device
RU2470011C2 (ru) * 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
EP2408303A4 (en) * 2009-03-19 2012-07-25 Alkermes Inc MORPHINANE DERIVATIVES HAVING HIGH ORAL BIOLOGICAL AVAILABILITY
LT2506712T (lt) * 2009-12-04 2019-06-25 Alkermes Pharma Ireland Limited Morfinano dariniai, skirti narkotinių medžiagų perdozavimo gydymui
EP3446565B1 (en) 2010-08-23 2023-11-01 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EA030609B8 (ru) 2011-12-15 2018-10-31 Алкермес Фарма Айэленд Лимитед Композиции бупренорфина и антагонистов мю-опиоидных рецепторов
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9133125B2 (en) 2013-05-24 2015-09-15 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
WO2014190271A2 (en) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limted Methods for treating depressive symptoms
CN104940709A (zh) * 2015-07-22 2015-09-30 张秋英 一种镇痛麻醉喷雾剂
CN105055756A (zh) * 2015-09-18 2015-11-18 张秋英 一种阴部挫伤用镇痛气雾剂
KR102603671B1 (ko) 2017-01-17 2023-11-17 메비아스 디스커버리 인코포레이티드 치환된 3-디알킬아미노메틸-피페리딘-4-일-벤즈아미드 및 이를 제조 및 사용하는 방법
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503517A (ja) * 1989-12-18 1993-06-10 バージニア・コモンウェルス・ユニバーシティ シグマレセプターリガンド及びその用途
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
EP1353909B1 (en) * 2000-10-31 2005-04-06 Rensselaer Polytechnic Institute 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioidreceptor binding agents
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
WO2003048113A1 (en) * 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
DE10213051B4 (de) 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
CA2503155A1 (en) * 2002-10-25 2004-05-06 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
CN102786476B (zh) 2004-03-15 2017-01-18 詹森药业有限公司 作为阿片受体调节剂的化合物
CA2566601C (en) * 2004-05-14 2013-04-09 Janssen Pharmaceutica N.V. Carboxamido opioid compounds

Also Published As

Publication number Publication date
US7745492B2 (en) 2010-06-29
EA200602115A1 (ru) 2007-04-27
CA2566601C (en) 2013-04-09
JP2007537278A (ja) 2007-12-20
CN1984879B (zh) 2011-07-27
KR20070015613A (ko) 2007-02-05
KR101204751B1 (ko) 2012-11-27
EP1748978B1 (en) 2014-06-04
ZA200610446B (en) 2008-07-30
IL179196A (en) 2012-10-31
EA013261B1 (ru) 2010-04-30
TW200605871A (en) 2006-02-16
CR8811A (es) 2009-01-14
US20080280990A1 (en) 2008-11-13
HK1101246A1 (en) 2007-10-12
CN1984879A (zh) 2007-06-20
NZ551288A (en) 2010-10-29
BRPI0511137A (pt) 2007-11-27
MXPA06013270A (es) 2007-04-23
NO20065768L (no) 2007-02-07
IL179196A0 (en) 2007-03-08
AU2005245403B2 (en) 2012-04-19
ES2485867T3 (es) 2014-08-14
JP5420170B2 (ja) 2014-02-19
CA2566601A1 (en) 2005-12-01
AU2005245403A1 (en) 2005-12-01
ECSP067008A (es) 2006-12-29
UA90432C2 (uk) 2010-04-26
EP1748978A1 (en) 2007-02-07
US7244866B2 (en) 2007-07-17
WO2005113486A1 (en) 2005-12-01
TWI418345B (zh) 2013-12-11
US20050256203A1 (en) 2005-11-17

Similar Documents

Publication Publication Date Title
AR049276A1 (es) Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen
TW200720266A (en) Benzodioxane and benzodioxolan derivatives and uses thereof
TW200716595A (en) Chromane and chromene derivatives and uses thereof
AR047538A1 (es) Piridazinonas como antagonistas de las integrinas alfa4
AR049138A1 (es) Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
PE20060531A1 (es) Derivados de piridazin-3-(2h)-ona como inhibidores de la fosfodiesterasa 4
TW200719886A (en) Dihydrobenzofuran derivatives and uses thereof
AR063602A1 (es) Derivados de espiroindolinona, formulaciones farmaceuticas que los contienen y su uso en la obtencion de un medicamento para el tratamiento de trastornos oncologicos.
AR062209A1 (es) Pirazolopirimidinas moduladoras de receptores de glutamato metabotropicos mglur5, proceso para su preparacion, medicamentos que las contienen y usos en la prevencion y/o tratamiento de trastornos neurologicos agudos y cronicos.
AR059249A1 (es) Compuesto amina trisustituido
AR065280A1 (es) Agentes antiparasitarios
CO5700824A2 (es) Nuevos compuestos heterociclicos utiles para el tratamiento de desordenes inflamatorios y alergicos: proceso para su preparacion y composiciones farmaceuticas que los contienen
AR066111A1 (es) Compuesto triciclico de imidazol, su uso para preparar un medicamento, composicion farmaceutica que lo comprende y compuestos intermediarios en la sintesis de dicho compuesto
AR062965A1 (es) Compuestos moduladores de receptores de glutamatometabotropicos mglur5, composiciones farmaceuticas que los contienen y usos terapeuticos en trastornos gastrointestinales, neurologicos y psiquiatricos agudos y cronicos
AR040278A1 (es) Ligandos del receptor de glucocorticoides para el tratamiento de trastornos metabolicos
AR033379A1 (es) Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
MX2010000658A (es) Derivados de pirimidina 934.
ES2496592T3 (es) Proceso para la preparación de Imatinib y compuestos intermedios del mismo
AR043485A1 (es) Derivados del 8'-piridinil-dihidrospiro-[cicloalquil]-pirimido[1,2a]pirimidin-6-ona y 8´-pirimidinil-dihidrospiro-[cicloalquil]-pirimido[1,2a]pirimidin-6-ona substituidos
AR055303A1 (es) Derivados de triazol sustituidos como antagonistas de oxitocina, composicion farmaceutica y uso del compuesto para preparar un medicamento
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
AR053554A1 (es) Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos
AR063577A1 (es) Derivados 8- piperidinil - pirimido [1 2 a] pirimidin -6-ona y 8- piperidinil-2- pirimidinil- pirimido [1,2-a] pirimidin -6- ona sustituidos
AR061111A1 (es) Derivados de isoindol utiles para tratar dolor,trastornos gastrointestinales y cancer
PE20090295A1 (es) Derivados de espirociclopropilpiperidina

Legal Events

Date Code Title Description
FA Abandonment or withdrawal