[go: up one dir, main page]

PE20090611A1 - Procedimiento para sintetizar compuestos utiles para tratar hepatitis c - Google Patents

Procedimiento para sintetizar compuestos utiles para tratar hepatitis c

Info

Publication number
PE20090611A1
PE20090611A1 PE2008001325A PE2008001325A PE20090611A1 PE 20090611 A1 PE20090611 A1 PE 20090611A1 PE 2008001325 A PE2008001325 A PE 2008001325A PE 2008001325 A PE2008001325 A PE 2008001325A PE 20090611 A1 PE20090611 A1 PE 20090611A1
Authority
PE
Peru
Prior art keywords
compound
procedure
formula
treat
compounds useful
Prior art date
Application number
PE2008001325A
Other languages
English (en)
Inventor
Shawn K Pack
Peng Geng
Michael J Smith
Jason Hamm
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090611(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20090611A1 publication Critical patent/PE20090611A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA UN PROCEDIMIENTO PARA SINTETIZAR UN COMPUESTO DE FORMULA (7), DONDE n ES 0-2; s ES 0-4; u Y v SON CADA UNO 0-3; X ES O, S, S(O), ENTRE OTROS; R1 Y R2 SON CADA UNO ALCOXI, ALQUILO, HALO QUE COMPRENDE: (a) REACCIONANDO UN COMPUESTO DE FORMULA (3) DONDE LG ES UN GRUPO SALIENTE TAL COMO HALURO Y UN COMPUESTO DE FORMULA (4) DONDE PG ES UN GRUPO PROTECTOR DE N TAL COMO TERCBUTOXICARBONILO; (b) TRATAR EL RPODUCTO DE LA ETAPA (a) CON UN REACTIVO TAL COMO ACETATO ARMONICO, FORMIATO AMONICO, CITRATO AMONICO, ENTRE OTROS; (c) TRATAR EL PRODUCTO DE LA ETAPA (b) CON UN AGENTE DE DESPROTECCION TAL COMO HCL. UN COMPUESTO SINTETIZADO POR DICHO METODO ES ((1S)-1-(((2S)-2-(5-(4ˆ-(2-((2S)-1-((2S)-2-((METOXICARBONIL)AMINO)-3-METILBUTANOIL)-2-PIRROLIDINIL)-2-METILPROPIL)CARBAMATO DE METILO. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE CELULAS INFECTADOS CON EL VIRUS VHC, UTILES EN EL TRATAMIENTO DE INFECCION VIRAL DE HEPATITIS C
PE2008001325A 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c PE20090611A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
PE20090611A1 true PE20090611A1 (es) 2009-05-16

Family

ID=39865546

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001325A PE20090611A1 (es) 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c

Country Status (24)

Country Link
US (1) US7728027B2 (es)
EP (1) EP2178863B1 (es)
JP (2) JP5324574B2 (es)
KR (1) KR101528542B1 (es)
CN (1) CN101778841B (es)
AR (2) AR067896A1 (es)
AU (1) AU2008284097B2 (es)
BR (1) BRPI0815611B1 (es)
CA (1) CA2695711C (es)
CL (1) CL2008002355A1 (es)
CO (1) CO6251317A2 (es)
CY (1) CY1113547T1 (es)
DK (1) DK2178863T3 (es)
EA (1) EA017173B1 (es)
ES (1) ES2396267T3 (es)
HR (1) HRP20120990T1 (es)
IL (1) IL203685A (es)
MX (1) MX2010001415A (es)
PE (1) PE20090611A1 (es)
PL (1) PL2178863T3 (es)
PT (1) PT2178863E (es)
SI (1) SI2178863T1 (es)
TW (1) TWI423963B (es)
WO (1) WO2009020825A1 (es)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8629171B2 (en) * 2007-08-08 2014-01-14 Bristol-Myers Squibb Company Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
US7728027B2 (en) * 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C
CA2715400A1 (en) 2008-02-12 2009-08-20 Bristol-Myers Squibb Company Heterocyclic derivatives as hepatitis c virus inhibitors
US7704992B2 (en) 2008-02-13 2010-04-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8147818B2 (en) 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7906655B2 (en) 2008-08-07 2011-03-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8383094B2 (en) 2008-10-01 2013-02-26 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2567047T3 (es) * 2008-12-23 2016-04-19 Abbvie Inc. Derivados de pirimidina anti-virales
SG172353A1 (en) 2008-12-23 2011-07-28 Abbott Lab Anti-viral compounds
US8394968B2 (en) 2009-02-17 2013-03-12 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI438200B (zh) 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
US8188132B2 (en) 2009-02-17 2012-05-29 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8242156B2 (en) 2009-02-17 2012-08-14 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
UY32462A (es) * 2009-02-23 2010-09-30 Arrow Therapeutics Ltd Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
US9765087B2 (en) 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
JP5628841B2 (ja) 2009-02-27 2014-11-19 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルスインヒビター
US8101643B2 (en) 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8673954B2 (en) 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8507522B2 (en) 2009-03-06 2013-08-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
MX2011010132A (es) * 2009-03-27 2011-10-14 Presidio Pharmaceuticals Inc Inhibidores de anillo fusionado de hepatitis c.
US8796466B2 (en) 2009-03-30 2014-08-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201038559A (en) 2009-04-09 2010-11-01 Bristol Myers Squibb Co Hepatitis C virus inhibitors
US8143414B2 (en) 2009-04-13 2012-03-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
RU2541571C2 (ru) * 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
KR101727876B1 (ko) 2009-05-13 2017-04-17 길리애드 파마셋 엘엘씨 항바이러스 화합물
US8211928B2 (en) 2009-05-29 2012-07-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8138215B2 (en) 2009-05-29 2012-03-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
EP2853531A3 (en) * 2009-06-11 2015-08-12 AbbVie Bahamas Ltd. Antiviral compounds
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8221737B2 (en) 2009-06-16 2012-07-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8609648B2 (en) 2009-07-02 2013-12-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
IN2012DN00999A (es) 2009-07-16 2015-04-10 Vertex Pharma
KR20120076343A (ko) 2009-09-04 2012-07-09 글락소스미스클라인 엘엘씨 화합물
US8822700B2 (en) 2009-09-11 2014-09-02 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8703938B2 (en) 2009-09-11 2014-04-22 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8759332B2 (en) 2009-09-11 2014-06-24 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8927709B2 (en) 2009-09-11 2015-01-06 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US9156818B2 (en) 2009-09-11 2015-10-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8815928B2 (en) 2009-09-11 2014-08-26 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8415374B2 (en) 2009-10-12 2013-04-09 Bristol-Myers Squibb Company Combinations of hepatitis C virus inhibitors
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110269956A1 (en) * 2009-11-11 2011-11-03 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110281910A1 (en) 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110137633A1 (en) * 2009-12-03 2011-06-09 Abbott Laboratories Anti-viral compounds and methods of identifying the same
CA2781140C (en) * 2009-12-04 2017-10-24 National Health Research Institutes Proline derivatives for use to treat hepatitis c infection
WO2011081918A1 (en) 2009-12-14 2011-07-07 Enanta Pharmaceuticals, Inc Hepatitis c virus inhibitors
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN102791687B (zh) * 2009-12-18 2015-02-11 北京凯因科技股份有限公司 C型肝炎病毒复制的新型抑制剂
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MA34013B1 (fr) 2010-01-25 2013-02-01 Enanta Pharm Inc Inhibiteurs du virus de l'hépatite c
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8178531B2 (en) 2010-02-23 2012-05-15 Enanta Pharmaceuticals, Inc. Antiviral agents
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
EA201201235A1 (ru) 2010-03-04 2013-04-30 Энанта Фармасьютиклз, Инк. Комбинации фармацевтических агентов в качестве ингибиторов репликации hcv
AU2011232331A1 (en) 2010-03-24 2012-10-11 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of Flavivirus infections
WO2011127350A1 (en) 2010-04-09 2011-10-13 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US8778938B2 (en) 2010-06-04 2014-07-15 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
WO2012006055A2 (en) 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
EP2585448A1 (en) 2010-06-28 2013-05-01 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
WO2012021704A1 (en) 2010-08-12 2012-02-16 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US20120195857A1 (en) * 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
AU2011292040A1 (en) 2010-08-17 2013-03-07 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of Flaviviridae viral infections
EP2963034A1 (en) 2010-08-26 2016-01-06 RFS Pharma, LLC. Potent and selective inhibitors of hepatitis c virus
CA2815537A1 (en) 2010-10-26 2012-05-03 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus
RU2452735C1 (ru) 2010-11-30 2012-06-10 Александр Васильевич Иващенко Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9546160B2 (en) 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
EP2709455A4 (en) 2011-05-18 2014-11-05 Enanta Pharm Inc PROCESSES FOR THE PREPARATION OF 5-AZASPIRO [2.4] HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES
WO2013016499A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Methods for preparation of thiophene compounds
AR087346A1 (es) 2011-07-26 2014-03-19 Vertex Pharma Formulaciones de compuestos de tiofeno
WO2013030750A1 (en) 2011-09-01 2013-03-07 Lupin Limited Antiviral compounds
KR20190075142A (ko) 2011-09-16 2019-06-28 길리애드 파마셋 엘엘씨 Hcv 치료 방법
SG2014011670A (en) 2011-10-21 2014-10-30 Abbvie Inc Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
SG2014011647A (en) 2011-10-21 2014-08-28 Abbvie Inc Methods for treating hcv comprising at least two direct acting antiviral agent, ribavirin but not interferon.
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CA2862755A1 (en) 2012-02-10 2013-08-15 Lupin Limited Antiviral compounds with a dibenzooxaheterocycle moiety
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
HUE047777T2 (hu) 2013-01-31 2020-05-28 Gilead Pharmasset Llc Két vírusellenes vegyület kombinációs készítménye
RU2507201C1 (ru) 2013-02-07 2014-02-20 Александр Васильевич Иващенко Алкил [(s)-1-((s)-2-{5-[4-(4-{2-[(s)-1-((s)-2-метоксикарбониламино-3-метил-бутирил)-пирролидин-2-ил]-3н-имидазол-4-ил}-бута-1,3-диинил)-фенил]-1н-имидазол-2-ил}-пирролидин-1-карбонил)-2-метил-пропил]-карбамат нафталин-1,5-дисульфонат, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TW201526899A (zh) 2013-02-28 2015-07-16 Alios Biopharma Inc 醫藥組成物
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
EP3019196B1 (en) 2013-07-09 2018-06-06 Bristol-Myers Squibb Company Combinations of hepatitis c virus inhibitors
CN105530933B (zh) 2013-07-17 2018-12-11 百时美施贵宝公司 用于治疗hcv的包含联苯衍生物的组合产品
EP3650014B1 (en) 2013-08-27 2021-10-06 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
CN104774194B (zh) * 2014-01-09 2018-01-30 正大天晴药业集团股份有限公司 氘代的丙型肝炎病毒抑制剂
CN106279122A (zh) * 2014-01-21 2017-01-04 杭州普晒医药科技有限公司 一种化合物的盐及晶型或无定型物、其制备方法、含有它们的药物组合物和用途
CN105524049B (zh) * 2014-09-28 2018-11-06 正大天晴药业集团股份有限公司 氘代的丙型肝炎病毒ns5a蛋白抑制剂
WO2016079697A1 (en) * 2014-11-19 2016-05-26 Sun Pharmaceutical Industries Limited Process for the preparation of an intermediate of daclatasvir dihydrochloride
WO2016089814A1 (en) 2014-12-02 2016-06-09 Concert Pharmaceuticals, Inc. Deuterated analogues of daclatasvir
CN105753944B (zh) * 2014-12-19 2019-10-01 正大天晴药业集团股份有限公司 达卡他韦及其衍生物的制备中间体
CN105985227A (zh) * 2015-02-06 2016-10-05 上海特化医药科技有限公司 4,4’-二卤乙酰联苯的制备及应用
CN106188015B (zh) * 2015-05-06 2019-10-18 广东东阳光药业有限公司 一种制备达卡他韦的方法
WO2016178250A1 (en) * 2015-05-07 2016-11-10 Mylan Laboratories Limited Process for the preparation of daclatasvir
CZ2015366A3 (cs) * 2015-05-29 2016-12-07 Zentiva, K.S. Pevné formy Daclatasviru
WO2017021904A1 (en) * 2015-08-03 2017-02-09 Laurus Labs Private Limited Daclatasvir free base and process for the preparation thereof
US10617675B2 (en) 2015-08-06 2020-04-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN105461701A (zh) * 2015-12-14 2016-04-06 上海步越化工科技有限公司 一种抗丙肝新药达卡他韦新的合成方法
CN105622583A (zh) * 2015-12-22 2016-06-01 苏州步跃医药科技有限公司 一种抗丙肝新药达卡他韦新的制备方法
CN105753844A (zh) * 2016-02-16 2016-07-13 江苏苏利精细化工股份有限公司 一种合成二氨基甲酸二甲酯二盐酸盐类化合物的新方法
CN107235884B (zh) * 2016-03-29 2021-03-26 上海医药工业研究院 一种达卡他韦中间体及其制备方法
CN107235965A (zh) * 2016-03-29 2017-10-10 上海医药工业研究院 一种达卡他韦的制备方法
CN105777719A (zh) * 2016-03-29 2016-07-20 安徽联创生物医药股份有限公司 一种达卡他韦的合成方法
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
CN106256825A (zh) * 2016-07-04 2016-12-28 四川同晟生物医药有限公司 达卡他韦的合成方法
US20190256498A1 (en) * 2016-07-08 2019-08-22 Lupin Limited Crystalline forms of daclatasvir dihydrochloride
CN106432204A (zh) * 2016-09-12 2017-02-22 上海步越化工科技有限公司 一种抗丙肝达卡他韦的合成方法
CN106496199A (zh) * 2016-10-19 2017-03-15 上海博志研新药物技术有限公司 达卡他韦及其中间体的制备方法
CN108069941A (zh) * 2016-11-15 2018-05-25 广东东阳光药业有限公司 一种制备达卡他韦的方法
CN109305962B (zh) * 2017-07-28 2022-01-18 扬子江药业集团有限公司 一种盐酸达拉他韦的精制方法
CN107501243A (zh) * 2017-09-08 2017-12-22 安徽灵药业有限公司 一种达卡他韦的合成方法
EP3891508A1 (en) 2018-12-04 2021-10-13 Bristol-Myers Squibb Company Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring
US11442659B2 (en) 2019-11-20 2022-09-13 International Business Machines Corporation Reading sequentially stored files based on read ahead groups
JP7723119B2 (ja) 2021-05-21 2025-08-13 ギリアード サイエンシーズ， インコーポレイテッド ジカウイルス感染症の治療のための四環系化合物
JP7725617B2 (ja) 2021-05-21 2025-08-19 ギリアード サイエンシーズ， インコーポレイテッド ジカウイルス阻害剤としての五環式誘導体

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
EP0679153A4 (en) 1993-01-14 1996-05-15 Magainin Pharma FINALLY MODIFIED AMINO ACIDS AND PEPTIDES.
US5654451B1 (en) 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
WO2006093867A1 (en) 2005-02-28 2006-09-08 The Rockefeller University Structure of the hepatitits c virus ns5a protein
US8143288B2 (en) 2005-06-06 2012-03-27 Bristol-Myers Squibb Company Inhibitors of HCV replication
PT1940786E (pt) 2005-09-16 2010-10-04 Arrow Therapeutics Ltd Derivados de bifenilo e sua utilização no tratamento de hepatite c
WO2007058384A1 (en) 2005-11-17 2007-05-24 Osaka University Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same
SG133452A1 (en) 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
EP2038253A1 (en) 2006-05-30 2009-03-25 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
US7759495B2 (en) 2006-08-11 2010-07-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2008133753A2 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
US7728027B2 (en) * 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C

Also Published As

Publication number Publication date
SI2178863T1 (sl) 2013-02-28
US7728027B2 (en) 2010-06-01
EA017173B1 (ru) 2012-10-30
CY1113547T1 (el) 2016-06-22
IL203685A (en) 2015-04-30
JP5324574B2 (ja) 2013-10-23
CL2008002355A1 (es) 2009-01-02
AR067896A1 (es) 2009-10-28
CA2695711A1 (en) 2009-02-12
MX2010001415A (es) 2010-03-01
ES2396267T3 (es) 2013-02-20
CO6251317A2 (es) 2011-02-21
EA201000300A1 (ru) 2010-06-30
EP2178863B1 (en) 2012-10-24
KR101528542B1 (ko) 2015-06-15
PT2178863E (pt) 2013-01-14
BRPI0815611B1 (pt) 2018-08-21
AU2008284097A1 (en) 2009-02-12
JP2010535784A (ja) 2010-11-25
AU2008284097B2 (en) 2013-01-10
PL2178863T3 (pl) 2013-03-29
JP2013231072A (ja) 2013-11-14
US20090043107A1 (en) 2009-02-12
CA2695711C (en) 2014-09-09
EP2178863A1 (en) 2010-04-28
AR106929A2 (es) 2018-02-28
KR20100045992A (ko) 2010-05-04
WO2009020825A1 (en) 2009-02-12
BRPI0815611A2 (pt) 2015-03-24
HK1137454A1 (en) 2010-07-30
TW200914441A (en) 2009-04-01
TWI423963B (zh) 2014-01-21
CN101778841A (zh) 2010-07-14
CN101778841B (zh) 2015-07-22
HRP20120990T1 (hr) 2012-12-31
DK2178863T3 (da) 2013-02-11

Similar Documents

Publication Publication Date Title
PE20090611A1 (es) Procedimiento para sintetizar compuestos utiles para tratar hepatitis c
PE20120258A1 (es) Derivados de bencimidazol-pirrolidina como inhibidores del virus de la hepatitis c
NZ594981A (en) Hepatitis c virus inhibitors
PE20130385A1 (es) Derivados del acido naft-2-ilacetico para tratar el sida
NZ601220A (en) Hepatitis c virus inhibitors
JP2011219498A5 (es)
NZ600505A (en) Hepatitis c virus inhibitors
JPWO2019155399A5 (es)
PE20040898A1 (es) Nuevos compuestos derivados de pirimidina
PE20090630A1 (es) Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion
JP2010527368A5 (es)
EA200500846A1 (ru) Замещенные арилтиомочевины и родственные соединения; ингибиторы вирусной репликации
JP2012523457A5 (es)
BRPI0412851A (pt) benzamidazóis de n-metila-substituìdos
MX2009012613A (es) Tiazoles substituidos por heteroarilo y su uso como agentes antivirales.
MY148145A (en) Methods of synthesis and/or purification of diaminophenothiazinium compounds
NZ609146A (en) Modified 4’-nucleosides as antiviral agents
PE20090618A1 (es) Compuestos para el tratamiento de hepatitis c
JP2010527913A5 (es)
EA201300494A1 (ru) Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения
RU2014145819A (ru) Бициклическое соединение
NO20052580L (no) Blandinger for behandling av infeksjon av Flavivirida viruser
JP2006515613A5 (es)
RU2009134516A (ru) Фармацевтическая композиция, содержащая производное пиразина, и способ применения производного пиразина в комбинации
NZ611410A (en) Alkylsulfinyl-substituted thiazolide compounds

Legal Events

Date Code Title Description
FD Application declared void or lapsed