AR030936A1 - Derivados de (tio)urea inhibitorios de factor viia, un proceso para su preparacion y su uso - Google Patents
Derivados de (tio)urea inhibitorios de factor viia, un proceso para su preparacion y su usoInfo
- Publication number
- AR030936A1 AR030936A1 ARP010102657A ARP010102657A AR030936A1 AR 030936 A1 AR030936 A1 AR 030936A1 AR P010102657 A ARP010102657 A AR P010102657A AR P010102657 A ARP010102657 A AR P010102657A AR 030936 A1 AR030936 A1 AR 030936A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- aryl
- alkoxy
- aminocarbonyl
- Prior art date
Links
- 229940012414 factor viia Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 7
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 7
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 5
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- -1 cyano, hydroxy Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 108010054265 Factor VIIa Proteins 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 4
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052760 oxygen Chemical group 0.000 abstract 4
- 239000001301 oxygen Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 239000011593 sulfur Substances 0.000 abstract 4
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000005974 C6-C14 arylcarbonyl group Chemical group 0.000 abstract 1
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 abstract 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005141 aryl amino sulfonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000001112 coagulating effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- SSGGNFYQMRDXFH-UHFFFAOYSA-N sulfanylurea Chemical compound NC(=O)NS SSGGNFYQMRDXFH-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados de (tio)urea inhibitorios de factor VIIa, que comprende compuestos de la formula (1) en la cual: m es 0, 1, 2, 3, o 4; n es 0, 1, 2, o 3; A es halogeno; X es azufre u oxígeno; R1 se selecciona entre hidrogeno, hidroxi, alcoxicarbonilo C1-12, aril C6-14-alcoxicarbonilo C1-4 y ariloxicarbonilo C6-14, donde cada uno de los grupos arilo es insustituido o sustituido con uno o más sustituyentes idénticos o diferentes seleccionados entre alquilo C1-12, halogeno y alcoxi C1-12; R2 se selecciona entre hidrogeno, alquilo C1-12, arilo C6-14, arilo C6-14-alquilo C1-4, R20-alquilo C1-12, R20-arilo C6-14 y R20-arilo C6-14-alquilo C1-4, donde R20 se selecciona entre hidroxicarbonilo, aminocarbonilo, alcoxicarbonilo C1-12 y arilo C6-14-alcoxicarbonilo C1-4; R3 se selecciona entre hidrogeno, ciano, hidroxi y alquilo C1-12; R4 se selecciona entre alquilo C1-12, arilo C6-14, arilo C6-14-alquilo C1-4, Het y Het-alquilo C1-4, donde los grupos alquilo, arilo y Het son insustituidos o sustituidos con uno o más sustituyentes idénticos o diferentes R10; R5 se selecciona entre hidrogeno, alquilo C1-12, arilo C6-14, arilo C6-14-alquilo C1-4, Het, Het-alquilo C1-4, arilo C6-14-alquilo C1-4-aminocarbonilo y Het-alquilo C1-4-aminocarbonilo, donde los grupos alquilo, arilo y Het son insustituidos o sustituidos con uno o más sustituyentes idénticos o diferentes R10; o R4 y R5 junto con el átomo de C al cual están enlazados forman un anillo de 3-8 miembros, saturado o insaturado, que es un anillo carbocíclico o un anillo heterocíclico que contiene 1, 2 o 3 heteroátomos de anillo idénticos o diferente, seleccionados entre nitrogeno, oxígeno y azufre, y que puede ser condensado a uno o dos sistemas de anillo heterocíclico o sistemas de anillo carbocíclico saturado o insaturado que contienen 5 a 10 átomos de anillo, de los cuales 1, 2 o 3 pueden ser heteroátomos de anillo idénticos o diferentes seleccionados entre nitrogeno, oxígeno y azufre, donde el grupo R4(R5)C resultante es insustituido o sustituido con uno o más sustituyentes idénticos o diferentes R10; R6 se selecciona entre hidrogeno, hidroxi, alcoxi C1-8 y arilo C6-14-alcoxi C1-4; R10 se selecciona entre alquilo C1-12, arilo C6-14-alquilo C1-4, alcoxi C1-8, alcoxi C1-4-alcoxi C2-4, arilo C6-14-alcoxi C1-4, ariloxi C6-14, Het-oxi, Het-alcoxi C1-4, arilo C6-14, Het, Het-alquilo C1-4, trifluorometoxi, trifluorometilo, halogeno, oxo, hidroxi, amino, alquilcarbonilamino C1-12, aminocarbonilamino, arilcarbonilamino C6-14, Het-carbonilamino, arilo C6-14-alquilcarbonilamino C1-4, Het-alquilcarbonilamino C1-4, alquilcarbonilo C1-8, arilcarbonilo C6-14, alquilaminocarbonilo C1-8, arilaminocarbonilo C6-14, arilo C6-14-alquilaminocarbonilo C1-4, Het-aminocarbonilo, Het-alquilaminocarbonilo C1-4, aminocarbonilo, alcoxicarbonilo C1-8, hidroxicarbonilo, ciano, nitro, amidino, acetimino, tri-(alquilo C1-4)amonio, alquilamino C1-8, di-(alquilo C1-8)amino, hidroxicarbonilmetoxi, alquilsulfonilo C1-8, arilsulfonilo C6-14, alquilaminosulfonilo C1-8, arilaminosulfonilo C6-14, arilo C6-14-alquilaminosulfonilo C1-4, Het-aminosulfonilo, Het-alquilaminosulfonilo C1-4, alquilsulfonilamino C1-8, arilsulfonilamino C6-14, arilo C6-14-alquilsulfonilamino C1-4, Het-sulfonilamino y Het-alquilsulfonilamino C1-4, donde alquilcarbonilamino representando R10 es insustituido o sustituido en el grupo alquilo con un sustituyente seleccionado entre amino, hidroxi y alcoxi C1-4, y donde alquilo C1-12 y alcoxi C1-8 representando R10 son insustituidos o sustituidos con uno o más sustituyentes idénticos o diferentes seleccionados entre alcoxicarbonilo C1-8, hidroxicarbonilo y aminocarbonilo, donde cada uno de los grupos arilo y grupo Het en un grupo R10 es insustituido o sustituido con uno o más sustituyentes idénticos o diferentes seleccionados entre halogeno, nitro, oxo, hidroxi, alquilo C1-8, alcoxi C1-8, alcoxi C1-4-alcoxi C2-4, ariloxi C6-14, arilo C6-14-alcoxi C1-4, Het-oxi, Het-alcoxi C1-4, arilo C6-14, arilo C6-14-alquilo C1-4, Het, Het-alquilo C1-4, trifluorometilo, ciano, trifluorometoxi, alquilsulfonilo C1-8, alcoxicarbonilo C1-8, hidroxicarbonilo, aminocarbonilo, amino, alquilamino C1-8, di-(alquilo C1-8)amino, alquilcarbonilamino C1-8, arilo C6-14-alquilcarbonilamino C1-4, arilcarbonilamino C6-14, Het-carbonilamino, Het-alquilcarbonilamino C1-4 y alquilcarbonilo C1-8, donde alquilo C1-8 y alcoxi C1-8 representando un sustituyente en un grupo arilo o grupo Het en un grupo R10, son insustituidos o sustituidos con uno o más sustituyentes idénticos o diferentes seleccionados entre alcoxicarbonilo C1-8, hidroxicarbonilo y aminocarbonilo; con la condicion que, cuando un sustituyente R10 está enlazado a un grupo alquilo, no puede ser alcoxicarbonilo C1-8, hidroxicarbonilo, aminocarbonilo, alquilaminocarbonilo C1-8, o alquilaminosulfonilo C1-8, y que, cuando un sustituyente R10 está enlazado a un grupo alquilo, no puede ser alquilo C1-8 que es sustituido con uno o más sustituyentes idénticos o diferentes seleccionados entre alcoxicarbonilo C1-8, hidroxicarbonilo y aminocarbonilo; Het es un residuo de un sistema de anillo heterocíclico de 3-10 miembros, monocíclico o bicíclico, saturado o insaturado, que contiene 1, 2 o 3 heteroátomos de anillo idénticos o diferentes seleccionados entre nitrogeno, oxígeno y azufre; en todas sus formas estereoisoméricas y mezclas de las mismas en cualquier relacion, y sus sales fisiologicamente tolerables. Los compuestos de la formula (1) son compuestos farmacologicamente activos de valor. Exhiben un fuerte efecto antitrombotico y son adecuados, por ejemplo, para la terapia y profilaxis de enfermedades tromboembolicas y restenosis. Son inhibidores reversibles de la enzima coagulante sanguínea factor VIIa, y en general pueden aplicarse en condiciones en las cuales está presente una actividad indeseada de factor VIIa, o para la curacion o prevencion de las cuales se propone una inhibicion de factor VIIa. Además se relaciona con procesos para la preparacion de compuestos de formula (1), con su uso, en particular como ingredientes activos en productos farmacéuticos, y con preparaciones farmacéuticas que comprenden los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00112116A EP1162194A1 (en) | 2000-06-06 | 2000-06-06 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030936A1 true AR030936A1 (es) | 2003-09-03 |
Family
ID=8168926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102657A AR030936A1 (es) | 2000-06-06 | 2001-06-04 | Derivados de (tio)urea inhibitorios de factor viia, un proceso para su preparacion y su uso |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6743790B2 (es) |
| EP (2) | EP1162194A1 (es) |
| JP (1) | JP4809570B2 (es) |
| KR (1) | KR101011345B1 (es) |
| CN (1) | CN1208314C (es) |
| AR (1) | AR030936A1 (es) |
| AU (2) | AU7749401A (es) |
| BR (1) | BR0111264A (es) |
| CA (1) | CA2410862C (es) |
| CZ (1) | CZ20023963A3 (es) |
| DE (1) | DE60139320D1 (es) |
| DK (1) | DK1299354T3 (es) |
| EE (1) | EE200200617A (es) |
| ES (1) | ES2330412T3 (es) |
| HR (1) | HRP20020961A2 (es) |
| HU (1) | HUP0301631A2 (es) |
| IL (2) | IL153220A0 (es) |
| MX (1) | MXPA02009789A (es) |
| MY (1) | MY129363A (es) |
| NO (1) | NO328546B1 (es) |
| NZ (1) | NZ522960A (es) |
| PL (1) | PL359584A1 (es) |
| PT (1) | PT1299354E (es) |
| RU (1) | RU2286337C2 (es) |
| SK (1) | SK17032002A3 (es) |
| TW (1) | TWI283662B (es) |
| WO (1) | WO2001094301A2 (es) |
| YU (1) | YU89202A (es) |
| ZA (1) | ZA200209018B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4567439B2 (ja) * | 2002-04-27 | 2010-10-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | カルボン酸アミド |
| AU2003265398A1 (en) * | 2002-08-09 | 2004-02-25 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| US7273886B2 (en) * | 2003-05-20 | 2007-09-25 | Genentech, Inc. | Benzofuran inhibitors of factor VIIa |
| US7250447B2 (en) * | 2003-05-20 | 2007-07-31 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
| WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| CA2531796A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| EP1810965A4 (en) * | 2004-10-13 | 2009-10-28 | Eisai R&D Man Co Ltd | HYDRAZIDE DERIVATIVES |
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| EP1855722A2 (en) * | 2005-02-24 | 2007-11-21 | Novo Nordisk Health Care AG | Compounds for stabilizing factor vii polypeptide formulations |
| US20090130085A1 (en) * | 2005-02-24 | 2009-05-21 | Novo Nordish Healthcare Ag | Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations |
| WO2006089953A1 (en) * | 2005-02-24 | 2006-08-31 | Novo Nordisk Health Care Ag | Compounds for stabilizing factor vii polypeptide formulations |
| EP1893632B1 (en) | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine |
| PT2000465E (pt) | 2006-03-24 | 2011-02-10 | Eisai R&D Man Co Ltd | Derivado de triazolona |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| US8791264B2 (en) * | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| WO2007118854A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
| US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| JPWO2009038157A1 (ja) * | 2007-09-21 | 2011-01-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ２，３−ジヒドロ−イミノイソインドール誘導体 |
| WO2009040659A2 (en) * | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| AU2012329098B2 (en) | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| CA2870356A1 (en) * | 2012-04-16 | 2013-10-24 | Allergan, Inc. | (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators |
| WO2014057069A1 (en) * | 2012-10-10 | 2014-04-17 | Novo Nordisk Health Care Ag | Liquid pharmaceutical composition of factor vii polypeptide |
| BR112015021392B1 (pt) | 2013-03-06 | 2021-11-16 | Allergan, Inc | Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas |
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| US5273982A (en) * | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
| US5506134A (en) | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| JPH06505978A (ja) * | 1991-02-05 | 1994-07-07 | スミスクライン・ビーチャム・コーポレイション | 芳香族エステルまたはアミドを含有する抗凝集性ペプチド |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| JP3387948B2 (ja) * | 1992-12-04 | 2003-03-17 | 富山化学工業株式会社 | 新規なフェニルアラニン誘導体またはその塩 |
| US5314902A (en) | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| DE4309867A1 (de) * | 1993-03-26 | 1994-09-29 | Cassella Ag | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| GB9313269D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Allophanic acid derivatives |
| WO1995008550A1 (en) * | 1993-09-24 | 1995-03-30 | Abbott Laboratories | Endothelin antagonists |
| US5707994A (en) * | 1993-10-19 | 1998-01-13 | Sumitomo Pharmaceuticals Company, Limited | 2,3-diaminopropionic acid derivative |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| AU712504B2 (en) * | 1996-01-30 | 1999-11-11 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CN1279668A (zh) * | 1997-11-18 | 2001-01-10 | 帝人株式会社 | 环胺衍生物及其作为药物的用途 |
| EP0987274A1 (en) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
-
2000
- 2000-06-06 EP EP00112116A patent/EP1162194A1/en not_active Withdrawn
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2001
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- 2001-05-26 DE DE60139320T patent/DE60139320D1/de not_active Expired - Lifetime
- 2001-05-26 HU HU0301631A patent/HUP0301631A2/hu unknown
- 2001-05-26 EE EEP200200617A patent/EE200200617A/xx unknown
- 2001-05-26 AU AU7749401A patent/AU7749401A/xx active Pending
- 2001-05-26 DK DK01955291T patent/DK1299354T3/da active
- 2001-05-26 EP EP01955291A patent/EP1299354B1/en not_active Expired - Lifetime
- 2001-05-26 HR HRP20020961 patent/HRP20020961A2/hr not_active Application Discontinuation
- 2001-05-26 ES ES01955291T patent/ES2330412T3/es not_active Expired - Lifetime
- 2001-05-26 PL PL01359584A patent/PL359584A1/xx not_active Application Discontinuation
- 2001-05-26 WO PCT/EP2001/006029 patent/WO2001094301A2/en not_active Ceased
- 2001-05-26 SK SK1703-2002A patent/SK17032002A3/sk not_active Application Discontinuation
- 2001-05-26 YU YU89202A patent/YU89202A/sh unknown
- 2001-05-26 KR KR1020027016691A patent/KR101011345B1/ko not_active Expired - Fee Related
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- 2001-05-26 AU AU2001277494A patent/AU2001277494B2/en not_active Ceased
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- 2001-05-26 JP JP2002501818A patent/JP4809570B2/ja not_active Expired - Fee Related
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- 2001-05-26 RU RU2002135308/04A patent/RU2286337C2/ru not_active IP Right Cessation
- 2001-05-26 PT PT01955291T patent/PT1299354E/pt unknown
- 2001-06-04 TW TW090113412A patent/TWI283662B/zh not_active IP Right Cessation
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