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AR032065A1 - Derivados de glucopiranosiloxipirazol y composicion farmaceutica - Google Patents

Derivados de glucopiranosiloxipirazol y composicion farmaceutica

Info

Publication number
AR032065A1
AR032065A1 ARP010106053A ARP010106053A AR032065A1 AR 032065 A1 AR032065 A1 AR 032065A1 AR P010106053 A ARP010106053 A AR P010106053A AR P010106053 A ARP010106053 A AR P010106053A AR 032065 A1 AR032065 A1 AR 032065A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
hydrogen atom
alkyl group
halo
Prior art date
Application number
ARP010106053A
Other languages
English (en)
Inventor
Hodeki Fujikura
Nobuhiko Fushimi
Toshiro Nishimura
Takeshi Nakabayashi
Masahuki Isaji
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18867638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR032065(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of AR032065A1 publication Critical patent/AR032065A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente proporciona derivados de glucopiranosiloxipirazol representados por la formula general (1), donde R representa un átomo de hidrogeno, un grupo alquilo inferior o un grupo formador de un profármaco; uno de Q y T representa un grupo de la formula general (2), donde P representa un átomo de hidrogeno o un grupo formador de un profármaco, mientras el otro representa un grupo alquilo inferior o un grupo halo (alquilo inferior); R2 representa un átomo de hidrogeno, un grupo alquilo inferior, un grupo alcoxi inferior, un grupo alquiltio inferior, un grupo halo (alquilo inferior) o un átomo de halogeno; y con la condicion de que P no represente un átomo de hidrogeno cuando R representa un átomo de hidrogeno o un grupo alquilo inferior, o sales farmacéuticamente aceptables de los mismos, los cuales ejercen una actividad inhibidora en SGLT2 humano y tienen una absorcion oral mejorada, y por lo tanto son utiles como agentes para la prevencion o tratamiento de una enfermedad asociada con la hiperglicemia tal como diabetes, complicaciones diabéticas u obesidad, y sales farmacéuticamente aceptables de los mismos, y los usos farmacéuticos de los mismos.
ARP010106053A 2000-12-28 2001-12-27 Derivados de glucopiranosiloxipirazol y composicion farmaceutica AR032065A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000403534 2000-12-28

Publications (1)

Publication Number Publication Date
AR032065A1 true AR032065A1 (es) 2003-10-22

Family

ID=18867638

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010106053A AR032065A1 (es) 2000-12-28 2001-12-27 Derivados de glucopiranosiloxipirazol y composicion farmaceutica

Country Status (30)

Country Link
US (5) US7084123B2 (es)
EP (1) EP1354888B1 (es)
JP (2) JP4035052B2 (es)
KR (1) KR100701437B1 (es)
CN (1) CN1238363C (es)
AR (1) AR032065A1 (es)
AT (1) ATE431830T1 (es)
AU (1) AU2002225356B2 (es)
BR (1) BRPI0116607B8 (es)
CA (1) CA2432145C (es)
CY (1) CY1109309T1 (es)
CZ (1) CZ305971B6 (es)
DE (1) DE60138768D1 (es)
DK (1) DK1354888T3 (es)
ES (1) ES2326158T3 (es)
HU (1) HU228915B1 (es)
IL (2) IL156678A0 (es)
MX (1) MXPA03005923A (es)
MY (1) MY136581A (es)
NO (1) NO326410B1 (es)
NZ (1) NZ526715A (es)
PE (1) PE20020722A1 (es)
PL (1) PL209375B1 (es)
PT (1) PT1354888E (es)
RU (1) RU2317302C2 (es)
SI (1) SI1354888T1 (es)
SK (1) SK287786B6 (es)
TW (1) TWI231298B (es)
WO (1) WO2002053573A1 (es)
ZA (1) ZA200304905B (es)

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