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AR046860A1 - Biaril sulfonamidas con capacidad moduladora de actividad de metaloproteasa. - Google Patents

Biaril sulfonamidas con capacidad moduladora de actividad de metaloproteasa.

Info

Publication number
AR046860A1
AR046860A1 ARP040104462A ARP040104462A AR046860A1 AR 046860 A1 AR046860 A1 AR 046860A1 AR P040104462 A ARP040104462 A AR P040104462A AR P040104462 A ARP040104462 A AR P040104462A AR 046860 A1 AR046860 A1 AR 046860A1
Authority
AR
Argentina
Prior art keywords
biaril
sulfonamids
metaloprotease
activity modulating
halogen
Prior art date
Application number
ARP040104462A
Other languages
English (en)
Inventor
Jason Shaoyun Xiang
Steve Yik-Kai Tam
Yonghan Hu
Phaik-Eng Sum
David Brain How
Darrin William Hopper
Joshua James Sabatini
Thomas Saltmarsh Rush Iii
Elisabeth Ann Morris
Katy Evangelia Georgiadis
Matthew Douglas Vera
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR046860A1 publication Critical patent/AR046860A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Estos compuestos presentan actividad como inhibidores de metaloproteinasas. Reivindicación 1: Compuesto de fórmula (1), caracterizado porque: R1 es H o alquilo C1-6; R2 es H, alquilo C1-6, (CH2)nR'2, fenilo o bencilo; n es 0-6; R'2 es arilo, heteroarilo, cicloalquilo, o heterocicloalquilo; R3 es, independientemente en cada una de las ocurrencias, H, halógeno, OC(halógeno)3, C(halógeno)3, alcoxi, o alquilo C1-6; X se escoge entre CH2O, OCH2, C(R3)=C(R3), C(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O), y CH2S(O)2; y Z es al menos un grupo arilo o heteroarilo.
ARP040104462A 2003-12-04 2004-12-01 Biaril sulfonamidas con capacidad moduladora de actividad de metaloproteasa. AR046860A1 (es)

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