AR044246A1 - Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas - Google Patents
Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicasInfo
- Publication number
- AR044246A1 AR044246A1 ARP040101521A ARP040101521A AR044246A1 AR 044246 A1 AR044246 A1 AR 044246A1 AR P040101521 A ARP040101521 A AR P040101521A AR P040101521 A ARP040101521 A AR P040101521A AR 044246 A1 AR044246 A1 AR 044246A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- vectors
- cells
- immunoprotector
- transgenic plants
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 241000711404 Avian avulavirus 1 Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108700001094 Plant Genes Proteins 0.000 abstract 1
- 230000002480 immunoprotective effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a la producción de vectores y métodos útiles para la preparación de células de plantas genéticamente transformadas que expresan inmunógenos de organismos patógenos los cuales son utilizados para producir partículas inmunoprotectoras útiles en la preparación de vacunas, incluye genes vegetales optimizados que codifican la proteína HN del virus de la enfermedad de Newcastle, también se refiere a métodos de producción de un antígeno en una planta transgénica. Reivindicación 1: Una secuencia nucleotídica optimizada vegetal aislada que codifica el antígeno HN del virus de la enfermedad de Newcastle que comprende la secuencia de SEQ ID Nº:1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46799803P | 2003-05-05 | 2003-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044246A1 true AR044246A1 (es) | 2005-09-07 |
Family
ID=33435152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101521A AR044246A1 (es) | 2003-05-05 | 2004-05-05 | Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7132291B2 (es) |
| EP (1) | EP1620550B1 (es) |
| KR (1) | KR20060035596A (es) |
| CN (1) | CN100393870C (es) |
| AR (1) | AR044246A1 (es) |
| AT (1) | ATE473271T1 (es) |
| AU (1) | AU2004235813B2 (es) |
| BR (1) | BRPI0410340A (es) |
| CA (1) | CA2524293A1 (es) |
| DE (1) | DE602004028004D1 (es) |
| NZ (1) | NZ543348A (es) |
| WO (1) | WO2004098533A2 (es) |
| ZA (1) | ZA200508930B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2526720C (en) | 2003-05-22 | 2013-10-22 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| CN1326998C (zh) * | 2004-11-25 | 2007-07-18 | 中国农业科学院哈尔滨兽医研究所 | 编码h5亚型禽流感病毒血凝素蛋白的基因及其应用 |
| CN101378781B (zh) | 2005-08-03 | 2013-08-07 | 美国弗劳恩霍夫股份有限公司 | 制造免疫球蛋白的组合物和方法 |
| AU2006312126A1 (en) | 2005-11-04 | 2007-05-18 | Dow Agrosciences Llc | Preparation of vaccine master cell lines using recombinant plant suspension cultures |
| EP1984405A4 (en) * | 2006-02-13 | 2010-06-30 | Fraunhofer Usa Inc | INFLUENZA ANTIGENES, VACCINE COMPOSITIONS AND RELATED METHODS |
| CA2642056A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
| US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| EP2010210A4 (en) * | 2006-04-21 | 2010-07-21 | Dow Agrosciences Llc | VACCINE AGAINST BIRD FLUID AND METHOD OF APPLICATION THEREFOR |
| KR100766775B1 (ko) * | 2006-04-24 | 2007-11-01 | 대한민국 | 장출혈성대장균(ehec) 감염증 예방용 톡소이드 백신 |
| CN100487119C (zh) * | 2006-05-09 | 2009-05-13 | 中国农业科学院哈尔滨兽医研究所 | 表达禽流感病毒H5亚型HA蛋白的重组新城疫LaSota弱毒疫苗株 |
| AU2007261196A1 (en) * | 2006-06-16 | 2007-12-27 | Dow Agrosciences Llc | Novel dna sequences, vectors and proteins of avian influenza hemagglutinin |
| US20080241188A1 (en) * | 2007-03-30 | 2008-10-02 | Zeon Corporation | Turkey herpesvirus vectored recombinant containing avian influenza genes |
| BRPI0810865A2 (pt) * | 2007-04-28 | 2017-05-09 | Fraunhofer Usa Inc | antígenos de tripanossoma, composições vacinais, e métodos relacionados |
| RU2499053C2 (ru) * | 2007-06-15 | 2013-11-20 | Медикаго Инк. | Способ синтеза белка с модифицированным профилем n-гликозилирования в растениях |
| KR100964462B1 (ko) * | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
| CA2692933C (en) * | 2007-07-11 | 2016-10-18 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| US20110059130A1 (en) * | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
| CN101978066A (zh) * | 2007-11-27 | 2011-02-16 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| KR101956910B1 (ko) * | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs) |
| CN102089432A (zh) * | 2008-07-08 | 2011-06-08 | 麦迪卡格公司 | 可溶性重组流感抗原 |
| ES2593277T3 (es) | 2008-07-18 | 2016-12-07 | Medicago Inc. | Nuevo epítopo de inmunización contra el virus de la influenza |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US9233148B2 (en) * | 2009-01-09 | 2016-01-12 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| BRPI1015053A2 (pt) * | 2009-06-24 | 2019-07-09 | Medicago Inc | partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina |
| TR201803560T4 (tr) | 2009-09-22 | 2019-01-21 | Medicago Inc | Bitkiden türetilen proteinlerin hazırlanma metotları. |
| EP2483307A1 (en) | 2009-09-29 | 2012-08-08 | Fraunhofer USA, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| US10633667B2 (en) | 2009-12-28 | 2020-04-28 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant NDV antigen and uses thereof |
| US9012197B2 (en) | 2009-12-28 | 2015-04-21 | Merial, Inc. | Production of hemagglutinin-neuraminidase protein in microalgae |
| KR20120132506A (ko) | 2010-02-18 | 2012-12-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 질환의 예방 및 치료에 사용되는 백신 |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| KR20130122947A (ko) | 2010-10-27 | 2013-11-11 | 필립모리스 프로덕츠 에스.에이. | 팽창성 베드 크로마토그래피를 사용하여 식물로부터 바이러스 유사 입자를 포획하는 방법 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| CN108164602A (zh) | 2011-09-20 | 2018-06-15 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| CA2850407C (en) * | 2011-09-30 | 2021-11-23 | Medicago Inc. | Increasing virus-like particle yield in plants |
| CN108641002A (zh) | 2012-12-18 | 2018-10-12 | 西奈山伊坎医学院 | 流感病毒疫苗及其用途 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| WO2014153674A1 (en) | 2013-03-28 | 2014-10-02 | Medicago Inc. | Influenza virus-like particle production in plants |
| US11441150B2 (en) | 2014-01-10 | 2022-09-13 | Medicago Inc. | CPMV enhancer elements |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP4392565A4 (en) * | 2021-08-24 | 2025-02-12 | Futuragene Israel Ltd. | SEQUENCES AND PROMOTERS FOR USE IN PLANT CELLS AND METHODS FOR THE PRODUCTION AND USE OF SUCH SEQUENCES |
| WO2023237726A1 (en) * | 2022-06-10 | 2023-12-14 | Pantarhei Oncology B.V. | An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339307C (en) * | 1988-09-06 | 1997-08-19 | Roy Curtiss, Iii | Oral immunization by transgenic plants |
| US20010053367A1 (en) * | 1991-08-26 | 2001-12-20 | Prodigene, Inc. | Vaccines expressed in plants |
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
| US5426108A (en) * | 1993-11-10 | 1995-06-20 | American Cyanamid Company | Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2 |
| AU691707B2 (en) * | 1994-10-24 | 1998-05-21 | The Administrators Of The Tulane Eductional Fund | Oral immunization with transgenic plants |
| EP0770397B1 (en) * | 1995-10-18 | 2004-04-21 | Akzo Nobel N.V. | Newcastle disease virus combination vaccine |
| US6395964B1 (en) * | 1995-10-24 | 2002-05-28 | The Texas A&M University System | Oral immunization with transgenic plants |
| EP0974660A1 (en) * | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| WO2002000169A2 (en) * | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agriculture | Production of vaccines using transgenic plants |
| JP4500493B2 (ja) | 2001-04-13 | 2010-07-14 | ボイス トンプソン インステイテュート フォア プラント リサーチ | 安定なトランスジェニック植物医薬品の作製方法および組成物ならびに避妊薬としてのその使用 |
-
2004
- 2004-05-04 AU AU2004235813A patent/AU2004235813B2/en not_active Ceased
- 2004-05-04 ZA ZA200508930A patent/ZA200508930B/en unknown
- 2004-05-04 BR BRPI0410340-8A patent/BRPI0410340A/pt not_active IP Right Cessation
- 2004-05-04 NZ NZ543348A patent/NZ543348A/en not_active Application Discontinuation
- 2004-05-04 WO PCT/US2004/014182 patent/WO2004098533A2/en not_active Ceased
- 2004-05-04 CN CNB2004800120987A patent/CN100393870C/zh not_active Expired - Fee Related
- 2004-05-04 US US10/838,834 patent/US7132291B2/en not_active Expired - Fee Related
- 2004-05-04 AT AT04751538T patent/ATE473271T1/de not_active IP Right Cessation
- 2004-05-04 KR KR1020057020819A patent/KR20060035596A/ko not_active Ceased
- 2004-05-04 CA CA002524293A patent/CA2524293A1/en not_active Abandoned
- 2004-05-04 DE DE602004028004T patent/DE602004028004D1/de not_active Expired - Lifetime
- 2004-05-04 EP EP04751538A patent/EP1620550B1/en not_active Expired - Lifetime
- 2004-05-05 AR ARP040101521A patent/AR044246A1/es unknown
-
2006
- 2006-06-08 US US11/450,102 patent/US7407802B2/en not_active Expired - Fee Related
-
2008
- 2008-04-30 US US12/150,900 patent/US20090017065A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN100393870C (zh) | 2008-06-11 |
| AU2004235813B2 (en) | 2010-07-29 |
| EP1620550B1 (en) | 2010-07-07 |
| US7132291B2 (en) | 2006-11-07 |
| ATE473271T1 (de) | 2010-07-15 |
| WO2004098533A2 (en) | 2004-11-18 |
| NZ543348A (en) | 2008-08-29 |
| CA2524293A1 (en) | 2004-11-18 |
| EP1620550A4 (en) | 2006-06-14 |
| US7407802B2 (en) | 2008-08-05 |
| US20090017065A1 (en) | 2009-01-15 |
| AU2004235813A1 (en) | 2004-11-18 |
| DE602004028004D1 (de) | 2010-08-19 |
| WO2004098533A3 (en) | 2005-08-04 |
| BRPI0410340A (pt) | 2006-05-30 |
| ZA200508930B (en) | 2007-03-28 |
| US20080076177A1 (en) | 2008-03-27 |
| CN1788077A (zh) | 2006-06-14 |
| US20050048074A1 (en) | 2005-03-03 |
| KR20060035596A (ko) | 2006-04-26 |
| EP1620550A2 (en) | 2006-02-01 |
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