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AR044169A1 - Uso de derivados del acido fenoxiacetico para el tratamiento de la vejiga hiperactiva - Google Patents

Uso de derivados del acido fenoxiacetico para el tratamiento de la vejiga hiperactiva

Info

Publication number
AR044169A1
AR044169A1 ARP040101519A ARP040101519A AR044169A1 AR 044169 A1 AR044169 A1 AR 044169A1 AR P040101519 A ARP040101519 A AR P040101519A AR P040101519 A ARP040101519 A AR P040101519A AR 044169 A1 AR044169 A1 AR 044169A1
Authority
AR
Argentina
Prior art keywords
group
amino
atom
alkyl
hydroxy
Prior art date
Application number
ARP040101519A
Other languages
English (en)
Inventor
Yoshinobu Yamazaki
Masami Kojima
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR044169(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10320084A external-priority patent/DE10320084A1/de
Priority claimed from DE2003123837 external-priority patent/DE10323837A1/de
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of AR044169A1 publication Critical patent/AR044169A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Campo de indicación para los derivados del ácido fenoxiacético descritos en la Solicitud de Patente Europea EP 1095932. los compuestos en ella descritos son adecuados para la preparación de un medicamento para tratar la vejiga hiperactiva (vejiga sobreactiva). En consecuencia, por medio de estas substancias activas se dispone de un método de tratamiento en este síndrome urológico. Formulación farmacéutica. Reivindicación 1: Uso de un compuesto de fórmula general (1) para preparar un medicamento para el tratamiento de la vejiga hiperactiva: donde X es un átomo de carbono quiral R o S; Y es un átomo de carbono quiral R o S; R1 es un grupo hidroxi, un grupo alcoxi C1-6, un grupo aril-alcoxi C1-6, un grupo amino primario o un grupo mono- o di(alquil C1-6)amino; uno de los grupos R2 y R3 es un átomo de H y el otro grupo es un átomo de H, un átomo de halógeno, un grupo alquilo C1-6, un grupo trifluorometilo o un grupo alcoxi C1-6, y R4 es un átomo de halógeno, un grupo alquilo C1-6, un grupo haloalquilo C1-6, un grupo hidroxi, un grupo alcoxi C1-6, un grupo aril-alcoxi C1-6, un grupo ciano, un grupo nitro, un grupo amino, un grupo mono- o di(alquil C1-6)amino, un grupo carbamoílo o un grupo mono- o di(alquil C1-6)carbamoílo, o corresponde al grupo -NHCOR5, donde R5 es un átomo de H o un grupo alquilo C1-6; o una sal del mismo farmacéuticamente aceptable. Reivindicación 8: Uso según la reivindicación 1, caracterizado porque el compuesto es 2-[4-(2-{[(1S, 2R)-2-hidroxi-2-(4-hidroxifenil)-1-metiletil]amino}etil)-2,5-dimetilfenoxi] acetato de (-)-etilo, clorhidrato de 2-[4-(2-{[(1S, 2R)-2-hidroxi-2-(4-hidroxifenil)-1-metiletil]-amino}etil)-2,5-dimetilfenoxi]acetato de (-)-etilo o ácido (-)-2-[4-(2-{[(1S, 2R)-2-hidroxi-2-(4-hidroxifenil)-1-metiletil]amino}etil)-2,5-dimetilfenoxi]acético.
ARP040101519A 2003-05-05 2004-05-05 Uso de derivados del acido fenoxiacetico para el tratamiento de la vejiga hiperactiva AR044169A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10320084A DE10320084A1 (de) 2003-05-05 2003-05-05 Verwendung von Phenoxyessigsäurederivaten zur Behandlung der hyperaktiven Blase
DE2003123837 DE10323837A1 (de) 2003-05-23 2003-05-23 Verwendung von Phenoxyessigsäurederivaten zur Behandlung der hyperaktiven Blase

Publications (1)

Publication Number Publication Date
AR044169A1 true AR044169A1 (es) 2005-08-24

Family

ID=33420009

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101519A AR044169A1 (es) 2003-05-05 2004-05-05 Uso de derivados del acido fenoxiacetico para el tratamiento de la vejiga hiperactiva

Country Status (26)

Country Link
US (1) US20040229947A1 (es)
EP (1) EP1620085B1 (es)
JP (1) JP4602969B2 (es)
KR (1) KR101052804B1 (es)
AR (1) AR044169A1 (es)
AT (1) ATE401878T1 (es)
AU (1) AU2004236596B2 (es)
BR (1) BRPI0409980A (es)
CA (1) CA2524023C (es)
CL (1) CL2004000952A1 (es)
CY (1) CY1108425T1 (es)
DE (1) DE602004015272D1 (es)
DK (1) DK1620085T3 (es)
ES (1) ES2309513T3 (es)
IL (1) IL171713A (es)
MX (1) MXPA05011862A (es)
MY (1) MY141756A (es)
NZ (1) NZ543347A (es)
PE (1) PE20050524A1 (es)
PL (1) PL1620085T3 (es)
PT (1) PT1620085E (es)
RU (1) RU2342133C2 (es)
SI (1) SI1620085T1 (es)
TW (1) TWI351279B (es)
UY (1) UY28306A1 (es)
WO (1) WO2004098586A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI356699B (en) * 2004-11-10 2012-01-21 Kissei Pharmaceutical Agent for treating interstitial cystitis and agent
EP1878719A4 (en) * 2005-04-26 2010-10-06 Kissei Pharmaceutical HYDROXYNOREPHEDRINE DERIVATIVE HYDROCHLORIDE POLYMORPH CRYSTAL
JPWO2006118087A1 (ja) * 2005-04-26 2008-12-18 キッセイ薬品工業株式会社 ヒドロキシノルエフェドリン誘導体塩酸塩・１／４水和物の結晶
EP1769792A1 (de) * 2005-09-30 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co.KG Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden
CN110869022A (zh) 2017-06-06 2020-03-06 乌洛万特科学有限公司 使用维贝隆以治疗膀胱过度活动症

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US6720014B1 (en) * 1997-08-13 2004-04-13 Diversa Corporation Phytase-containing foodstuffs and methods of making and using them
MY126489A (en) * 1998-07-08 2006-10-31 Kissei Pharmaceutical Phenoxyacetic acid derivatives and medicinal compositions containing the same
DE60041110D1 (de) * 1999-11-01 2009-01-29 Sumitomo Chemical Co 6-Hydroxy-5,6-dihydrouracile als Herbizide
EA006022B1 (ru) * 2001-09-13 2005-08-25 Киссеи Фармасьютикал Ко., Лтд. Кристаллы производных гидроксинорэфедрина

Also Published As

Publication number Publication date
AU2004236596A1 (en) 2004-11-18
AU2004236596B2 (en) 2010-03-11
EP1620085A1 (en) 2006-02-01
TWI351279B (en) 2011-11-01
DE602004015272D1 (de) 2008-09-04
KR101052804B1 (ko) 2011-07-29
PT1620085E (pt) 2008-08-07
CA2524023C (en) 2011-11-22
IL171713A (en) 2011-12-29
MXPA05011862A (es) 2006-02-17
MY141756A (en) 2010-06-30
TW200509902A (en) 2005-03-16
JP4602969B2 (ja) 2010-12-22
PE20050524A1 (es) 2005-07-07
CL2004000952A1 (es) 2005-03-04
NZ543347A (en) 2008-05-30
SI1620085T1 (sl) 2008-12-31
JP2006525318A (ja) 2006-11-09
ATE401878T1 (de) 2008-08-15
CA2524023A1 (en) 2004-11-18
RU2342133C2 (ru) 2008-12-27
PL1620085T3 (pl) 2009-01-30
DK1620085T3 (da) 2008-11-24
UY28306A1 (es) 2004-12-31
US20040229947A1 (en) 2004-11-18
BRPI0409980A (pt) 2006-05-09
KR20060009886A (ko) 2006-02-01
CY1108425T1 (el) 2014-04-09
RU2005137701A (ru) 2006-06-10
ES2309513T3 (es) 2008-12-16
WO2004098586A1 (en) 2004-11-18
EP1620085B1 (en) 2008-07-23

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