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AR044138A1 - Derivados plaguicidas de benzodioxol y benzodioxolano sustituidos con (dihalopropenilo) fenilalquilo - Google Patents

Derivados plaguicidas de benzodioxol y benzodioxolano sustituidos con (dihalopropenilo) fenilalquilo

Info

Publication number
AR044138A1
AR044138A1 ARP040101474A ARP040101474A AR044138A1 AR 044138 A1 AR044138 A1 AR 044138A1 AR P040101474 A ARP040101474 A AR P040101474A AR P040101474 A ARP040101474 A AR P040101474A AR 044138 A1 AR044138 A1 AR 044138A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
halo
alkoxy
independently selected
Prior art date
Application number
ARP040101474A
Other languages
English (en)
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of AR044138A1 publication Critical patent/AR044138A1/es

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A01N43/30Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/32Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/601,4-Diazines; Hydrogenated 1,4-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Fertilizers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuesto insecticidas, aplicación de las composiciones que los incluyen en el área donde los insectos se encuentran presentes o donde se presumen que podrían hacerse presente. Reivindicación 1: UN compuesto de la fórmula (1) en la que R y R3 son seleccionados independientemente del H, halógeno, hidroxi,(C1-3)alquilo, (C3-6)cicloalquilo, (C2-5)alquenilo, (C2-5)alquinilo, halo(C1-3)alquilo, (C1-3)alcoxi, halo(C1-3)alcoxi, (C1-3)alquiltio, Halo(C1-3)alquiltio, (C1-3)alquilsulfonilo, halo(C1-3)alquilsulfonilo, ciano, nitro, opcionalmente amino sustituido, en el que el sustituyente opcional se selecciona de (C1-4)alquilo, (C1-3)alquilcarbonilo y (C1-3)alcoxicarbonilo; opcionalmente imidazolilo sustituido, opcionalmente imidazolinilo sustituido, opcionalmente oxazolinilo sustituido, opcionalmente oxazolilo sustituido, opcionalmente oxadiazolilo sustituido, opcionalmente tiazolilo sustituido, opcionalmente pirazolilo sustituido, opcionalmente triazolilo sustituido, opcionalmente furanilo sustituido, opcionalmente tetrahidrofuranilo sustituido, opcionalmente dioxolanilo sustituido, opcionalmente dioxanilo sustituido, -C(=J)-K, y -C(R12)-Q-R13, en la que el sustituyente opcional se selecciona de (C1-4)alquilo, halo(C1-4) alquilo, (C1-4)alcoxi, (C1-4)alcoxi(C1-4)alquilo, (C3-6)cicloalquilo, (C2-5)alquenilo, (C2-5)alquinilo, ciano, nitro y arilo; en la que J se selecciona de O, S, NR14, y NOR14, cuando R14 es H, (C1-4)alquilo, halo(C1-4)alquilo, arilo y arilo(C1-4)alquilo; K se selecciona del H, (C1-3)alquilo, halo(C1-3)alquilo, (C1-3)alcoxi, (C1-3)alquilamino y di(C1-3)alquilamino; Q se selecciona de O, S y NR14, en la que R14 se encuentra según se describió anteriormente; R12 y R13 son independientemente seleccionados del H, (C1-4)alquilo y halo(C1-4)alquilo, y R12 y R13 pueden tomarse conjuntamente con T(CHR14)m-, en la que m es un entero de 2 a 4; T es seleccionado de O, S, y NR14, en el que R14 se encuentra como previamente se describió; R1 y R2 son independientemente seleccionados del H, halógeno y (C1-3)alquilo; R4 es H; R5 y R6 son independientemente seleccionado del halógeno; E es seleccionado del CH2, O, S y NR15 en el que R15 se selecciona del H, (C1-3)alquilo, (C1-3)alcoxi(C1-3)alquilo, arilo(C1-3)alquilo, (C2-4)alquenilo(C1-3)alquilo, halo(C2-4)alquenilo(C1-3)alquilo, di(C1-3)alquilfosfonato, formilo, (C1-3)alquilcarbonilo, halo(C1-3)alquilcarbonilo, (C1-3)alcoxi(C1-3)alquilcarbonilo, arilcarbonilo y (C1-3)alquilsulfonilo; G se selecciona de O, S, CH2O* y (CH2)n en el que el asterisco denota unión con E, y n es un entero seleccionado de 1, 2 y 3, siempre que E y G no sean simultáneamente O o S, x es un entero seleccionado de 0 o 1; y cuando x es 1, A es seleccionado de O, S(O)p y -NR15, en la que p es un entero seleccionado de 0,1 y 2, y R15 se encuentra de la forma anteriormente descripta; B es un grupo de refuerzo, *-(CR16R17)q-(CR18R19)r-(CR20R21)s-Lt-(CR22R23)u-(CR24R25)v-(CR26R27)w-, en la que el asterisco denota unión en A; q, r, s, u, v y w son enteros independientemente seleccionados de 0, 1 y 2; y cuyo q, r, s, u v o w son 1 o 2, R16 y hasta R27, inclusive, son independientemente seleccionados del H, (C1-3)alquilo, halo(C1-3)alquilo, (C1-3)alcoxi(C1-3)alquilo, y (C3-6)cicloalquilo; t es un entero seleccionado de 0, o 1; y cuyo t es 1, L se selecciona de CH=CH; O, S(O)p, OS(O)2, S(O)2O, NR28; N(óxido)R28; NR28SO2, NR28C(=O)NR29; Si(CH3)2, C(=O), OC(=O), NHC(=O), ON=CH; HC=NO, C(=O)O, C(=O)NH, C(=NOR14) y [CR30R31]z, en el que p se encuentra de la forma anteriormente descripta, R28 y R29 son independientemente seleccionados del H, (C1-3)alquilo, (C1-3)alquilsulfonilo, (C1-3)alquilcarbonilo, (C2-5)alquenilo, y (C2-5)alquinilo; z es un entero seleccionado de 1 o 2; y R30 y R31 son independientemente seleccionados del H y (C1-3)alquilo; y es un entero seleccionado de 0 o 1; y cuando y es 1, D se selecciona de O, S(O)p, y NR15, en el que p y R15 se encuentran de la manera anteriormente descripta, en la que D se encuentra unida a la porción del anillo de unión benzo que se estipula en la fórmula (1) en cualquiera de las posiciones designadas como 1 o 2; en el que R7, R8, R9 y R10 son independientemente seleccionados del H, halógeno, (C1-4)alquilo, (C3-6)cicloalquilo, (C2-5)alquenilo, (C2-5)alquinilo, halo(C1-4)alquilo, (C1-4)alcoxi, halo(C1-4)alcoxi, (C1-4)alquiltio, halo(C1-4)alquiltio, (C1-4)alquilsulfonilo, halo(C1-4)alquilsulfonilo, ciano, nitro, arilo, alquilcarbonilamino, arilcarbonilamino, y (C1-4)alcoxicarbonilamino; M se selecciona de -CR32R33- y -CR32R33CR34R35-, y cuando M es -CR32R33-, R32 y R33 son independientemente seleccionados del halógeno, (C1-3)alquilo, halo(C1-3)alquilo y (C1-43)alcoxi(C1-3)alquilo, y cuando M es -CR32R33CR34R35-, R32, R33, R34 y R35 son independientemente seleccionados del H, halógeno, (C1-3)alquilo, halo(C1-3)alquilo y (C1-3)alcoxi(C1-3)alquilo; y las sales de la misma que son aceptadas con fines agrícolas.
ARP040101474A 2003-04-30 2004-04-29 Derivados plaguicidas de benzodioxol y benzodioxolano sustituidos con (dihalopropenilo) fenilalquilo AR044138A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46667403P 2003-04-30 2003-04-30

Publications (1)

Publication Number Publication Date
AR044138A1 true AR044138A1 (es) 2005-08-24

Family

ID=33418411

Family Applications (4)

Application Number Title Priority Date Filing Date
ARP040101474A AR044138A1 (es) 2003-04-30 2004-04-29 Derivados plaguicidas de benzodioxol y benzodioxolano sustituidos con (dihalopropenilo) fenilalquilo
ARP040101472A AR045679A1 (es) 2003-04-30 2004-04-29 Derivados insecticidas de dihidrobenzopiran y dihidrobenzofuran sustituidos con (dihalopropenil)fenilalquilo
ARP040101473A AR044137A1 (es) 2003-04-30 2004-04-29 Derivados plaguicidas de benzotiazol y benzoxazol sustituidos con (dihalopropenil) fenilalquilo
ARP040101471A AR045678A1 (es) 2003-04-30 2004-04-29 Derivados ciclicos fenil substituidos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP040101472A AR045679A1 (es) 2003-04-30 2004-04-29 Derivados insecticidas de dihidrobenzopiran y dihidrobenzofuran sustituidos con (dihalopropenil)fenilalquilo
ARP040101473A AR044137A1 (es) 2003-04-30 2004-04-29 Derivados plaguicidas de benzotiazol y benzoxazol sustituidos con (dihalopropenil) fenilalquilo
ARP040101471A AR045678A1 (es) 2003-04-30 2004-04-29 Derivados ciclicos fenil substituidos

Country Status (16)

Country Link
US (5) US6987194B2 (es)
EP (4) EP1620421B1 (es)
JP (4) JP2006525335A (es)
KR (4) KR20060003055A (es)
CN (4) CN1780818A (es)
AR (4) AR044138A1 (es)
AT (2) ATE434612T1 (es)
AU (4) AU2004237745A1 (es)
BR (4) BRPI0409684A (es)
CA (4) CA2523191A1 (es)
DE (2) DE602004021689D1 (es)
MX (4) MXPA05011323A (es)
TW (4) TW200503618A (es)
UA (1) UA82875C2 (es)
WO (4) WO2004099145A2 (es)
ZA (4) ZA200508622B (es)

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BRPI0613535A2 (pt) * 2005-06-02 2011-01-18 Bayer Cropscience Ag derivados de heteroarila substituìda por fenilalquila
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JP4904948B2 (ja) 2006-07-04 2012-03-28 住友化学株式会社 中間体アルコール化合物の製造方法
KR100836172B1 (ko) * 2007-07-26 2008-06-09 한국생명공학연구원 아졸계 화합물을 유효성분으로 하는 살충제 조성물
US8580709B2 (en) * 2009-11-27 2013-11-12 Syngenta Crop Protection, Llc Plant growth regulation
CN102464612B (zh) * 2010-11-19 2014-12-24 中国中化股份有限公司 含哌嗪氨基甲酸酯的二卤丙烯醚类化合物与应用
WO2014172871A1 (en) * 2013-04-25 2014-10-30 Syngenta Participations Ag Dihydrobenzofuran derivatives as insecticidal compounds
CN104447677B (zh) * 2014-12-18 2016-07-06 湖南海利常德农药化工有限公司 4-羟基-2,2-二甲基-1,3-苯并二噁茂的制备方法
US20200347043A1 (en) 2019-04-30 2020-11-05 Calico Life Sciences Llc Modulators of the integrated stress pathway
CN111812229B (zh) * 2020-06-19 2023-08-01 广电计量检测(合肥)有限公司 一种气相色谱-质谱测定土壤/沉积物中2-甲基苯并噻唑的分析方法
CN113024528B (zh) * 2021-03-11 2024-01-09 西华大学 2-(2-噻吩甲酰氨基)苯并吡喃类化合物及其在农药中的用途
CN113004260B (zh) * 2021-03-11 2023-12-26 西华大学 2-(2-呋喃甲酰氨基)苯并吡喃类化合物及其在农药中的用途
CN113912592B (zh) * 2021-11-03 2023-03-10 西北农林科技大学 一种和厚朴酚并二氢呋喃酯类衍生物、制备方法及其应用

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