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NO20062645L - Fremgangsmate for behandling av adamts-5-assosiert sykdom - Google Patents

Fremgangsmate for behandling av adamts-5-assosiert sykdom

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Publication number
NO20062645L
NO20062645L NO20062645A NO20062645A NO20062645L NO 20062645 L NO20062645 L NO 20062645L NO 20062645 A NO20062645 A NO 20062645A NO 20062645 A NO20062645 A NO 20062645A NO 20062645 L NO20062645 L NO 20062645L
Authority
NO
Norway
Prior art keywords
adamts
animals
osteoarthritis
activity
treating
Prior art date
Application number
NO20062645A
Other languages
English (en)
Inventor
Elisabeth A Morris
Sonya S Glasson
Jason Shaoyun Xiang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20062645L publication Critical patent/NO20062645L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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Abstract

Foreliggende oppfinnelse angår metoder for behandling av ADAMTS-5-assosierte sykdommer og spesielt osteoartritt omfattende administrering av et middel som er i stand til a modulere ADMATS-5-aktivitet hos et individ rammet av sykdommen. Midlet er fortrinnsvis en biarylsulfonamidforbindelse. Oppfinnelsen er basert, til dels, på oppdagelsen at transgene dyr som ikke uttrykker funksjonell ADAMTS-5 viser en reduksjon i graden av osteoartritt etter fremkalling av osteoartritt sammenlignet med WT-dyr. Videre har ADAMTS-5 transgene dyr redusert aggrekanase-aktivitet i artikulært vev sammenlignet med WT-dyr. Disse dyr er gode modeller for ADAMTS-5-assosierte sykdommer og for screening av medikamenter anvendelige for behandling og/eller forebygging av disse sykdommer. Det er ingen andre dyremodeller hvor delesjon av aktiviteten til et enkelt gen kan avbryte forløpet av osteoartritt. Følgelig viser disse dyr også at osteoartritt kan forhindres og/eller behandles ved administrering til et individ av et ADAMTS-5-hemmende middel og spesielt et middel som er i stand til a hemme aggrekanase-aktiviteten til ADAMTS-5.
NO20062645A 2003-12-04 2006-06-08 Fremgangsmate for behandling av adamts-5-assosiert sykdom NO20062645L (no)

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